Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.47626/2237-6089-2020-0078 http://hdl.handle.net/11449/223298 |
Resumo: | INTRODUCTION: Schizophrenia is a complex psychiatric disorder that affects approximately twenty million people worldwide. Various factors have been associated with the physiopathology of this disease such as oxidative stress, which is an imbalance between pro-oxidant and antioxidant molecules. OBJECTIVE: This study evaluated the association between biomarkers of oxidative stress and response to pharmacological treatment among patients with schizophrenia in the context of their clinical information, demographic data, and lifestyle. METHODS: A total of 89 subjects were included, 26 of whom were treatment-responsive schizophrenia patients (Group 1), 27 treatment-resistant schizophrenia patients (Group 2), and 36 healthy controls (Group 3). All of the subjects completed a questionnaire to provide clinical and demographic data, and all provided peripheral blood samples. The oxidative stress markers analyzed using spectrophotometry were catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), total glutathione (GSH-t), malondialdehyde (MDA), and Trolox-equivalent antioxidant capacity (TEAC; p < 0.05). RESULTS: When all schizophrenia patients (G1 + G2) were compared to the control group, SOD levels were found to be lower among schizophrenia patients (p < 0.0001), while MDA and CAT levels were higher (p < 0.0001 and p = 0.0191, respectively). GPx, GSH-t, and TEAC levels were similar in all three groups (p > 0.05). CONCLUSION: Lower SOD levels and higher MDA and CAT levels indicate oxidative damage in schizophrenia patients, regardless of their response to pharmacological treatment. Smoking is associated with oxidative stress, in addition, a family history of the disease was also found to be correlated with cases of schizophrenia, which reflects the relevance of genetics in disease development. |
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Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patientsantioxidantsfree radicalsoxidative stressPsychotic disorderstreatment resistanceINTRODUCTION: Schizophrenia is a complex psychiatric disorder that affects approximately twenty million people worldwide. Various factors have been associated with the physiopathology of this disease such as oxidative stress, which is an imbalance between pro-oxidant and antioxidant molecules. OBJECTIVE: This study evaluated the association between biomarkers of oxidative stress and response to pharmacological treatment among patients with schizophrenia in the context of their clinical information, demographic data, and lifestyle. METHODS: A total of 89 subjects were included, 26 of whom were treatment-responsive schizophrenia patients (Group 1), 27 treatment-resistant schizophrenia patients (Group 2), and 36 healthy controls (Group 3). All of the subjects completed a questionnaire to provide clinical and demographic data, and all provided peripheral blood samples. The oxidative stress markers analyzed using spectrophotometry were catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), total glutathione (GSH-t), malondialdehyde (MDA), and Trolox-equivalent antioxidant capacity (TEAC; p < 0.05). RESULTS: When all schizophrenia patients (G1 + G2) were compared to the control group, SOD levels were found to be lower among schizophrenia patients (p < 0.0001), while MDA and CAT levels were higher (p < 0.0001 and p = 0.0191, respectively). GPx, GSH-t, and TEAC levels were similar in all three groups (p > 0.05). CONCLUSION: Lower SOD levels and higher MDA and CAT levels indicate oxidative damage in schizophrenia patients, regardless of their response to pharmacological treatment. Smoking is associated with oxidative stress, in addition, a family history of the disease was also found to be correlated with cases of schizophrenia, which reflects the relevance of genetics in disease development.Hospital de Base Faculdade de Medicina de São José do Rio Preto (FAMERP)FAMERPUniversidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Universidade Paulista (UNIP), São José do Rio Preto, SP, BrazilUniversidade Estadual Paulista São José do Rio Preto Campus (UNESP), Instituto de Biociencias Letras e Ciencias Exatas Campus de São José do Rio Preto (IBILCE)Departamento de Ciências Naturais Universidade Regional de Blumenau (FURB) SCUniversidade Estadual Paulista São José do Rio Preto Campus (UNESP), Instituto de Biociencias Letras e Ciencias Exatas Campus de São José do Rio Preto (IBILCE)Faculdade de Medicina de São José do Rio Preto (FAMERP)FAMERPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)SCBuosi, PatrickBorghi, Fábio AparecidoLopes, Angélica MartaFacincani, Isabela da SilvaFernandes-Ferreira, RafaelOliveira-Brancati, Camila Ive Ferreirado Carmo, Tayanne SilvaSouza, Dorotéia Rossi Silvada Silva, Danilo Grünig Humberto [UNESP]de Almeida, Eduardo Grünig Humbertode Araújo Filho, Gerardo Maria2022-04-28T19:49:45Z2022-04-28T19:49:45Z2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article278-285http://dx.doi.org/10.47626/2237-6089-2020-0078Trends in psychiatry and psychotherapy, v. 43, n. 4, p. 278-285, 2021.2238-0019http://hdl.handle.net/11449/22329810.47626/2237-6089-2020-00782-s2.0-85123227526Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTrends in psychiatry and psychotherapyinfo:eu-repo/semantics/openAccess2022-04-28T19:49:45Zoai:repositorio.unesp.br:11449/223298Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:49:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients |
