Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.theriogenology.2017.05.032 http://hdl.handle.net/11449/174766 |
Resumo: | The objective of the current study was to evaluate the effects of deslorelin and hCG, two ovulation-inducing therapies, on LH surge and follicle vascularity in mares. Thirty mares were either treated with 1.5 mg IM of deslorelin, 2,500 IU IV of hCG or 2 mL IM of NaCl 0.9% (GnRH, hCG and Saline groups, respectively). Power-flow Doppler examination and blood collection were performed every hour during the first 12 hours after treatment (H0) and every six hours between hours 12 (H12) and 30 (H30) after treatment. Moreover, endpoints were evaluated every hour through the last six hours before ovulation (OV-6 to OV-1). In GnRH group, plasma LH concentration progressively increased (P < 0.001) during the first 6 hours after treatment and remained high (P > 0.1) until OV-1. A significant increase in LH concentrations was first detected (P < 0.05) at 24 hours after treatment in hCG group, while no changes (P > 0.1) on LH levels were found during H0-H30 and between OV-6 and OV-1 in the Saline group. Independent of the treatment, significant variations on the percentage of the follicle wall with Doppler signals were not observed (P > 0.1) throughout the entire experiment. A weak correlation between the preovulatory follicle vascularity and the plasma LH concentration was found in GnRH, hCG and Saline groups (r = +0.29, +0.29 and −0.23, respectively; P ˂ 0.0001). These results described for the first time the immediate and continuous pituitary response to ovulation-inducing therapy with injectable deslorelin. Moreover, spontaneous and induced ovulations were not preceded by an increased follicle vascularity, which differs from previous reports in large animals. |
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Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in maresDeslorelinDoppler ultrasonographyFollicle vascularityhCGLHThe objective of the current study was to evaluate the effects of deslorelin and hCG, two ovulation-inducing therapies, on LH surge and follicle vascularity in mares. Thirty mares were either treated with 1.5 mg IM of deslorelin, 2,500 IU IV of hCG or 2 mL IM of NaCl 0.9% (GnRH, hCG and Saline groups, respectively). Power-flow Doppler examination and blood collection were performed every hour during the first 12 hours after treatment (H0) and every six hours between hours 12 (H12) and 30 (H30) after treatment. Moreover, endpoints were evaluated every hour through the last six hours before ovulation (OV-6 to OV-1). In GnRH group, plasma LH concentration progressively increased (P < 0.001) during the first 6 hours after treatment and remained high (P > 0.1) until OV-1. A significant increase in LH concentrations was first detected (P < 0.05) at 24 hours after treatment in hCG group, while no changes (P > 0.1) on LH levels were found during H0-H30 and between OV-6 and OV-1 in the Saline group. Independent of the treatment, significant variations on the percentage of the follicle wall with Doppler signals were not observed (P > 0.1) throughout the entire experiment. A weak correlation between the preovulatory follicle vascularity and the plasma LH concentration was found in GnRH, hCG and Saline groups (r = +0.29, +0.29 and −0.23, respectively; P ˂ 0.0001). These results described for the first time the immediate and continuous pituitary response to ovulation-inducing therapy with injectable deslorelin. Moreover, spontaneous and induced ovulations were not preceded by an increased follicle vascularity, which differs from previous reports in large animals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science UNESPGluck Equine Research Center Department of Veterinary Science University of KentuckyDepartment of Veterinary Clinical Medicine College of Veterinary Medicine University of IllinoisSchool of Animal Sciences Louisiana State University Agricultural CenterDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science UNESPFAPESP: 2012/11117-3FAPESP: 2012/12288Universidade Estadual Paulista (Unesp)University of KentuckyUniversity of IllinoisLouisiana State University Agricultural CenterBoakari, Y. L. [UNESP]Ferreira, J. C.Canesin, H. S. [UNESP]Thompson, D. L.Lima, F. S.Pantoja, J. C.F. [UNESP]Meira, C. [UNESP]2018-12-11T17:12:46Z2018-12-11T17:12:46Z2017-09-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article95-99application/pdfhttp://dx.doi.org/10.1016/j.theriogenology.2017.05.032Theriogenology, v. 100, p. 95-99.0093-691Xhttp://hdl.handle.net/11449/17476610.1016/j.theriogenology.2017.05.0322-s2.0-850208113022-s2.0-85020811302.pdf00429054157111990000-0002-2245-800XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTheriogenologyinfo:eu-repo/semantics/openAccess2024-09-09T14:06:05Zoai:repositorio.unesp.br:11449/174766Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:06:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares |
