Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties

Detalhes bibliográficos
Autor(a) principal: Godoy, Roberta Ferro
Data de Publicação: 2016
Outros Autores: Coathup, M. J., Blunn, G. W., Alves, A. L.G. [UNESP], Robotti, P., Goodship, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.22203/eCM.v031a17
http://hdl.handle.net/11449/228161
Resumo: We explored the osseointegration potential of two macroporous titanium surfaces obtained using fast plasma sintering (FPS): Ti macroporous structures with 400-600 µmØ pores (TiMac400) and 850-1000 µmØ pores (TiMac850). They were compared against two surfaces currently in clinical use: Ti-Growth® and air plasma spray (Ti-Y367). Each surface was tested, once placed over a Ti-alloy and once onto a CoCr bulk substrate. Implants were placed in medial femoral condyles in 24 sheep. Samples were explanted at four and eight weeks after surgery. Push-out loads were measured using a material-testing system. Bone contact and ingrowth were assessed by histomorphometry and SEM and EDX analyses. Histology showed early osseointegration for all the surfaces tested. At 8 weeks, TiMac400, TiMac850 and Ti-Growths® showed deep bone ingrowth and extended colonisation with newly formed bone. The mechanical push-out force was equal in all tested surfaces. Plasma spray surfaces showed greater bone-implant contact and higher level of pores colonisation with new bone than FPS produced surfaces. However, the void pore area in FPS specimens was significantly higher, yet the FPS porous surfaces allowed a deeper osseointegration of bone to implant. FPS manufactured specimens showed similar osseointegration potential to the plasma spray surfaces for orthopaedic implants. FPS is a useful technology for manufacturing macroporous titanium surfaces. Furthermore, its capability to combine two implantable materials, using bulk CoCr with macroporous titanium surfaces, could be of interest as it enables designers to conceive and manufacture innovative components. FPS delivers functional graded materials components with macroporous structures optimised for osseointegration.
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spelling Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration propertiesBone colonisationFast plasma sinteringImplantMacroporousPlasma spraySheepSurgeryTitaniumWe explored the osseointegration potential of two macroporous titanium surfaces obtained using fast plasma sintering (FPS): Ti macroporous structures with 400-600 µmØ pores (TiMac400) and 850-1000 µmØ pores (TiMac850). They were compared against two surfaces currently in clinical use: Ti-Growth® and air plasma spray (Ti-Y367). Each surface was tested, once placed over a Ti-alloy and once onto a CoCr bulk substrate. Implants were placed in medial femoral condyles in 24 sheep. Samples were explanted at four and eight weeks after surgery. Push-out loads were measured using a material-testing system. Bone contact and ingrowth were assessed by histomorphometry and SEM and EDX analyses. Histology showed early osseointegration for all the surfaces tested. At 8 weeks, TiMac400, TiMac850 and Ti-Growths® showed deep bone ingrowth and extended colonisation with newly formed bone. The mechanical push-out force was equal in all tested surfaces. Plasma spray surfaces showed greater bone-implant contact and higher level of pores colonisation with new bone than FPS produced surfaces. However, the void pore area in FPS specimens was significantly higher, yet the FPS porous surfaces allowed a deeper osseointegration of bone to implant. FPS manufactured specimens showed similar osseointegration potential to the plasma spray surfaces for orthopaedic implants. FPS is a useful technology for manufacturing macroporous titanium surfaces. Furthermore, its capability to combine two implantable materials, using bulk CoCr with macroporous titanium surfaces, could be of interest as it enables designers to conceive and manufacture innovative components. FPS delivers functional graded materials components with macroporous structures optimised for osseointegration.Institute of Orthopaedics and Musculoskeletal Science University College London Royal National Orthopaedic HospitalDepartment of Veterinary Surgery and Anaesthesiology School of Veterinary Medicine and Animal Science São Paulo State UniversityResearch and Development Department Eurocoating SpaDepartment of Veterinary Surgery and Anaesthesiology School of Veterinary Medicine and Animal Science São Paulo State UniversityRoyal National Orthopaedic HospitalUniversidade Estadual Paulista (UNESP)Eurocoating SpaGodoy, Roberta FerroCoathup, M. J.Blunn, G. W.Alves, A. L.G. [UNESP]Robotti, P.Goodship, A. E.2022-04-29T07:37:27Z2022-04-29T07:37:27Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article250-263http://dx.doi.org/10.22203/eCM.v031a17European Cells and Materials, v. 31, p. 250-263.1473-2262http://hdl.handle.net/11449/22816110.22203/eCM.v031a172-s2.0-84973659261Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Cells and Materialsinfo:eu-repo/semantics/openAccess2022-04-29T07:37:27Zoai:repositorio.unesp.br:11449/228161Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T07:37:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
title Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
spellingShingle Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
Godoy, Roberta Ferro
Bone colonisation
Fast plasma sintering
Implant
Macroporous
Plasma spray
Sheep
Surgery
Titanium
title_short Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
title_full Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
title_fullStr Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
title_full_unstemmed Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
title_sort Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
author Godoy, Roberta Ferro
author_facet Godoy, Roberta Ferro
Coathup, M. J.
