Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis

Detalhes bibliográficos
Autor(a) principal: dos Santos, Paulo Victor P.
Data de Publicação: 2021
Outros Autores: Ribeiro, Camila M. [UNESP], Pavan, Fernando R. [UNESP], Corbi, Pedro P., Bergamini, Fernando R.G., Carvalho, Marcos A., D'Oliveria, Kaique A., Cuin, Alexandre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.molstruc.2021.130193
http://hdl.handle.net/11449/208478
Resumo: In the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 µg/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis.
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spelling Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosisMycobacterium tuberculosisN-acylhydrazonesPowder X-ray diffractionSilver complexesIn the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 µg/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis.Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)LQBin – Laboratory of BioInorganic Chemistry Chemistry Department Institute of Exact Sciences Federal University of Juiz de Fora – UFJFSão Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory AraraquaraInstitute of Chemistry University of Campinas – UNICAMPLaboratory of Synthesis of Bioinspired Molecules Institute of Chemistry Federal University of Uberlândia – UFUChemistry Department Federal University of Mato Grosso – UFMTSão Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory AraraquaraFAPEMIG: 2018Federal University of Juiz de Fora – UFJFUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Universidade Federal de Uberlândia (UFU)Federal University of Mato Grosso – UFMTdos Santos, Paulo Victor P.Ribeiro, Camila M. [UNESP]Pavan, Fernando R. [UNESP]Corbi, Pedro P.Bergamini, Fernando R.G.Carvalho, Marcos A.D'Oliveria, Kaique A.Cuin, Alexandre2021-06-25T11:12:49Z2021-06-25T11:12:49Z2021-06-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.molstruc.2021.130193Journal of Molecular Structure, v. 1234.0022-2860http://hdl.handle.net/11449/20847810.1016/j.molstruc.2021.1301932-s2.0-85102039591Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Molecular Structureinfo:eu-repo/semantics/openAccess2021-10-23T19:02:13Zoai:repositorio.unesp.br:11449/208478Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:02:13Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
title Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
spellingShingle Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
dos Santos, Paulo Victor P.
Mycobacterium tuberculosis
N-acylhydrazones
Powder X-ray diffraction
Silver complexes
title_short Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
title_full Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
title_fullStr Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
title_full_unstemmed Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
title_sort Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis
author dos Santos, Paulo Victor P.
author_facet dos Santos, Paulo Victor P.
Ribeiro, Camila M. [UNESP]
Pavan, Fernando R. [UNESP]
Corbi, Pedro P.
Bergamini, Fernando R.G.
Carvalho, Marcos A.
D'Oliveria, Kaique A.
Cuin, Alexandre
author_role author
author2 Ribeiro, Camila M. [UNESP]
Pavan, Fernando R. [UNESP]
Corbi, Pedro P.
Bergamini, Fernando R.G.
Carvalho, Marcos A.
D'Oliveria, Kaique A.
Cuin, Alexandre
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Federal University of Juiz de Fora – UFJF
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de Uberlândia (UFU)
Federal University of Mato Grosso – UFMT
dc.contributor.author.fl_str_mv dos Santos, Paulo Victor P.
Ribeiro, Camila M. [UNESP]
Pavan, Fernando R. [UNESP]
Corbi, Pedro P.
Bergamini, Fernando R.G.
Carvalho, Marcos A.
D'Oliveria, Kaique A.
Cuin, Alexandre
dc.subject.por.fl_str_mv Mycobacterium tuberculosis
N-acylhydrazones
Powder X-ray diffraction
Silver complexes
topic Mycobacterium tuberculosis
N-acylhydrazones
Powder X-ray diffraction
Silver complexes
description In the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 µg/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:12:49Z
2021-06-25T11:12:49Z
2021-06-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.molstruc.2021.130193
Journal of Molecular Structure, v. 1234.
0022-2860
http://hdl.handle.net/11449/208478
10.1016/j.molstruc.2021.130193
2-s2.0-85102039591
url http://dx.doi.org/10.1016/j.molstruc.2021.130193
http://hdl.handle.net/11449/208478
identifier_str_mv Journal of Molecular Structure, v. 1234.
0022-2860
10.1016/j.molstruc.2021.130193
2-s2.0-85102039591
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Molecular Structure
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965585671454720

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