Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jnutbio.2019.108303 http://hdl.handle.net/11449/199758 |
Resumo: | The development of obesity-associated complications is related to various pathogenic events including chronic inflammation, oxidative stress and generation of advanced glycation end products (AGEs). Due to their antioxidant, anti-inflammatory and antiglycation properties, trigonelline and curcumin are interesting candidates to counteract complications of obesity and diabetes mellitus. The current study aimed to investigate the effects of treatment with curcumin or trigonelline mixed into yoghurt, alone or in combination, on mice fed high-fat diet (HFD); the focus was mainly on the potential of these phytochemicals to counteract oxidative and glycative stress. Yoghurt alone improved glucose tolerance and reduced proinflammatory cytokine levels in HFD mice; however, it did not affect the antioxidant status. Trigonelline-enriched yoghurt prevented fat accumulation in adipose tissue, improved both insulin sensitivity and glucose tolerance and exerted anti-inflammatory and antiglycation activities (reduced AGEs and AGE receptor levels and increased the levels of components related to AGE detoxification) in liver and kidney of HFD mice. Curcumin-enriched yoghurt exerted anti-inflammatory and potent antioxidant properties (increased antioxidant enzyme activities and decreased lipid peroxidation) in liver and kidney of HFD mice. However, several beneficial effects were nullified when trigonelline and curcumin were administered in combination. Trigonelline and curcumin have emerged as promising complementary therapy candidates for liver and kidney complications associated with obesity. However, the administration of these phytochemicals in combination, at least in HFD mice, was not effective; inhibition of biotransformation processes and/or the reaching of toxic doses during combined treatment may be prevailing over the individual pharmacodynamic actions of these phytochemicals. |
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Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesityAdvanced glycationCurcuminInflammationObesityOxidative stressTrigonellineThe development of obesity-associated complications is related to various pathogenic events including chronic inflammation, oxidative stress and generation of advanced glycation end products (AGEs). Due to their antioxidant, anti-inflammatory and antiglycation properties, trigonelline and curcumin are interesting candidates to counteract complications of obesity and diabetes mellitus. The current study aimed to investigate the effects of treatment with curcumin or trigonelline mixed into yoghurt, alone or in combination, on mice fed high-fat diet (HFD); the focus was mainly on the potential of these phytochemicals to counteract oxidative and glycative stress. Yoghurt alone improved glucose tolerance and reduced proinflammatory cytokine levels in HFD mice; however, it did not affect the antioxidant status. Trigonelline-enriched yoghurt prevented fat accumulation in adipose tissue, improved both insulin sensitivity and glucose tolerance and exerted anti-inflammatory and antiglycation activities (reduced AGEs and AGE receptor levels and increased the levels of components related to AGE detoxification) in liver and kidney of HFD mice. Curcumin-enriched yoghurt exerted anti-inflammatory and potent antioxidant properties (increased antioxidant enzyme activities and decreased lipid peroxidation) in liver and kidney of HFD mice. However, several beneficial effects were nullified when trigonelline and curcumin were administered in combination. Trigonelline and curcumin have emerged as promising complementary therapy candidates for liver and kidney complications associated with obesity. However, the administration of these phytochemicals in combination, at least in HFD mice, was not effective; inhibition of biotransformation processes and/or the reaching of toxic doses during combined treatment may be prevailing over the individual pharmacodynamic actions of these phytochemicals.São Paulo State University (Unesp) School of Pharmaceutical Sciences Department of Clinical AnalysisSão Paulo State University (Unesp) Araraquara School of Dentistry Department of Physiology and PathologyPaulista University (UNIP) Institute of Health SciencesSão Paulo State University (Unesp) School of Pharmaceutical Sciences Department of Clinical AnalysisSão Paulo State University (Unesp) Araraquara School of Dentistry Department of Physiology and PathologyUniversidade Estadual Paulista (Unesp)Institute of Health SciencesCosta, Mariana Campos [UNESP]Lima, Tayra Ferreira Oliveira [UNESP]Arcaro, Carlos Alberto [UNESP]Inacio, Maiara Destro [UNESP]Batista-Duharte, Alexander [UNESP]Carlos, Iracilda Zeppone [UNESP]Spolidorio, Luís Carlos [UNESP]Assis, Renata Pires [UNESP]Brunetti, Iguatemy Lourenço [UNESP]Baviera, Amanda Martins [UNESP]2020-12-12T01:48:30Z2020-12-12T01:48:30Z2020-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jnutbio.2019.108303Journal of Nutritional Biochemistry, v. 76.1873-48470955-2863http://hdl.handle.net/11449/19975810.1016/j.jnutbio.2019.1083032-s2.0-85075987144Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Nutritional Biochemistryinfo:eu-repo/semantics/openAccess2021-10-23T09:33:56Zoai:repositorio.unesp.br:11449/199758Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T09:33:56Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity |
title |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity |
spellingShingle |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity Costa, Mariana Campos [UNESP] Advanced glycation Curcumin Inflammation Obesity Oxidative stress Trigonelline |
title_short |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity |
title_full |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity |
title_fullStr |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity |
title_full_unstemmed |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity |
title_sort |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity |
author |
Costa, Mariana Campos [UNESP] |
author_facet |
Costa, Mariana Campos [UNESP] Lima, Tayra Ferreira Oliveira [UNESP] Arcaro, Carlos Alberto [UNESP] Inacio, Maiara Destro [UNESP] Batista-Duharte, Alexander [UNESP] Carlos, Iracilda Zeppone [UNESP] Spolidorio, Luís Carlos [UNESP] Assis, Renata Pires [UNESP] Brunetti, Iguatemy Lourenço [UNESP] Baviera, Amanda Martins [UNESP] |
author_role |
author |
author2 |
Lima, Tayra Ferreira Oliveira [UNESP] Arcaro, Carlos Alberto [UNESP] Inacio, Maiara Destro [UNESP] Batista-Duharte, Alexander [UNESP] Carlos, Iracilda Zeppone [UNESP] Spolidorio, Luís Carlos [UNESP] Assis, Renata Pires [UNESP] Brunetti, Iguatemy Lourenço [UNESP] Baviera, Amanda Martins [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Institute of Health Sciences |
dc.contributor.author.fl_str_mv |
Costa, Mariana Campos [UNESP] Lima, Tayra Ferreira Oliveira [UNESP] Arcaro, Carlos Alberto [UNESP] Inacio, Maiara Destro [UNESP] Batista-Duharte, Alexander [UNESP] Carlos, Iracilda Zeppone [UNESP] Spolidorio, Luís Carlos [UNESP] Assis, Renata Pires [UNESP] Brunetti, Iguatemy Lourenço [UNESP] Baviera, Amanda Martins [UNESP] |
dc.subject.por.fl_str_mv |
Advanced glycation Curcumin Inflammation Obesity Oxidative stress Trigonelline |
topic |
Advanced glycation Curcumin Inflammation Obesity Oxidative stress Trigonelline |
description |
The development of obesity-associated complications is related to various pathogenic events including chronic inflammation, oxidative stress and generation of advanced glycation end products (AGEs). Due to their antioxidant, anti-inflammatory and antiglycation properties, trigonelline and curcumin are interesting candidates to counteract complications of obesity and diabetes mellitus. The current study aimed to investigate the effects of treatment with curcumin or trigonelline mixed into yoghurt, alone or in combination, on mice fed high-fat diet (HFD); the focus was mainly on the potential of these phytochemicals to counteract oxidative and glycative stress. Yoghurt alone improved glucose tolerance and reduced proinflammatory cytokine levels in HFD mice; however, it did not affect the antioxidant status. Trigonelline-enriched yoghurt prevented fat accumulation in adipose tissue, improved both insulin sensitivity and glucose tolerance and exerted anti-inflammatory and antiglycation activities (reduced AGEs and AGE receptor levels and increased the levels of components related to AGE detoxification) in liver and kidney of HFD mice. Curcumin-enriched yoghurt exerted anti-inflammatory and potent antioxidant properties (increased antioxidant enzyme activities and decreased lipid peroxidation) in liver and kidney of HFD mice. However, several beneficial effects were nullified when trigonelline and curcumin were administered in combination. Trigonelline and curcumin have emerged as promising complementary therapy candidates for liver and kidney complications associated with obesity. However, the administration of these phytochemicals in combination, at least in HFD mice, was not effective; inhibition of biotransformation processes and/or the reaching of toxic doses during combined treatment may be prevailing over the individual pharmacodynamic actions of these phytochemicals. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:48:30Z 2020-12-12T01:48:30Z 2020-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jnutbio.2019.108303 Journal of Nutritional Biochemistry, v. 76. 1873-4847 0955-2863 http://hdl.handle.net/11449/199758 10.1016/j.jnutbio.2019.108303 2-s2.0-85075987144 |
url |
http://dx.doi.org/10.1016/j.jnutbio.2019.108303 http://hdl.handle.net/11449/199758 |
identifier_str_mv |
Journal of Nutritional Biochemistry, v. 76. 1873-4847 0955-2863 10.1016/j.jnutbio.2019.108303 2-s2.0-85075987144 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Nutritional Biochemistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965044571635712 |