Leishmania sp. amastigotes identification in canine transmissible venereal tumor
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2014/603852 http://hdl.handle.net/11449/133096 |
Resumo: | Leishmaniasis is a vector-borne disease with Leishmania chagasi being the etiological agent of canine visceral leishmaniasis in South America. Canine venereal tumor is a transplantable round cell tumor of histiocytic origin which is mostly observed in sexually active male and female intact dogs. It has been shown that Leishmania amastigotes have higher tropism for the canine male genital tract tissues and venereal leishmaniasis transmission has been documented in dogs but, to date, a canine venereal tumor-dependent transmission route has not been fully demonstrated. In this report, a 10-year-old, mixed breed, intact female dog presented a vaginal venereal transmissible tumor but no other clinical abnormalities otherwise. Unexpectedly, tumor tissue imprint smears examination revealed Leishmania sp. amastigotes within infiltrating macrophages. In addition to the cytological direct identification, the protozoan was confirmed within the neoplastic tissue by means of immunohistochemistry and polymerase chain reaction. This report illustrates an asymptomatic Leishmania sp. infection that may have started on or from the canine venereal tumor tissue, the latter option further supporting previous evidence of such an alternative vector-independent route of transmission for canine visceral leishmaniasis in areas where these diseases coexist. |
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spelling |
Leishmania sp. amastigotes identification in canine transmissible venereal tumorLeishmaniasis is a vector-borne disease with Leishmania chagasi being the etiological agent of canine visceral leishmaniasis in South America. Canine venereal tumor is a transplantable round cell tumor of histiocytic origin which is mostly observed in sexually active male and female intact dogs. It has been shown that Leishmania amastigotes have higher tropism for the canine male genital tract tissues and venereal leishmaniasis transmission has been documented in dogs but, to date, a canine venereal tumor-dependent transmission route has not been fully demonstrated. In this report, a 10-year-old, mixed breed, intact female dog presented a vaginal venereal transmissible tumor but no other clinical abnormalities otherwise. Unexpectedly, tumor tissue imprint smears examination revealed Leishmania sp. amastigotes within infiltrating macrophages. In addition to the cytological direct identification, the protozoan was confirmed within the neoplastic tissue by means of immunohistochemistry and polymerase chain reaction. This report illustrates an asymptomatic Leishmania sp. infection that may have started on or from the canine venereal tumor tissue, the latter option further supporting previous evidence of such an alternative vector-independent route of transmission for canine visceral leishmaniasis in areas where these diseases coexist.Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Cirurgia e Reprodução Animal, Aracatuba, Rua Clóvis Pestana, 793, Jardim Dona Amelia, CEP 16050-680, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Cirurgia e Reprodução Animal, Aracatuba, Rua Clóvis Pestana, 793, Jardim Dona Amelia, CEP 16050-680, SP, BrasilUniversidade Estadual Paulista (Unesp)University of CincinnatiLouisiana State UniversityVeterinary Medical CenterUniversidade de São Paulo (USP)Carreira, Vinicius Soares [UNESP]Ferrari, Heitor Flavio [UNESP]Langohr, Ingeborg MariaMackenzie, CharlesMontezzo, Luiz CarlosTaira, Edson [UNESP]Floeter-Winter, Lucile MariaLuvizotto, Maria Cecília Rui [UNESP]2016-01-28T16:53:36Z2016-01-28T16:53:36Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article01-04application/pdfhttp://dx.doi.org/10.1155/2014/603852Case Reports in Veterinary Medicine, v. 2014, p. 1-4, 2014.2090-7001http://hdl.handle.net/11449/13309610.1155/2014/603852ISSN2090-7001-2014-2014-01-04.pdf28504531837243614584674909952477Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCase Reports in Veterinary Medicineinfo:eu-repo/semantics/openAccess2024-09-04T18:03:25Zoai:repositorio.unesp.br:11449/133096Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T18:03:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Leishmania sp. amastigotes identification in canine transmissible venereal tumor |
title |
Leishmania sp. amastigotes identification in canine transmissible venereal tumor |
spellingShingle |
Leishmania sp. amastigotes identification in canine transmissible venereal tumor Carreira, Vinicius Soares [UNESP] |
title_short |
Leishmania sp. amastigotes identification in canine transmissible venereal tumor |
title_full |
Leishmania sp. amastigotes identification in canine transmissible venereal tumor |
title_fullStr |
Leishmania sp. amastigotes identification in canine transmissible venereal tumor |
title_full_unstemmed |
Leishmania sp. amastigotes identification in canine transmissible venereal tumor |
title_sort |
Leishmania sp. amastigotes identification in canine transmissible venereal tumor |
author |
Carreira, Vinicius Soares [UNESP] |
author_facet |
Carreira, Vinicius Soares [UNESP] Ferrari, Heitor Flavio [UNESP] Langohr, Ingeborg Maria Mackenzie, Charles Montezzo, Luiz Carlos Taira, Edson [UNESP] Floeter-Winter, Lucile Maria Luvizotto, Maria Cecília Rui [UNESP] |
author_role |
author |
author2 |
Ferrari, Heitor Flavio [UNESP] Langohr, Ingeborg Maria Mackenzie, Charles Montezzo, Luiz Carlos Taira, Edson [UNESP] Floeter-Winter, Lucile Maria Luvizotto, Maria Cecília Rui [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Cincinnati Louisiana State University Veterinary Medical Center Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Carreira, Vinicius Soares [UNESP] Ferrari, Heitor Flavio [UNESP] Langohr, Ingeborg Maria Mackenzie, Charles Montezzo, Luiz Carlos Taira, Edson [UNESP] Floeter-Winter, Lucile Maria Luvizotto, Maria Cecília Rui [UNESP] |
description |
Leishmaniasis is a vector-borne disease with Leishmania chagasi being the etiological agent of canine visceral leishmaniasis in South America. Canine venereal tumor is a transplantable round cell tumor of histiocytic origin which is mostly observed in sexually active male and female intact dogs. It has been shown that Leishmania amastigotes have higher tropism for the canine male genital tract tissues and venereal leishmaniasis transmission has been documented in dogs but, to date, a canine venereal tumor-dependent transmission route has not been fully demonstrated. In this report, a 10-year-old, mixed breed, intact female dog presented a vaginal venereal transmissible tumor but no other clinical abnormalities otherwise. Unexpectedly, tumor tissue imprint smears examination revealed Leishmania sp. amastigotes within infiltrating macrophages. In addition to the cytological direct identification, the protozoan was confirmed within the neoplastic tissue by means of immunohistochemistry and polymerase chain reaction. This report illustrates an asymptomatic Leishmania sp. infection that may have started on or from the canine venereal tumor tissue, the latter option further supporting previous evidence of such an alternative vector-independent route of transmission for canine visceral leishmaniasis in areas where these diseases coexist. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2016-01-28T16:53:36Z 2016-01-28T16:53:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2014/603852 Case Reports in Veterinary Medicine, v. 2014, p. 1-4, 2014. 2090-7001 http://hdl.handle.net/11449/133096 10.1155/2014/603852 ISSN2090-7001-2014-2014-01-04.pdf 2850453183724361 4584674909952477 |
url |
http://dx.doi.org/10.1155/2014/603852 http://hdl.handle.net/11449/133096 |
identifier_str_mv |
Case Reports in Veterinary Medicine, v. 2014, p. 1-4, 2014. 2090-7001 10.1155/2014/603852 ISSN2090-7001-2014-2014-01-04.pdf 2850453183724361 4584674909952477 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Case Reports in Veterinary Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
01-04 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021360931438592 |