Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fnbeh.2022.810051 http://hdl.handle.net/11449/230559 |
Resumo: | Individuals differ in their preference for alcohol and propensity to develop alcoholism, where the behavioral profile, such as the bold-shy axis, plays an important role for such a difference. However, literature is limited and conflicting on the causes and consequences of this relationship. Translational studies using animal models, such as zebrafish, can help identify behavioral traits that predispose individuals to drink alcohol compulsively. Here, the preference for alcohol was investigated in two distinct traits in zebrafish: shy and bold. For this purpose, fish were separated into shy and bold traits and then a conditioned place preference paradigm was used, a strategy that allows the rewarding effects from alcohol to be assessed by the ability to enhance the animal’s preference for an environment that initially was not preferred. It was found that bold zebrafish actively searched for the environment that was paired to alcohol after one acute exposure, whereas, shy fish changed their place preference even without alcohol administration, showing that the conditioned place preference protocol, given the short amount time to assess place preference, is not ample enough for shy fish to choose. Our results show that behavioral profiles must be considered in further studies since differences between shy and bold individuals on preference behavior can strongly interfere in the assessment of drug preference, mainly when using the conditioned place preference paradigm. |
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Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafishalcohol preferenceboldnesscomparative behaviorconditioned place preferencepersonalityreinforcementrewardzebrafishIndividuals differ in their preference for alcohol and propensity to develop alcoholism, where the behavioral profile, such as the bold-shy axis, plays an important role for such a difference. However, literature is limited and conflicting on the causes and consequences of this relationship. Translational studies using animal models, such as zebrafish, can help identify behavioral traits that predispose individuals to drink alcohol compulsively. Here, the preference for alcohol was investigated in two distinct traits in zebrafish: shy and bold. For this purpose, fish were separated into shy and bold traits and then a conditioned place preference paradigm was used, a strategy that allows the rewarding effects from alcohol to be assessed by the ability to enhance the animal’s preference for an environment that initially was not preferred. It was found that bold zebrafish actively searched for the environment that was paired to alcohol after one acute exposure, whereas, shy fish changed their place preference even without alcohol administration, showing that the conditioned place preference protocol, given the short amount time to assess place preference, is not ample enough for shy fish to choose. Our results show that behavioral profiles must be considered in further studies since differences between shy and bold individuals on preference behavior can strongly interfere in the assessment of drug preference, mainly when using the conditioned place preference paradigm.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, BotucatuAquaculture Center of Unesp São Paulo State University, JaboticabalDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, BotucatuAquaculture Center of Unesp São Paulo State University, JaboticabalFAPESP: 2019/19952-8CNPq: 800571/2016-9Universidade Estadual Paulista (UNESP)Bellot, Marina Sanson [UNESP]Guermandi, Isabela Inforzato [UNESP]Camargo-dos-Santos, Bruno [UNESP]Giaquinto, Percília Cardoso [UNESP]2022-04-29T08:40:46Z2022-04-29T08:40:46Z2022-02-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fnbeh.2022.810051Frontiers in Behavioral Neuroscience, v. 16.1662-5153http://hdl.handle.net/11449/23055910.3389/fnbeh.2022.8100512-s2.0-85126193155Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Behavioral Neuroscienceinfo:eu-repo/semantics/openAccess2024-04-09T15:43:35Zoai:repositorio.unesp.br:11449/230559Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:09:27.096651Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish |
title |
Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish |
spellingShingle |
Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish Bellot, Marina Sanson [UNESP] alcohol preference boldness comparative behavior conditioned place preference personality reinforcement reward zebrafish |
title_short |
Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish |
title_full |
Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish |
title_fullStr |
Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish |
title_full_unstemmed |
Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish |
title_sort |
Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish |
author |
Bellot, Marina Sanson [UNESP] |
author_facet |
Bellot, Marina Sanson [UNESP] Guermandi, Isabela Inforzato [UNESP] Camargo-dos-Santos, Bruno [UNESP] Giaquinto, Percília Cardoso [UNESP] |
author_role |
author |
author2 |
Guermandi, Isabela Inforzato [UNESP] Camargo-dos-Santos, Bruno [UNESP] Giaquinto, Percília Cardoso [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Bellot, Marina Sanson [UNESP] Guermandi, Isabela Inforzato [UNESP] Camargo-dos-Santos, Bruno [UNESP] Giaquinto, Percília Cardoso [UNESP] |
dc.subject.por.fl_str_mv |
alcohol preference boldness comparative behavior conditioned place preference personality reinforcement reward zebrafish |
topic |
alcohol preference boldness comparative behavior conditioned place preference personality reinforcement reward zebrafish |
description |
Individuals differ in their preference for alcohol and propensity to develop alcoholism, where the behavioral profile, such as the bold-shy axis, plays an important role for such a difference. However, literature is limited and conflicting on the causes and consequences of this relationship. Translational studies using animal models, such as zebrafish, can help identify behavioral traits that predispose individuals to drink alcohol compulsively. Here, the preference for alcohol was investigated in two distinct traits in zebrafish: shy and bold. For this purpose, fish were separated into shy and bold traits and then a conditioned place preference paradigm was used, a strategy that allows the rewarding effects from alcohol to be assessed by the ability to enhance the animal’s preference for an environment that initially was not preferred. It was found that bold zebrafish actively searched for the environment that was paired to alcohol after one acute exposure, whereas, shy fish changed their place preference even without alcohol administration, showing that the conditioned place preference protocol, given the short amount time to assess place preference, is not ample enough for shy fish to choose. Our results show that behavioral profiles must be considered in further studies since differences between shy and bold individuals on preference behavior can strongly interfere in the assessment of drug preference, mainly when using the conditioned place preference paradigm. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:40:46Z 2022-04-29T08:40:46Z 2022-02-24 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fnbeh.2022.810051 Frontiers in Behavioral Neuroscience, v. 16. 1662-5153 http://hdl.handle.net/11449/230559 10.3389/fnbeh.2022.810051 2-s2.0-85126193155 |
url |
http://dx.doi.org/10.3389/fnbeh.2022.810051 http://hdl.handle.net/11449/230559 |
identifier_str_mv |
Frontiers in Behavioral Neuroscience, v. 16. 1662-5153 10.3389/fnbeh.2022.810051 2-s2.0-85126193155 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Behavioral Neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129495539908608 |