Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1755-7682-5-31 http://hdl.handle.net/11449/73692 |
Resumo: | Background: Decreased heart rate variability (HRV) is related to higher morbidity and mortality. In this study we evaluated the linear and nonlinear indices of the HRV in stable angina patients submitted to coronary angiography. Methods. We studied 77 unselected patients for elective coronary angiography, which were divided into two groups: coronary artery disease (CAD) and non-CAD groups. For analysis of HRV indices, HRV was recorded beat by beat with the volunteers in the supine position for 40 minutes. We analyzed the linear indices in the time (SDNN [standard deviation of normal to normal], NN50 [total number of adjacent RR intervals with a difference of duration greater than 50ms] and RMSSD [root-mean square of differences]) and frequency domains ultra-low frequency (ULF) ≤ 0,003 Hz, very low frequency (VLF) 0,003 - 0,04 Hz, low frequency (LF) (0.04-0.15 Hz), and high frequency (HF) (0.15-0.40 Hz) as well as the ratio between LF and HF components (LF/HF). In relation to the nonlinear indices we evaluated SD1, SD2, SD1/SD2, approximate entropy (-ApEn), α1, α2, Lyapunov Exponent, Hurst Exponent, autocorrelation and dimension correlation. The definition of the cutoff point of the variables for predictive tests was obtained by the Receiver Operating Characteristic curve (ROC). The area under the ROC curve was calculated by the extended trapezoidal rule, assuming as relevant areas under the curve ≥ 0.650. Results: Coronary arterial disease patients presented reduced values of SDNN, RMSSD, NN50, HF, SD1, SD2 and -ApEn. HF ≤ 66 ms§ssup§2§esup§, RMSSD ≤ 23.9 ms, ApEn ≤-0.296 and NN50 ≤ 16 presented the best discriminatory power for the presence of significant coronary obstruction. Conclusion: We suggest the use of Heart Rate Variability Analysis in linear and nonlinear domains, for prognostic purposes in patients with stable angina pectoris, in view of their overall impairment. © 2012 Pivatelli et al.; licensee BioMed Central Ltd. |
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Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patientsCardiovascular physiologyCoronary artery diseaseHeart rate variabilityNonlinear dynamicsStable anginaadultangiocardiographycoronary artery diseasecoronary artery obstructionentropyfemaleheart rate variabilityhumanmajor clinical studymalepredictive valueprognosissensitivity and specificitystable angina pectorissupine positionBackground: Decreased heart rate variability (HRV) is related to higher morbidity and mortality. In this study we evaluated the linear and nonlinear indices of the HRV in stable angina patients submitted to coronary angiography. Methods. We studied 77 unselected patients for elective coronary angiography, which were divided into two groups: coronary artery disease (CAD) and non-CAD groups. For analysis of HRV indices, HRV was recorded beat by beat with the volunteers in the supine position for 40 minutes. We analyzed the linear indices in the time (SDNN [standard deviation of normal to normal], NN50 [total number of adjacent RR intervals with a difference of duration greater than 50ms] and RMSSD [root-mean square of differences]) and frequency domains ultra-low frequency (ULF) ≤ 0,003 Hz, very low frequency (VLF) 0,003 - 0,04 Hz, low frequency (LF) (0.04-0.15 Hz), and high frequency (HF) (0.15-0.40 Hz) as well as the ratio between LF and HF components (LF/HF). In relation to the nonlinear indices we evaluated SD1, SD2, SD1/SD2, approximate entropy (-ApEn), α1, α2, Lyapunov Exponent, Hurst Exponent, autocorrelation and dimension correlation. The definition of the cutoff point of the variables for predictive tests was obtained by the Receiver Operating Characteristic curve (ROC). The area under the ROC curve was calculated by the extended trapezoidal rule, assuming as relevant areas under the curve ≥ 0.650. Results: Coronary arterial disease patients presented reduced values of SDNN, RMSSD, NN50, HF, SD1, SD2 and -ApEn. HF ≤ 66 ms§ssup§2§esup§, RMSSD ≤ 23.9 ms, ApEn ≤-0.296 and NN50 ≤ 16 presented the best discriminatory power for the presence of significant coronary obstruction. Conclusion: We suggest the use of Heart Rate Variability Analysis in linear and nonlinear domains, for prognostic purposes in patients with stable angina pectoris, in view of their overall impairment. © 2012 Pivatelli et al.; licensee BioMed Central Ltd.Serviço de Hemodinâmica e Cardiologia Intervencionista Do Hospital de Base Fundação Faculdade Regional de Medicina (FUNFARME) Depto. de Cardiologia e Cirurgia Cardiovascular da Faculdade de Medicina de Sao Jose Do Rio Preto, Av. Brigadeiro Faria Lima, 5416, 15090-000, São José do Rio Preto, SPDepartamento de Enfermagem em Saúde Coletiva e Orientaç ão Profissional (DESCOP) Curso de Enfermagem Faculdade de Medicina de São José Do Rio Preto (FAMERP), Av. Brigadeiro Faria Lima, 5416, 15090-000, São José do Rio Preto, SPDepartamento de Especialidades Cirúrgicas Faculdade de Medicina de São José Do Rio Preto (FAMERP), Av. Brigadeiro Faria Lima, 5416, 15090-000, São José do Rio Preto, SPLaboratório de Escrita Científica Departamento de Morfologia e Fisiologia Faculdade de Medicina Do ABC, Av. Príncipe de Gales, 821, CEP 09060-650, Santo André, SPPrograma de Pós-Graduação em Fisioterapia Faculdade de Ciências e Tecnologia UNESP, Rua Roberto Simonsen, 305, 19060-900, Presidente Prudente, SPNUTECC - Núcleo Transdisciplinar Para Estudo Do Caos e da Complexidade (FAMERP), Av. Brigadeiro Faria Lima, 5416, 15090-000, São José do Rio Preto, SP, Rua Garabed Karabashian 570, 15070-600, São José do Rio Preto, SPPrograma de Pós-Graduação em Fisioterapia Faculdade de Ciências e Tecnologia UNESP, Rua Roberto Simonsen, 305, 19060-900, Presidente Prudente, SPFaculdade de Medicina de São José do Rio Preto (FAMERP)Faculdade de Medicina do ABC (FMABC)Universidade Estadual Paulista (Unesp)Pivatelli, Flávio CorreaDos Santos, Marcio AntonioFernandes, Gislaine BuzziniGatti, MarcioDe Abreu, Luiz CarlosValenti, Vitor E. [UNESP]Vanderlei, Luiz Carlos M. [UNESP]Ferreira, CelsoAdami, FernandoDe Carvalho, Tatiana DiasMonteiro, Carlos Bandeira de MelloDe Godoy, Moacir Fernandes2014-05-27T11:27:07Z2014-05-27T11:27:07Z2012-10-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/1755-7682-5-31International Archives of Medicine, v. 5, n. 1, 2012.1755-7682http://hdl.handle.net/11449/7369210.1186/1755-7682-5-312-s2.0-848678966842-s2.0-84867896684.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Archives of Medicine0,237info:eu-repo/semantics/openAccess2024-06-18T18:44:14Zoai:repositorio.unesp.br:11449/73692Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:05:57.204327Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients |
title |
Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients |
spellingShingle |
Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients Pivatelli, Flávio Correa Cardiovascular physiology Coronary artery disease Heart rate variability Nonlinear dynamics Stable angina adult angiocardiography coronary artery disease coronary artery obstruction entropy female heart rate variability human major clinical study male predictive value prognosis sensitivity and specificity stable angina pectoris supine position |
title_short |
Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients |
title_full |
Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients |
title_fullStr |
Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients |
title_full_unstemmed |
Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients |
title_sort |
Sensitivity, specificity and predictive values of linear and nonlinear indices of heart rate variability in stable angina patients |
author |
Pivatelli, Flávio Correa |
author_facet |
Pivatelli, Flávio Correa Dos Santos, Marcio Antonio Fernandes, Gislaine Buzzini Gatti, Marcio De Abreu, Luiz Carlos Valenti, Vitor E. [UNESP] Vanderlei, Luiz Carlos M. [UNESP] Ferreira, Celso Adami, Fernando De Carvalho, Tatiana Dias Monteiro, Carlos Bandeira de Mello De Godoy, Moacir Fernandes |
author_role |
author |
author2 |
