The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

Detalhes bibliográficos
Autor(a) principal: Azevedo, Vera Lucia Fernandes de [UNESP]
Data de Publicação: 2013
Outros Autores: Santos, Paulo Sergio Santana [UNESP], Oliveira Jr, Gildàsio Silveira de, Módolo, Gabriel Pinheiro, Domingues, Maria Aparecida Custódio [UNESP], Castiglia, Yara Marcondes Machado [UNESP], Vianna, Pedro Thadeu Galvão [UNESP], Vane, Luiz Antonio [UNESP], Módolo, Norma Sueli Pinheiro [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502013000100002
http://hdl.handle.net/11449/250375
Resumo: PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
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spelling The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in ratsAcute kidney injuryColloidsFluid therapyHetastarchRatsPURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Santa Casa Faculty of Medicine of São PauloUNESP Botucatu Medical School Postgraduate Program in AnesthesiologyNorthwestern University Feinberg School of Medicine Department of AnesthesiologyUNESP Botucatu Medical School Department of PathologyPostgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao PauloDepartment of Anesthesiology Northwestern University Feinberg School of Medicine, Chicago, ILDepartment of Pathology Botucatu Medical School, UNESP, Sao PauloDepartment of Anesthesiology Botucatu Medical School, UNESP, Sao PauloUNESP Botucatu Medical School Postgraduate Program in AnesthesiologyUNESP Botucatu Medical School Department of PathologyUNESP Botucatu Medical School Department of AnesthesiologyPostgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao PauloDepartment of Pathology Botucatu Medical School, UNESP, Sao PauloDepartment of Anesthesiology Botucatu Medical School, UNESP, Sao PauloFAPESP: 10/08562-0Sociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Estadual Paulista (Unesp)Northwestern University (NU)Santa Casa Faculty of Medicine of São PauloFeinberg School of MedicineSanta Casa Faculty of MedicineAzevedo, Vera Lucia Fernandes de [UNESP]Santos, Paulo Sergio Santana [UNESP]Oliveira Jr, Gildàsio Silveira deMódolo, Gabriel PinheiroDomingues, Maria Aparecida Custódio [UNESP]Castiglia, Yara Marcondes Machado [UNESP]Vianna, Pedro Thadeu Galvão [UNESP]Vane, Luiz Antonio [UNESP]Módolo, Norma Sueli Pinheiro [UNESP]2014-05-20T13:37:10Z2022-04-29T06:48:19Z2014-05-20T13:37:10Z2022-04-29T06:48:19Z2013-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article05-09application/pdfhttp://dx.doi.org/10.1590/S0102-86502013000100002Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013.Acta Cirurgica Brasileira, v. 28, n. 1, p. 5-9, 2013.0102-86501678-2674http://hdl.handle.net/11449/25037510.1590/S0102-86502013000100002S0102-86502013000100002WOS:0003138666000012-s2.0-84872905611S0102-86502013000100002.pdf822354647572405878028301253420700585723113037140SciELOScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirúrgica Brasileira0,395info:eu-repo/semantics/openAccess2024-09-03T13:14:53Zoai:repositorio.unesp.br:11449/250375Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
spellingShingle The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Azevedo, Vera Lucia Fernandes de [UNESP]
Acute kidney injury
Colloids
Fluid therapy
Hetastarch
Rats
title_short The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title_full The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title_fullStr The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title_full_unstemmed The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
title_sort The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
author Azevedo, Vera Lucia Fernandes de [UNESP]
author_facet Azevedo, Vera Lucia Fernandes de [UNESP]
Santos, Paulo Sergio Santana [UNESP]
Oliveira Jr, Gildàsio Silveira de
Módolo, Gabriel Pinheiro
Domingues, Maria Aparecida Custódio [UNESP]
Castiglia, Yara Marcondes Machado [UNESP]
Vianna, Pedro Thadeu Galvão [UNESP]
Vane, Luiz Antonio [UNESP]
Módolo, Norma Sueli Pinheiro [UNESP]
author_role author
author2 Santos, Paulo Sergio Santana [UNESP]
Oliveira Jr, Gildàsio Silveira de
Módolo, Gabriel Pinheiro
Domingues, Maria Aparecida Custódio [UNESP]
Castiglia, Yara Marcondes Machado [UNESP]
Vianna, Pedro Thadeu Galvão [UNESP]
Vane, Luiz Antonio [UNESP]
Módolo, Norma Sueli Pinheiro [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Northwestern University (NU)
Santa Casa Faculty of Medicine of São Paulo
Feinberg School of Medicine
Santa Casa Faculty of Medicine
dc.contributor.author.fl_str_mv Azevedo, Vera Lucia Fernandes de [UNESP]
Santos, Paulo Sergio Santana [UNESP]
Oliveira Jr, Gildàsio Silveira de
Módolo, Gabriel Pinheiro
Domingues, Maria Aparecida Custódio [UNESP]
Castiglia, Yara Marcondes Machado [UNESP]
Vianna, Pedro Thadeu Galvão [UNESP]
Vane, Luiz Antonio [UNESP]
Módolo, Norma Sueli Pinheiro [UNESP]
dc.subject.por.fl_str_mv Acute kidney injury
Colloids
Fluid therapy
Hetastarch
Rats
topic Acute kidney injury
Colloids
Fluid therapy
Hetastarch
Rats
description PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2014-05-20T13:37:10Z
2014-05-20T13:37:10Z
2022-04-29T06:48:19Z
2022-04-29T06:48:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502013000100002
Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013.
Acta Cirurgica Brasileira, v. 28, n. 1, p. 5-9, 2013.
0102-8650
1678-2674
http://hdl.handle.net/11449/250375
10.1590/S0102-86502013000100002
S0102-86502013000100002
WOS:000313866600001
2-s2.0-84872905611
S0102-86502013000100002.pdf
8223546475724058
7802830125342070
0585723113037140
url http://dx.doi.org/10.1590/S0102-86502013000100002
http://hdl.handle.net/11449/250375
identifier_str_mv Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013.
Acta Cirurgica Brasileira, v. 28, n. 1, p. 5-9, 2013.
0102-8650
1678-2674
10.1590/S0102-86502013000100002
S0102-86502013000100002
WOS:000313866600001
2-s2.0-84872905611
S0102-86502013000100002.pdf
8223546475724058
7802830125342070
0585723113037140
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirúrgica Brasileira
0,395
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 05-09
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv SciELO
Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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