Blunn, G. W.
Alves, A. L.G. [UNESP]
Robotti, P.
Goodship, A. E.
author_role author
author2 Coathup, M. J.
Blunn, G. W.
Alves, A. L.G. [UNESP]
Robotti, P.
Goodship, A. E.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Royal National Orthopaedic Hospital
Universidade Estadual Paulista (UNESP)
Eurocoating Spa
dc.contributor.author.fl_str_mv Godoy, Roberta Ferro
Coathup, M. J.
Blunn, G. W.
Alves, A. L.G. [UNESP]
Robotti, P.
Goodship, A. E.
dc.subject.por.fl_str_mv Bone colonisation
Fast plasma sintering
Implant
Macroporous
Plasma spray
Sheep
Surgery
Titanium
topic Bone colonisation
Fast plasma sintering
Implant
Macroporous
Plasma spray
Sheep
Surgery
Titanium
description We explored the osseointegration potential of two macroporous titanium surfaces obtained using fast plasma sintering (FPS): Ti macroporous structures with 400-600 µmØ pores (TiMac400) and 850-1000 µmØ pores (TiMac850). They were compared against two surfaces currently in clinical use: Ti-Growth® and air plasma spray (Ti-Y367). Each surface was tested, once placed over a Ti-alloy and once onto a CoCr bulk substrate. Implants were placed in medial femoral condyles in 24 sheep. Samples were explanted at four and eight weeks after surgery. Push-out loads were measured using a material-testing system. Bone contact and ingrowth were assessed by histomorphometry and SEM and EDX analyses. Histology showed early osseointegration for all the surfaces tested. At 8 weeks, TiMac400, TiMac850 and Ti-Growths® showed deep bone ingrowth and extended colonisation with newly formed bone. The mechanical push-out force was equal in all tested surfaces. Plasma spray surfaces showed greater bone-implant contact and higher level of pores colonisation with new bone than FPS produced surfaces. However, the void pore area in FPS specimens was significantly higher, yet the FPS porous surfaces allowed a deeper osseointegration of bone to implant. FPS manufactured specimens showed similar osseointegration potential to the plasma spray surfaces for orthopaedic implants. FPS is a useful technology for manufacturing macroporous titanium surfaces. Furthermore, its capability to combine two implantable materials, using bulk CoCr with macroporous titanium surfaces, could be of interest as it enables designers to conceive and manufacture innovative components. FPS delivers functional graded materials components with macroporous structures optimised for osseointegration.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
2022-04-29T07:37:27Z
2022-04-29T07:37:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.22203/eCM.v031a17
European Cells and Materials, v. 31, p. 250-263.
1473-2262
http://hdl.handle.net/11449/228161
10.22203/eCM.v031a17
2-s2.0-84973659261
url http://dx.doi.org/10.22203/eCM.v031a17
http://hdl.handle.net/11449/228161
identifier_str_mv European Cells and Materials, v. 31, p. 250-263.
1473-2262
10.22203/eCM.v031a17
2-s2.0-84973659261
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv European Cells and Materials
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 250-263
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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