Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00203-018-1502-6 http://hdl.handle.net/11449/164351 |
Resumo: | Asiatic citrus canker (ACC) is an incurable disease of citrus plants caused by the Gram-negative bacterium Xanthomonas citri subsp. citri (X. citri). It affects all the commercially important citrus varieties in the major orange producing areas around the world. Control of the pathogen requires recurrent sprays of copper formulations that accumulate in soil and water reservoirs. Here, we describe the improvement of the alkyl gallates, which are potent anti-X. citri compounds, intended to be used as alternatives to copper in the control of ACC. Acetylation of alkyl gallates increased their lipophilicity, which resulted in potentiation of the antibacterial activity. X. citri exposed to the acetylated compounds exhibited increased cell length that is consistent with the disruption of the cell division apparatus. Finally, we show that inhibition of cell division is an indirect effect that seemed to be caused by membrane permeabilization, which is apparently the primary target of the acetylated alkyl gallates. |
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Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citriCitrus cankerGallic acidCell divisionMembrane disruptionAsiatic citrus canker (ACC) is an incurable disease of citrus plants caused by the Gram-negative bacterium Xanthomonas citri subsp. citri (X. citri). It affects all the commercially important citrus varieties in the major orange producing areas around the world. Control of the pathogen requires recurrent sprays of copper formulations that accumulate in soil and water reservoirs. Here, we describe the improvement of the alkyl gallates, which are potent anti-X. citri compounds, intended to be used as alternatives to copper in the control of ACC. Acetylation of alkyl gallates increased their lipophilicity, which resulted in potentiation of the antibacterial activity. X. citri exposed to the acetylated compounds exhibited increased cell length that is consistent with the disruption of the cell division apparatus. Finally, we show that inhibition of cell division is an indirect effect that seemed to be caused by membrane permeabilization, which is apparently the primary target of the acetylated alkyl gallates.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)bilateral research program Biobased Economy from the Netherlands Organization for Scientific researchINCT CitrosUniv Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Ave 24A,1515, BR-13506900 Rio Claro, SP, BrazilUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Dept Quim & Ciencias Ambientais, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP, BrazilUniv Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, Nijenborgh 7, NL-9747 AG Groningen, NetherlandsUniv Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Ave 24A,1515, BR-13506900 Rio Claro, SP, BrazilUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Dept Quim & Ciencias Ambientais, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP, BrazilFAPESP: 2014/114025bilateral research program Biobased Economy from the Netherlands Organization for Scientific research: NWO 729.004.005FAPESP: FAPESP 2013/50367-8INCT Citros: FAPESP 2014/50880-0INCT Citros: CNPq 465440/2014-2SpringerUniversidade Estadual Paulista (Unesp)Univ GroningenSavietto, Abigail [UNESP]Polaquini, Carlos Roberto [UNESP]Kopacz, MalgorzataScheffers, Dirk-JanMarques, Beatriz Carvalho [UNESP]Regasini, Luis Octavio [UNESP]Ferreira, Henrique [UNESP]2018-11-26T17:52:14Z2018-11-26T17:52:14Z2018-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article929-937application/pdfhttp://dx.doi.org/10.1007/s00203-018-1502-6Archives Of Microbiology. New York: Springer, v. 200, n. 6, p. 929-937, 2018.0302-8933http://hdl.handle.net/11449/16435110.1007/s00203-018-1502-6WOS:000436399900010WOS000436399900010.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives Of Microbiology0,644info:eu-repo/semantics/openAccess2023-12-30T06:18:57Zoai:repositorio.unesp.br:11449/164351Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:41:41.168064Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri |
title |
Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri |
spellingShingle |
Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri Savietto, Abigail [UNESP] Citrus canker Gallic acid Cell division Membrane disruption |
title_short |
Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri |
title_full |
Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri |
title_fullStr |
Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri |
title_full_unstemmed |
Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri |
title_sort |
Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri |
author |
Savietto, Abigail [UNESP] |
author_facet |
Savietto, Abigail [UNESP] Polaquini, Carlos Roberto [UNESP] Kopacz, Malgorzata Scheffers, Dirk-Jan Marques, Beatriz Carvalho [UNESP] Regasini, Luis Octavio [UNESP] Ferreira, Henrique [UNESP] |
author_role |
author |
author2 |
Polaquini, Carlos Roberto [UNESP] Kopacz, Malgorzata Scheffers, Dirk-Jan Marques, Beatriz Carvalho [UNESP] Regasini, Luis Octavio [UNESP] Ferreira, Henrique [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Groningen |
dc.contributor.author.fl_str_mv |
Savietto, Abigail [UNESP] Polaquini, Carlos Roberto [UNESP] Kopacz, Malgorzata Scheffers, Dirk-Jan Marques, Beatriz Carvalho [UNESP] Regasini, Luis Octavio [UNESP] Ferreira, Henrique [UNESP] |
dc.subject.por.fl_str_mv |
Citrus canker Gallic acid Cell division Membrane disruption |
topic |
Citrus canker Gallic acid Cell division Membrane disruption |
description |
Asiatic citrus canker (ACC) is an incurable disease of citrus plants caused by the Gram-negative bacterium Xanthomonas citri subsp. citri (X. citri). It affects all the commercially important citrus varieties in the major orange producing areas around the world. Control of the pathogen requires recurrent sprays of copper formulations that accumulate in soil and water reservoirs. Here, we describe the improvement of the alkyl gallates, which are potent anti-X. citri compounds, intended to be used as alternatives to copper in the control of ACC. Acetylation of alkyl gallates increased their lipophilicity, which resulted in potentiation of the antibacterial activity. X. citri exposed to the acetylated compounds exhibited increased cell length that is consistent with the disruption of the cell division apparatus. Finally, we show that inhibition of cell division is an indirect effect that seemed to be caused by membrane permeabilization, which is apparently the primary target of the acetylated alkyl gallates. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:52:14Z 2018-11-26T17:52:14Z 2018-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00203-018-1502-6 Archives Of Microbiology. New York: Springer, v. 200, n. 6, p. 929-937, 2018. 0302-8933 http://hdl.handle.net/11449/164351 10.1007/s00203-018-1502-6 WOS:000436399900010 WOS000436399900010.pdf |
url |
http://dx.doi.org/10.1007/s00203-018-1502-6 http://hdl.handle.net/11449/164351 |
identifier_str_mv |
Archives Of Microbiology. New York: Springer, v. 200, n. 6, p. 929-937, 2018. 0302-8933 10.1007/s00203-018-1502-6 WOS:000436399900010 WOS000436399900010.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives Of Microbiology 0,644 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
929-937 application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129347799744512 |