title |
Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares |
spellingShingle |
Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares Boakari, Y. L. [UNESP] Deslorelin Doppler ultrasonography Follicle vascularity hCG LH |
title_short |
Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares |
title_full |
Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares |
title_fullStr |
Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares |
title_full_unstemmed |
Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares |
title_sort |
Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares |
author |
Boakari, Y. L. [UNESP] |
author_facet |
Boakari, Y. L. [UNESP] Ferreira, J. C. Canesin, H. S. [UNESP] Thompson, D. L. Lima, F. S. Pantoja, J. C.F. [UNESP] Meira, C. [UNESP] |
author_role |
author |
author2 |
Ferreira, J. C. Canesin, H. S. [UNESP] Thompson, D. L. Lima, F. S. Pantoja, J. C.F. [UNESP] Meira, C. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Kentucky University of Illinois Louisiana State University Agricultural Center |
dc.contributor.author.fl_str_mv |
Boakari, Y. L. [UNESP] Ferreira, J. C. Canesin, H. S. [UNESP] Thompson, D. L. Lima, F. S. Pantoja, J. C.F. [UNESP] Meira, C. [UNESP] |
dc.subject.por.fl_str_mv |
Deslorelin Doppler ultrasonography Follicle vascularity hCG LH |
topic |
Deslorelin Doppler ultrasonography Follicle vascularity hCG LH |
description |
The objective of the current study was to evaluate the effects of deslorelin and hCG, two ovulation-inducing therapies, on LH surge and follicle vascularity in mares. Thirty mares were either treated with 1.5 mg IM of deslorelin, 2,500 IU IV of hCG or 2 mL IM of NaCl 0.9% (GnRH, hCG and Saline groups, respectively). Power-flow Doppler examination and blood collection were performed every hour during the first 12 hours after treatment (H0) and every six hours between hours 12 (H12) and 30 (H30) after treatment. Moreover, endpoints were evaluated every hour through the last six hours before ovulation (OV-6 to OV-1). In GnRH group, plasma LH concentration progressively increased (P < 0.001) during the first 6 hours after treatment and remained high (P > 0.1) until OV-1. A significant increase in LH concentrations was first detected (P < 0.05) at 24 hours after treatment in hCG group, while no changes (P > 0.1) on LH levels were found during H0-H30 and between OV-6 and OV-1 in the Saline group. Independent of the treatment, significant variations on the percentage of the follicle wall with Doppler signals were not observed (P > 0.1) throughout the entire experiment. A weak correlation between the preovulatory follicle vascularity and the plasma LH concentration was found in GnRH, hCG and Saline groups (r = +0.29, +0.29 and −0.23, respectively; P ˂ 0.0001). These results described for the first time the immediate and continuous pituitary response to ovulation-inducing therapy with injectable deslorelin. Moreover, spontaneous and induced ovulations were not preceded by an increased follicle vascularity, which differs from previous reports in large animals. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-15 2018-12-11T17:12:46Z 2018-12-11T17:12:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.theriogenology.2017.05.032 Theriogenology, v. 100, p. 95-99. 0093-691X http://hdl.handle.net/11449/174766 10.1016/j.theriogenology.2017.05.032 2-s2.0-85020811302 2-s2.0-85020811302.pdf 0042905415711199 0000-0002-2245-800X |
url |
http://dx.doi.org/10.1016/j.theriogenology.2017.05.032 http://hdl.handle.net/11449/174766 |
identifier_str_mv |
Theriogenology, v. 100, p. 95-99. 0093-691X 10.1016/j.theriogenology.2017.05.032 2-s2.0-85020811302 2-s2.0-85020811302.pdf 0042905415711199 0000-0002-2245-800X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Theriogenology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
95-99 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546610623250432 |