Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women

Detalhes bibliográficos
Autor(a) principal: Ferreira, P. P. [UNESP]
Data de Publicação: 2019
Outros Autores: Cangussu, L. [UNESP], Bueloni-Dias, F. N. [UNESP], Orsatti, C. L. [UNESP], Schmitt, E. B. [UNESP], Nahas-Neto, J. [UNESP], Nahas, E. A. P. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/13697137.2019.1611761
http://hdl.handle.net/11449/185770
Resumo: Objective: This study aimed to evaluate the effect of isolated vitamin D (VD) supplementation on the metabolic syndrome (MetS) risk profile in postmenopausal women. Methods: In this double-blind, placebo-controlled trial, 160 postmenopausal women aged 50-65 years were randomized into two groups: VD group, supplementation with 1000 IU vitamin D-3/day (n = 80); or placebo group (n = 80). The intervention time was 9 months, and the women were assessed at baseline and endpoint. Clinical and anthropometric data were collected. Biochemical parameters, including total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, glucose, and insulin, were measured. The plasma concentration of 25-hydroxyvitamin D (25(OH)D) was measured by high-performance liquid chromatography. Results: After 9 months, there was a significant increase in the 25(OH)D levels for VD group (+45.4%, p < 0.001), and a decrease (-18.5%, p = 0.049) in the placebo group. In the VD group, a significant reduction was observed in triglycerides (-12.2%, p = 0.001), insulin (-13.7%, p = 0.008), and the homeostasis model assessment of insulin resistance (-17.9%, p = 0.007). In the placebo group, there was an increase in glucose (+6.2%, p = 0.009). Analysis of the risk adjusted for age, time since menopause, and body mass index showed that women supplemented with VD had a lower risk of MetS (odds ratio [OR] 0.42; 95% confidence interval [CI] 0.21-0.83), hypertriglyceridemia (OR 0.43; 95% CI 0.22-0.85), and hyperglycemia (OR 0.23; 95% CI 0.10-0.52) compared to the placebo group (p < 0.05). Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D-3 for 9 months was associated with a reduction in the MetS risk profile. Women undergoing VD supplementation had a lower risk of MetS, hypertriglyceridemia, and hyperglycemia.
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spelling Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal womenVitamin Dsupplementationpostmenopausal womenmetabolic syndromeObjective: This study aimed to evaluate the effect of isolated vitamin D (VD) supplementation on the metabolic syndrome (MetS) risk profile in postmenopausal women. Methods: In this double-blind, placebo-controlled trial, 160 postmenopausal women aged 50-65 years were randomized into two groups: VD group, supplementation with 1000 IU vitamin D-3/day (n = 80); or placebo group (n = 80). The intervention time was 9 months, and the women were assessed at baseline and endpoint. Clinical and anthropometric data were collected. Biochemical parameters, including total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, glucose, and insulin, were measured. The plasma concentration of 25-hydroxyvitamin D (25(OH)D) was measured by high-performance liquid chromatography. Results: After 9 months, there was a significant increase in the 25(OH)D levels for VD group (+45.4%, p < 0.001), and a decrease (-18.5%, p = 0.049) in the placebo group. In the VD group, a significant reduction was observed in triglycerides (-12.2%, p = 0.001), insulin (-13.7%, p = 0.008), and the homeostasis model assessment of insulin resistance (-17.9%, p = 0.007). In the placebo group, there was an increase in glucose (+6.2%, p = 0.009). Analysis of the risk adjusted for age, time since menopause, and body mass index showed that women supplemented with VD had a lower risk of MetS (odds ratio [OR] 0.42; 95% confidence interval [CI] 0.21-0.83), hypertriglyceridemia (OR 0.43; 95% CI 0.22-0.85), and hyperglycemia (OR 0.23; 95% CI 0.10-0.52) compared to the placebo group (p < 0.05). Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D-3 for 9 months was associated with a reduction in the MetS risk profile. Women undergoing VD supplementation had a lower risk of MetS, hypertriglyceridemia, and hyperglycemia.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, Dist Rubiao Jr S-N, BR-18618970 Botucatu, SP, BrazilSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, Dist Rubiao Jr S-N, BR-18618970 Botucatu, SP, BrazilFAPESP: 2014/19382-3Taylor & Francis LtdUniversidade Estadual Paulista (Unesp)Ferreira, P. P. [UNESP]Cangussu, L. [UNESP]Bueloni-Dias, F. N. [UNESP]Orsatti, C. L. [UNESP]Schmitt, E. B. [UNESP]Nahas-Neto, J. [UNESP]Nahas, E. A. P. [UNESP]2019-10-04T12:38:21Z2019-10-04T12:38:21Z2019-05-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8http://dx.doi.org/10.1080/13697137.2019.1611761Climacteric. Abingdon: Taylor & Francis Ltd, 8 p., 2019.1369-7137http://hdl.handle.net/11449/18577010.1080/13697137.2019.1611761WOS:000470401000001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClimactericinfo:eu-repo/semantics/openAccess2024-08-16T14:07:33Zoai:repositorio.unesp.br:11449/185770Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women
title Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women
spellingShingle Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women
Ferreira, P. P. [UNESP]
Vitamin D
supplementation
postmenopausal women
metabolic syndrome
title_short Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women
title_full Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women
title_fullStr Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women
title_full_unstemmed Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women
title_sort Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women
author Ferreira, P. P. [UNESP]
author_facet Ferreira, P. P. [UNESP]
Cangussu, L. [UNESP]
Bueloni-Dias, F. N. [UNESP]
Orsatti, C. L. [UNESP]
Schmitt, E. B. [UNESP]
Nahas-Neto, J. [UNESP]
Nahas, E. A. P. [UNESP]
author_role author
author2 Cangussu, L. [UNESP]
Bueloni-Dias, F. N. [UNESP]
Orsatti, C. L. [UNESP]
Schmitt, E. B. [UNESP]
Nahas-Neto, J. [UNESP]
Nahas, E. A. P. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ferreira, P. P. [UNESP]
Cangussu, L. [UNESP]
Bueloni-Dias, F. N. [UNESP]
Orsatti, C. L. [UNESP]
Schmitt, E. B. [UNESP]
Nahas-Neto, J. [UNESP]
Nahas, E. A. P. [UNESP]
dc.subject.por.fl_str_mv Vitamin D
supplementation
postmenopausal women
metabolic syndrome
topic Vitamin D
supplementation
postmenopausal women
metabolic syndrome
description Objective: This study aimed to evaluate the effect of isolated vitamin D (VD) supplementation on the metabolic syndrome (MetS) risk profile in postmenopausal women. Methods: In this double-blind, placebo-controlled trial, 160 postmenopausal women aged 50-65 years were randomized into two groups: VD group, supplementation with 1000 IU vitamin D-3/day (n = 80); or placebo group (n = 80). The intervention time was 9 months, and the women were assessed at baseline and endpoint. Clinical and anthropometric data were collected. Biochemical parameters, including total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, glucose, and insulin, were measured. The plasma concentration of 25-hydroxyvitamin D (25(OH)D) was measured by high-performance liquid chromatography. Results: After 9 months, there was a significant increase in the 25(OH)D levels for VD group (+45.4%, p < 0.001), and a decrease (-18.5%, p = 0.049) in the placebo group. In the VD group, a significant reduction was observed in triglycerides (-12.2%, p = 0.001), insulin (-13.7%, p = 0.008), and the homeostasis model assessment of insulin resistance (-17.9%, p = 0.007). In the placebo group, there was an increase in glucose (+6.2%, p = 0.009). Analysis of the risk adjusted for age, time since menopause, and body mass index showed that women supplemented with VD had a lower risk of MetS (odds ratio [OR] 0.42; 95% confidence interval [CI] 0.21-0.83), hypertriglyceridemia (OR 0.43; 95% CI 0.22-0.85), and hyperglycemia (OR 0.23; 95% CI 0.10-0.52) compared to the placebo group (p < 0.05). Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D-3 for 9 months was associated with a reduction in the MetS risk profile. Women undergoing VD supplementation had a lower risk of MetS, hypertriglyceridemia, and hyperglycemia.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T12:38:21Z
2019-10-04T12:38:21Z
2019-05-24
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/13697137.2019.1611761
Climacteric. Abingdon: Taylor & Francis Ltd, 8 p., 2019.
1369-7137
http://hdl.handle.net/11449/185770
10.1080/13697137.2019.1611761
WOS:000470401000001
url http://dx.doi.org/10.1080/13697137.2019.1611761
http://hdl.handle.net/11449/185770
identifier_str_mv Climacteric. Abingdon: Taylor & Francis Ltd, 8 p., 2019.
1369-7137
10.1080/13697137.2019.1611761
WOS:000470401000001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Climacteric
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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