Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)

Detalhes bibliográficos
Autor(a) principal: Toro Ospina, Alejandra Maria [UNESP]
Data de Publicação: 2020
Outros Autores: da Silva Faria, Ricardo António [UNESP], Vercesi Filho, Anibal Eugenio, Cyrillo, Joslaine Noely dos Santos Goncalves, Zerlotti Mercadante, Maria Eugenia, Curi, Rogerio Abdallah [UNESP], II de Vasconcelos Silva, Josineudson Augusto [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/rda.13639
http://hdl.handle.net/11449/201529
Resumo: Runs of homozygosity (ROH) are contiguous homozygous regions of the genome. These regions can be used to identify genes associated with traits of economic interest, as well as inbreeding levels. The aim of the present study was to analyse the length and distribution of ROH islands in Gyr cattle and to identify genes within these regions. A population of 173 animals selected for beef production and a population of 291 animals selected for dairy production were used. Differences in the number of short ROH (ROH1-2 Mb) were observed between the two populations, while the number of long ROH (ROH>16 Mb) was similar. ROH islands with the highest incidences (>0.50) overlapped in several segments of the genome in the two populations. The genes identified were associated with milk production, growth, reproduction, immune response and resistance traits. Our results contribute to the understanding of how selection can shape the distribution of ROH and ROH islands within the same breed when animals are selected for different purposes such as dairy or beef production.
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spelling Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)beefdairydual-purposegenesinbreedingRuns of homozygosity (ROH) are contiguous homozygous regions of the genome. These regions can be used to identify genes associated with traits of economic interest, as well as inbreeding levels. The aim of the present study was to analyse the length and distribution of ROH islands in Gyr cattle and to identify genes within these regions. A population of 173 animals selected for beef production and a population of 291 animals selected for dairy production were used. Differences in the number of short ROH (ROH1-2 Mb) were observed between the two populations, while the number of long ROH (ROH>16 Mb) was similar. ROH islands with the highest incidences (>0.50) overlapped in several segments of the genome in the two populations. The genes identified were associated with milk production, growth, reproduction, immune response and resistance traits. Our results contribute to the understanding of how selection can shape the distribution of ROH and ROH islands within the same breed when animals are selected for different purposes such as dairy or beef production.Agence Universitaire de la FrancophonieFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Faculdade de Ciências Agrárias e Veterinárias UNESPInstituto de ZootecniaFaculdade de Medicina Veterinária e Zootecnia UNESPFaculdade de Ciências Agrárias e Veterinárias UNESPFaculdade de Medicina Veterinária e Zootecnia UNESPAgence Universitaire de la Francophonie: 1140/2018FAPESP: 2015/06686-7CNPq: 304047/2017-1Universidade Estadual Paulista (Unesp)Instituto de ZootecniaToro Ospina, Alejandra Maria [UNESP]da Silva Faria, Ricardo António [UNESP]Vercesi Filho, Anibal EugenioCyrillo, Joslaine Noely dos Santos GoncalvesZerlotti Mercadante, Maria EugeniaCuri, Rogerio Abdallah [UNESP]II de Vasconcelos Silva, Josineudson Augusto [UNESP]2020-12-12T02:34:59Z2020-12-12T02:34:59Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article333-342http://dx.doi.org/10.1111/rda.13639Reproduction in Domestic Animals, v. 55, n. 3, p. 333-342, 2020.1439-05310936-6768http://hdl.handle.net/11449/20152910.1111/rda.136392-s2.0-8507905278335147134139191260000-0001-6289-0406Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproduction in Domestic Animalsinfo:eu-repo/semantics/openAccess2024-09-06T18:55:50Zoai:repositorio.unesp.br:11449/201529Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-06T18:55:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
title Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
spellingShingle Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
Toro Ospina, Alejandra Maria [UNESP]
beef
dairy
dual-purpose
genes
inbreeding
title_short Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
title_full Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
title_fullStr Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
title_full_unstemmed Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
title_sort Genome-wide identification of runs of homozygosity islands in the Gyr breed (Bos indicus)
author Toro Ospina, Alejandra Maria [UNESP]
author_facet Toro Ospina, Alejandra Maria [UNESP]
da Silva Faria, Ricardo António [UNESP]
Vercesi Filho, Anibal Eugenio
Cyrillo, Joslaine Noely dos Santos Goncalves
Zerlotti Mercadante, Maria Eugenia
Curi, Rogerio Abdallah [UNESP]
II de Vasconcelos Silva, Josineudson Augusto [UNESP]
author_role author
author2 da Silva Faria, Ricardo António [UNESP]
Vercesi Filho, Anibal Eugenio
Cyrillo, Joslaine Noely dos Santos Goncalves
Zerlotti Mercadante, Maria Eugenia
Curi, Rogerio Abdallah [UNESP]
II de Vasconcelos Silva, Josineudson Augusto [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Instituto de Zootecnia
dc.contributor.author.fl_str_mv Toro Ospina, Alejandra Maria [UNESP]
da Silva Faria, Ricardo António [UNESP]
Vercesi Filho, Anibal Eugenio
Cyrillo, Joslaine Noely dos Santos Goncalves
Zerlotti Mercadante, Maria Eugenia
Curi, Rogerio Abdallah [UNESP]
II de Vasconcelos Silva, Josineudson Augusto [UNESP]
dc.subject.por.fl_str_mv beef
dairy
dual-purpose
genes
inbreeding
topic beef
dairy
dual-purpose
genes
inbreeding
description Runs of homozygosity (ROH) are contiguous homozygous regions of the genome. These regions can be used to identify genes associated with traits of economic interest, as well as inbreeding levels. The aim of the present study was to analyse the length and distribution of ROH islands in Gyr cattle and to identify genes within these regions. A population of 173 animals selected for beef production and a population of 291 animals selected for dairy production were used. Differences in the number of short ROH (ROH1-2 Mb) were observed between the two populations, while the number of long ROH (ROH>16 Mb) was similar. ROH islands with the highest incidences (>0.50) overlapped in several segments of the genome in the two populations. The genes identified were associated with milk production, growth, reproduction, immune response and resistance traits. Our results contribute to the understanding of how selection can shape the distribution of ROH and ROH islands within the same breed when animals are selected for different purposes such as dairy or beef production.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:34:59Z
2020-12-12T02:34:59Z
2020-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/rda.13639
Reproduction in Domestic Animals, v. 55, n. 3, p. 333-342, 2020.
1439-0531
0936-6768
http://hdl.handle.net/11449/201529
10.1111/rda.13639
2-s2.0-85079052783
3514713413919126
0000-0001-6289-0406
url http://dx.doi.org/10.1111/rda.13639
http://hdl.handle.net/11449/201529
identifier_str_mv Reproduction in Domestic Animals, v. 55, n. 3, p. 333-342, 2020.
1439-0531
0936-6768
10.1111/rda.13639
2-s2.0-85079052783
3514713413919126
0000-0001-6289-0406
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Reproduction in Domestic Animals
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 333-342
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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