Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X1997000400010 http://hdl.handle.net/11449/65079 |
Resumo: | We investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure. |
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Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbacholcarbacholcentral angiotensinpressor responseangiotensinlosartanlosartan potassiumramiprilanimal experimentcholinergic systemconference papercontrolled studyintracerebroventricular drug administrationmalenonhumanratrenin angiotensin aldosterone systemAngiotensin-Converting Enzyme InhibitorsAnimalsBlood PressureCarbacholCerebral VentriclesCholinergic AgonistsLosartanMalePressoreceptorsRamiprilRatsRats, Sprague-DawleyReceptors, AngiotensinRenin-Angiotensin SystemAnimaliaWe investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.Depto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SPDepto. de Cie. Fisiológicas Faculdade de Odontologia UNESP, Rua Humaitá, 1680, 14801-903 Araraquara, SPDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SPDepto. de Cie. Fisiológicas Faculdade de Odontologia UNESP, Rua Humaitá, 1680, 14801-903 Araraquara, SPUniversidade Estadual Paulista (Unesp)Saad, William A. [UNESP]Luiz, A. C. [UNESP]Camargo, L. A A [UNESP]Silveira, J. E N [UNESP]Fóglia, S. [UNESP]Menani, José Vanderlei [UNESP]2014-05-27T11:18:13Z2014-05-27T11:18:13Z1997-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject493-496application/pdfhttp://dx.doi.org/10.1590/S0100-879X1997000400010Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997.0100-879Xhttp://hdl.handle.net/11449/6507910.1590/S0100-879X1997000400010S0100-879X1997000400010WOS:A1997WT020000102-s2.0-00309580972-s2.0-0030958097.pdf1023597870118105Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Research1.492info:eu-repo/semantics/openAccess2024-01-04T06:28:47Zoai:repositorio.unesp.br:11449/65079Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T19:50:25.876576Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol |
title |
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol |
spellingShingle |
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol Saad, William A. [UNESP] carbachol central angiotensin pressor response angiotensin losartan losartan potassium ramipril animal experiment cholinergic system conference paper controlled study intracerebroventricular drug administration male nonhuman rat renin angiotensin aldosterone system Angiotensin-Converting Enzyme Inhibitors Animals Blood Pressure Carbachol Cerebral Ventricles Cholinergic Agonists Losartan Male Pressoreceptors Ramipril Rats Rats, Sprague-Dawley Receptors, Angiotensin Renin-Angiotensin System Animalia |
title_short |
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol |
title_full |
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol |
title_fullStr |
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol |
title_full_unstemmed |
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol |
title_sort |
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol |
author |
Saad, William A. [UNESP] |
author_facet |
Saad, William A. [UNESP] Luiz, A. C. [UNESP] Camargo, L. A A [UNESP] Silveira, J. E N [UNESP] Fóglia, S. [UNESP] Menani, José Vanderlei [UNESP] |
author_role |
author |
author2 |
Luiz, A. C. [UNESP] Camargo, L. A A [UNESP] Silveira, J. E N [UNESP] Fóglia, S. [UNESP] Menani, José Vanderlei [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Saad, William A. [UNESP] Luiz, A. C. [UNESP] Camargo, L. A A [UNESP] Silveira, J. E N [UNESP] Fóglia, S. [UNESP] Menani, José Vanderlei [UNESP] |
dc.subject.por.fl_str_mv |
carbachol central angiotensin pressor response angiotensin losartan losartan potassium ramipril animal experiment cholinergic system conference paper controlled study intracerebroventricular drug administration male nonhuman rat renin angiotensin aldosterone system Angiotensin-Converting Enzyme Inhibitors Animals Blood Pressure Carbachol Cerebral Ventricles Cholinergic Agonists Losartan Male Pressoreceptors Ramipril Rats Rats, Sprague-Dawley Receptors, Angiotensin Renin-Angiotensin System Animalia |
topic |
carbachol central angiotensin pressor response angiotensin losartan losartan potassium ramipril animal experiment cholinergic system conference paper controlled study intracerebroventricular drug administration male nonhuman rat renin angiotensin aldosterone system Angiotensin-Converting Enzyme Inhibitors Animals Blood Pressure Carbachol Cerebral Ventricles Cholinergic Agonists Losartan Male Pressoreceptors Ramipril Rats Rats, Sprague-Dawley Receptors, Angiotensin Renin-Angiotensin System Animalia |
description |
We investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-04-01 2014-05-27T11:18:13Z 2014-05-27T11:18:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X1997000400010 Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997. 0100-879X http://hdl.handle.net/11449/65079 10.1590/S0100-879X1997000400010 S0100-879X1997000400010 WOS:A1997WT02000010 2-s2.0-0030958097 2-s2.0-0030958097.pdf 1023597870118105 |
url |
http://dx.doi.org/10.1590/S0100-879X1997000400010 http://hdl.handle.net/11449/65079 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997. 0100-879X 10.1590/S0100-879X1997000400010 S0100-879X1997000400010 WOS:A1997WT02000010 2-s2.0-0030958097 2-s2.0-0030958097.pdf 1023597870118105 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research 1.492 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
493-496 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803045630092771328 |