Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1055/s-0039-1692209 http://hdl.handle.net/11449/232973 |
Resumo: | Introduction It is indicated that aging reduces muscular vascularity. Thus, strategies that aim to reverse or decrease the progression of these changes are suggested. Therefore, the present study aimed to analyze the blood capillary density of the plantaris muscle (PL) of aged rats submitted to strength training and exogenous testosterone use. Methods A total of 30 rats were divided equally into the following groups: EA: 20 months old; OLD: 24 months old; OLD + S: testosterone; ST: strength training; and ST + S: strength training + testosterone. Strength training was performed 3 times a week for 15 weeks. Testosterone administration was performed by the intraperitoneal method 2 times a week at a dose of 10mg/kg. All of the morphological parameters were analyzed using morphoquantitative techniques. Results A significant increase in the capillaries numerical density of the OLD + S and ST + S groups. The OLD + S and ST + S groups demonstrated a higher ratio of capillaries per myofiber than the EA, OLD and ST groups. The OLD and ST groups had a higher ratio than the EA group. The OLD + S, ST and ST + S groups presented a statistically significant increase in the cross-sectional area in the type I fibers when compared with the EA and OLD groups. However, the ST group showed a significant increase compared with the OLD group. In type II fibers, the ST and ST + S groups showed a greater cross-sectional area than the EA group. As for the mean cross-sectional area, the ST and ST + S groups presented significantly larger areas than the other groups. Conclusion Anabolic steroid administration is crucial to increase the blood capillary density of the plantaris muscle of old rats, independently of the effects of strength training. |
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Repositório Institucional da UNESP |
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Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Ratsagingblood vesselsskeletal musclesteroidstrainingIntroduction It is indicated that aging reduces muscular vascularity. Thus, strategies that aim to reverse or decrease the progression of these changes are suggested. Therefore, the present study aimed to analyze the blood capillary density of the plantaris muscle (PL) of aged rats submitted to strength training and exogenous testosterone use. Methods A total of 30 rats were divided equally into the following groups: EA: 20 months old; OLD: 24 months old; OLD + S: testosterone; ST: strength training; and ST + S: strength training + testosterone. Strength training was performed 3 times a week for 15 weeks. Testosterone administration was performed by the intraperitoneal method 2 times a week at a dose of 10mg/kg. All of the morphological parameters were analyzed using morphoquantitative techniques. Results A significant increase in the capillaries numerical density of the OLD + S and ST + S groups. The OLD + S and ST + S groups demonstrated a higher ratio of capillaries per myofiber than the EA, OLD and ST groups. The OLD and ST groups had a higher ratio than the EA group. The OLD + S, ST and ST + S groups presented a statistically significant increase in the cross-sectional area in the type I fibers when compared with the EA and OLD groups. However, the ST group showed a significant increase compared with the OLD group. In type II fibers, the ST and ST + S groups showed a greater cross-sectional area than the EA group. As for the mean cross-sectional area, the ST and ST + S groups presented significantly larger areas than the other groups. Conclusion Anabolic steroid administration is crucial to increase the blood capillary density of the plantaris muscle of old rats, independently of the effects of strength training.Department of Physical Education Laboratory of Morphoquantitative Studies and Immunohistochemistry Universidade São Judas TadeuDepartment of Physical Education Laboratory of Morphology and Physical Activity Universidade Estadual Paulista Júlio de Mesquita FilhoDepartment of Physical Education Laboratory of Morphology and Physical Activity Universidade Estadual Paulista Júlio de Mesquita FilhoUniversidade São Judas TadeuUniversidade Estadual Paulista (UNESP)Krause Neto, WalterSilva, Wellington De AssisSilva, Amanda Dos Santos DaCiena, Adriano Polican [UNESP]Souza, Romeu Rodrigues DeCarbone, Patricia OlivaAnaruma, Carlos Alberto [UNESP]Gama, Eliane Florencio2022-04-30T22:56:30Z2022-04-30T22:56:30Z2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article182-189http://dx.doi.org/10.1055/s-0039-1692209Journal of Morphological Sciences, v. 36, n. 3, p. 182-189, 2019.2177-0298http://hdl.handle.net/11449/23297310.1055/s-0039-16922092-s2.0-85080063274Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Morphological Sciencesinfo:eu-repo/semantics/openAccess2022-04-30T22:56:30Zoai:repositorio.unesp.br:11449/232973Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-30T22:56:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats |
