Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.vaa.2020.08.006 http://hdl.handle.net/11449/206605 |
Resumo: | Objective: To evaluate the analgesic efficacy and safety of tumescent local anesthesia (TLA) in cats undergoing unilateral mastectomy. Study design: Prospective clinical trial. Animals: A total of 12 ovariohysterectomized female cats. Methods: All animals were premedicated with pethidine (4 mg kg–1) intramuscularly (IM), followed by induction of anesthesia with propofol (5 mg kg–1) intravenously and maintenance with isoflurane in oxygen. A refrigerated TLA solution (15 mL kg–1, 8 °C) was injected using a Klein cannula. The solution was composed of 0.5 mL of epinephrine (1 mg mL–1) and 40 mL of 2% lidocaine added to 210 mL lactated Ringer's solution (final lidocaine concentration 0.32%). Heart and respiratory rates, systolic arterial blood pressure, temperature and oxygen saturation were measured during anesthesia. Blood samples were collected from the jugular vein for measurement of plasma lidocaine concentration using high performance liquid chromatography. Postoperative pain scores were evaluated hourly for 6 hours. Analgesic rescue was performed with tramadol (2 mg kg–1) IM and meloxicam (0.15 mg kg–1) subcutaneously. Results: Plasma lidocaine concentration peaked at 90 minutes after injection of TLA, but no concentration considered toxic for the species was measured. The median postoperative analgesia time was 6 hours after injection of TLA. Conclusions: This study found that TLA prevented sympathetic response to noxious stimuli during anesthesia and provided satisfactory postoperative analgesia in cats submitted to total unilateral mastectomy, with no apparent signs of toxicity. Clinical relevance: TLA can prevent sympathetic stimulation resulting from noxious stimuli during anesthesia, promoting good intraoperative conditions, proving to be a viable addition to analgesia in cats submitted to a total unilateral mastectomy. |
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Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomyanalgesiacatlidocainelocal anesthesiamastectomytumescent local anesthesiaObjective: To evaluate the analgesic efficacy and safety of tumescent local anesthesia (TLA) in cats undergoing unilateral mastectomy. Study design: Prospective clinical trial. Animals: A total of 12 ovariohysterectomized female cats. Methods: All animals were premedicated with pethidine (4 mg kg–1) intramuscularly (IM), followed by induction of anesthesia with propofol (5 mg kg–1) intravenously and maintenance with isoflurane in oxygen. A refrigerated TLA solution (15 mL kg–1, 8 °C) was injected using a Klein cannula. The solution was composed of 0.5 mL of epinephrine (1 mg mL–1) and 40 mL of 2% lidocaine added to 210 mL lactated Ringer's solution (final lidocaine concentration 0.32%). Heart and respiratory rates, systolic arterial blood pressure, temperature and oxygen saturation were measured during anesthesia. Blood samples were collected from the jugular vein for measurement of plasma lidocaine concentration using high performance liquid chromatography. Postoperative pain scores were evaluated hourly for 6 hours. Analgesic rescue was performed with tramadol (2 mg kg–1) IM and meloxicam (0.15 mg kg–1) subcutaneously. Results: Plasma lidocaine concentration peaked at 90 minutes after injection of TLA, but no concentration considered toxic for the species was measured. The median postoperative analgesia time was 6 hours after injection of TLA. Conclusions: This study found that TLA prevented sympathetic response to noxious stimuli during anesthesia and provided satisfactory postoperative analgesia in cats submitted to total unilateral mastectomy, with no apparent signs of toxicity. Clinical relevance: TLA can prevent sympathetic stimulation resulting from noxious stimuli during anesthesia, promoting good intraoperative conditions, proving to be a viable addition to analgesia in cats submitted to a total unilateral mastectomy.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Graduate Program in Veterinary Medicine (Pathology and Clinical Sciences) Universidade Federal Rural do Rio de JaneiroAutonomous VeterinarianDepartment of Veterinary Surgery and Anaesthesiology Faculty of Veterinary Medicine and Animal Science São Paulo State University (UNESP)Department of Veterinary Medicine and Surgery Universidade Federal Rural do Rio de JaneiroDepartment of Veterinary Surgery and Anaesthesiology Faculty of Veterinary Medicine and Animal Science São Paulo State University (UNESP)CAPES: 88881.188458/2018-01Universidade Federal Rural do Rio de JaneiroAutonomous VeterinarianUniversidade Estadual Paulista (Unesp)Moreira, Clarissa MR.Oliveira, Renato LS.Costa, Gilberto A.Corgozinho, Katia B.Luna, Stelio PL. [UNESP]Souza, Heloisa JM.2021-06-25T10:35:01Z2021-06-25T10:35:01Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article134-141http://dx.doi.org/10.1016/j.vaa.2020.08.006Veterinary Anaesthesia and Analgesia, v. 48, n. 1, p. 134-141, 2021.1467-29951467-2987http://hdl.handle.net/11449/20660510.1016/j.vaa.2020.08.0062-s2.0-85092017145Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Anaesthesia and Analgesiainfo:eu-repo/semantics/openAccess2021-10-23T07:59:27Zoai:repositorio.unesp.br:11449/206605Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T07:59:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy |
