Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition

Bibliographic Details
Main Author: Nunes-de-Souza, Ricardo Luiz [UNESP]
Publication Date: 2010
Other Authors: Miguel, Tarciso Tadeu [UNESP], Gomes, Karina Santos [UNESP], Fugimoto, Juliana Sayuri [UNESP], Mendes-Gomes, Joyce [UNESP], Amaral, Vanessa Cristiane Santana [UNESP], de carvalho-Netto, Eduardo Ferreira
Format: Article
Language: eng
Source: Repositório Institucional da UNESP
Download full: http://dx.doi.org/10.3922/j.psns.2010.1.xxx
http://hdl.handle.net/11449/231938
Summary: Glutamate N-methyl-D-aspartate (NMDA) receptor activation within the dorsal column of the periaqueductal gray (dPAG) leads to antinociceptive, autonomic, and behavioral responses characterized as the fear reaction. Activation of NMDA receptors in the brain increases nitric oxide (NO) synthesis, and NO has been proposed to be a mediator of the aversive action of glutamate. This paper reviews a series of studies investigating the effects of neuronal NO synthase (nNOS) inhibition in the dPAG of mice in different aversive conditions. nNOS inhibition by infusion of Nω-propyl-L- arginine (NPLA) prevents fear-like reactions (e.g., jumping, running, freezing) induced by NMDA receptor stimulation within the dPAG and produces anti-aversive effects when injected into the same midbrain site in mice confronted with a predator. Interestingly, nNOS inhibition within the dPAG does not change anxiety-like behavior in mice exposed to the elevated plus maze (EPM), but it reverses the effect of an anxiogenic dose of NMDA injected into the same site in animals subjected to the EPM. Altogether, the results support a role for glutamate NMDA receptors and NO in the dPAG in the regulation of defensive behaviors in mice. However, dPAG nitrergic modulation of anxiety-like behavior appears to depend on the magnitude of the aversive stimulus. Psychology & Neuroscience © 2010.
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spelling Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive conditionElevated plus maze (EPM)MouseNeuronal nitric oxide synthase (nNOS)NMDA receptorsPeriaqueductal gray matter (PAG)Rat exposure test (RET)Glutamate N-methyl-D-aspartate (NMDA) receptor activation within the dorsal column of the periaqueductal gray (dPAG) leads to antinociceptive, autonomic, and behavioral responses characterized as the fear reaction. Activation of NMDA receptors in the brain increases nitric oxide (NO) synthesis, and NO has been proposed to be a mediator of the aversive action of glutamate. This paper reviews a series of studies investigating the effects of neuronal NO synthase (nNOS) inhibition in the dPAG of mice in different aversive conditions. nNOS inhibition by infusion of Nω-propyl-L- arginine (NPLA) prevents fear-like reactions (e.g., jumping, running, freezing) induced by NMDA receptor stimulation within the dPAG and produces anti-aversive effects when injected into the same midbrain site in mice confronted with a predator. Interestingly, nNOS inhibition within the dPAG does not change anxiety-like behavior in mice exposed to the elevated plus maze (EPM), but it reverses the effect of an anxiogenic dose of NMDA injected into the same site in animals subjected to the EPM. Altogether, the results support a role for glutamate NMDA receptors and NO in the dPAG in the regulation of defensive behaviors in mice. However, dPAG nitrergic modulation of anxiety-like behavior appears to depend on the magnitude of the aversive stimulus. Psychology & Neuroscience © 2010.UFSCAR-UNESP (Araraquara), São Carlos, SPFFCLRP-Campus USP, Ribeirão Preto, SPLaboratório de Neuropsicofarmacologia FCFAr-Campus UNESP, Araraquara, SPInstituto de Neurociências and Comportamento - INeC Campus USP, Ribeirão Preto, SPGenome Research Institute University of Cincinnati, Cincinnati, OHUFSCAR-UNESP (Araraquara), São Carlos, SPLaboratório de Neuropsicofarmacologia FCFAr-Campus UNESP, Araraquara, SPUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)University of CincinnatiNunes-de-Souza, Ricardo Luiz [UNESP]Miguel, Tarciso Tadeu [UNESP]Gomes, Karina Santos [UNESP]Fugimoto, Juliana Sayuri [UNESP]Mendes-Gomes, Joyce [UNESP]Amaral, Vanessa Cristiane Santana [UNESP]de carvalho-Netto, Eduardo Ferreira2022-04-29T08:48:16Z2022-04-29T08:48:16Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3922/j.psns.2010.1.xxxPsychology and Neuroscience, v. 3, n. 1, 2010.1983-32881984-3054http://hdl.handle.net/11449/23193810.3922/j.psns.2010.1.xxx2-s2.0-77954557029Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPsychology and Neuroscienceinfo:eu-repo/semantics/openAccess2022-04-29T08:48:16Zoai:repositorio.unesp.br:11449/231938Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:48:16Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
title Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
spellingShingle Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
Nunes-de-Souza, Ricardo Luiz [UNESP]
Elevated plus maze (EPM)
Mouse
Neuronal nitric oxide synthase (nNOS)
NMDA receptors
Periaqueductal gray matter (PAG)
Rat exposure test (RET)
title_short Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
title_full Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
title_fullStr Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
title_full_unstemmed Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
title_sort Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
author Nunes-de-Souza, Ricardo Luiz [UNESP]
author_facet Nunes-de-Souza, Ricardo Luiz [UNESP]
Miguel, Tarciso Tadeu [UNESP]
Gomes, Karina Santos [UNESP]
Fugimoto, Juliana Sayuri [UNESP]
Mendes-Gomes, Joyce [UNESP]
Amaral, Vanessa Cristiane Santana [UNESP]
de carvalho-Netto, Eduardo Ferreira
author_role author
author2 Miguel, Tarciso Tadeu [UNESP]
Gomes, Karina Santos [UNESP]
Fugimoto, Juliana Sayuri [UNESP]
Mendes-Gomes, Joyce [UNESP]
Amaral, Vanessa Cristiane Santana [UNESP]
de carvalho-Netto, Eduardo Ferreira
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)
University of Cincinnati
dc.contributor.author.fl_str_mv Nunes-de-Souza, Ricardo Luiz [UNESP]
Miguel, Tarciso Tadeu [UNESP]
Gomes, Karina Santos [UNESP]
Fugimoto, Juliana Sayuri [UNESP]
Mendes-Gomes, Joyce [UNESP]
Amaral, Vanessa Cristiane Santana [UNESP]
de carvalho-Netto, Eduardo Ferreira
dc.subject.por.fl_str_mv Elevated plus maze (EPM)
Mouse
Neuronal nitric oxide synthase (nNOS)
NMDA receptors
Periaqueductal gray matter (PAG)
Rat exposure test (RET)
topic Elevated plus maze (EPM)
Mouse
Neuronal nitric oxide synthase (nNOS)
NMDA receptors
Periaqueductal gray matter (PAG)
Rat exposure test (RET)
description Glutamate N-methyl-D-aspartate (NMDA) receptor activation within the dorsal column of the periaqueductal gray (dPAG) leads to antinociceptive, autonomic, and behavioral responses characterized as the fear reaction. Activation of NMDA receptors in the brain increases nitric oxide (NO) synthesis, and NO has been proposed to be a mediator of the aversive action of glutamate. This paper reviews a series of studies investigating the effects of neuronal NO synthase (nNOS) inhibition in the dPAG of mice in different aversive conditions. nNOS inhibition by infusion of Nω-propyl-L- arginine (NPLA) prevents fear-like reactions (e.g., jumping, running, freezing) induced by NMDA receptor stimulation within the dPAG and produces anti-aversive effects when injected into the same midbrain site in mice confronted with a predator. Interestingly, nNOS inhibition within the dPAG does not change anxiety-like behavior in mice exposed to the elevated plus maze (EPM), but it reverses the effect of an anxiogenic dose of NMDA injected into the same site in animals subjected to the EPM. Altogether, the results support a role for glutamate NMDA receptors and NO in the dPAG in the regulation of defensive behaviors in mice. However, dPAG nitrergic modulation of anxiety-like behavior appears to depend on the magnitude of the aversive stimulus. Psychology & Neuroscience © 2010.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2022-04-29T08:48:16Z
2022-04-29T08:48:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3922/j.psns.2010.1.xxx
Psychology and Neuroscience, v. 3, n. 1, 2010.
1983-3288
1984-3054
http://hdl.handle.net/11449/231938
10.3922/j.psns.2010.1.xxx
2-s2.0-77954557029
url http://dx.doi.org/10.3922/j.psns.2010.1.xxx
http://hdl.handle.net/11449/231938
identifier_str_mv Psychology and Neuroscience, v. 3, n. 1, 2010.
1983-3288
1984-3054
10.3922/j.psns.2010.1.xxx
2-s2.0-77954557029
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Psychology and Neuroscience
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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