Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity

Detalhes bibliográficos
Autor(a) principal: Pozzato, Laura Bernardo
Data de Publicação: 2018
Outros Autores: da Silva, Rafaela Alves, Saldanha, Luiz Leonardo [UNESP], Neppelenbroek, Karin Hermana, Dokkedal, Anne Lígia [UNESP], Lara, Vanessa Soares, Porto, Vinicius Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/245871
Resumo: Punica granatum L. (Lythraceae) is traditionally used to treat various diseases. Due to the resistance of Candida albicans biofilms to conventional treatments, natural products have been extensively studied. The increase of cell surface hydrophobicity (CSH) has been related to an increment in fungal resistance and virulence. This study evaluated the susceptibility and CSH of C. albicans clinical isolate after exposure to P. granatum, in order to establish whether there is correlation between the two properties. P. granatum showed a fungistatic activity (MIC50 – 8 and 12 mg/ml) (MIC90 – 25 mg/ml). Exposure to 4, 8 and 25 mg/ml did not change fungal CSH. Anti-Candida activity of P. granatum was observed for up to 48 h, indicating that the extract possess a therapeutic potential for treatment and prevention of oral infections, such as denture stomatitis. Also, their fungistatic action was associated with maintenance of the cell wall hydrophilicity of the fungus.
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spelling Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicitySusceptibilidade de Candida albicans à Punica granatum e correlação com a hidrofobicidade de superfície celularAntifungal activityBiofilmsDenture StomatitisMicrobial Sensitivity TestsPunica granatumPunica granatum L. (Lythraceae) is traditionally used to treat various diseases. Due to the resistance of Candida albicans biofilms to conventional treatments, natural products have been extensively studied. The increase of cell surface hydrophobicity (CSH) has been related to an increment in fungal resistance and virulence. This study evaluated the susceptibility and CSH of C. albicans clinical isolate after exposure to P. granatum, in order to establish whether there is correlation between the two properties. P. granatum showed a fungistatic activity (MIC50 – 8 and 12 mg/ml) (MIC90 – 25 mg/ml). Exposure to 4, 8 and 25 mg/ml did not change fungal CSH. Anti-Candida activity of P. granatum was observed for up to 48 h, indicating that the extract possess a therapeutic potential for treatment and prevention of oral infections, such as denture stomatitis. Also, their fungistatic action was associated with maintenance of the cell wall hydrophilicity of the fungus.Bauru School of Dentistry University of São Paulo (USP), SPDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP), SPInstitute of Biosciences São Paulo State University (UNESP), São PauloDepartment of Prosthodontics and Periodontics Bauru School of Dentistry University of São Paulo (USP), SPDepartment of Biological Sciences Faculty of Sciences São Paulo State University (UNESP), São PauloInstitute of Biosciences São Paulo State University (UNESP), São PauloDepartment of Biological Sciences Faculty of Sciences São Paulo State University (UNESP), São PauloUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Pozzato, Laura Bernardoda Silva, Rafaela AlvesSaldanha, Luiz Leonardo [UNESP]Neppelenbroek, Karin HermanaDokkedal, Anne Lígia [UNESP]Lara, Vanessa SoaresPorto, Vinicius Carvalho2023-07-29T12:25:30Z2023-07-29T12:25:30Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article75-82Revista Brasileira de Plantas Medicinais, v. 20, n. 1, p. 75-82, 2018.1983-084X1516-0572http://hdl.handle.net/11449/2458712-s2.0-85125847145Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Plantas Medicinaisinfo:eu-repo/semantics/openAccess2023-07-29T12:25:30Zoai:repositorio.unesp.br:11449/245871Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:52:31.306837Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
Susceptibilidade de Candida albicans à Punica granatum e correlação com a hidrofobicidade de superfície celular
title Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
spellingShingle Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
Pozzato, Laura Bernardo
Antifungal activity
Biofilms
Denture Stomatitis
Microbial Sensitivity Tests
Punica granatum
title_short Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
title_full Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
title_fullStr Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
title_full_unstemmed Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
title_sort Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity
author Pozzato, Laura Bernardo
author_facet Pozzato, Laura Bernardo
da Silva, Rafaela Alves
Saldanha, Luiz Leonardo [UNESP]
Neppelenbroek, Karin Hermana
Dokkedal, Anne Lígia [UNESP]
Lara, Vanessa Soares
Porto, Vinicius Carvalho
author_role author
author2 da Silva, Rafaela Alves
Saldanha, Luiz Leonardo [UNESP]
Neppelenbroek, Karin Hermana
Dokkedal, Anne Lígia [UNESP]
Lara, Vanessa Soares
Porto, Vinicius Carvalho
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Pozzato, Laura Bernardo
da Silva, Rafaela Alves
Saldanha, Luiz Leonardo [UNESP]
Neppelenbroek, Karin Hermana
Dokkedal, Anne Lígia [UNESP]
Lara, Vanessa Soares
Porto, Vinicius Carvalho
dc.subject.por.fl_str_mv Antifungal activity
Biofilms
Denture Stomatitis
Microbial Sensitivity Tests
Punica granatum
topic Antifungal activity
Biofilms
Denture Stomatitis
Microbial Sensitivity Tests
Punica granatum
description Punica granatum L. (Lythraceae) is traditionally used to treat various diseases. Due to the resistance of Candida albicans biofilms to conventional treatments, natural products have been extensively studied. The increase of cell surface hydrophobicity (CSH) has been related to an increment in fungal resistance and virulence. This study evaluated the susceptibility and CSH of C. albicans clinical isolate after exposure to P. granatum, in order to establish whether there is correlation between the two properties. P. granatum showed a fungistatic activity (MIC50 – 8 and 12 mg/ml) (MIC90 – 25 mg/ml). Exposure to 4, 8 and 25 mg/ml did not change fungal CSH. Anti-Candida activity of P. granatum was observed for up to 48 h, indicating that the extract possess a therapeutic potential for treatment and prevention of oral infections, such as denture stomatitis. Also, their fungistatic action was associated with maintenance of the cell wall hydrophilicity of the fungus.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
2023-07-29T12:25:30Z
2023-07-29T12:25:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Revista Brasileira de Plantas Medicinais, v. 20, n. 1, p. 75-82, 2018.
1983-084X
1516-0572
http://hdl.handle.net/11449/245871
2-s2.0-85125847145
identifier_str_mv Revista Brasileira de Plantas Medicinais, v. 20, n. 1, p. 75-82, 2018.
1983-084X
1516-0572
2-s2.0-85125847145
url http://hdl.handle.net/11449/245871
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira de Plantas Medicinais
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 75-82
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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