Topography-specific spindle frequency changes in Obstructive Sleep Apnea
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1471-2202-13-89 http://hdl.handle.net/11449/17713 |
Resumo: | Background: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, the aim of this study was to investigate sleep spindle frequency distribution in OSA. Seven non-OSA subjects and 21 patients with OSA (11 mild and 10 moderate) were studied. A matching pursuit procedure was used for automatic detection of fast (>= 13Hz) and slow(< 13Hz) spindles obtained from 30min samples of NREM sleep stage 2 taken from initial, middle and final night thirds (sections I, II and III) of frontal, central and parietal scalp regions.Results: Compared to non-OSA subjects, Moderate OSA patients had higher central and parietal slow spindle percentage (SSP) in all night sections studied, and higher frontal SSP in sections II and III. As the night progressed, there was a reduction in central and parietal SSP, while frontal SSP remained high. Frontal slow spindle percentage in night section III predicted OSA with good accuracy, with OSA likelihood increased by 12.1% for every SSP unit increase (OR 1.121, 95% CI 1.013 - 1.239, p=0.027).Conclusions: These results are consistent with diffuse, predominantly frontal thalamo-cortical dysfunction during sleep in OSA, as more posterior brain regions appear to maintain some physiological spindle frequency modulation across the night. Displaying changes in an opposite direction to what is expected from the aging process itself, spindle frequency appears to be informative in OSA even with small sample sizes, and to represent a sensitive electrophysiological marker of brain dysfunction in OSA. |
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Repositório Institucional da UNESP |
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Topography-specific spindle frequency changes in Obstructive Sleep ApneaTime seriesMatching pursuitEEGSleep spindlesOSABackground: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, the aim of this study was to investigate sleep spindle frequency distribution in OSA. Seven non-OSA subjects and 21 patients with OSA (11 mild and 10 moderate) were studied. A matching pursuit procedure was used for automatic detection of fast (>= 13Hz) and slow(< 13Hz) spindles obtained from 30min samples of NREM sleep stage 2 taken from initial, middle and final night thirds (sections I, II and III) of frontal, central and parietal scalp regions.Results: Compared to non-OSA subjects, Moderate OSA patients had higher central and parietal slow spindle percentage (SSP) in all night sections studied, and higher frontal SSP in sections II and III. As the night progressed, there was a reduction in central and parietal SSP, while frontal SSP remained high. Frontal slow spindle percentage in night section III predicted OSA with good accuracy, with OSA likelihood increased by 12.1% for every SSP unit increase (OR 1.121, 95% CI 1.013 - 1.239, p=0.027).Conclusions: These results are consistent with diffuse, predominantly frontal thalamo-cortical dysfunction during sleep in OSA, as more posterior brain regions appear to maintain some physiological spindle frequency modulation across the night. Displaying changes in an opposite direction to what is expected from the aging process itself, spindle frequency appears to be informative in OSA even with small sample sizes, and to represent a sensitive electrophysiological marker of brain dysfunction in OSA.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista UNESP, Inst Biosci, Dept Phys & Biophys, Botucatu, SP, BrazilHosp Clin Porto Alegre, Div Pulm Med, Sleep Lab, BR-90035003 Porto Alegre, RS, BrazilUniv Fed Sergipe, Dept Phys, Sao Cristovao, BrazilUniv Caxias do Sul, Dept Phys & Chem, BR-95001970 Caxias do Sul, BrazilUniv Estadual Paulista UNESP, Inst Biosci, Dept Phys & Biophys, Botucatu, SP, BrazilFAPESP: 09/10382-2Biomed Central Ltd.Universidade Estadual Paulista (Unesp)Hosp Clin Porto AlegreUniversidade Federal de Sergipe (UFS)Univ Caxias do SulSchoenwald, Suzana V.Carvalho, Diego Z.de Santa-Helena, Emerson L.Lemke, Ney [UNESP]Gerhardt, Guenther J. L.2014-05-20T13:49:41Z2014-05-20T13:49:41Z2012-07-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://dx.doi.org/10.1186/1471-2202-13-89Bmc Neuroscience. London: Biomed Central Ltd., v. 13, p. 12, 2012.1471-2202http://hdl.handle.net/11449/1771310.1186/1471-2202-13-89WOS:000311166100001WOS000311166100001.pdf7977035910952141Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBmc Neuroscience2.1731,120info:eu-repo/semantics/openAccess2023-12-30T06:18:16Zoai:repositorio.unesp.br:11449/17713Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:41:32.119878Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Topography-specific spindle frequency changes in Obstructive Sleep Apnea |
