Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/245871 |
Resumo: | Punica granatum L. (Lythraceae) is traditionally used to treat various diseases. Due to the resistance of Candida albicans biofilms to conventional treatments, natural products have been extensively studied. The increase of cell surface hydrophobicity (CSH) has been related to an increment in fungal resistance and virulence. This study evaluated the susceptibility and CSH of C. albicans clinical isolate after exposure to P. granatum, in order to establish whether there is correlation between the two properties. P. granatum showed a fungistatic activity (MIC50 – 8 and 12 mg/ml) (MIC90 – 25 mg/ml). Exposure to 4, 8 and 25 mg/ml did not change fungal CSH. Anti-Candida activity of P. granatum was observed for up to 48 h, indicating that the extract possess a therapeutic potential for treatment and prevention of oral infections, such as denture stomatitis. Also, their fungistatic action was associated with maintenance of the cell wall hydrophilicity of the fungus. |
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Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicitySusceptibilidade de Candida albicans à Punica granatum e correlação com a hidrofobicidade de superfície celularAntifungal activityBiofilmsDenture StomatitisMicrobial Sensitivity TestsPunica granatumPunica granatum L. (Lythraceae) is traditionally used to treat various diseases. Due to the resistance of Candida albicans biofilms to conventional treatments, natural products have been extensively studied. The increase of cell surface hydrophobicity (CSH) has been related to an increment in fungal resistance and virulence. This study evaluated the susceptibility and CSH of C. albicans clinical isolate after exposure to P. granatum, in order to establish whether there is correlation between the two properties. P. granatum showed a fungistatic activity (MIC50 – 8 and 12 mg/ml) (MIC90 – 25 mg/ml). Exposure to 4, 8 and 25 mg/ml did not change fungal CSH. Anti-Candida activity of P. granatum was observed for up to 48 h, indicating that the extract possess a therapeutic potential for treatment and prevention of oral infections, such as denture stomatitis. Also, their fungistatic action was associated with maintenance of the cell wall hydrophilicity of the fungus.Bauru School of Dentistry University of São Paulo (USP), SPDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP), SPInstitute of Biosciences São Paulo State University (UNESP), São PauloDepartment of Prosthodontics and Periodontics Bauru School of Dentistry University of São Paulo (USP), SPDepartment of Biological Sciences Faculty of Sciences São Paulo State University (UNESP), São PauloInstitute of Biosciences São Paulo State University (UNESP), São PauloDepartment of Biological Sciences Faculty of Sciences São Paulo State University (UNESP), São PauloUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Pozzato, Laura Bernardoda Silva, Rafaela AlvesSaldanha, Luiz Leonardo [UNESP]Neppelenbroek, Karin HermanaDokkedal, Anne Lígia [UNESP]Lara, Vanessa SoaresPorto, Vinicius Carvalho2023-07-29T12:25:30Z2023-07-29T12:25:30Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article75-82Revista Brasileira de Plantas Medicinais, v. 20, n. 1, p. 75-82, 2018.1983-084X1516-0572http://hdl.handle.net/11449/2458712-s2.0-85125847145Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Plantas Medicinaisinfo:eu-repo/semantics/openAccess2023-07-29T12:25:30Zoai:repositorio.unesp.br:11449/245871Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:52:31.306837Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity Susceptibilidade de Candida albicans à Punica granatum e correlação com a hidrofobicidade de superfície celular |
title |
Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity |
spellingShingle |
Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity Pozzato, Laura Bernardo Antifungal activity Biofilms Denture Stomatitis Microbial Sensitivity Tests Punica granatum |
title_short |
Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity |
title_full |
Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity |
title_fullStr |
Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity |
title_full_unstemmed |
Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity |
title_sort |
Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity |
author |
Pozzato, Laura Bernardo |
author_facet |
Pozzato, Laura Bernardo da Silva, Rafaela Alves Saldanha, Luiz Leonardo [UNESP] Neppelenbroek, Karin Hermana Dokkedal, Anne Lígia [UNESP] Lara, Vanessa Soares Porto, Vinicius Carvalho |
author_role |
author |
author2 |
da Silva, Rafaela Alves Saldanha, Luiz Leonardo [UNESP] Neppelenbroek, Karin Hermana Dokkedal, Anne Lígia [UNESP] Lara, Vanessa Soares Porto, Vinicius Carvalho |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Pozzato, Laura Bernardo da Silva, Rafaela Alves Saldanha, Luiz Leonardo [UNESP] Neppelenbroek, Karin Hermana Dokkedal, Anne Lígia [UNESP] Lara, Vanessa Soares Porto, Vinicius Carvalho |
dc.subject.por.fl_str_mv |
Antifungal activity Biofilms Denture Stomatitis Microbial Sensitivity Tests Punica granatum |
topic |
Antifungal activity Biofilms Denture Stomatitis Microbial Sensitivity Tests Punica granatum |
description |
Punica granatum L. (Lythraceae) is traditionally used to treat various diseases. Due to the resistance of Candida albicans biofilms to conventional treatments, natural products have been extensively studied. The increase of cell surface hydrophobicity (CSH) has been related to an increment in fungal resistance and virulence. This study evaluated the susceptibility and CSH of C. albicans clinical isolate after exposure to P. granatum, in order to establish whether there is correlation between the two properties. P. granatum showed a fungistatic activity (MIC50 – 8 and 12 mg/ml) (MIC90 – 25 mg/ml). Exposure to 4, 8 and 25 mg/ml did not change fungal CSH. Anti-Candida activity of P. granatum was observed for up to 48 h, indicating that the extract possess a therapeutic potential for treatment and prevention of oral infections, such as denture stomatitis. Also, their fungistatic action was associated with maintenance of the cell wall hydrophilicity of the fungus. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 2023-07-29T12:25:30Z 2023-07-29T12:25:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Revista Brasileira de Plantas Medicinais, v. 20, n. 1, p. 75-82, 2018. 1983-084X 1516-0572 http://hdl.handle.net/11449/245871 2-s2.0-85125847145 |
identifier_str_mv |
Revista Brasileira de Plantas Medicinais, v. 20, n. 1, p. 75-82, 2018. 1983-084X 1516-0572 2-s2.0-85125847145 |
url |
http://hdl.handle.net/11449/245871 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Plantas Medicinais |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
75-82 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128993645297664 |