Topography-specific spindle frequency changes in Obstructive Sleep Apnea

Detalhes bibliográficos
Autor(a) principal: Schoenwald, Suzana V.
Data de Publicação: 2012
Outros Autores: Carvalho, Diego Z., de Santa-Helena, Emerson L., Lemke, Ney [UNESP], Gerhardt, Guenther J. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/1471-2202-13-89
http://hdl.handle.net/11449/17713
Resumo: Background: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, the aim of this study was to investigate sleep spindle frequency distribution in OSA. Seven non-OSA subjects and 21 patients with OSA (11 mild and 10 moderate) were studied. A matching pursuit procedure was used for automatic detection of fast (>= 13Hz) and slow(< 13Hz) spindles obtained from 30min samples of NREM sleep stage 2 taken from initial, middle and final night thirds (sections I, II and III) of frontal, central and parietal scalp regions.Results: Compared to non-OSA subjects, Moderate OSA patients had higher central and parietal slow spindle percentage (SSP) in all night sections studied, and higher frontal SSP in sections II and III. As the night progressed, there was a reduction in central and parietal SSP, while frontal SSP remained high. Frontal slow spindle percentage in night section III predicted OSA with good accuracy, with OSA likelihood increased by 12.1% for every SSP unit increase (OR 1.121, 95% CI 1.013 - 1.239, p=0.027).Conclusions: These results are consistent with diffuse, predominantly frontal thalamo-cortical dysfunction during sleep in OSA, as more posterior brain regions appear to maintain some physiological spindle frequency modulation across the night. Displaying changes in an opposite direction to what is expected from the aging process itself, spindle frequency appears to be informative in OSA even with small sample sizes, and to represent a sensitive electrophysiological marker of brain dysfunction in OSA.
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spelling Topography-specific spindle frequency changes in Obstructive Sleep ApneaTime seriesMatching pursuitEEGSleep spindlesOSABackground: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, the aim of this study was to investigate sleep spindle frequency distribution in OSA. Seven non-OSA subjects and 21 patients with OSA (11 mild and 10 moderate) were studied. A matching pursuit procedure was used for automatic detection of fast (>= 13Hz) and slow(< 13Hz) spindles obtained from 30min samples of NREM sleep stage 2 taken from initial, middle and final night thirds (sections I, II and III) of frontal, central and parietal scalp regions.Results: Compared to non-OSA subjects, Moderate OSA patients had higher central and parietal slow spindle percentage (SSP) in all night sections studied, and higher frontal SSP in sections II and III. As the night progressed, there was a reduction in central and parietal SSP, while frontal SSP remained high. Frontal slow spindle percentage in night section III predicted OSA with good accuracy, with OSA likelihood increased by 12.1% for every SSP unit increase (OR 1.121, 95% CI 1.013 - 1.239, p=0.027).Conclusions: These results are consistent with diffuse, predominantly frontal thalamo-cortical dysfunction during sleep in OSA, as more posterior brain regions appear to maintain some physiological spindle frequency modulation across the night. Displaying changes in an opposite direction to what is expected from the aging process itself, spindle frequency appears to be informative in OSA even with small sample sizes, and to represent a sensitive electrophysiological marker of brain dysfunction in OSA.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista UNESP, Inst Biosci, Dept Phys & Biophys, Botucatu, SP, BrazilHosp Clin Porto Alegre, Div Pulm Med, Sleep Lab, BR-90035003 Porto Alegre, RS, BrazilUniv Fed Sergipe, Dept Phys, Sao Cristovao, BrazilUniv Caxias do Sul, Dept Phys & Chem, BR-95001970 Caxias do Sul, BrazilUniv Estadual Paulista UNESP, Inst Biosci, Dept Phys & Biophys, Botucatu, SP, BrazilFAPESP: 09/10382-2Biomed Central Ltd.Universidade Estadual Paulista (Unesp)Hosp Clin Porto AlegreUniversidade Federal de Sergipe (UFS)Univ Caxias do SulSchoenwald, Suzana V.Carvalho, Diego Z.de Santa-Helena, Emerson L.Lemke, Ney [UNESP]Gerhardt, Guenther J. L.2014-05-20T13:49:41Z2014-05-20T13:49:41Z2012-07-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://dx.doi.org/10.1186/1471-2202-13-89Bmc Neuroscience. London: Biomed Central Ltd., v. 13, p. 12, 2012.1471-2202http://hdl.handle.net/11449/1771310.1186/1471-2202-13-89WOS:000311166100001WOS000311166100001.pdf7977035910952141Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBmc Neuroscience2.1731,120info:eu-repo/semantics/openAccess2023-12-30T06:18:16Zoai:repositorio.unesp.br:11449/17713Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:41:32.119878Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Topography-specific spindle frequency changes in Obstructive Sleep Apnea
title Topography-specific spindle frequency changes in Obstructive Sleep Apnea
spellingShingle Topography-specific spindle frequency changes in Obstructive Sleep Apnea
Schoenwald, Suzana V.
