Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse
Main Author: | |
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Publication Date: | 2021 |
Other Authors: | , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1007/s00784-020-03679-6 http://hdl.handle.net/11449/206824 |
Summary: | Objectives: Androgenic anabolic steroids (AAS) abuse is a serious health problem associated to several systemic complications. Here, we evaluated the periodontal clinical status, microbial profile, and expression of total protein (TP) and interleukin (IL)-1β in men using AAS. Materials and methods: Men using AAS were recruited (case group) and matched for age with men who had never used AAS (control group) but also performed physical activities. Plaque index (PI), marginal bleeding (MB), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BoP) were evaluated. Crevicular fluid and subgingival biofilm were collected from healthy and diseased sites (PD ≥ 4 mm with CAL ≥ 1 mm and BoP) and evaluated for TP, IL-1β, and proportions of 40 bacterial species. Results: Thirty patients were included (n = 15/group). AAS consumers had significantly higher mean PD and higher percentage of diseased sites; sites with PD ≥ 4 mm or with CAL ≥ 1 mm than non-consumers. Also, AAS users showed a more dysbiotic biofilm containing lower proportions of host-compatible species and higher proportions of pathogens. IL-1β expression was statistically higher in diseased than in healthy sites only in the control group. A statistically positive correlation was detected between periodontal pathogens and IL-1β expression. The number of AAS cycles was positively associated with higher percentages of periodontal pathogens, but not with IL-1β or total protein concentrations. Conclusions: AAS intake can worsen clinical and immunological periodontal conditions and the biofilm composition in healthy sites. Clinical relevance: Dental care professionals should perform full mouth periodontal screening and schedule regular follow-up appointments for patients under AAS use. |
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Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abusePeriodontitisPeriodontiumSteroidsTestosteroneObjectives: Androgenic anabolic steroids (AAS) abuse is a serious health problem associated to several systemic complications. Here, we evaluated the periodontal clinical status, microbial profile, and expression of total protein (TP) and interleukin (IL)-1β in men using AAS. Materials and methods: Men using AAS were recruited (case group) and matched for age with men who had never used AAS (control group) but also performed physical activities. Plaque index (PI), marginal bleeding (MB), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BoP) were evaluated. Crevicular fluid and subgingival biofilm were collected from healthy and diseased sites (PD ≥ 4 mm with CAL ≥ 1 mm and BoP) and evaluated for TP, IL-1β, and proportions of 40 bacterial species. Results: Thirty patients were included (n = 15/group). AAS consumers had significantly higher mean PD and higher percentage of diseased sites; sites with PD ≥ 4 mm or with CAL ≥ 1 mm than non-consumers. Also, AAS users showed a more dysbiotic biofilm containing lower proportions of host-compatible species and higher proportions of pathogens. IL-1β expression was statistically higher in diseased than in healthy sites only in the control group. A statistically positive correlation was detected between periodontal pathogens and IL-1β expression. The number of AAS cycles was positively associated with higher percentages of periodontal pathogens, but not with IL-1β or total protein concentrations. Conclusions: AAS intake can worsen clinical and immunological periodontal conditions and the biofilm composition in healthy sites. Clinical relevance: Dental care professionals should perform full mouth periodontal screening and schedule regular follow-up appointments for patients under AAS use.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação AraucáriaGraduate Program in Dentistry Universidade Federal do Paraná, Av. Pref. Lothário Meissner, 632School of Dentistry Universidade Federal do Paraná, Av. Pref. Lothário Meissner, 632Department of Physiology and Pathology School of Dentistry at Araraquara UNESP—Univ Est Paulista, Rua Humaitá, 1680Postgraduate Program in Dentistry Universidade Guarulhos, R. Eng. Prestes Maia, 88Department of Physiology and Pathology School of Dentistry at Araraquara UNESP—Univ Est Paulista, Rua Humaitá, 1680CAPES: 001Fundação Araucária: 001Universidade Federal do Paraná (UFPR)Universidade Estadual Paulista (Unesp)Universidade Guarulhosvon Stein Cubas Warnavin, StephanieValenga, Henrique MeisterCosta, Thainá Biudes ConfortoChaves, Joao Daniel PaganellaSpolidorio, Luis Carlos [UNESP]Spolidorio, Denise Madalena Palomari [UNESP]Feres, MagdaSoares, Geisla Mary SilvaSteffens, Joao Paulo2021-06-25T10:44:24Z2021-06-25T10:44:24Z2021-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3567-3575http://dx.doi.org/10.1007/s00784-020-03679-6Clinical Oral Investigations, v. 25, n. 6, p. 3567-3575, 2021.1436-37711432-6981http://hdl.handle.net/11449/20682410.1007/s00784-020-03679-62-s2.0-85095999423Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigationsinfo:eu-repo/semantics/openAccess2021-10-23T12:31:48Zoai:repositorio.unesp.br:11449/206824Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T12:31:48Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse |
title |
Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse |
spellingShingle |
Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse von Stein Cubas Warnavin, Stephanie Periodontitis Periodontium Steroids Testosterone |
title_short |
Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse |
title_full |
Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse |
title_fullStr |
Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse |
title_full_unstemmed |
Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse |
title_sort |
Periodontal clinical status, microbial profile, and expression of interleukin-1β in men under androgenic anabolic steroids abuse |
author |
von Stein Cubas Warnavin, Stephanie |
author_facet |
von Stein Cubas Warnavin, Stephanie Valenga, Henrique Meister Costa, Thainá Biudes Conforto Chaves, Joao Daniel Paganella Spolidorio, Luis Carlos [UNESP] Spolidorio, Denise Madalena Palomari [UNESP] Feres, Magda Soares, Geisla Mary Silva Steffens, Joao Paulo |
author_role |
author |
author2 |
Valenga, Henrique Meister Costa, Thainá Biudes Conforto Chaves, Joao Daniel Paganella Spolidorio, Luis Carlos [UNESP] Spolidorio, Denise Madalena Palomari [UNESP] Feres, Magda Soares, Geisla Mary Silva Steffens, Joao Paulo |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Paraná (UFPR) Universidade Estadual Paulista (Unesp) Universidade Guarulhos |
dc.contributor.author.fl_str_mv |
von Stein Cubas Warnavin, Stephanie Valenga, Henrique Meister Costa, Thainá Biudes Conforto Chaves, Joao Daniel Paganella Spolidorio, Luis Carlos [UNESP] Spolidorio, Denise Madalena Palomari [UNESP] Feres, Magda Soares, Geisla Mary Silva Steffens, Joao Paulo |
dc.subject.por.fl_str_mv |
Periodontitis Periodontium Steroids Testosterone |
topic |
Periodontitis Periodontium Steroids Testosterone |
description |
Objectives: Androgenic anabolic steroids (AAS) abuse is a serious health problem associated to several systemic complications. Here, we evaluated the periodontal clinical status, microbial profile, and expression of total protein (TP) and interleukin (IL)-1β in men using AAS. Materials and methods: Men using AAS were recruited (case group) and matched for age with men who had never used AAS (control group) but also performed physical activities. Plaque index (PI), marginal bleeding (MB), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BoP) were evaluated. Crevicular fluid and subgingival biofilm were collected from healthy and diseased sites (PD ≥ 4 mm with CAL ≥ 1 mm and BoP) and evaluated for TP, IL-1β, and proportions of 40 bacterial species. Results: Thirty patients were included (n = 15/group). AAS consumers had significantly higher mean PD and higher percentage of diseased sites; sites with PD ≥ 4 mm or with CAL ≥ 1 mm than non-consumers. Also, AAS users showed a more dysbiotic biofilm containing lower proportions of host-compatible species and higher proportions of pathogens. IL-1β expression was statistically higher in diseased than in healthy sites only in the control group. A statistically positive correlation was detected between periodontal pathogens and IL-1β expression. The number of AAS cycles was positively associated with higher percentages of periodontal pathogens, but not with IL-1β or total protein concentrations. Conclusions: AAS intake can worsen clinical and immunological periodontal conditions and the biofilm composition in healthy sites. Clinical relevance: Dental care professionals should perform full mouth periodontal screening and schedule regular follow-up appointments for patients under AAS use. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:44:24Z 2021-06-25T10:44:24Z 2021-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00784-020-03679-6 Clinical Oral Investigations, v. 25, n. 6, p. 3567-3575, 2021. 1436-3771 1432-6981 http://hdl.handle.net/11449/206824 10.1007/s00784-020-03679-6 2-s2.0-85095999423 |
url |
http://dx.doi.org/10.1007/s00784-020-03679-6 http://hdl.handle.net/11449/206824 |
identifier_str_mv |
Clinical Oral Investigations, v. 25, n. 6, p. 3567-3575, 2021. 1436-3771 1432-6981 10.1007/s00784-020-03679-6 2-s2.0-85095999423 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Oral Investigations |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3567-3575 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965461234843648 |