Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia

Detalhes bibliográficos
Autor(a) principal: Sandrim, Valeria [UNESP]
Data de Publicação: 2019
Outros Autores: Coeli-Lacchini, Fernanda Borchers, Tanus-Santos, Jose Eduardo, Lacchini, Riccardo, Cavalli, Ricardo Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/10641955.2019.1582664
http://hdl.handle.net/11449/188808
Resumo: Objectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene. Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis. Results: We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed. Conclusion: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GT n polymorphism.
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spelling Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsiaHMOX1 genotypingoxidative stressplasma HO-1plasma sFLT-1polymorphismPreeclampsiaObjectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene. Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis. Results: We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed. Conclusion: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GT n polymorphism.Department of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)Departments of Internal Medicine Ribeirao Preto College of Nursing University of Sao PauloDepartments of Pharmacology Ribeirao Preto College of Nursing University of Sao PauloDepartment of Psychiatric Nursing and Human Sciences Ribeirao Preto College of Nursing University of Sao PauloDepartments of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto Ribeirao Preto College of Nursing University of Sao PauloDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Sandrim, Valeria [UNESP]Coeli-Lacchini, Fernanda BorchersTanus-Santos, Jose EduardoLacchini, RiccardoCavalli, Ricardo Carvalho2019-10-06T16:19:52Z2019-10-06T16:19:52Z2019-04-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article73-77http://dx.doi.org/10.1080/10641955.2019.1582664Hypertension in Pregnancy, v. 38, n. 2, p. 73-77, 2019.1525-60651064-1955http://hdl.handle.net/11449/18880810.1080/10641955.2019.15826642-s2.0-85062514252Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHypertension in Pregnancyinfo:eu-repo/semantics/openAccess2021-10-22T18:57:03Zoai:repositorio.unesp.br:11449/188808Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T18:57:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
title Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
spellingShingle Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
Sandrim, Valeria [UNESP]
HMOX1 genotyping
oxidative stress
plasma HO-1
plasma sFLT-1
polymorphism
Preeclampsia
title_short Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
title_full Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
title_fullStr Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
title_full_unstemmed Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
title_sort Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia
author Sandrim, Valeria [UNESP]
author_facet Sandrim, Valeria [UNESP]
Coeli-Lacchini, Fernanda Borchers
Tanus-Santos, Jose Eduardo
Lacchini, Riccardo
Cavalli, Ricardo Carvalho
author_role author
author2 Coeli-Lacchini, Fernanda Borchers
Tanus-Santos, Jose Eduardo
Lacchini, Riccardo
Cavalli, Ricardo Carvalho
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Sandrim, Valeria [UNESP]
Coeli-Lacchini, Fernanda Borchers
Tanus-Santos, Jose Eduardo
Lacchini, Riccardo
Cavalli, Ricardo Carvalho
dc.subject.por.fl_str_mv HMOX1 genotyping
oxidative stress
plasma HO-1
plasma sFLT-1
polymorphism
Preeclampsia
topic HMOX1 genotyping
oxidative stress
plasma HO-1
plasma sFLT-1
polymorphism
Preeclampsia
description Objectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene. Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis. Results: We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed. Conclusion: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GT n polymorphism.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:19:52Z
2019-10-06T16:19:52Z
2019-04-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/10641955.2019.1582664
Hypertension in Pregnancy, v. 38, n. 2, p. 73-77, 2019.
1525-6065
1064-1955
http://hdl.handle.net/11449/188808
10.1080/10641955.2019.1582664
2-s2.0-85062514252
url http://dx.doi.org/10.1080/10641955.2019.1582664
http://hdl.handle.net/11449/188808
identifier_str_mv Hypertension in Pregnancy, v. 38, n. 2, p. 73-77, 2019.
1525-6065
1064-1955
10.1080/10641955.2019.1582664
2-s2.0-85062514252
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Hypertension in Pregnancy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 73-77
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964425748217856

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