Time series
Matching pursuit
EEG
Sleep spindles
OSA
title_short Topography-specific spindle frequency changes in Obstructive Sleep Apnea
title_full Topography-specific spindle frequency changes in Obstructive Sleep Apnea
title_fullStr Topography-specific spindle frequency changes in Obstructive Sleep Apnea
title_full_unstemmed Topography-specific spindle frequency changes in Obstructive Sleep Apnea
title_sort Topography-specific spindle frequency changes in Obstructive Sleep Apnea
author Schoenwald, Suzana V.
author_facet Schoenwald, Suzana V.
Carvalho, Diego Z.
de Santa-Helena, Emerson L.
Lemke, Ney [UNESP]
Gerhardt, Guenther J. L.
author_role author
author2 Carvalho, Diego Z.
de Santa-Helena, Emerson L.
Lemke, Ney [UNESP]
Gerhardt, Guenther J. L.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Hosp Clin Porto Alegre
Universidade Federal de Sergipe (UFS)
Univ Caxias do Sul
dc.contributor.author.fl_str_mv Schoenwald, Suzana V.
Carvalho, Diego Z.
de Santa-Helena, Emerson L.
Lemke, Ney [UNESP]
Gerhardt, Guenther J. L.
dc.subject.por.fl_str_mv Time series
Matching pursuit
EEG
Sleep spindles
OSA
topic Time series
Matching pursuit
EEG
Sleep spindles
OSA
description Background: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, the aim of this study was to investigate sleep spindle frequency distribution in OSA. Seven non-OSA subjects and 21 patients with OSA (11 mild and 10 moderate) were studied. A matching pursuit procedure was used for automatic detection of fast (>= 13Hz) and slow(< 13Hz) spindles obtained from 30min samples of NREM sleep stage 2 taken from initial, middle and final night thirds (sections I, II and III) of frontal, central and parietal scalp regions.Results: Compared to non-OSA subjects, Moderate OSA patients had higher central and parietal slow spindle percentage (SSP) in all night sections studied, and higher frontal SSP in sections II and III. As the night progressed, there was a reduction in central and parietal SSP, while frontal SSP remained high. Frontal slow spindle percentage in night section III predicted OSA with good accuracy, with OSA likelihood increased by 12.1% for every SSP unit increase (OR 1.121, 95% CI 1.013 - 1.239, p=0.027).Conclusions: These results are consistent with diffuse, predominantly frontal thalamo-cortical dysfunction during sleep in OSA, as more posterior brain regions appear to maintain some physiological spindle frequency modulation across the night. Displaying changes in an opposite direction to what is expected from the aging process itself, spindle frequency appears to be informative in OSA even with small sample sizes, and to represent a sensitive electrophysiological marker of brain dysfunction in OSA.
publishDate 2012
dc.date.none.fl_str_mv 2012-07-31
2014-05-20T13:49:41Z
2014-05-20T13:49:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/1471-2202-13-89
Bmc Neuroscience. London: Biomed Central Ltd., v. 13, p. 12, 2012.
1471-2202
http://hdl.handle.net/11449/17713
10.1186/1471-2202-13-89
WOS:000311166100001
WOS000311166100001.pdf
7977035910952141
url http://dx.doi.org/10.1186/1471-2202-13-89
http://hdl.handle.net/11449/17713
identifier_str_mv Bmc Neuroscience. London: Biomed Central Ltd., v. 13, p. 12, 2012.
1471-2202
10.1186/1471-2202-13-89
WOS:000311166100001
WOS000311166100001.pdf
7977035910952141
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bmc Neuroscience
2.173
1,120
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
application/pdf
dc.publisher.none.fl_str_mv Biomed Central Ltd.
publisher.none.fl_str_mv Biomed Central Ltd.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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