Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/rda.13639 http://hdl.handle.net/11449/201529 |
Resumo: | Runs of homozygosity (ROH) are contiguous homozygous regions of the genome. These regions can be used to identify genes associated with traits of economic interest, as well as inbreeding levels. The aim of the present study was to analyse the length and distribution of ROH islands in Gyr cattle and to identify genes within these regions. A population of 173 animals selected for beef production and a population of 291 animals selected for dairy production were used. Differences in the number of short ROH (ROH1-2 Mb) were observed between the two populations, while the number of long ROH (ROH>16 Mb) was similar. ROH islands with the highest incidences (>0.50) overlapped in several segments of the genome in the two populations. The genes identified were associated with milk production, growth, reproduction, immune response and resistance traits. Our results contribute to the understanding of how selection can shape the distribution of ROH and ROH islands within the same breed when animals are selected for different purposes such as dairy or beef production. |
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Repositório Institucional da UNESP |
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spelling |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)beefdairydual-purposegenesinbreedingRuns of homozygosity (ROH) are contiguous homozygous regions of the genome. These regions can be used to identify genes associated with traits of economic interest, as well as inbreeding levels. The aim of the present study was to analyse the length and distribution of ROH islands in Gyr cattle and to identify genes within these regions. A population of 173 animals selected for beef production and a population of 291 animals selected for dairy production were used. Differences in the number of short ROH (ROH1-2 Mb) were observed between the two populations, while the number of long ROH (ROH>16 Mb) was similar. ROH islands with the highest incidences (>0.50) overlapped in several segments of the genome in the two populations. The genes identified were associated with milk production, growth, reproduction, immune response and resistance traits. Our results contribute to the understanding of how selection can shape the distribution of ROH and ROH islands within the same breed when animals are selected for different purposes such as dairy or beef production.Agence Universitaire de la FrancophonieFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Faculdade de Ciências Agrárias e Veterinárias UNESPInstituto de ZootecniaFaculdade de Medicina Veterinária e Zootecnia UNESPFaculdade de Ciências Agrárias e Veterinárias UNESPFaculdade de Medicina Veterinária e Zootecnia UNESPAgence Universitaire de la Francophonie: 1140/2018FAPESP: 2015/06686-7CNPq: 304047/2017-1Universidade Estadual Paulista (Unesp)Instituto de ZootecniaToro Ospina, Alejandra Maria [UNESP]da Silva Faria, Ricardo António [UNESP]Vercesi Filho, Anibal EugenioCyrillo, Joslaine Noely dos Santos GoncalvesZerlotti Mercadante, Maria EugeniaCuri, Rogerio Abdallah [UNESP]II de Vasconcelos Silva, Josineudson Augusto [UNESP]2020-12-12T02:34:59Z2020-12-12T02:34:59Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article333-342http://dx.doi.org/10.1111/rda.13639Reproduction in Domestic Animals, v. 55, n. 3, p. 333-342, 2020.1439-05310936-6768http://hdl.handle.net/11449/20152910.1111/rda.136392-s2.0-8507905278335147134139191260000-0001-6289-0406Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproduction in Domestic Animalsinfo:eu-repo/semantics/openAccess2024-09-06T18:55:50Zoai:repositorio.unesp.br:11449/201529Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-06T18:55:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus) |
title |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus) |
spellingShingle |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus) Toro Ospina, Alejandra Maria [UNESP] beef dairy dual-purpose genes inbreeding |
title_short |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus) |
title_full |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus) |
title_fullStr |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus) |
title_full_unstemmed |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus) |
title_sort |
Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus) |
author |
Toro Ospina, Alejandra Maria [UNESP] |
author_facet |
Toro Ospina, Alejandra Maria [UNESP] da Silva Faria, Ricardo António [UNESP] Vercesi Filho, Anibal Eugenio Cyrillo, Joslaine Noely dos Santos Goncalves Zerlotti Mercadante, Maria Eugenia Curi, Rogerio Abdallah [UNESP] II de Vasconcelos Silva, Josineudson Augusto [UNESP] |
author_role |
author |
author2 |
da Silva Faria, Ricardo António [UNESP] Vercesi Filho, Anibal Eugenio Cyrillo, Joslaine Noely dos Santos Goncalves Zerlotti Mercadante, Maria Eugenia Curi, Rogerio Abdallah [UNESP] II de Vasconcelos Silva, Josineudson Augusto [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Instituto de Zootecnia |
dc.contributor.author.fl_str_mv |
Toro Ospina, Alejandra Maria [UNESP] da Silva Faria, Ricardo António [UNESP] Vercesi Filho, Anibal Eugenio Cyrillo, Joslaine Noely dos Santos Goncalves Zerlotti Mercadante, Maria Eugenia Curi, Rogerio Abdallah [UNESP] II de Vasconcelos Silva, Josineudson Augusto [UNESP] |
dc.subject.por.fl_str_mv |
beef dairy dual-purpose genes inbreeding |
topic |
beef dairy dual-purpose genes inbreeding |
description |
Runs of homozygosity (ROH) are contiguous homozygous regions of the genome. These regions can be used to identify genes associated with traits of economic interest, as well as inbreeding levels. The aim of the present study was to analyse the length and distribution of ROH islands in Gyr cattle and to identify genes within these regions. A population of 173 animals selected for beef production and a population of 291 animals selected for dairy production were used. Differences in the number of short ROH (ROH1-2 Mb) were observed between the two populations, while the number of long ROH (ROH>16 Mb) was similar. ROH islands with the highest incidences (>0.50) overlapped in several segments of the genome in the two populations. The genes identified were associated with milk production, growth, reproduction, immune response and resistance traits. Our results contribute to the understanding of how selection can shape the distribution of ROH and ROH islands within the same breed when animals are selected for different purposes such as dairy or beef production. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:34:59Z 2020-12-12T02:34:59Z 2020-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/rda.13639 Reproduction in Domestic Animals, v. 55, n. 3, p. 333-342, 2020. 1439-0531 0936-6768 http://hdl.handle.net/11449/201529 10.1111/rda.13639 2-s2.0-85079052783 3514713413919126 0000-0001-6289-0406 |
url |
http://dx.doi.org/10.1111/rda.13639 http://hdl.handle.net/11449/201529 |
identifier_str_mv |
Reproduction in Domestic Animals, v. 55, n. 3, p. 333-342, 2020. 1439-0531 0936-6768 10.1111/rda.13639 2-s2.0-85079052783 3514713413919126 0000-0001-6289-0406 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Reproduction in Domestic Animals |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
333-342 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546612116422656 |