title |
Topography-specific spindle frequency changes in Obstructive Sleep Apnea |
spellingShingle |
Topography-specific spindle frequency changes in Obstructive Sleep Apnea Schoenwald, Suzana V. Time series Matching pursuit EEG Sleep spindles OSA |
title_short |
Topography-specific spindle frequency changes in Obstructive Sleep Apnea |
title_full |
Topography-specific spindle frequency changes in Obstructive Sleep Apnea |
title_fullStr |
Topography-specific spindle frequency changes in Obstructive Sleep Apnea |
title_full_unstemmed |
Topography-specific spindle frequency changes in Obstructive Sleep Apnea |
title_sort |
Topography-specific spindle frequency changes in Obstructive Sleep Apnea |
author |
Schoenwald, Suzana V. |
author_facet |
Schoenwald, Suzana V. Carvalho, Diego Z. de Santa-Helena, Emerson L. Lemke, Ney [UNESP] Gerhardt, Guenther J. L. |
author_role |
author |
author2 |
Carvalho, Diego Z. de Santa-Helena, Emerson L. Lemke, Ney [UNESP] Gerhardt, Guenther J. L. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Hosp Clin Porto Alegre Universidade Federal de Sergipe (UFS) Univ Caxias do Sul |
dc.contributor.author.fl_str_mv |
Schoenwald, Suzana V. Carvalho, Diego Z. de Santa-Helena, Emerson L. Lemke, Ney [UNESP] Gerhardt, Guenther J. L. |
dc.subject.por.fl_str_mv |
Time series Matching pursuit EEG Sleep spindles OSA |
topic |
Time series Matching pursuit EEG Sleep spindles OSA |
description |
Background: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, the aim of this study was to investigate sleep spindle frequency distribution in OSA. Seven non-OSA subjects and 21 patients with OSA (11 mild and 10 moderate) were studied. A matching pursuit procedure was used for automatic detection of fast (>= 13Hz) and slow(< 13Hz) spindles obtained from 30min samples of NREM sleep stage 2 taken from initial, middle and final night thirds (sections I, II and III) of frontal, central and parietal scalp regions.Results: Compared to non-OSA subjects, Moderate OSA patients had higher central and parietal slow spindle percentage (SSP) in all night sections studied, and higher frontal SSP in sections II and III. As the night progressed, there was a reduction in central and parietal SSP, while frontal SSP remained high. Frontal slow spindle percentage in night section III predicted OSA with good accuracy, with OSA likelihood increased by 12.1% for every SSP unit increase (OR 1.121, 95% CI 1.013 - 1.239, p=0.027).Conclusions: These results are consistent with diffuse, predominantly frontal thalamo-cortical dysfunction during sleep in OSA, as more posterior brain regions appear to maintain some physiological spindle frequency modulation across the night. Displaying changes in an opposite direction to what is expected from the aging process itself, spindle frequency appears to be informative in OSA even with small sample sizes, and to represent a sensitive electrophysiological marker of brain dysfunction in OSA. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-07-31 2014-05-20T13:49:41Z 2014-05-20T13:49:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1471-2202-13-89 Bmc Neuroscience. London: Biomed Central Ltd., v. 13, p. 12, 2012. 1471-2202 http://hdl.handle.net/11449/17713 10.1186/1471-2202-13-89 WOS:000311166100001 WOS000311166100001.pdf 7977035910952141 |
url |
http://dx.doi.org/10.1186/1471-2202-13-89 http://hdl.handle.net/11449/17713 |
identifier_str_mv |
Bmc Neuroscience. London: Biomed Central Ltd., v. 13, p. 12, 2012. 1471-2202 10.1186/1471-2202-13-89 WOS:000311166100001 WOS000311166100001.pdf 7977035910952141 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bmc Neuroscience 2.173 1,120 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129347584786432 |