title |
Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats |
spellingShingle |
Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats Krause Neto, Walter aging blood vessels skeletal muscle steroids training |
title_short |
Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats |
title_full |
Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats |
title_fullStr |
Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats |
title_full_unstemmed |
Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats |
title_sort |
Testosterone is Key to Increase the Muscle Capillary Density of Old and Trained Rats |
author |
Krause Neto, Walter |
author_facet |
Krause Neto, Walter Silva, Wellington De Assis Silva, Amanda Dos Santos Da Ciena, Adriano Polican [UNESP] Souza, Romeu Rodrigues De Carbone, Patricia Oliva Anaruma, Carlos Alberto [UNESP] Gama, Eliane Florencio |
author_role |
author |
author2 |
Silva, Wellington De Assis Silva, Amanda Dos Santos Da Ciena, Adriano Polican [UNESP] Souza, Romeu Rodrigues De Carbone, Patricia Oliva Anaruma, Carlos Alberto [UNESP] Gama, Eliane Florencio |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade São Judas Tadeu Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Krause Neto, Walter Silva, Wellington De Assis Silva, Amanda Dos Santos Da Ciena, Adriano Polican [UNESP] Souza, Romeu Rodrigues De Carbone, Patricia Oliva Anaruma, Carlos Alberto [UNESP] Gama, Eliane Florencio |
dc.subject.por.fl_str_mv |
aging blood vessels skeletal muscle steroids training |
topic |
aging blood vessels skeletal muscle steroids training |
description |
Introduction It is indicated that aging reduces muscular vascularity. Thus, strategies that aim to reverse or decrease the progression of these changes are suggested. Therefore, the present study aimed to analyze the blood capillary density of the plantaris muscle (PL) of aged rats submitted to strength training and exogenous testosterone use. Methods A total of 30 rats were divided equally into the following groups: EA: 20 months old; OLD: 24 months old; OLD + S: testosterone; ST: strength training; and ST + S: strength training + testosterone. Strength training was performed 3 times a week for 15 weeks. Testosterone administration was performed by the intraperitoneal method 2 times a week at a dose of 10mg/kg. All of the morphological parameters were analyzed using morphoquantitative techniques. Results A significant increase in the capillaries numerical density of the OLD + S and ST + S groups. The OLD + S and ST + S groups demonstrated a higher ratio of capillaries per myofiber than the EA, OLD and ST groups. The OLD and ST groups had a higher ratio than the EA group. The OLD + S, ST and ST + S groups presented a statistically significant increase in the cross-sectional area in the type I fibers when compared with the EA and OLD groups. However, the ST group showed a significant increase compared with the OLD group. In type II fibers, the ST and ST + S groups showed a greater cross-sectional area than the EA group. As for the mean cross-sectional area, the ST and ST + S groups presented significantly larger areas than the other groups. Conclusion Anabolic steroid administration is crucial to increase the blood capillary density of the plantaris muscle of old rats, independently of the effects of strength training. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-01 2022-04-30T22:56:30Z 2022-04-30T22:56:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1055/s-0039-1692209 Journal of Morphological Sciences, v. 36, n. 3, p. 182-189, 2019. 2177-0298 http://hdl.handle.net/11449/232973 10.1055/s-0039-1692209 2-s2.0-85080063274 |
url |
http://dx.doi.org/10.1055/s-0039-1692209 http://hdl.handle.net/11449/232973 |
identifier_str_mv |
Journal of Morphological Sciences, v. 36, n. 3, p. 182-189, 2019. 2177-0298 10.1055/s-0039-1692209 2-s2.0-85080063274 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Morphological Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
182-189 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803650144296501248 |