Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil

Detalhes bibliográficos
Autor(a) principal: Maciel-Guerra, Helena [UNESP]
Data de Publicação: 2018
Outros Autores: Jorge, Marília Formentini Scotton [UNESP], Carrijo, Ana Cláudia Nazareno dos Anjos [UNESP], Miot, Hélio Amante [UNESP], Penha, Mariana Álvares [UNESP], Libório, Ricardo da Silva [UNESP], Parise-Fortes, Maria Rita [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20186807
http://hdl.handle.net/11449/176257
Resumo: Background: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines. Objectives: To evaluate the tolerability and efficacy of the main commercial brand and generic H1 antihistamines, regarding the suppression of the wheal and flare to the histamine test. Methods: A quasi-experimental, open study with 10 healthy adults submitted to the histamine test on the ventral aspect of the forearms. After 20 minutes, wheal and flares were measured. The tests were performed after two hours of intake of dexchlorpheniramine, hydroxyzine, levocetirizine, fexofenadine, cetirizine, loratadine, ebastine, desloratadine, epinastine and rupatadine, as well as generics of loratadine, cetirizine and fexofenadine. Results: All antihistamines presented a reduction in the wheal compared to the control (p <0.02), as well as in the flare, except for rupatadine (p = 0.70). In the internal comparison, cetirizine, fexofenadine, epinastine, levocetirizine, dexchlorpheniramine and hydroxyzine were the most potent, with no difference between them (p > 0.1). As for halo, cetirizine, epinastine, hydroxyzine and fexofenadine were the most potent, with no difference between them (p > 0.1). The most common adverse effect was drowsiness, which was more prevalent among first-generation drugs (p < 0.01). Generic loratadine, fexofenadine and cetirizine halos were higher than their controls (p <0.03). Study limitations: A single-center study evaluating only aspects related to histamine. Conclusions: Brazilian commercial antihistamines presented different profiles of inhibition of wheal and flares in the histamine test, as well as adverse effects. Generic loratadine, fexofenadine and cetirizine presented larger flares than brand drugs.
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spelling Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in BrazilAngioedemaHistamine antagonistsHistamine H1 antagonistsHistamine H2 antagonistsUrticariaBackground: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines. Objectives: To evaluate the tolerability and efficacy of the main commercial brand and generic H1 antihistamines, regarding the suppression of the wheal and flare to the histamine test. Methods: A quasi-experimental, open study with 10 healthy adults submitted to the histamine test on the ventral aspect of the forearms. After 20 minutes, wheal and flares were measured. The tests were performed after two hours of intake of dexchlorpheniramine, hydroxyzine, levocetirizine, fexofenadine, cetirizine, loratadine, ebastine, desloratadine, epinastine and rupatadine, as well as generics of loratadine, cetirizine and fexofenadine. Results: All antihistamines presented a reduction in the wheal compared to the control (p <0.02), as well as in the flare, except for rupatadine (p = 0.70). In the internal comparison, cetirizine, fexofenadine, epinastine, levocetirizine, dexchlorpheniramine and hydroxyzine were the most potent, with no difference between them (p > 0.1). As for halo, cetirizine, epinastine, hydroxyzine and fexofenadine were the most potent, with no difference between them (p > 0.1). The most common adverse effect was drowsiness, which was more prevalent among first-generation drugs (p < 0.01). Generic loratadine, fexofenadine and cetirizine halos were higher than their controls (p <0.03). Study limitations: A single-center study evaluating only aspects related to histamine. Conclusions: Brazilian commercial antihistamines presented different profiles of inhibition of wheal and flares in the histamine test, as well as adverse effects. Generic loratadine, fexofenadine and cetirizine presented larger flares than brand drugs.Faculdade de Medicina de Botucatu Universidade Estadual Paulista “Júlio de Mesquita Filho” (FMB-Unesp)Department of Dermatology and Radiotherapy Faculdade de Medicina de Botucatu Universidade Estadual Paulista “Júlio de Mesquita Filho” (FMB-Unesp)Faculdade de Medicina de Botucatu Universidade Estadual Paulista “Júlio de Mesquita Filho” (FMB-Unesp)Department of Dermatology and Radiotherapy Faculdade de Medicina de Botucatu Universidade Estadual Paulista “Júlio de Mesquita Filho” (FMB-Unesp)Universidade Estadual Paulista (Unesp)Maciel-Guerra, Helena [UNESP]Jorge, Marília Formentini Scotton [UNESP]Carrijo, Ana Cláudia Nazareno dos Anjos [UNESP]Miot, Hélio Amante [UNESP]Penha, Mariana Álvares [UNESP]Libório, Ricardo da Silva [UNESP]Parise-Fortes, Maria Rita [UNESP]2018-12-11T17:19:49Z2018-12-11T17:19:49Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article233-237application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20186807Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 233-237, 2018.1806-48410365-0596http://hdl.handle.net/11449/17625710.1590/abd1806-4841.20186807S0365-059620180002002332-s2.0-85046400733S0365-05962018000200233.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0,520info:eu-repo/semantics/openAccess2024-08-14T18:45:21Zoai:repositorio.unesp.br:11449/176257Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T18:45:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
title Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
spellingShingle Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
Maciel-Guerra, Helena [UNESP]
Angioedema
Histamine antagonists
Histamine H1 antagonists
Histamine H2 antagonists
Urticaria
title_short Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
title_full Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
title_fullStr Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
title_full_unstemmed Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
title_sort Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
author Maciel-Guerra, Helena [UNESP]
author_facet Maciel-Guerra, Helena [UNESP]
Jorge, Marília Formentini Scotton [UNESP]
Carrijo, Ana Cláudia Nazareno dos Anjos [UNESP]
Miot, Hélio Amante [UNESP]
Penha, Mariana Álvares [UNESP]
Libório, Ricardo da Silva [UNESP]
Parise-Fortes, Maria Rita [UNESP]
author_role author
author2 Jorge, Marília Formentini Scotton [UNESP]
Carrijo, Ana Cláudia Nazareno dos Anjos [UNESP]
Miot, Hélio Amante [UNESP]
Penha, Mariana Álvares [UNESP]
Libório, Ricardo da Silva [UNESP]
Parise-Fortes, Maria Rita [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Maciel-Guerra, Helena [UNESP]
Jorge, Marília Formentini Scotton [UNESP]
Carrijo, Ana Cláudia Nazareno dos Anjos [UNESP]
Miot, Hélio Amante [UNESP]
Penha, Mariana Álvares [UNESP]
Libório, Ricardo da Silva [UNESP]
Parise-Fortes, Maria Rita [UNESP]
dc.subject.por.fl_str_mv Angioedema
Histamine antagonists
Histamine H1 antagonists
Histamine H2 antagonists
Urticaria
topic Angioedema
Histamine antagonists
Histamine H1 antagonists
Histamine H2 antagonists
Urticaria
description Background: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines. Objectives: To evaluate the tolerability and efficacy of the main commercial brand and generic H1 antihistamines, regarding the suppression of the wheal and flare to the histamine test. Methods: A quasi-experimental, open study with 10 healthy adults submitted to the histamine test on the ventral aspect of the forearms. After 20 minutes, wheal and flares were measured. The tests were performed after two hours of intake of dexchlorpheniramine, hydroxyzine, levocetirizine, fexofenadine, cetirizine, loratadine, ebastine, desloratadine, epinastine and rupatadine, as well as generics of loratadine, cetirizine and fexofenadine. Results: All antihistamines presented a reduction in the wheal compared to the control (p <0.02), as well as in the flare, except for rupatadine (p = 0.70). In the internal comparison, cetirizine, fexofenadine, epinastine, levocetirizine, dexchlorpheniramine and hydroxyzine were the most potent, with no difference between them (p > 0.1). As for halo, cetirizine, epinastine, hydroxyzine and fexofenadine were the most potent, with no difference between them (p > 0.1). The most common adverse effect was drowsiness, which was more prevalent among first-generation drugs (p < 0.01). Generic loratadine, fexofenadine and cetirizine halos were higher than their controls (p <0.03). Study limitations: A single-center study evaluating only aspects related to histamine. Conclusions: Brazilian commercial antihistamines presented different profiles of inhibition of wheal and flares in the histamine test, as well as adverse effects. Generic loratadine, fexofenadine and cetirizine presented larger flares than brand drugs.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:19:49Z
2018-12-11T17:19:49Z
2018-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/abd1806-4841.20186807
Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 233-237, 2018.
1806-4841
0365-0596
http://hdl.handle.net/11449/176257
10.1590/abd1806-4841.20186807
S0365-05962018000200233
2-s2.0-85046400733
S0365-05962018000200233.pdf
url http://dx.doi.org/10.1590/abd1806-4841.20186807
http://hdl.handle.net/11449/176257
identifier_str_mv Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 233-237, 2018.
1806-4841
0365-0596
10.1590/abd1806-4841.20186807
S0365-05962018000200233
2-s2.0-85046400733
S0365-05962018000200233.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Brasileiros de Dermatologia
0,520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 233-237
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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