title |
Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy |
spellingShingle |
Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy Moreira, Clarissa MR. analgesia cat lidocaine local anesthesia mastectomy tumescent local anesthesia |
title_short |
Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy |
title_full |
Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy |
title_fullStr |
Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy |
title_full_unstemmed |
Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy |
title_sort |
Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy |
author |
Moreira, Clarissa MR. |
author_facet |
Moreira, Clarissa MR. Oliveira, Renato LS. Costa, Gilberto A. Corgozinho, Katia B. Luna, Stelio PL. [UNESP] Souza, Heloisa JM. |
author_role |
author |
author2 |
Oliveira, Renato LS. Costa, Gilberto A. Corgozinho, Katia B. Luna, Stelio PL. [UNESP] Souza, Heloisa JM. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal Rural do Rio de Janeiro Autonomous Veterinarian Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Moreira, Clarissa MR. Oliveira, Renato LS. Costa, Gilberto A. Corgozinho, Katia B. Luna, Stelio PL. [UNESP] Souza, Heloisa JM. |
dc.subject.por.fl_str_mv |
analgesia cat lidocaine local anesthesia mastectomy tumescent local anesthesia |
topic |
analgesia cat lidocaine local anesthesia mastectomy tumescent local anesthesia |
description |
Objective: To evaluate the analgesic efficacy and safety of tumescent local anesthesia (TLA) in cats undergoing unilateral mastectomy. Study design: Prospective clinical trial. Animals: A total of 12 ovariohysterectomized female cats. Methods: All animals were premedicated with pethidine (4 mg kg–1) intramuscularly (IM), followed by induction of anesthesia with propofol (5 mg kg–1) intravenously and maintenance with isoflurane in oxygen. A refrigerated TLA solution (15 mL kg–1, 8 °C) was injected using a Klein cannula. The solution was composed of 0.5 mL of epinephrine (1 mg mL–1) and 40 mL of 2% lidocaine added to 210 mL lactated Ringer's solution (final lidocaine concentration 0.32%). Heart and respiratory rates, systolic arterial blood pressure, temperature and oxygen saturation were measured during anesthesia. Blood samples were collected from the jugular vein for measurement of plasma lidocaine concentration using high performance liquid chromatography. Postoperative pain scores were evaluated hourly for 6 hours. Analgesic rescue was performed with tramadol (2 mg kg–1) IM and meloxicam (0.15 mg kg–1) subcutaneously. Results: Plasma lidocaine concentration peaked at 90 minutes after injection of TLA, but no concentration considered toxic for the species was measured. The median postoperative analgesia time was 6 hours after injection of TLA. Conclusions: This study found that TLA prevented sympathetic response to noxious stimuli during anesthesia and provided satisfactory postoperative analgesia in cats submitted to total unilateral mastectomy, with no apparent signs of toxicity. Clinical relevance: TLA can prevent sympathetic stimulation resulting from noxious stimuli during anesthesia, promoting good intraoperative conditions, proving to be a viable addition to analgesia in cats submitted to a total unilateral mastectomy. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:35:01Z 2021-06-25T10:35:01Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.vaa.2020.08.006 Veterinary Anaesthesia and Analgesia, v. 48, n. 1, p. 134-141, 2021. 1467-2995 1467-2987 http://hdl.handle.net/11449/206605 10.1016/j.vaa.2020.08.006 2-s2.0-85092017145 |
url |
http://dx.doi.org/10.1016/j.vaa.2020.08.006 http://hdl.handle.net/11449/206605 |
identifier_str_mv |
Veterinary Anaesthesia and Analgesia, v. 48, n. 1, p. 134-141, 2021. 1467-2995 1467-2987 10.1016/j.vaa.2020.08.006 2-s2.0-85092017145 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Veterinary Anaesthesia and Analgesia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
134-141 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1792961705255370752 |