Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares

Detalhes bibliográficos
Autor(a) principal: Boakari, Y. L. [UNESP]
Data de Publicação: 2017
Outros Autores: Ferreira, J. C., Canesin, H. S. [UNESP], Thompson, D. L., Lima, F. S., Pantoja, J. C.F. [UNESP], Meira, C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.theriogenology.2017.05.032
http://hdl.handle.net/11449/174766
Resumo: The objective of the current study was to evaluate the effects of deslorelin and hCG, two ovulation-inducing therapies, on LH surge and follicle vascularity in mares. Thirty mares were either treated with 1.5 mg IM of deslorelin, 2,500 IU IV of hCG or 2 mL IM of NaCl 0.9% (GnRH, hCG and Saline groups, respectively). Power-flow Doppler examination and blood collection were performed every hour during the first 12 hours after treatment (H0) and every six hours between hours 12 (H12) and 30 (H30) after treatment. Moreover, endpoints were evaluated every hour through the last six hours before ovulation (OV-6 to OV-1). In GnRH group, plasma LH concentration progressively increased (P < 0.001) during the first 6 hours after treatment and remained high (P > 0.1) until OV-1. A significant increase in LH concentrations was first detected (P < 0.05) at 24 hours after treatment in hCG group, while no changes (P > 0.1) on LH levels were found during H0-H30 and between OV-6 and OV-1 in the Saline group. Independent of the treatment, significant variations on the percentage of the follicle wall with Doppler signals were not observed (P > 0.1) throughout the entire experiment. A weak correlation between the preovulatory follicle vascularity and the plasma LH concentration was found in GnRH, hCG and Saline groups (r = +0.29, +0.29 and −0.23, respectively; P ˂ 0.0001). These results described for the first time the immediate and continuous pituitary response to ovulation-inducing therapy with injectable deslorelin. Moreover, spontaneous and induced ovulations were not preceded by an increased follicle vascularity, which differs from previous reports in large animals.
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spelling Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in maresDeslorelinDoppler ultrasonographyFollicle vascularityhCGLHThe objective of the current study was to evaluate the effects of deslorelin and hCG, two ovulation-inducing therapies, on LH surge and follicle vascularity in mares. Thirty mares were either treated with 1.5 mg IM of deslorelin, 2,500 IU IV of hCG or 2 mL IM of NaCl 0.9% (GnRH, hCG and Saline groups, respectively). Power-flow Doppler examination and blood collection were performed every hour during the first 12 hours after treatment (H0) and every six hours between hours 12 (H12) and 30 (H30) after treatment. Moreover, endpoints were evaluated every hour through the last six hours before ovulation (OV-6 to OV-1). In GnRH group, plasma LH concentration progressively increased (P < 0.001) during the first 6 hours after treatment and remained high (P > 0.1) until OV-1. A significant increase in LH concentrations was first detected (P < 0.05) at 24 hours after treatment in hCG group, while no changes (P > 0.1) on LH levels were found during H0-H30 and between OV-6 and OV-1 in the Saline group. Independent of the treatment, significant variations on the percentage of the follicle wall with Doppler signals were not observed (P > 0.1) throughout the entire experiment. A weak correlation between the preovulatory follicle vascularity and the plasma LH concentration was found in GnRH, hCG and Saline groups (r = +0.29, +0.29 and −0.23, respectively; P ˂ 0.0001). These results described for the first time the immediate and continuous pituitary response to ovulation-inducing therapy with injectable deslorelin. Moreover, spontaneous and induced ovulations were not preceded by an increased follicle vascularity, which differs from previous reports in large animals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science UNESPGluck Equine Research Center Department of Veterinary Science University of KentuckyDepartment of Veterinary Clinical Medicine College of Veterinary Medicine University of IllinoisSchool of Animal Sciences Louisiana State University Agricultural CenterDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science UNESPFAPESP: 2012/11117-3FAPESP: 2012/12288Universidade Estadual Paulista (Unesp)University of KentuckyUniversity of IllinoisLouisiana State University Agricultural CenterBoakari, Y. L. [UNESP]Ferreira, J. C.Canesin, H. S. [UNESP]Thompson, D. L.Lima, F. S.Pantoja, J. C.F. [UNESP]Meira, C. [UNESP]2018-12-11T17:12:46Z2018-12-11T17:12:46Z2017-09-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article95-99application/pdfhttp://dx.doi.org/10.1016/j.theriogenology.2017.05.032Theriogenology, v. 100, p. 95-99.0093-691Xhttp://hdl.handle.net/11449/17476610.1016/j.theriogenology.2017.05.0322-s2.0-850208113022-s2.0-85020811302.pdf00429054157111990000-0002-2245-800XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTheriogenologyinfo:eu-repo/semantics/openAccess2024-09-09T14:06:05Zoai:repositorio.unesp.br:11449/174766Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:06:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
title Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
spellingShingle Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
Boakari, Y. L. [UNESP]
Deslorelin
Doppler ultrasonography
Follicle vascularity
hCG
LH
title_short Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
title_full Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
title_fullStr Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
title_full_unstemmed Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
title_sort Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
author Boakari, Y. L. [UNESP]
author_facet Boakari, Y. L. [UNESP]
Ferreira, J. C.
