Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats

Detalhes bibliográficos
Autor(a) principal: Oliveira, Lucienne C. [UNESP]
Data de Publicação: 2011
Outros Autores: Gaiolla, Paula Schmidt Azevedo [UNESP], Minicucci, Marcos Ferreira [UNESP], Rafacho, Bruna P. M. [UNESP], Duarte, Daniella R. [UNESP], Matsubara, Luiz Shiguero [UNESP], Matsubara, Beatriz Bojikian [UNESP], Paiva, Sergio Alberto Rupp de [UNESP], Zornoff, Leonardo Antonio Mamede [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2143/AC.66.1.2064960
http://hdl.handle.net/11449/11431
Resumo: Objective Our objective was to test the hypothesis that retinoic acid supplementation could attenuate ventricular remodelling induced by tobacco smoke exposure in rats.Methods and results Wistar rats were allocated into three groups: control (C, n = 8); exposed to tobacco smoke (ETS, n = 9); exposed to tobacco smoke and all-trans-retinoic acid (ETS-RA, n = 9). After two months, cardiac function and geometry were assessed by echocardiography, and geometry changes were confirmed by morphometric analysis. Data are expressed as mean +/- SD or medians (including the lower quartile and upper quartile). ETS showed higher normalized left ventricular diastolic diameters than groups C and ETS-RA (C = 18.4 +/- 3.57 mm/kg, ETS = 23.0 +/- 1.8, ETS-RA = 19.5 +/- 0.99; P < 0.05) and systolic diameters (C = 8.25 +/- 2.16 mm/kg, ETS = 11.5 +/- 1.31, ETS-RA = 8.25 +/- 0.71 mm/kg; P < 0.05). ETS showed reduced ejection fraction (C = 91 +/- 2.0, ETS = 87 +/- 3.0, ETS-RA = 92 +/- 3.0; P < 0.05) and fractional shortening (C = 55.8 +/- 4.41 %, ETS = 49.7 +/- 4.43 %, ETS-RA = 57.6 +/- 5.15 %; P = 0.01) compared to C and ETS-RA. ETS had increased myocyte cross-sectional area (C = 294 +/- 21 mm2, ETS = 352 +/- 44, ETS-RA = 310 +/- 35; P < 0.05) compared to C and ETS-RA. Considering all variables, there were no differences between groups C and ETS-RA.Conclusion Retinoic acid prevented ventricular remodelling induced by tobacco smoke exposure.
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spelling Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in ratsRemodellingheart failuremyocardial hypertrophysmokingObjective Our objective was to test the hypothesis that retinoic acid supplementation could attenuate ventricular remodelling induced by tobacco smoke exposure in rats.Methods and results Wistar rats were allocated into three groups: control (C, n = 8); exposed to tobacco smoke (ETS, n = 9); exposed to tobacco smoke and all-trans-retinoic acid (ETS-RA, n = 9). After two months, cardiac function and geometry were assessed by echocardiography, and geometry changes were confirmed by morphometric analysis. Data are expressed as mean +/- SD or medians (including the lower quartile and upper quartile). ETS showed higher normalized left ventricular diastolic diameters than groups C and ETS-RA (C = 18.4 +/- 3.57 mm/kg, ETS = 23.0 +/- 1.8, ETS-RA = 19.5 +/- 0.99; P < 0.05) and systolic diameters (C = 8.25 +/- 2.16 mm/kg, ETS = 11.5 +/- 1.31, ETS-RA = 8.25 +/- 0.71 mm/kg; P < 0.05). ETS showed reduced ejection fraction (C = 91 +/- 2.0, ETS = 87 +/- 3.0, ETS-RA = 92 +/- 3.0; P < 0.05) and fractional shortening (C = 55.8 +/- 4.41 %, ETS = 49.7 +/- 4.43 %, ETS-RA = 57.6 +/- 5.15 %; P = 0.01) compared to C and ETS-RA. ETS had increased myocyte cross-sectional area (C = 294 +/- 21 mm2, ETS = 352 +/- 44, ETS-RA = 310 +/- 35; P < 0.05) compared to C and ETS-RA. Considering all variables, there were no differences between groups C and ETS-RA.Conclusion Retinoic acid prevented ventricular remodelling induced by tobacco smoke exposure.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)UNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, BrazilUNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, BrazilActa CardiologicaUniversidade Estadual Paulista (Unesp)Oliveira, Lucienne C. [UNESP]Gaiolla, Paula Schmidt Azevedo [UNESP]Minicucci, Marcos Ferreira [UNESP]Rafacho, Bruna P. M. [UNESP]Duarte, Daniella R. [UNESP]Matsubara, Luiz Shiguero [UNESP]Matsubara, Beatriz Bojikian [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]2014-05-20T13:33:23Z2014-05-20T13:33:23Z2011-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.2143/AC.66.1.2064960Acta Cardiologica. Brussels: Acta Cardiologica, v. 66, n. 1, p. 3-7, 2011.0001-5385http://hdl.handle.net/11449/1143110.2143/AC.66.1.2064960WOS:000287980400002630983513799876669909771223407955016839015394547121314080140264774387040344716730000-0002-5843-6232Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cardiologica0.8760,404info:eu-repo/semantics/openAccess2024-08-14T17:37:04Zoai:repositorio.unesp.br:11449/11431Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:37:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
title Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
spellingShingle Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
Oliveira, Lucienne C. [UNESP]
Remodelling
heart failure
myocardial hypertrophy
smoking
title_short Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
title_full Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
title_fullStr Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
title_full_unstemmed Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
title_sort Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
author Oliveira, Lucienne C. [UNESP]
author_facet Oliveira, Lucienne C. [UNESP]
Gaiolla, Paula Schmidt Azevedo [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Rafacho, Bruna P. M. [UNESP]
Duarte, Daniella R. [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
author_role author
author2 Gaiolla, Paula Schmidt Azevedo [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Rafacho, Bruna P. M. [UNESP]
Duarte, Daniella R. [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Oliveira, Lucienne C. [UNESP]
Gaiolla, Paula Schmidt Azevedo [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Rafacho, Bruna P. M. [UNESP]
Duarte, Daniella R. [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
dc.subject.por.fl_str_mv Remodelling
heart failure
myocardial hypertrophy
smoking
topic Remodelling
heart failure
myocardial hypertrophy
smoking
description Objective Our objective was to test the hypothesis that retinoic acid supplementation could attenuate ventricular remodelling induced by tobacco smoke exposure in rats.Methods and results Wistar rats were allocated into three groups: control (C, n = 8); exposed to tobacco smoke (ETS, n = 9); exposed to tobacco smoke and all-trans-retinoic acid (ETS-RA, n = 9). After two months, cardiac function and geometry were assessed by echocardiography, and geometry changes were confirmed by morphometric analysis. Data are expressed as mean +/- SD or medians (including the lower quartile and upper quartile). ETS showed higher normalized left ventricular diastolic diameters than groups C and ETS-RA (C = 18.4 +/- 3.57 mm/kg, ETS = 23.0 +/- 1.8, ETS-RA = 19.5 +/- 0.99; P < 0.05) and systolic diameters (C = 8.25 +/- 2.16 mm/kg, ETS = 11.5 +/- 1.31, ETS-RA = 8.25 +/- 0.71 mm/kg; P < 0.05). ETS showed reduced ejection fraction (C = 91 +/- 2.0, ETS = 87 +/- 3.0, ETS-RA = 92 +/- 3.0; P < 0.05) and fractional shortening (C = 55.8 +/- 4.41 %, ETS = 49.7 +/- 4.43 %, ETS-RA = 57.6 +/- 5.15 %; P = 0.01) compared to C and ETS-RA. ETS had increased myocyte cross-sectional area (C = 294 +/- 21 mm2, ETS = 352 +/- 44, ETS-RA = 310 +/- 35; P < 0.05) compared to C and ETS-RA. Considering all variables, there were no differences between groups C and ETS-RA.Conclusion Retinoic acid prevented ventricular remodelling induced by tobacco smoke exposure.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
2014-05-20T13:33:23Z
2014-05-20T13:33:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2143/AC.66.1.2064960
Acta Cardiologica. Brussels: Acta Cardiologica, v. 66, n. 1, p. 3-7, 2011.
0001-5385
http://hdl.handle.net/11449/11431
10.2143/AC.66.1.2064960
WOS:000287980400002
6309835137998766
6990977122340795
5016839015394547
1213140801402647
7438704034471673
0000-0002-5843-6232
url http://dx.doi.org/10.2143/AC.66.1.2064960
http://hdl.handle.net/11449/11431
identifier_str_mv Acta Cardiologica. Brussels: Acta Cardiologica, v. 66, n. 1, p. 3-7, 2011.
0001-5385
10.2143/AC.66.1.2064960
WOS:000287980400002
6309835137998766
6990977122340795
5016839015394547
1213140801402647
7438704034471673
0000-0002-5843-6232
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cardiologica
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Acta Cardiologica
publisher.none.fl_str_mv Acta Cardiologica
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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