Obtenção de nanopartículas ferromagnéticas por síntese hidrotérmica assistida por microondas para aplicação em magneto-hipertermia

• Autor(a) principal: Freire, Breno Gonçalves Galvão [UNESP]
• Data de Publicação: 2016
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/155333; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-04-17/000881907.pdf
• topic: Bioengenharia; Nanopartículas; Microondas; Hipotermia; Nanoparticles

A variety of clinical procedures have been developed for cancer therapy. Classic cancer treatment includes total removal of the tumor and adjacent tissues in combination with chemotherapy, immunotherapy, or radiation treatment. The development of hyperthermia has brought an additional boost to cancer therapy, since treatments such as radiotherapy and surgery are limited to the liver. In addition, if combined with chemotherapy or radiotherapy, the effects of these treatments are increased. In the magneto-hyperthermia treatment, ferromagnetic nanoparticles of composition Y3Fe5-xAlxO12 (1.6 ≤ x ≤1.7) are introduced into the tumors and heated by induction through a variable magnetic field at a moderate temperature (43-45 ° C). The major disadvantage of this material is cytotoxicity. As a solution, the nanoparticles must be encapsulated in a biocompatible polymer, in this case an epoxy polymer matrix of bisphenol A diglycidyl ether (DGEBA). The objective of this work is to synthesize and characterize Y3Fe5-xAlxO12 (1.6 ≤ x ≤1.7) ferromagnetic nanoparticles through microwave-assisted hydrothermal synthesis technique and then encapsulate these nanoparticles through polymer dispersion in a DGEBA matrix. The best synthesis conditions were evaluated, such as temperature, time, solution's pH, observation of pressure, use of mineralizing agent. The results obtained by the characterization thrtough DR-X, FT-Raman, FT-IR indicated that it is possible to carry out the synthesis in this type of material by the hydrothermal route assisted by microwave. Magnetic hysteresis curve showed that all the nanoparticles synthesized had superparamagnetic characteristics. With the previous results and micrographs obtained by scanning electron microscopy, an evaluation showed that the nanoparticles synthesized at 140 ° C in 30 min and acid pH (2-3) ...(Complete abstrac click electonic access below)