Dos Santos, Marcio Antonio Fernandes, Gislaine Buzzini Gatti, Marcio De Abreu, Luiz Carlos Valenti, Vitor E. [UNESP] Vanderlei, Luiz Carlos M. [UNESP] Ferreira, Celso Adami, Fernando De Carvalho, Tatiana Dias Monteiro, Carlos Bandeira de Mello De Godoy, Moacir Fernandes |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina de São José do Rio Preto (FAMERP) Faculdade de Medicina do ABC (FMABC) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pivatelli, Flávio Correa Dos Santos, Marcio Antonio Fernandes, Gislaine Buzzini Gatti, Marcio De Abreu, Luiz Carlos Valenti, Vitor E. [UNESP] Vanderlei, Luiz Carlos M. [UNESP] Ferreira, Celso Adami, Fernando De Carvalho, Tatiana Dias Monteiro, Carlos Bandeira de Mello De Godoy, Moacir Fernandes |
dc.subject.por.fl_str_mv |
Cardiovascular physiology Coronary artery disease Heart rate variability Nonlinear dynamics Stable angina adult angiocardiography coronary artery disease coronary artery obstruction entropy female heart rate variability human major clinical study male predictive value prognosis sensitivity and specificity stable angina pectoris supine position |
topic |
Cardiovascular physiology Coronary artery disease Heart rate variability Nonlinear dynamics Stable angina adult angiocardiography coronary artery disease coronary artery obstruction entropy female heart rate variability human major clinical study male predictive value prognosis sensitivity and specificity stable angina pectoris supine position |
description |
Background: Decreased heart rate variability (HRV) is related to higher morbidity and mortality. In this study we evaluated the linear and nonlinear indices of the HRV in stable angina patients submitted to coronary angiography. Methods. We studied 77 unselected patients for elective coronary angiography, which were divided into two groups: coronary artery disease (CAD) and non-CAD groups. For analysis of HRV indices, HRV was recorded beat by beat with the volunteers in the supine position for 40 minutes. We analyzed the linear indices in the time (SDNN [standard deviation of normal to normal], NN50 [total number of adjacent RR intervals with a difference of duration greater than 50ms] and RMSSD [root-mean square of differences]) and frequency domains ultra-low frequency (ULF) ≤ 0,003 Hz, very low frequency (VLF) 0,003 - 0,04 Hz, low frequency (LF) (0.04-0.15 Hz), and high frequency (HF) (0.15-0.40 Hz) as well as the ratio between LF and HF components (LF/HF). In relation to the nonlinear indices we evaluated SD1, SD2, SD1/SD2, approximate entropy (-ApEn), α1, α2, Lyapunov Exponent, Hurst Exponent, autocorrelation and dimension correlation. The definition of the cutoff point of the variables for predictive tests was obtained by the Receiver Operating Characteristic curve (ROC). The area under the ROC curve was calculated by the extended trapezoidal rule, assuming as relevant areas under the curve ≥ 0.650. Results: Coronary arterial disease patients presented reduced values of SDNN, RMSSD, NN50, HF, SD1, SD2 and -ApEn. HF ≤ 66 ms§ssup§2§esup§, RMSSD ≤ 23.9 ms, ApEn ≤-0.296 and NN50 ≤ 16 presented the best discriminatory power for the presence of significant coronary obstruction. Conclusion: We suggest the use of Heart Rate Variability Analysis in linear and nonlinear domains, for prognostic purposes in patients with stable angina pectoris, in view of their overall impairment. © 2012 Pivatelli et al.; licensee BioMed Central Ltd. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-31 2014-05-27T11:27:07Z 2014-05-27T11:27:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1755-7682-5-31 International Archives of Medicine, v. 5, n. 1, 2012. 1755-7682 http://hdl.handle.net/11449/73692 10.1186/1755-7682-5-31 2-s2.0-84867896684 2-s2.0-84867896684.pdf |
url |
http://dx.doi.org/10.1186/1755-7682-5-31 http://hdl.handle.net/11449/73692 |
identifier_str_mv |
International Archives of Medicine, v. 5, n. 1, 2012. 1755-7682 10.1186/1755-7682-5-31 2-s2.0-84867896684 2-s2.0-84867896684.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Archives of Medicine 0,237 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129018878230528 |