NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia

Detalhes bibliográficos
Autor(a) principal: Pereira, Daniela A.
Data de Publicação: 2021
Outros Autores: Sandrim, Valeria C. [UNESP], Palei, Ana C., Amaral, Lorena M., Belo, Vanessa A., Lacchini, Riccardo, Cavalli, Ricardo C., Tanus-Santos, Jose E., Luizon, Marcelo R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2217/pgs-2021-0006
http://hdl.handle.net/11449/207954
Resumo: Aim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite concentrations in PE and 206 healthy pregnant women. Patients & methods: Circulating visfatin/NAMPT and sFlt-1 levels were measured by ELISA, and nitrite concentrations by using an ozone-based chemiluminescence assay. Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. NAMPT SNP rs1319501 affected nitrite concentrations in nonresponsive PE patients and was tightly linked with NAMPT functional SNPs in Europeans. Conclusion: NAMPT SNP rs1319501 and visfatin/NAMPT affect NO formation, sFlt-1 levels and antihypertensive therapy response in PE.
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spelling NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsiaantihypertensive agentsgenetic polymorphismsnicotinamide phosphoribosyltransferasenitric oxidepharmacogeneticspreeclampsiasFlt-1visfatin/NAMPTAim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite concentrations in PE and 206 healthy pregnant women. Patients & methods: Circulating visfatin/NAMPT and sFlt-1 levels were measured by ELISA, and nitrite concentrations by using an ozone-based chemiluminescence assay. Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. NAMPT SNP rs1319501 affected nitrite concentrations in nonresponsive PE patients and was tightly linked with NAMPT functional SNPs in Europeans. Conclusion: NAMPT SNP rs1319501 and visfatin/NAMPT affect NO formation, sFlt-1 levels and antihypertensive therapy response in PE.Graduate Program in Genetics Institute of Biological Sciences Federal University of Minas GeraisDepartment of Biophysics and Pharmacology Institute of Biosciences Universidade Estadual Paulista (UNESP)Department of Surgery University of Mississippi Medical CenterDepartment of Pharmacology and Toxicology University of Mississippi Medical CenterDepartment of Psychiatric Nursing and Human Sciences Ribeirao Preto College of Nursing University of Sao PauloDepartment of Gynecology and Obstetrics Ribeirao Preto Medical School University of Sao PauloDepartment of Pharmacology Ribeirao Preto Medical School University of Sao PauloDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas GeraisDepartment of Biophysics and Pharmacology Institute of Biosciences Universidade Estadual Paulista (UNESP)Universidade Federal de Minas Gerais (UFMG)Universidade Estadual Paulista (Unesp)University of Mississippi Medical CenterUniversidade de São Paulo (USP)Pereira, Daniela A.Sandrim, Valeria C. [UNESP]Palei, Ana C.Amaral, Lorena M.Belo, Vanessa A.Lacchini, RiccardoCavalli, Ricardo C.Tanus-Santos, Jose E.Luizon, Marcelo R.2021-06-25T11:03:48Z2021-06-25T11:03:48Z2021-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article451-464http://dx.doi.org/10.2217/pgs-2021-0006Pharmacogenomics, v. 22, n. 8, p. 451-464, 2021.1744-80421462-2416http://hdl.handle.net/11449/20795410.2217/pgs-2021-00062-s2.0-85107488118Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmacogenomicsinfo:eu-repo/semantics/openAccess2021-10-23T17:52:08Zoai:repositorio.unesp.br:11449/207954Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T17:52:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia
title NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia
spellingShingle NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia
Pereira, Daniela A.
antihypertensive agents
genetic polymorphisms
nicotinamide phosphoribosyltransferase
nitric oxide
pharmacogenetics
preeclampsia
sFlt-1
visfatin/NAMPT
title_short NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia
title_full NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia
title_fullStr NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia
title_full_unstemmed NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia
title_sort NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia
author Pereira, Daniela A.
author_facet Pereira, Daniela A.
Sandrim, Valeria C. [UNESP]
Palei, Ana C.
Amaral, Lorena M.
Belo, Vanessa A.
Lacchini, Riccardo
Cavalli, Ricardo C.
Tanus-Santos, Jose E.
Luizon, Marcelo R.
author_role author
author2 Sandrim, Valeria C. [UNESP]
Palei, Ana C.
Amaral, Lorena M.
Belo, Vanessa A.
Lacchini, Riccardo
Cavalli, Ricardo C.
Tanus-Santos, Jose E.
Luizon, Marcelo R.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Minas Gerais (UFMG)
Universidade Estadual Paulista (Unesp)
University of Mississippi Medical Center
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Pereira, Daniela A.
Sandrim, Valeria C. [UNESP]
Palei, Ana C.
Amaral, Lorena M.
Belo, Vanessa A.
Lacchini, Riccardo
Cavalli, Ricardo C.
Tanus-Santos, Jose E.
Luizon, Marcelo R.
dc.subject.por.fl_str_mv antihypertensive agents
genetic polymorphisms
nicotinamide phosphoribosyltransferase
nitric oxide
pharmacogenetics
preeclampsia
sFlt-1
visfatin/NAMPT
topic antihypertensive agents
genetic polymorphisms
nicotinamide phosphoribosyltransferase
nitric oxide
pharmacogenetics
preeclampsia
sFlt-1
visfatin/NAMPT
description Aim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite concentrations in PE and 206 healthy pregnant women. Patients & methods: Circulating visfatin/NAMPT and sFlt-1 levels were measured by ELISA, and nitrite concentrations by using an ozone-based chemiluminescence assay. Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. NAMPT SNP rs1319501 affected nitrite concentrations in nonresponsive PE patients and was tightly linked with NAMPT functional SNPs in Europeans. Conclusion: NAMPT SNP rs1319501 and visfatin/NAMPT affect NO formation, sFlt-1 levels and antihypertensive therapy response in PE.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:03:48Z
2021-06-25T11:03:48Z
2021-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2217/pgs-2021-0006
Pharmacogenomics, v. 22, n. 8, p. 451-464, 2021.
1744-8042
1462-2416
http://hdl.handle.net/11449/207954
10.2217/pgs-2021-0006
2-s2.0-85107488118
url http://dx.doi.org/10.2217/pgs-2021-0006
http://hdl.handle.net/11449/207954
identifier_str_mv Pharmacogenomics, v. 22, n. 8, p. 451-464, 2021.
1744-8042
1462-2416
10.2217/pgs-2021-0006
2-s2.0-85107488118
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmacogenomics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 451-464
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964686121172992

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