Canesin, H. S. [UNESP]
Thompson, D. L.
Lima, F. S.
Pantoja, J. C.F. [UNESP]
Meira, C. [UNESP]
author_role author
author2 Ferreira, J. C.
Canesin, H. S. [UNESP]
Thompson, D. L.
Lima, F. S.
Pantoja, J. C.F. [UNESP]
Meira, C. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
University of Kentucky
University of Illinois
Louisiana State University Agricultural Center
dc.contributor.author.fl_str_mv Boakari, Y. L. [UNESP]
Ferreira, J. C.
Canesin, H. S. [UNESP]
Thompson, D. L.
Lima, F. S.
Pantoja, J. C.F. [UNESP]
Meira, C. [UNESP]
dc.subject.por.fl_str_mv Deslorelin
Doppler ultrasonography
Follicle vascularity
hCG
LH
topic Deslorelin
Doppler ultrasonography
Follicle vascularity
hCG
LH
description The objective of the current study was to evaluate the effects of deslorelin and hCG, two ovulation-inducing therapies, on LH surge and follicle vascularity in mares. Thirty mares were either treated with 1.5 mg IM of deslorelin, 2,500 IU IV of hCG or 2 mL IM of NaCl 0.9% (GnRH, hCG and Saline groups, respectively). Power-flow Doppler examination and blood collection were performed every hour during the first 12 hours after treatment (H0) and every six hours between hours 12 (H12) and 30 (H30) after treatment. Moreover, endpoints were evaluated every hour through the last six hours before ovulation (OV-6 to OV-1). In GnRH group, plasma LH concentration progressively increased (P < 0.001) during the first 6 hours after treatment and remained high (P > 0.1) until OV-1. A significant increase in LH concentrations was first detected (P < 0.05) at 24 hours after treatment in hCG group, while no changes (P > 0.1) on LH levels were found during H0-H30 and between OV-6 and OV-1 in the Saline group. Independent of the treatment, significant variations on the percentage of the follicle wall with Doppler signals were not observed (P > 0.1) throughout the entire experiment. A weak correlation between the preovulatory follicle vascularity and the plasma LH concentration was found in GnRH, hCG and Saline groups (r = +0.29, +0.29 and −0.23, respectively; P ˂ 0.0001). These results described for the first time the immediate and continuous pituitary response to ovulation-inducing therapy with injectable deslorelin. Moreover, spontaneous and induced ovulations were not preceded by an increased follicle vascularity, which differs from previous reports in large animals.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-15
2018-12-11T17:12:46Z
2018-12-11T17:12:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.theriogenology.2017.05.032
Theriogenology, v. 100, p. 95-99.
0093-691X
http://hdl.handle.net/11449/174766
10.1016/j.theriogenology.2017.05.032
2-s2.0-85020811302
2-s2.0-85020811302.pdf
0042905415711199
0000-0002-2245-800X
url http://dx.doi.org/10.1016/j.theriogenology.2017.05.032
http://hdl.handle.net/11449/174766
identifier_str_mv Theriogenology, v. 100, p. 95-99.
0093-691X
10.1016/j.theriogenology.2017.05.032
2-s2.0-85020811302
2-s2.0-85020811302.pdf
0042905415711199
0000-0002-2245-800X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Theriogenology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 95-99
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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