Pilot study of homologous platelet gel in venous ulcers

Detalhes bibliográficos
Autor(a) principal: de Oliveira, Mariele Gobo [UNESP]
Data de Publicação: 2017
Outros Autores: Abbade, Luciana Patricia Fernandes [UNESP], Miot, Hélio Amante [UNESP], Ferreira, Rosana Rossi [UNESP], Deffune, Elenice [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20175496
http://hdl.handle.net/11449/175245
Resumo: Background: Venous ulcers represent 70% of the lower limb ulcers. They are difficult to heal, requiring a correct diagnostic and therapeutic approach. Many products have been developed to healing, such as homologous platelet gel obtained from the platelet concentrate exceeding from blood transfusion. Objective: To evaluate the safety and efficacy of homologous platelet gel in venous ulcers compared with hydrocolloid dressing. Method: A pilot randomized clinical trial in patients with venous ulcers. Randomized groups (homologous platelet gel and hydrocolloid groups) were followed for 90 days and were assessed through the evolution of ulcerated area, qualitative analysis of vascularization and adverse events. Both groups used elastic compression. Results: We included 16 participants, with a total of 21 venous ulcers. Both treatments promoted a reduction of the areas of the ulcers in 90 days (mean 69%), there was significant difference between the groups concerning the gradual reduction of the ulcers areas, favorably to the hydrocolloid (70% vs 64%; p <0.01). There were some mild adverse events in both groups. Study limitations: Single-center study with a small number of patients, preventing more accurate assessment of the effects of platelet gel. Conclusion: The homologous platelet gel associated with the elastic compression can be an alternative to the venous ulcer treatment and is safe due to the occurrence of a few mild local adverse events and no serious adverse events. Clinical trials with larger numbers of patients must be performed to maintain the indication of this treatment for venous ulcer.
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spelling Pilot study of homologous platelet gel in venous ulcersHydrocolloid bandagesPlatelet-rich plasmaVaricose ulcerWound healingBackground: Venous ulcers represent 70% of the lower limb ulcers. They are difficult to heal, requiring a correct diagnostic and therapeutic approach. Many products have been developed to healing, such as homologous platelet gel obtained from the platelet concentrate exceeding from blood transfusion. Objective: To evaluate the safety and efficacy of homologous platelet gel in venous ulcers compared with hydrocolloid dressing. Method: A pilot randomized clinical trial in patients with venous ulcers. Randomized groups (homologous platelet gel and hydrocolloid groups) were followed for 90 days and were assessed through the evolution of ulcerated area, qualitative analysis of vascularization and adverse events. Both groups used elastic compression. Results: We included 16 participants, with a total of 21 venous ulcers. Both treatments promoted a reduction of the areas of the ulcers in 90 days (mean 69%), there was significant difference between the groups concerning the gradual reduction of the ulcers areas, favorably to the hydrocolloid (70% vs 64%; p <0.01). There were some mild adverse events in both groups. Study limitations: Single-center study with a small number of patients, preventing more accurate assessment of the effects of platelet gel. Conclusion: The homologous platelet gel associated with the elastic compression can be an alternative to the venous ulcer treatment and is safe due to the occurrence of a few mild local adverse events and no serious adverse events. Clinical trials with larger numbers of patients must be performed to maintain the indication of this treatment for venous ulcer.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Nursing Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)Department of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)Department of Biological Sciences Faculty of Sciences of Bauru São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)Cellular Engineering Laboratory Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)Department of Nursing Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)Department of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)Department of Biological Sciences Faculty of Sciences of Bauru São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)Cellular Engineering Laboratory Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)FAPESP: 2009/03559-3Universidade Estadual Paulista (Unesp)de Oliveira, Mariele Gobo [UNESP]Abbade, Luciana Patricia Fernandes [UNESP]Miot, Hélio Amante [UNESP]Ferreira, Rosana Rossi [UNESP]Deffune, Elenice [UNESP]2018-12-11T17:14:59Z2018-12-11T17:14:59Z2017-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article499-504application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20175496Anais Brasileiros de Dermatologia, v. 92, n. 4, p. 499-504, 2017.1806-48410365-0596http://hdl.handle.net/11449/17524510.1590/abd1806-4841.20175496S0365-059620170004004992-s2.0-85029825717S0365-05962017000400499.pdf8084974543029515Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0,520info:eu-repo/semantics/openAccess2024-08-15T18:46:26Zoai:repositorio.unesp.br:11449/175245Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T18:46:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pilot study of homologous platelet gel in venous ulcers
title Pilot study of homologous platelet gel in venous ulcers
spellingShingle Pilot study of homologous platelet gel in venous ulcers
de Oliveira, Mariele Gobo [UNESP]
Hydrocolloid bandages
Platelet-rich plasma
Varicose ulcer
Wound healing
title_short Pilot study of homologous platelet gel in venous ulcers
title_full Pilot study of homologous platelet gel in venous ulcers
title_fullStr Pilot study of homologous platelet gel in venous ulcers
title_full_unstemmed Pilot study of homologous platelet gel in venous ulcers
title_sort Pilot study of homologous platelet gel in venous ulcers
author de Oliveira, Mariele Gobo [UNESP]
author_facet de Oliveira, Mariele Gobo [UNESP]
Abbade, Luciana Patricia Fernandes [UNESP]
Miot, Hélio Amante [UNESP]
Ferreira, Rosana Rossi [UNESP]
Deffune, Elenice [UNESP]
author_role author
author2 Abbade, Luciana Patricia Fernandes [UNESP]
Miot, Hélio Amante [UNESP]
Ferreira, Rosana Rossi [UNESP]
Deffune, Elenice [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Oliveira, Mariele Gobo [UNESP]
Abbade, Luciana Patricia Fernandes [UNESP]
Miot, Hélio Amante [UNESP]
Ferreira, Rosana Rossi [UNESP]
Deffune, Elenice [UNESP]
dc.subject.por.fl_str_mv Hydrocolloid bandages
Platelet-rich plasma
Varicose ulcer
Wound healing
topic Hydrocolloid bandages
Platelet-rich plasma
Varicose ulcer
Wound healing
description Background: Venous ulcers represent 70% of the lower limb ulcers. They are difficult to heal, requiring a correct diagnostic and therapeutic approach. Many products have been developed to healing, such as homologous platelet gel obtained from the platelet concentrate exceeding from blood transfusion. Objective: To evaluate the safety and efficacy of homologous platelet gel in venous ulcers compared with hydrocolloid dressing. Method: A pilot randomized clinical trial in patients with venous ulcers. Randomized groups (homologous platelet gel and hydrocolloid groups) were followed for 90 days and were assessed through the evolution of ulcerated area, qualitative analysis of vascularization and adverse events. Both groups used elastic compression. Results: We included 16 participants, with a total of 21 venous ulcers. Both treatments promoted a reduction of the areas of the ulcers in 90 days (mean 69%), there was significant difference between the groups concerning the gradual reduction of the ulcers areas, favorably to the hydrocolloid (70% vs 64%; p <0.01). There were some mild adverse events in both groups. Study limitations: Single-center study with a small number of patients, preventing more accurate assessment of the effects of platelet gel. Conclusion: The homologous platelet gel associated with the elastic compression can be an alternative to the venous ulcer treatment and is safe due to the occurrence of a few mild local adverse events and no serious adverse events. Clinical trials with larger numbers of patients must be performed to maintain the indication of this treatment for venous ulcer.
publishDate 2017
dc.date.none.fl_str_mv 2017-07-01
2018-12-11T17:14:59Z
2018-12-11T17:14:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/abd1806-4841.20175496
Anais Brasileiros de Dermatologia, v. 92, n. 4, p. 499-504, 2017.
1806-4841
0365-0596
http://hdl.handle.net/11449/175245
10.1590/abd1806-4841.20175496
S0365-05962017000400499
2-s2.0-85029825717
S0365-05962017000400499.pdf
8084974543029515
url http://dx.doi.org/10.1590/abd1806-4841.20175496
http://hdl.handle.net/11449/175245
identifier_str_mv Anais Brasileiros de Dermatologia, v. 92, n. 4, p. 499-504, 2017.
1806-4841
0365-0596
10.1590/abd1806-4841.20175496
S0365-05962017000400499
2-s2.0-85029825717
S0365-05962017000400499.pdf
8084974543029515
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Brasileiros de Dermatologia
0,520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 499-504
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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