Metabolic profile and adipokine levels in overweight and obese dogs
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3906/vet-2004-44 http://hdl.handle.net/11449/208904 |
Resumo: | Obesity in dogs is increasingly present in the veterinary practice. In humans, it is known that there is a significant correlation between obesity and the development of hypertension and insulin resistance (IR), a clinical picture called metabolic syndrome. In dogs, however, there are only anecdotes about the syndrome. The objectives of this study were to determine serum levels of adiponectin, leptin, triglycerides, cholesterol, insulin, glucose, homeostasis assessment of B cell function (HOMA-B), homeostasis assessment of insulin resistance (HOMA-IR), and systolic blood pressure (SBP) in dogs with different body conditions (BC) and body fat (BF) without endocrine disease. For this purpose, 76 healthy dogs were submitted to evaluation of body conditions score (BCS) and morphometry. The dogs were separated into 3 groups: optimal BC [BCS 3,4, or 5 of 9 and BF% of 13 to 27-Group 1 (G1)], overweight [BCS 6 and 7 of 9 and BF% of 14 to 38- Group 2 (G2)], obese [BCS 8 and 9 of 9 and BF% greater than or equal to 34-Group 3 (G3)]. G3 presented higher serum levels of total protein, triglycerides, glucose, insulin, and HOMA-IR. Adipokines did not correlate to any other parameter, but the occurrence of hyperinsulinemia was higher in G3. The results have shown that obese dogs presented IR and alterations in fat metabolism. |
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Metabolic profile and adipokine levels in overweight and obese dogsAdipokinessystolic hypertensionobesityinsulin resistanceObesity in dogs is increasingly present in the veterinary practice. In humans, it is known that there is a significant correlation between obesity and the development of hypertension and insulin resistance (IR), a clinical picture called metabolic syndrome. In dogs, however, there are only anecdotes about the syndrome. The objectives of this study were to determine serum levels of adiponectin, leptin, triglycerides, cholesterol, insulin, glucose, homeostasis assessment of B cell function (HOMA-B), homeostasis assessment of insulin resistance (HOMA-IR), and systolic blood pressure (SBP) in dogs with different body conditions (BC) and body fat (BF) without endocrine disease. For this purpose, 76 healthy dogs were submitted to evaluation of body conditions score (BCS) and morphometry. The dogs were separated into 3 groups: optimal BC [BCS 3,4, or 5 of 9 and BF% of 13 to 27-Group 1 (G1)], overweight [BCS 6 and 7 of 9 and BF% of 14 to 38- Group 2 (G2)], obese [BCS 8 and 9 of 9 and BF% greater than or equal to 34-Group 3 (G3)]. G3 presented higher serum levels of total protein, triglycerides, glucose, insulin, and HOMA-IR. Adipokines did not correlate to any other parameter, but the occurrence of hyperinsulinemia was higher in G3. The results have shown that obese dogs presented IR and alterations in fat metabolism.Araucaria FoundationConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Paulista State Univ Julio de Mesquita Filho, Coll Vet Med & Anim Sci, Botucatu, SP, BrazilState Univ Northern Parana, Coll Vet Med, Bandeirantes, Parana, BrazilUniv North Parana, Coll Prod Engn, Londrina, Parana, BrazilUniv Estadual Londrina, Agr Sci Ctr, Londrina, Parana, BrazilPaulista State Univ Julio de Mesquita Filho, Coll Vet Med & Anim Sci, Botucatu, SP, BrazilAraucaria Foundation: 931/2013Scientific Technical Research Council Turkey-tubitakUniversidade Estadual Paulista (Unesp)State Univ Northern ParanaUniv North ParanaUniversidade Estadual de Londrina (UEL)De Marchi, Paula Nassar [UNESP]Araujo Machado, Luiz Henrique de [UNESP]Holsback, LucianeCalesso, Jessica RagazziFagnani, RafaelZacarias Junior, AdemirLahm Cardoso, Mauro Jose2021-06-25T11:24:18Z2021-06-25T11:24:18Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1093-1099http://dx.doi.org/10.3906/vet-2004-44Turkish Journal Of Veterinary & Animal Sciences. Ankara: Scientific Technical Research Council Turkey-tubitak, v. 44, n. 5, p. 1093-1099, 2020.1300-0128http://hdl.handle.net/11449/20890410.3906/vet-2004-44WOS:000582646000016Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTurkish Journal Of Veterinary & Animal Sciencesinfo:eu-repo/semantics/openAccess2021-10-23T19:23:18Zoai:repositorio.unesp.br:11449/208904Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:10:54.697950Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Metabolic profile and adipokine levels in overweight and obese dogs |