title |
Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients |
spellingShingle |
Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients Buosi, Patrick antioxidants free radicals oxidative stress Psychotic disorders treatment resistance |
title_short |
Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients |
title_full |
Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients |
title_fullStr |
Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients |
title_full_unstemmed |
Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients |
title_sort |
Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients |
author |
Buosi, Patrick |
author_facet |
Buosi, Patrick Borghi, Fábio Aparecido Lopes, Angélica Marta Facincani, Isabela da Silva Fernandes-Ferreira, Rafael Oliveira-Brancati, Camila Ive Ferreira do Carmo, Tayanne Silva Souza, Dorotéia Rossi Silva da Silva, Danilo Grünig Humberto [UNESP] de Almeida, Eduardo Grünig Humberto de Araújo Filho, Gerardo Maria |
author_role |
author |
author2 |
Borghi, Fábio Aparecido Lopes, Angélica Marta Facincani, Isabela da Silva Fernandes-Ferreira, Rafael Oliveira-Brancati, Camila Ive Ferreira do Carmo, Tayanne Silva Souza, Dorotéia Rossi Silva da Silva, Danilo Grünig Humberto [UNESP] de Almeida, Eduardo Grünig Humberto de Araújo Filho, Gerardo Maria |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina de São José do Rio Preto (FAMERP) FAMERP Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (UNESP) SC |
dc.contributor.author.fl_str_mv |
Buosi, Patrick Borghi, Fábio Aparecido Lopes, Angélica Marta Facincani, Isabela da Silva Fernandes-Ferreira, Rafael Oliveira-Brancati, Camila Ive Ferreira do Carmo, Tayanne Silva Souza, Dorotéia Rossi Silva da Silva, Danilo Grünig Humberto [UNESP] de Almeida, Eduardo Grünig Humberto de Araújo Filho, Gerardo Maria |
dc.subject.por.fl_str_mv |
antioxidants free radicals oxidative stress Psychotic disorders treatment resistance |
topic |
antioxidants free radicals oxidative stress Psychotic disorders treatment resistance |
description |
INTRODUCTION: Schizophrenia is a complex psychiatric disorder that affects approximately twenty million people worldwide. Various factors have been associated with the physiopathology of this disease such as oxidative stress, which is an imbalance between pro-oxidant and antioxidant molecules. OBJECTIVE: This study evaluated the association between biomarkers of oxidative stress and response to pharmacological treatment among patients with schizophrenia in the context of their clinical information, demographic data, and lifestyle. METHODS: A total of 89 subjects were included, 26 of whom were treatment-responsive schizophrenia patients (Group 1), 27 treatment-resistant schizophrenia patients (Group 2), and 36 healthy controls (Group 3). All of the subjects completed a questionnaire to provide clinical and demographic data, and all provided peripheral blood samples. The oxidative stress markers analyzed using spectrophotometry were catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), total glutathione (GSH-t), malondialdehyde (MDA), and Trolox-equivalent antioxidant capacity (TEAC; p < 0.05). RESULTS: When all schizophrenia patients (G1 + G2) were compared to the control group, SOD levels were found to be lower among schizophrenia patients (p < 0.0001), while MDA and CAT levels were higher (p < 0.0001 and p = 0.0191, respectively). GPx, GSH-t, and TEAC levels were similar in all three groups (p > 0.05). CONCLUSION: Lower SOD levels and higher MDA and CAT levels indicate oxidative damage in schizophrenia patients, regardless of their response to pharmacological treatment. Smoking is associated with oxidative stress, in addition, a family history of the disease was also found to be correlated with cases of schizophrenia, which reflects the relevance of genetics in disease development. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-01 2022-04-28T19:49:45Z 2022-04-28T19:49:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.47626/2237-6089-2020-0078 Trends in psychiatry and psychotherapy, v. 43, n. 4, p. 278-285, 2021. 2238-0019 http://hdl.handle.net/11449/223298 10.47626/2237-6089-2020-0078 2-s2.0-85123227526 |
url |
http://dx.doi.org/10.47626/2237-6089-2020-0078 http://hdl.handle.net/11449/223298 |
identifier_str_mv |
Trends in psychiatry and psychotherapy, v. 43, n. 4, p. 278-285, 2021. 2238-0019 10.47626/2237-6089-2020-0078 2-s2.0-85123227526 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Trends in psychiatry and psychotherapy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
278-285 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803047132542795776 |