The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-86502013000100002 http://hdl.handle.net/11449/250375 |
Resumo: | PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion. |
id |
UNSP_6a053cebab6db156d81a1b7d342fb946 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/250375 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in ratsAcute kidney injuryColloidsFluid therapyHetastarchRatsPURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Santa Casa Faculty of Medicine of São PauloUNESP Botucatu Medical School Postgraduate Program in AnesthesiologyNorthwestern University Feinberg School of Medicine Department of AnesthesiologyUNESP Botucatu Medical School Department of PathologyPostgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao PauloDepartment of Anesthesiology Northwestern University Feinberg School of Medicine, Chicago, ILDepartment of Pathology Botucatu Medical School, UNESP, Sao PauloDepartment of Anesthesiology Botucatu Medical School, UNESP, Sao PauloUNESP Botucatu Medical School Postgraduate Program in AnesthesiologyUNESP Botucatu Medical School Department of PathologyUNESP Botucatu Medical School Department of AnesthesiologyPostgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao PauloDepartment of Pathology Botucatu Medical School, UNESP, Sao PauloDepartment of Anesthesiology Botucatu Medical School, UNESP, Sao PauloFAPESP: 10/08562-0Sociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Estadual Paulista (Unesp)Northwestern University (NU)Santa Casa Faculty of Medicine of São PauloFeinberg School of MedicineSanta Casa Faculty of MedicineAzevedo, Vera Lucia Fernandes de [UNESP]Santos, Paulo Sergio Santana [UNESP]Oliveira Jr, Gildàsio Silveira deMódolo, Gabriel PinheiroDomingues, Maria Aparecida Custódio [UNESP]Castiglia, Yara Marcondes Machado [UNESP]Vianna, Pedro Thadeu Galvão [UNESP]Vane, Luiz Antonio [UNESP]Módolo, Norma Sueli Pinheiro [UNESP]2014-05-20T13:37:10Z2022-04-29T06:48:19Z2014-05-20T13:37:10Z2022-04-29T06:48:19Z2013-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article05-09application/pdfhttp://dx.doi.org/10.1590/S0102-86502013000100002Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013.Acta Cirurgica Brasileira, v. 28, n. 1, p. 5-9, 2013.0102-86501678-2674http://hdl.handle.net/11449/25037510.1590/S0102-86502013000100002S0102-86502013000100002WOS:0003138666000012-s2.0-84872905611S0102-86502013000100002.pdf822354647572405878028301253420700585723113037140SciELOScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirúrgica Brasileira0,395info:eu-repo/semantics/openAccess2024-09-03T13:14:53Zoai:repositorio.unesp.br:11449/250375Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
title |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
spellingShingle |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats Azevedo, Vera Lucia Fernandes de [UNESP] Acute kidney injury Colloids Fluid therapy Hetastarch Rats |
title_short |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
title_full |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
title_fullStr |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
title_full_unstemmed |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
title_sort |
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
author |
Azevedo, Vera Lucia Fernandes de [UNESP] |
author_facet |
Azevedo, Vera Lucia Fernandes de [UNESP] Santos, Paulo Sergio Santana [UNESP] Oliveira Jr, Gildàsio Silveira de Módolo, Gabriel Pinheiro Domingues, Maria Aparecida Custódio [UNESP] Castiglia, Yara Marcondes Machado [UNESP] Vianna, Pedro Thadeu Galvão [UNESP] Vane, Luiz Antonio [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] |
author_role |
author |
author2 |
Santos, Paulo Sergio Santana [UNESP] Oliveira Jr, Gildàsio Silveira de Módolo, Gabriel Pinheiro Domingues, Maria Aparecida Custódio [UNESP] Castiglia, Yara Marcondes Machado [UNESP] Vianna, Pedro Thadeu Galvão [UNESP] Vane, Luiz Antonio [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Northwestern University (NU) Santa Casa Faculty of Medicine of São Paulo Feinberg School of Medicine Santa Casa Faculty of Medicine |
dc.contributor.author.fl_str_mv |
Azevedo, Vera Lucia Fernandes de [UNESP] Santos, Paulo Sergio Santana [UNESP] Oliveira Jr, Gildàsio Silveira de Módolo, Gabriel Pinheiro Domingues, Maria Aparecida Custódio [UNESP] Castiglia, Yara Marcondes Machado [UNESP] Vianna, Pedro Thadeu Galvão [UNESP] Vane, Luiz Antonio [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] |
dc.subject.por.fl_str_mv |
Acute kidney injury Colloids Fluid therapy Hetastarch Rats |
topic |
Acute kidney injury Colloids Fluid therapy Hetastarch Rats |
description |
PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 2014-05-20T13:37:10Z 2014-05-20T13:37:10Z 2022-04-29T06:48:19Z 2022-04-29T06:48:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502013000100002 Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013. Acta Cirurgica Brasileira, v. 28, n. 1, p. 5-9, 2013. 0102-8650 1678-2674 http://hdl.handle.net/11449/250375 10.1590/S0102-86502013000100002 S0102-86502013000100002 WOS:000313866600001 2-s2.0-84872905611 S0102-86502013000100002.pdf 8223546475724058 7802830125342070 0585723113037140 |
url |
http://dx.doi.org/10.1590/S0102-86502013000100002 http://hdl.handle.net/11449/250375 |
identifier_str_mv |
Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013. Acta Cirurgica Brasileira, v. 28, n. 1, p. 5-9, 2013. 0102-8650 1678-2674 10.1590/S0102-86502013000100002 S0102-86502013000100002 WOS:000313866600001 2-s2.0-84872905611 S0102-86502013000100002.pdf 8223546475724058 7802830125342070 0585723113037140 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirúrgica Brasileira 0,395 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
05-09 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
SciELO Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021374539857920 |