title |
Metabolic profile and adipokine levels in overweight and obese dogs |
spellingShingle |
Metabolic profile and adipokine levels in overweight and obese dogs De Marchi, Paula Nassar [UNESP] Adipokines systolic hypertension obesity insulin resistance |
title_short |
Metabolic profile and adipokine levels in overweight and obese dogs |
title_full |
Metabolic profile and adipokine levels in overweight and obese dogs |
title_fullStr |
Metabolic profile and adipokine levels in overweight and obese dogs |
title_full_unstemmed |
Metabolic profile and adipokine levels in overweight and obese dogs |
title_sort |
Metabolic profile and adipokine levels in overweight and obese dogs |
author |
De Marchi, Paula Nassar [UNESP] |
author_facet |
De Marchi, Paula Nassar [UNESP] Araujo Machado, Luiz Henrique de [UNESP] Holsback, Luciane Calesso, Jessica Ragazzi Fagnani, Rafael Zacarias Junior, Ademir Lahm Cardoso, Mauro Jose |
author_role |
author |
author2 |
Araujo Machado, Luiz Henrique de [UNESP] Holsback, Luciane Calesso, Jessica Ragazzi Fagnani, Rafael Zacarias Junior, Ademir Lahm Cardoso, Mauro Jose |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) State Univ Northern Parana Univ North Parana Universidade Estadual de Londrina (UEL) |
dc.contributor.author.fl_str_mv |
De Marchi, Paula Nassar [UNESP] Araujo Machado, Luiz Henrique de [UNESP] Holsback, Luciane Calesso, Jessica Ragazzi Fagnani, Rafael Zacarias Junior, Ademir Lahm Cardoso, Mauro Jose |
dc.subject.por.fl_str_mv |
Adipokines systolic hypertension obesity insulin resistance |
topic |
Adipokines systolic hypertension obesity insulin resistance |
description |
Obesity in dogs is increasingly present in the veterinary practice. In humans, it is known that there is a significant correlation between obesity and the development of hypertension and insulin resistance (IR), a clinical picture called metabolic syndrome. In dogs, however, there are only anecdotes about the syndrome. The objectives of this study were to determine serum levels of adiponectin, leptin, triglycerides, cholesterol, insulin, glucose, homeostasis assessment of B cell function (HOMA-B), homeostasis assessment of insulin resistance (HOMA-IR), and systolic blood pressure (SBP) in dogs with different body conditions (BC) and body fat (BF) without endocrine disease. For this purpose, 76 healthy dogs were submitted to evaluation of body conditions score (BCS) and morphometry. The dogs were separated into 3 groups: optimal BC [BCS 3,4, or 5 of 9 and BF% of 13 to 27-Group 1 (G1)], overweight [BCS 6 and 7 of 9 and BF% of 14 to 38- Group 2 (G2)], obese [BCS 8 and 9 of 9 and BF% greater than or equal to 34-Group 3 (G3)]. G3 presented higher serum levels of total protein, triglycerides, glucose, insulin, and HOMA-IR. Adipokines did not correlate to any other parameter, but the occurrence of hyperinsulinemia was higher in G3. The results have shown that obese dogs presented IR and alterations in fat metabolism. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 2021-06-25T11:24:18Z 2021-06-25T11:24:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3906/vet-2004-44 Turkish Journal Of Veterinary & Animal Sciences. Ankara: Scientific Technical Research Council Turkey-tubitak, v. 44, n. 5, p. 1093-1099, 2020. 1300-0128 http://hdl.handle.net/11449/208904 10.3906/vet-2004-44 WOS:000582646000016 |
url |
http://dx.doi.org/10.3906/vet-2004-44 http://hdl.handle.net/11449/208904 |
identifier_str_mv |
Turkish Journal Of Veterinary & Animal Sciences. Ankara: Scientific Technical Research Council Turkey-tubitak, v. 44, n. 5, p. 1093-1099, 2020. 1300-0128 10.3906/vet-2004-44 WOS:000582646000016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Turkish Journal Of Veterinary & Animal Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1093-1099 |
dc.publisher.none.fl_str_mv |
Scientific Technical Research Council Turkey-tubitak |
publisher.none.fl_str_mv |
Scientific Technical Research Council Turkey-tubitak |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128767821873152 |