Taboo obsessions and their association with suicidality in obsessive-compulsive disorder
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jpsychires.2022.07.044 http://hdl.handle.net/11449/241462 |
Resumo: | Individuals with obsessive-compulsive disorder (OCD) more often think about, attempt, and die by suicide than individuals from the general population. Sexual and religious obsessions (i.e., taboo obsessions) have been linked to increased risk of suicidality, but it is unclear if they explain additional risk over and above other risk factors. We refined the recently proposed multidimensional hierarchical model of OCD and explored how each symptom dimension in the model was associated with suicidality in a random half (n = 500) of a well-characterized cohort of patients with OCD. Symptom dimensions and other risk factors significantly associated with suicidality were included in a confirmatory multivariable model conducted with the other half of the sample (n = 501). The predictive confirmatory model accounted for 19% of the variance in suicidality. Taboo obsessions, the general OCD factor (i.e., having many different OCD symptoms at the same time), lifetime major depression, and lifetime substance use disorders significantly predicted suicidality in this model. Lifetime major depression explained most unique variance in suicidality (5.6%) followed by taboo obsessions and the general OCD factor (1.9% each). Taboo obsessions explain a small but significant proportion of variance in suicidality and should be considered an independent risk factor for suicidality in patients with OCD. |
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Taboo obsessions and their association with suicidality in obsessive-compulsive disorderComorbidityHeterogeneityobsessive-Compulsive disorderSuicidalitySymptom dimensionsIndividuals with obsessive-compulsive disorder (OCD) more often think about, attempt, and die by suicide than individuals from the general population. Sexual and religious obsessions (i.e., taboo obsessions) have been linked to increased risk of suicidality, but it is unclear if they explain additional risk over and above other risk factors. We refined the recently proposed multidimensional hierarchical model of OCD and explored how each symptom dimension in the model was associated with suicidality in a random half (n = 500) of a well-characterized cohort of patients with OCD. Symptom dimensions and other risk factors significantly associated with suicidality were included in a confirmatory multivariable model conducted with the other half of the sample (n = 501). The predictive confirmatory model accounted for 19% of the variance in suicidality. Taboo obsessions, the general OCD factor (i.e., having many different OCD symptoms at the same time), lifetime major depression, and lifetime substance use disorders significantly predicted suicidality in this model. Lifetime major depression explained most unique variance in suicidality (5.6%) followed by taboo obsessions and the general OCD factor (1.9% each). Taboo obsessions explain a small but significant proportion of variance in suicidality and should be considered an independent risk factor for suicidality in patients with OCD.Department of Clinical Sciences Lund Lund UniversityDepartment of Psychiatry Federal University of São Paulo (UNIFESP)D'Or Institute for Research and Education (IDOR) and Institute of Psychiatry (IPUB) Federal University of Rio de Janeiro (UFRJ) Rio de Janeiro Brazil and Department of Psychiatry School of Clinical Sciences Monash University, ClaytonDepartment of Clinical Medicine (Neurosciences) Porto Alegre Health Sciences Federal UniversityDepartment of Psychiatry Faculdade de Medicina Universidade de São Paulo São Paulo Brazil & Department of Methods and Techniques in Psychology Pontifical Catholic University, SPDepartment of Neurology Psychology and Psychiatry Botucatu Medical School Universidade Estadual Paulista (Unesp)Departamento e Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São PauloDepartment of Clinical Neuroscience Centre for Psychiatry Research Karolinska Institutet, Stockholm, Sweden & Stockholm Health Care Services, Region StockholmDepartamento de Psiquiatria da Faculdade de Medicina da Universidade de São Paulo, São PauloDepartment of Neurology Psychology and Psychiatry Botucatu Medical School Universidade Estadual Paulista (Unesp)Lund UniversityUniversidade de São Paulo (USP)Universidade Federal do Rio de Janeiro (UFRJ)Porto Alegre Health Sciences Federal UniversityUniversidade Estadual Paulista (UNESP)Karolinska InstitutetCervin, Mattido Rosário, Maria ConceiçãoFontenelle, Leonardo F.Ferrão, Ygor A.Batistuzzo, Marcelo C.Torres, Albina R. [UNESP]Damiano, Rodolfo F.Fernández de la Cruz, LorenaMiguel, Euripedes C.Mataix-Cols, David2023-03-01T21:04:22Z2023-03-01T21:04:22Z2022-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article117-122http://dx.doi.org/10.1016/j.jpsychires.2022.07.044Journal of Psychiatric Research, v. 154, p. 117-122.1879-13790022-3956http://hdl.handle.net/11449/24146210.1016/j.jpsychires.2022.07.0442-s2.0-85135384750Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Psychiatric Researchinfo:eu-repo/semantics/openAccess2023-03-01T21:04:22Zoai:repositorio.unesp.br:11449/241462Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T21:04:22Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder |
title |
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder |
spellingShingle |
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder Cervin, Matti Comorbidity Heterogeneity obsessive-Compulsive disorder Suicidality Symptom dimensions |
title_short |
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder |
title_full |
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder |
title_fullStr |
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder |
title_full_unstemmed |
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder |
title_sort |
Taboo obsessions and their association with suicidality in obsessive-compulsive disorder |
author |
Cervin, Matti |
author_facet |
Cervin, Matti do Rosário, Maria Conceição Fontenelle, Leonardo F. Ferrão, Ygor A. Batistuzzo, Marcelo C. Torres, Albina R. [UNESP] Damiano, Rodolfo F. Fernández de la Cruz, Lorena Miguel, Euripedes C. Mataix-Cols, David |
author_role |
author |
author2 |
do Rosário, Maria Conceição Fontenelle, Leonardo F. Ferrão, Ygor A. Batistuzzo, Marcelo C. Torres, Albina R. [UNESP] Damiano, Rodolfo F. Fernández de la Cruz, Lorena Miguel, Euripedes C. Mataix-Cols, David |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Lund University Universidade de São Paulo (USP) Universidade Federal do Rio de Janeiro (UFRJ) Porto Alegre Health Sciences Federal University Universidade Estadual Paulista (UNESP) Karolinska Institutet |
dc.contributor.author.fl_str_mv |
Cervin, Matti do Rosário, Maria Conceição Fontenelle, Leonardo F. Ferrão, Ygor A. Batistuzzo, Marcelo C. Torres, Albina R. [UNESP] Damiano, Rodolfo F. Fernández de la Cruz, Lorena Miguel, Euripedes C. Mataix-Cols, David |
dc.subject.por.fl_str_mv |
Comorbidity Heterogeneity obsessive-Compulsive disorder Suicidality Symptom dimensions |
topic |
Comorbidity Heterogeneity obsessive-Compulsive disorder Suicidality Symptom dimensions |
description |
Individuals with obsessive-compulsive disorder (OCD) more often think about, attempt, and die by suicide than individuals from the general population. Sexual and religious obsessions (i.e., taboo obsessions) have been linked to increased risk of suicidality, but it is unclear if they explain additional risk over and above other risk factors. We refined the recently proposed multidimensional hierarchical model of OCD and explored how each symptom dimension in the model was associated with suicidality in a random half (n = 500) of a well-characterized cohort of patients with OCD. Symptom dimensions and other risk factors significantly associated with suicidality were included in a confirmatory multivariable model conducted with the other half of the sample (n = 501). The predictive confirmatory model accounted for 19% of the variance in suicidality. Taboo obsessions, the general OCD factor (i.e., having many different OCD symptoms at the same time), lifetime major depression, and lifetime substance use disorders significantly predicted suicidality in this model. Lifetime major depression explained most unique variance in suicidality (5.6%) followed by taboo obsessions and the general OCD factor (1.9% each). Taboo obsessions explain a small but significant proportion of variance in suicidality and should be considered an independent risk factor for suicidality in patients with OCD. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-01 2023-03-01T21:04:22Z 2023-03-01T21:04:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jpsychires.2022.07.044 Journal of Psychiatric Research, v. 154, p. 117-122. 1879-1379 0022-3956 http://hdl.handle.net/11449/241462 10.1016/j.jpsychires.2022.07.044 2-s2.0-85135384750 |
url |
http://dx.doi.org/10.1016/j.jpsychires.2022.07.044 http://hdl.handle.net/11449/241462 |
identifier_str_mv |
Journal of Psychiatric Research, v. 154, p. 117-122. 1879-1379 0022-3956 10.1016/j.jpsychires.2022.07.044 2-s2.0-85135384750 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Psychiatric Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
117-122 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965432629690368 |