Metabolic profile and adipokine levels in overweight and obese dogs

Detalhes bibliográficos
Autor(a) principal: De Marchi, Paula Nassar [UNESP]
Data de Publicação: 2020
Outros Autores: Araujo Machado, Luiz Henrique de [UNESP], Holsback, Luciane, Calesso, Jessica Ragazzi, Fagnani, Rafael, Zacarias Junior, Ademir, Lahm Cardoso, Mauro Jose
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3906/vet-2004-44
http://hdl.handle.net/11449/208904
Resumo: Obesity in dogs is increasingly present in the veterinary practice. In humans, it is known that there is a significant correlation between obesity and the development of hypertension and insulin resistance (IR), a clinical picture called metabolic syndrome. In dogs, however, there are only anecdotes about the syndrome. The objectives of this study were to determine serum levels of adiponectin, leptin, triglycerides, cholesterol, insulin, glucose, homeostasis assessment of B cell function (HOMA-B), homeostasis assessment of insulin resistance (HOMA-IR), and systolic blood pressure (SBP) in dogs with different body conditions (BC) and body fat (BF) without endocrine disease. For this purpose, 76 healthy dogs were submitted to evaluation of body conditions score (BCS) and morphometry. The dogs were separated into 3 groups: optimal BC [BCS 3,4, or 5 of 9 and BF% of 13 to 27-Group 1 (G1)], overweight [BCS 6 and 7 of 9 and BF% of 14 to 38- Group 2 (G2)], obese [BCS 8 and 9 of 9 and BF% greater than or equal to 34-Group 3 (G3)]. G3 presented higher serum levels of total protein, triglycerides, glucose, insulin, and HOMA-IR. Adipokines did not correlate to any other parameter, but the occurrence of hyperinsulinemia was higher in G3. The results have shown that obese dogs presented IR and alterations in fat metabolism.
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spelling Metabolic profile and adipokine levels in overweight and obese dogsAdipokinessystolic hypertensionobesityinsulin resistanceObesity in dogs is increasingly present in the veterinary practice. In humans, it is known that there is a significant correlation between obesity and the development of hypertension and insulin resistance (IR), a clinical picture called metabolic syndrome. In dogs, however, there are only anecdotes about the syndrome. The objectives of this study were to determine serum levels of adiponectin, leptin, triglycerides, cholesterol, insulin, glucose, homeostasis assessment of B cell function (HOMA-B), homeostasis assessment of insulin resistance (HOMA-IR), and systolic blood pressure (SBP) in dogs with different body conditions (BC) and body fat (BF) without endocrine disease. For this purpose, 76 healthy dogs were submitted to evaluation of body conditions score (BCS) and morphometry. The dogs were separated into 3 groups: optimal BC [BCS 3,4, or 5 of 9 and BF% of 13 to 27-Group 1 (G1)], overweight [BCS 6 and 7 of 9 and BF% of 14 to 38- Group 2 (G2)], obese [BCS 8 and 9 of 9 and BF% greater than or equal to 34-Group 3 (G3)]. G3 presented higher serum levels of total protein, triglycerides, glucose, insulin, and HOMA-IR. Adipokines did not correlate to any other parameter, but the occurrence of hyperinsulinemia was higher in G3. The results have shown that obese dogs presented IR and alterations in fat metabolism.Araucaria FoundationConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Paulista State Univ Julio de Mesquita Filho, Coll Vet Med & Anim Sci, Botucatu, SP, BrazilState Univ Northern Parana, Coll Vet Med, Bandeirantes, Parana, BrazilUniv North Parana, Coll Prod Engn, Londrina, Parana, BrazilUniv Estadual Londrina, Agr Sci Ctr, Londrina, Parana, BrazilPaulista State Univ Julio de Mesquita Filho, Coll Vet Med & Anim Sci, Botucatu, SP, BrazilAraucaria Foundation: 931/2013Scientific Technical Research Council Turkey-tubitakUniversidade Estadual Paulista (Unesp)State Univ Northern ParanaUniv North ParanaUniversidade Estadual de Londrina (UEL)De Marchi, Paula Nassar [UNESP]Araujo Machado, Luiz Henrique de [UNESP]Holsback, LucianeCalesso, Jessica RagazziFagnani, RafaelZacarias Junior, AdemirLahm Cardoso, Mauro Jose2021-06-25T11:24:18Z2021-06-25T11:24:18Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1093-1099http://dx.doi.org/10.3906/vet-2004-44Turkish Journal Of Veterinary & Animal Sciences. Ankara: Scientific Technical Research Council Turkey-tubitak, v. 44, n. 5, p. 1093-1099, 2020.1300-0128http://hdl.handle.net/11449/20890410.3906/vet-2004-44WOS:000582646000016Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTurkish Journal Of Veterinary & Animal Sciencesinfo:eu-repo/semantics/openAccess2021-10-23T19:23:18Zoai:repositorio.unesp.br:11449/208904Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:10:54.697950Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Metabolic profile and adipokine levels in overweight and obese dogs
