Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.22203/eCM.v031a17 http://hdl.handle.net/11449/228161 |
Resumo: | We explored the osseointegration potential of two macroporous titanium surfaces obtained using fast plasma sintering (FPS): Ti macroporous structures with 400-600 µmØ pores (TiMac400) and 850-1000 µmØ pores (TiMac850). They were compared against two surfaces currently in clinical use: Ti-Growth® and air plasma spray (Ti-Y367). Each surface was tested, once placed over a Ti-alloy and once onto a CoCr bulk substrate. Implants were placed in medial femoral condyles in 24 sheep. Samples were explanted at four and eight weeks after surgery. Push-out loads were measured using a material-testing system. Bone contact and ingrowth were assessed by histomorphometry and SEM and EDX analyses. Histology showed early osseointegration for all the surfaces tested. At 8 weeks, TiMac400, TiMac850 and Ti-Growths® showed deep bone ingrowth and extended colonisation with newly formed bone. The mechanical push-out force was equal in all tested surfaces. Plasma spray surfaces showed greater bone-implant contact and higher level of pores colonisation with new bone than FPS produced surfaces. However, the void pore area in FPS specimens was significantly higher, yet the FPS porous surfaces allowed a deeper osseointegration of bone to implant. FPS manufactured specimens showed similar osseointegration potential to the plasma spray surfaces for orthopaedic implants. FPS is a useful technology for manufacturing macroporous titanium surfaces. Furthermore, its capability to combine two implantable materials, using bulk CoCr with macroporous titanium surfaces, could be of interest as it enables designers to conceive and manufacture innovative components. FPS delivers functional graded materials components with macroporous structures optimised for osseointegration. |
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Repositório Institucional da UNESP |
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Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration propertiesBone colonisationFast plasma sinteringImplantMacroporousPlasma spraySheepSurgeryTitaniumWe explored the osseointegration potential of two macroporous titanium surfaces obtained using fast plasma sintering (FPS): Ti macroporous structures with 400-600 µmØ pores (TiMac400) and 850-1000 µmØ pores (TiMac850). They were compared against two surfaces currently in clinical use: Ti-Growth® and air plasma spray (Ti-Y367). Each surface was tested, once placed over a Ti-alloy and once onto a CoCr bulk substrate. Implants were placed in medial femoral condyles in 24 sheep. Samples were explanted at four and eight weeks after surgery. Push-out loads were measured using a material-testing system. Bone contact and ingrowth were assessed by histomorphometry and SEM and EDX analyses. Histology showed early osseointegration for all the surfaces tested. At 8 weeks, TiMac400, TiMac850 and Ti-Growths® showed deep bone ingrowth and extended colonisation with newly formed bone. The mechanical push-out force was equal in all tested surfaces. Plasma spray surfaces showed greater bone-implant contact and higher level of pores colonisation with new bone than FPS produced surfaces. However, the void pore area in FPS specimens was significantly higher, yet the FPS porous surfaces allowed a deeper osseointegration of bone to implant. FPS manufactured specimens showed similar osseointegration potential to the plasma spray surfaces for orthopaedic implants. FPS is a useful technology for manufacturing macroporous titanium surfaces. Furthermore, its capability to combine two implantable materials, using bulk CoCr with macroporous titanium surfaces, could be of interest as it enables designers to conceive and manufacture innovative components. FPS delivers functional graded materials components with macroporous structures optimised for osseointegration.Institute of Orthopaedics and Musculoskeletal Science University College London Royal National Orthopaedic HospitalDepartment of Veterinary Surgery and Anaesthesiology School of Veterinary Medicine and Animal Science São Paulo State UniversityResearch and Development Department Eurocoating SpaDepartment of Veterinary Surgery and Anaesthesiology School of Veterinary Medicine and Animal Science São Paulo State UniversityRoyal National Orthopaedic HospitalUniversidade Estadual Paulista (UNESP)Eurocoating SpaGodoy, Roberta FerroCoathup, M. J.Blunn, G. W.Alves, A. L.G. [UNESP]Robotti, P.Goodship, A. E.2022-04-29T07:37:27Z2022-04-29T07:37:27Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article250-263http://dx.doi.org/10.22203/eCM.v031a17European Cells and Materials, v. 31, p. 250-263.1473-2262http://hdl.handle.net/11449/22816110.22203/eCM.v031a172-s2.0-84973659261Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Cells and Materialsinfo:eu-repo/semantics/openAccess2022-04-29T07:37:27Zoai:repositorio.unesp.br:11449/228161Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:06:52.867489Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties |
