Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jcoa.2023.100082 http://hdl.handle.net/11449/247220 |
Resumo: | Per- and polyfluoroalkyl substances (PFAS) present interesting features for several applications and have great commercial relevance. However, PFAS bioaccumulate, persist in the environment, and are toxic, so regulating and controlling their use and evaluating the risks of human exposure to them is vital. Liquid chromatography with tandem mass spectrometry (LC–MS/MS) has been employed to analyze PFAS, especially in biomonitoring studies. Unfortunately, these studies have been met with challenges, such as the low PFAS concentrations in the samples, small sample amount, contamination of labware and reagents, and signal suppression due to the sample matrix. A suitable sample preparation method could preconcentrate PFAS in the sample and remove the matrix before chromatographic analysis, thereby helping to overcome these challenges. Moreover, the right sample preparation method could reduce the analysis time and enhance the selectivity and sensitivity achieved with HPLC–MS/MS and other correlated techniques. Solid Phase Extraction (SPE) is the most common sample preparation technique. SPE is usually employed with protein precipitation (PPT) in multistep sample preparation methods. Nevertheless, depending on the sample type and composition, presence of contaminants, and analytes, other sample preparation techniques may be relevant. In this paper, we provide a critical review of the sample preparation techniques applied for PFAS analysis in biological matrices. We exploit the benefits, challenges, and future perspectives of these techniques. |
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Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - ReviewBiological matricesEmerging contaminantsHPLCLC-MS/MSPFASSample preparationPer- and polyfluoroalkyl substances (PFAS) present interesting features for several applications and have great commercial relevance. However, PFAS bioaccumulate, persist in the environment, and are toxic, so regulating and controlling their use and evaluating the risks of human exposure to them is vital. Liquid chromatography with tandem mass spectrometry (LC–MS/MS) has been employed to analyze PFAS, especially in biomonitoring studies. Unfortunately, these studies have been met with challenges, such as the low PFAS concentrations in the samples, small sample amount, contamination of labware and reagents, and signal suppression due to the sample matrix. A suitable sample preparation method could preconcentrate PFAS in the sample and remove the matrix before chromatographic analysis, thereby helping to overcome these challenges. Moreover, the right sample preparation method could reduce the analysis time and enhance the selectivity and sensitivity achieved with HPLC–MS/MS and other correlated techniques. Solid Phase Extraction (SPE) is the most common sample preparation technique. SPE is usually employed with protein precipitation (PPT) in multistep sample preparation methods. Nevertheless, depending on the sample type and composition, presence of contaminants, and analytes, other sample preparation techniques may be relevant. In this paper, we provide a critical review of the sample preparation techniques applied for PFAS analysis in biological matrices. We exploit the benefits, challenges, and future perspectives of these techniques.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Departamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo, SPNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT–DATREM) Unesp Institute of Chemistry, P.O. Box 355, SPNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT–DATREM) Unesp Institute of Chemistry, P.O. Box 355, SPFAPESP: 2014/50945-4FAPESP: 2020/02139-0FAPESP: 2021/10098-4CNPq: 306186/2021-7CNPq: 465571/2014-0Universidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Perovani, Icaro SalgadoBarbetta, Maike Felipe SantosDuarte, Leandro Okade Oliveira, Anderson Rodrigo Moraes [UNESP]2023-07-29T13:10:01Z2023-07-29T13:10:01Z2023-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jcoa.2023.100082Journal of Chromatography Open, v. 3.2772-3917http://hdl.handle.net/11449/24722010.1016/j.jcoa.2023.1000822-s2.0-85153280381Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Chromatography Openinfo:eu-repo/semantics/openAccess2023-07-29T13:10:01Zoai:repositorio.unesp.br:11449/247220Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:58:51.707027Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review |
title |
Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review |
spellingShingle |
Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review Perovani, Icaro Salgado Biological matrices Emerging contaminants HPLC LC-MS/MS PFAS Sample preparation |
title_short |
Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review |
title_full |
Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review |
title_fullStr |
Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review |
title_full_unstemmed |
Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review |
title_sort |
Determination of polyfluoroalkyl substances in biological matrices by chromatography techniques: A review focused on the sample preparation techniques - Review |
author |
Perovani, Icaro Salgado |
author_facet |
Perovani, Icaro Salgado Barbetta, Maike Felipe Santos Duarte, Leandro Oka de Oliveira, Anderson Rodrigo Moraes [UNESP] |
author_role |
author |
author2 |
Barbetta, Maike Felipe Santos Duarte, Leandro Oka de Oliveira, Anderson Rodrigo Moraes [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Perovani, Icaro Salgado Barbetta, Maike Felipe Santos Duarte, Leandro Oka de Oliveira, Anderson Rodrigo Moraes [UNESP] |
dc.subject.por.fl_str_mv |
Biological matrices Emerging contaminants HPLC LC-MS/MS PFAS Sample preparation |
topic |
Biological matrices Emerging contaminants HPLC LC-MS/MS PFAS Sample preparation |
description |
Per- and polyfluoroalkyl substances (PFAS) present interesting features for several applications and have great commercial relevance. However, PFAS bioaccumulate, persist in the environment, and are toxic, so regulating and controlling their use and evaluating the risks of human exposure to them is vital. Liquid chromatography with tandem mass spectrometry (LC–MS/MS) has been employed to analyze PFAS, especially in biomonitoring studies. Unfortunately, these studies have been met with challenges, such as the low PFAS concentrations in the samples, small sample amount, contamination of labware and reagents, and signal suppression due to the sample matrix. A suitable sample preparation method could preconcentrate PFAS in the sample and remove the matrix before chromatographic analysis, thereby helping to overcome these challenges. Moreover, the right sample preparation method could reduce the analysis time and enhance the selectivity and sensitivity achieved with HPLC–MS/MS and other correlated techniques. Solid Phase Extraction (SPE) is the most common sample preparation technique. SPE is usually employed with protein precipitation (PPT) in multistep sample preparation methods. Nevertheless, depending on the sample type and composition, presence of contaminants, and analytes, other sample preparation techniques may be relevant. In this paper, we provide a critical review of the sample preparation techniques applied for PFAS analysis in biological matrices. We exploit the benefits, challenges, and future perspectives of these techniques. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:10:01Z 2023-07-29T13:10:01Z 2023-11-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jcoa.2023.100082 Journal of Chromatography Open, v. 3. 2772-3917 http://hdl.handle.net/11449/247220 10.1016/j.jcoa.2023.100082 2-s2.0-85153280381 |
url |
http://dx.doi.org/10.1016/j.jcoa.2023.100082 http://hdl.handle.net/11449/247220 |
identifier_str_mv |
Journal of Chromatography Open, v. 3. 2772-3917 10.1016/j.jcoa.2023.100082 2-s2.0-85153280381 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Chromatography Open |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128444011118592 |