title Metabolic profile and adipokine levels in overweight and obese dogs
spellingShingle Metabolic profile and adipokine levels in overweight and obese dogs
De Marchi, Paula Nassar [UNESP]
Adipokines
systolic hypertension
obesity
insulin resistance
title_short Metabolic profile and adipokine levels in overweight and obese dogs
title_full Metabolic profile and adipokine levels in overweight and obese dogs
title_fullStr Metabolic profile and adipokine levels in overweight and obese dogs
title_full_unstemmed Metabolic profile and adipokine levels in overweight and obese dogs
title_sort Metabolic profile and adipokine levels in overweight and obese dogs
author De Marchi, Paula Nassar [UNESP]
author_facet De Marchi, Paula Nassar [UNESP]
Araujo Machado, Luiz Henrique de [UNESP]
Holsback, Luciane
Calesso, Jessica Ragazzi
Fagnani, Rafael
Zacarias Junior, Ademir
Lahm Cardoso, Mauro Jose
author_role author
author2 Araujo Machado, Luiz Henrique de [UNESP]
Holsback, Luciane
Calesso, Jessica Ragazzi
Fagnani, Rafael
Zacarias Junior, Ademir
Lahm Cardoso, Mauro Jose
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
State Univ Northern Parana
Univ North Parana
Universidade Estadual de Londrina (UEL)
dc.contributor.author.fl_str_mv De Marchi, Paula Nassar [UNESP]
Araujo Machado, Luiz Henrique de [UNESP]
Holsback, Luciane
Calesso, Jessica Ragazzi
Fagnani, Rafael
Zacarias Junior, Ademir
Lahm Cardoso, Mauro Jose
dc.subject.por.fl_str_mv Adipokines
systolic hypertension
obesity
insulin resistance
topic Adipokines
systolic hypertension
obesity
insulin resistance
description Obesity in dogs is increasingly present in the veterinary practice. In humans, it is known that there is a significant correlation between obesity and the development of hypertension and insulin resistance (IR), a clinical picture called metabolic syndrome. In dogs, however, there are only anecdotes about the syndrome. The objectives of this study were to determine serum levels of adiponectin, leptin, triglycerides, cholesterol, insulin, glucose, homeostasis assessment of B cell function (HOMA-B), homeostasis assessment of insulin resistance (HOMA-IR), and systolic blood pressure (SBP) in dogs with different body conditions (BC) and body fat (BF) without endocrine disease. For this purpose, 76 healthy dogs were submitted to evaluation of body conditions score (BCS) and morphometry. The dogs were separated into 3 groups: optimal BC [BCS 3,4, or 5 of 9 and BF% of 13 to 27-Group 1 (G1)], overweight [BCS 6 and 7 of 9 and BF% of 14 to 38- Group 2 (G2)], obese [BCS 8 and 9 of 9 and BF% greater than or equal to 34-Group 3 (G3)]. G3 presented higher serum levels of total protein, triglycerides, glucose, insulin, and HOMA-IR. Adipokines did not correlate to any other parameter, but the occurrence of hyperinsulinemia was higher in G3. The results have shown that obese dogs presented IR and alterations in fat metabolism.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
2021-06-25T11:24:18Z
2021-06-25T11:24:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3906/vet-2004-44
Turkish Journal Of Veterinary & Animal Sciences. Ankara: Scientific Technical Research Council Turkey-tubitak, v. 44, n. 5, p. 1093-1099, 2020.
1300-0128
http://hdl.handle.net/11449/208904
10.3906/vet-2004-44
WOS:000582646000016
url http://dx.doi.org/10.3906/vet-2004-44
http://hdl.handle.net/11449/208904
identifier_str_mv Turkish Journal Of Veterinary & Animal Sciences. Ankara: Scientific Technical Research Council Turkey-tubitak, v. 44, n. 5, p. 1093-1099, 2020.
1300-0128
10.3906/vet-2004-44
WOS:000582646000016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Turkish Journal Of Veterinary & Animal Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1093-1099
dc.publisher.none.fl_str_mv Scientific Technical Research Council Turkey-tubitak
publisher.none.fl_str_mv Scientific Technical Research Council Turkey-tubitak
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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