In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides

Detalhes bibliográficos
Autor(a) principal: Devienne, Karina F. [UNESP]
Data de Publicação: 2002
Outros Autores: Raddi, Maria Stella Gonçalves [UNESP], Varanda, Eliana Aparecida [UNESP], Vilegas, Wagner [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.znaturforsch.com/ac/v57c/c57c.htm
http://hdl.handle.net/11449/66790
Resumo: Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromelioides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.
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spelling In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioidesCytotoxicity ActivityIsocoumarinPaepalanthus bromelioidesantiinfective agentcisplatincoumarin derivativeangiospermanimalcell linecell survivalchemistrydrug effectfibroblastmetabolismmousestructure activity relationAnimalsAnti-Infective AgentsCell LineCell SurvivalCisplatinCoumarinsFibroblastsLiliaceaeMiceStructure-Activity RelationshipNumerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromelioides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.Faculdade Ciencias Farm. Araraquara Univ. E. Paul. Julio Mesquita Filho, Rodovia Araraquara-Jaú, Km 1, 14801-902 Araraquara, SPFaculdade Ciencias Farm. Araraquara Univ. E. Paul. Julio Mesquita Filho, Rodovia Araraquara-Jaú, Km 1, 14801-902 Araraquara, SPUniversidade Estadual Paulista (Unesp)Devienne, Karina F. [UNESP]Raddi, Maria Stella Gonçalves [UNESP]Varanda, Eliana Aparecida [UNESP]Vilegas, Wagner [UNESP]2014-05-27T11:20:24Z2014-05-27T11:20:24Z2002-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article85-88application/pdfhttp://www.znaturforsch.com/ac/v57c/c57c.htmZeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 57, n. 1-2, p. 85-88, 2002.0939-5075http://hdl.handle.net/11449/66790WOS:0001747387000152-s2.0-00361297552-s2.0-0036129755.pdf79278772243268370000-0003-3032-2556Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengZeitschrift fur Naturforschung - Section C Journal of Biosciences0.8820,288info:eu-repo/semantics/openAccess2024-06-24T13:07:27Zoai:repositorio.unesp.br:11449/66790Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:57:51.139569Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
title In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
spellingShingle In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
Devienne, Karina F. [UNESP]
Cytotoxicity Activity
Isocoumarin
Paepalanthus bromelioides
antiinfective agent
cisplatin
coumarin derivative
angiosperm
animal
cell line
cell survival
chemistry
drug effect
fibroblast
metabolism
mouse
structure activity relation
Animals
Anti-Infective Agents
Cell Line
Cell Survival
Cisplatin
Coumarins
Fibroblasts
Liliaceae
Mice
Structure-Activity Relationship
title_short In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
title_full In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
title_fullStr In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
title_full_unstemmed In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
title_sort In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
author Devienne, Karina F. [UNESP]
author_facet Devienne, Karina F. [UNESP]
Raddi, Maria Stella Gonçalves [UNESP]
Varanda, Eliana Aparecida [UNESP]
Vilegas, Wagner [UNESP]
author_role author
author2 Raddi, Maria Stella Gonçalves [UNESP]
Varanda, Eliana Aparecida [UNESP]
Vilegas, Wagner [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Devienne, Karina F. [UNESP]
Raddi, Maria Stella Gonçalves [UNESP]
Varanda, Eliana Aparecida [UNESP]
Vilegas, Wagner [UNESP]
dc.subject.por.fl_str_mv Cytotoxicity Activity
Isocoumarin
Paepalanthus bromelioides
antiinfective agent
cisplatin
coumarin derivative
angiosperm
animal
cell line
cell survival
chemistry
drug effect
fibroblast
metabolism
mouse
structure activity relation
Animals
Anti-Infective Agents
Cell Line
Cell Survival
Cisplatin
Coumarins
Fibroblasts
Liliaceae
Mice
Structure-Activity Relationship
topic Cytotoxicity Activity
Isocoumarin
Paepalanthus bromelioides
antiinfective agent
cisplatin
coumarin derivative
angiosperm
animal
cell line
cell survival
chemistry
drug effect
fibroblast
metabolism
mouse
structure activity relation
Animals
Anti-Infective Agents
Cell Line
Cell Survival
Cisplatin
Coumarins
Fibroblasts
Liliaceae
Mice
Structure-Activity Relationship
description Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromelioides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.
publishDate 2002
dc.date.none.fl_str_mv 2002-01-01
2014-05-27T11:20:24Z
2014-05-27T11:20:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.znaturforsch.com/ac/v57c/c57c.htm
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 57, n. 1-2, p. 85-88, 2002.
0939-5075
http://hdl.handle.net/11449/66790
WOS:000174738700015
2-s2.0-0036129755
2-s2.0-0036129755.pdf
7927877224326837
0000-0003-3032-2556
url http://www.znaturforsch.com/ac/v57c/c57c.htm
http://hdl.handle.net/11449/66790
identifier_str_mv Zeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 57, n. 1-2, p. 85-88, 2002.
0939-5075
WOS:000174738700015
2-s2.0-0036129755
2-s2.0-0036129755.pdf
7927877224326837
0000-0003-3032-2556
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Zeitschrift fur Naturforschung - Section C Journal of Biosciences
0.882
0,288
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 85-88
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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