title |
Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties |
spellingShingle |
Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties Godoy, Roberta Ferro Bone colonisation Fast plasma sintering Implant Macroporous Plasma spray Sheep Surgery Titanium |
title_short |
Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties |
title_full |
Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties |
title_fullStr |
Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties |
title_full_unstemmed |
Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties |
title_sort |
Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties |
author |
Godoy, Roberta Ferro |
author_facet |
Godoy, Roberta Ferro Coathup, M. J. Blunn, G. W. Alves, A. L.G. [UNESP] Robotti, P. Goodship, A. E. |
author_role |
author |
author2 |
Coathup, M. J. Blunn, G. W. Alves, A. L.G. [UNESP] Robotti, P. Goodship, A. E. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Royal National Orthopaedic Hospital Universidade Estadual Paulista (UNESP) Eurocoating Spa |
dc.contributor.author.fl_str_mv |
Godoy, Roberta Ferro Coathup, M. J. Blunn, G. W. Alves, A. L.G. [UNESP] Robotti, P. Goodship, A. E. |
dc.subject.por.fl_str_mv |
Bone colonisation Fast plasma sintering Implant Macroporous Plasma spray Sheep Surgery Titanium |
topic |
Bone colonisation Fast plasma sintering Implant Macroporous Plasma spray Sheep Surgery Titanium |
description |
We explored the osseointegration potential of two macroporous titanium surfaces obtained using fast plasma sintering (FPS): Ti macroporous structures with 400-600 µmØ pores (TiMac400) and 850-1000 µmØ pores (TiMac850). They were compared against two surfaces currently in clinical use: Ti-Growth® and air plasma spray (Ti-Y367). Each surface was tested, once placed over a Ti-alloy and once onto a CoCr bulk substrate. Implants were placed in medial femoral condyles in 24 sheep. Samples were explanted at four and eight weeks after surgery. Push-out loads were measured using a material-testing system. Bone contact and ingrowth were assessed by histomorphometry and SEM and EDX analyses. Histology showed early osseointegration for all the surfaces tested. At 8 weeks, TiMac400, TiMac850 and Ti-Growths® showed deep bone ingrowth and extended colonisation with newly formed bone. The mechanical push-out force was equal in all tested surfaces. Plasma spray surfaces showed greater bone-implant contact and higher level of pores colonisation with new bone than FPS produced surfaces. However, the void pore area in FPS specimens was significantly higher, yet the FPS porous surfaces allowed a deeper osseointegration of bone to implant. FPS manufactured specimens showed similar osseointegration potential to the plasma spray surfaces for orthopaedic implants. FPS is a useful technology for manufacturing macroporous titanium surfaces. Furthermore, its capability to combine two implantable materials, using bulk CoCr with macroporous titanium surfaces, could be of interest as it enables designers to conceive and manufacture innovative components. FPS delivers functional graded materials components with macroporous structures optimised for osseointegration. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2022-04-29T07:37:27Z 2022-04-29T07:37:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.22203/eCM.v031a17 European Cells and Materials, v. 31, p. 250-263. 1473-2262 http://hdl.handle.net/11449/228161 10.22203/eCM.v031a17 2-s2.0-84973659261 |
url |
http://dx.doi.org/10.22203/eCM.v031a17 http://hdl.handle.net/11449/228161 |
identifier_str_mv |
European Cells and Materials, v. 31, p. 250-263. 1473-2262 10.22203/eCM.v031a17 2-s2.0-84973659261 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Cells and Materials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
250-263 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128463851225088 |