Mucoadhesive drug delivery systems

Detalhes bibliográficos
Autor(a) principal: Carvalho, Flavia Chiva [UNESP]
Data de Publicação: 2010
Outros Autores: Bruschi, Marcos Luciano, Evangelista, Raul Cesar [UNESP], Gremião, Maria Palmira Daflon [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1984-82502010000100002
http://hdl.handle.net/11449/7805
Resumo: Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing, the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion. fracture and mechanical. Several in vitro and in vivo methodologies arc proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
id UNSP_6e04c3e1c5e926c7701ef0a2cc7f61a2
oai_identifier_str oai:repositorio.unesp.br:11449/7805
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Mucoadhesive drug delivery systemsMucoadhesionBioadhesionMucoadhesive systemsDrugs/deliveryDrug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing, the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion. fracture and mechanical. Several in vitro and in vivo methodologies arc proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.O efeito de fármacos pode ser potencializado através do desenvolvimento de novos sistemas de liberação como os sistemas mucoadesivos. Estes sistemas permanecem em contato íntimo com o tecido de absorção, as mucosas, liberando o fármaco no local de ação, com o consequente aumento da biodisponibilidade, podendo promover efeitos locais e sistêmicos. A mucoadesão, atualmente, é explicada por seis teorias, a eletrônica, da adsorção, da molhabilidade, da difusão, da fratura e a mecânica. Para estudar seus mecanismos e quantificá-la, são propostas várias metodologias in vitro e in vivo. Porém, a mucoadesão ainda não é totalmente compreendida. Esse trabalho tem por objetivo revisar os mecanismos e as teorias envolvidas na mucoadesão, além de descrever as metodologias e os polímeros mais utilizados em sistemas mucoadesivos para liberação de fármacos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)UNESP, Sch Pharmaceut Sci, Pharmaceut Sci Postgrad Program, São Paulo State Univ, BR-14801902 Araraquara, SP, BrazilUniversidade Estadual de Maringá (UEM), State Universidade Estadual de Maringá (UEM), Dept Pharm, Maringa, Parana, BrazilUNESP, São Paulo State Univ, Dept Drugs & Pharmaceut, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, BrazilUNESP, Sch Pharmaceut Sci, Pharmaceut Sci Postgrad Program, São Paulo State Univ, BR-14801902 Araraquara, SP, BrazilUNESP, São Paulo State Univ, Dept Drugs & Pharmaceut, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, BrazilUniversidade de São Paulo (USP), Conjunto QuimicasUniversidade Estadual Paulista (Unesp)Universidade Estadual de Maringá (UEM)Carvalho, Flavia Chiva [UNESP]Bruschi, Marcos LucianoEvangelista, Raul Cesar [UNESP]Gremião, Maria Palmira Daflon [UNESP]2014-05-20T13:24:50Z2014-05-20T13:24:50Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-17application/pdfhttp://dx.doi.org/10.1590/S1984-82502010000100002Brazilian Journal of Pharmaceutical Sciences. São Paulo: Univ São Paulo, Conjunto Quimicas, v. 46, n. 1, p. 1-17, 2010.1984-8250http://hdl.handle.net/11449/7805S1984-82502010000100002WOS:000279574800002S1984-82502010000100002-en.pdf53615691845795579129780536724256Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Pharmaceutical Sciences0.4830,214info:eu-repo/semantics/openAccess2024-06-24T13:45:39Zoai:repositorio.unesp.br:11449/7805Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:00:49.497094Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Mucoadhesive drug delivery systems
title Mucoadhesive drug delivery systems
spellingShingle Mucoadhesive drug delivery systems
Carvalho, Flavia Chiva [UNESP]
Mucoadhesion
Bioadhesion
Mucoadhesive systems
Drugs/delivery
title_short Mucoadhesive drug delivery systems
title_full Mucoadhesive drug delivery systems
title_fullStr Mucoadhesive drug delivery systems
title_full_unstemmed Mucoadhesive drug delivery systems
title_sort Mucoadhesive drug delivery systems
author Carvalho, Flavia Chiva [UNESP]
author_facet Carvalho, Flavia Chiva [UNESP]
Bruschi, Marcos Luciano
Evangelista, Raul Cesar [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
author_role author
author2 Bruschi, Marcos Luciano
Evangelista, Raul Cesar [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Maringá (UEM)
dc.contributor.author.fl_str_mv Carvalho, Flavia Chiva [UNESP]
Bruschi, Marcos Luciano
Evangelista, Raul Cesar [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
dc.subject.por.fl_str_mv Mucoadhesion
Bioadhesion
Mucoadhesive systems
Drugs/delivery
topic Mucoadhesion
Bioadhesion
Mucoadhesive systems
Drugs/delivery
description Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing, the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion. fracture and mechanical. Several in vitro and in vivo methodologies arc proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2014-05-20T13:24:50Z
2014-05-20T13:24:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1984-82502010000100002
Brazilian Journal of Pharmaceutical Sciences. São Paulo: Univ São Paulo, Conjunto Quimicas, v. 46, n. 1, p. 1-17, 2010.
1984-8250
http://hdl.handle.net/11449/7805
S1984-82502010000100002
WOS:000279574800002
S1984-82502010000100002-en.pdf
5361569184579557
9129780536724256
url http://dx.doi.org/10.1590/S1984-82502010000100002
http://hdl.handle.net/11449/7805
identifier_str_mv Brazilian Journal of Pharmaceutical Sciences. São Paulo: Univ São Paulo, Conjunto Quimicas, v. 46, n. 1, p. 1-17, 2010.
1984-8250
S1984-82502010000100002
WOS:000279574800002
S1984-82502010000100002-en.pdf
5361569184579557
9129780536724256
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences
0.483
0,214
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-17
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo (USP), Conjunto Quimicas
publisher.none.fl_str_mv Universidade de São Paulo (USP), Conjunto Quimicas
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128884999192576

Registros relacionados