Isolated flavonoids against mammary tumour cells LM2
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.znaturforsch.com/ac/v64c/c64c.htm http://hdl.handle.net/11449/70961 |
Resumo: | The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC 50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities. © 2009 Verlag der Zeitschrift für Naturforschung. |
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Isolated flavonoids against mammary tumour cells LM2Antitumour activityCytokineFlavonoidsantineoplastic agentcisplatinflavonoidanimalBagg albino mousecell survivaldrug effectexperimental neoplasmfemaleisolation and purificationMalpighiaceaemouseMyrtaceaepathologytumor cell lineAnimalsAntineoplastic AgentsCell Line, TumorCell SurvivalCisplatinFemaleMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CByrsonima crassaDavillaMouririMurinaePusaThe purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC 50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities. © 2009 Verlag der Zeitschrift für Naturforschung.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP São Paulo State University Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SPUNESP São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SPBuenos Aires University Instituto de Oncologia UBA, Buenos AiresUNESP São Paulo State University Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SPUNESP São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SPFAPESP: 02/05503-6Universidade Estadual Paulista (Unesp)Univ Buenos Aires (UBA)Carli, Camila B. de A. [UNESP]De Matos, Djamile C. [UNESP]Lopes, Flávia C. M. [UNESP]Maia, Danielle C. G. [UNESP]Dias, Maristela B. [UNESP]Sannomiya, Miriam [UNESP]Rodrigues, Clenilson M. [UNESP]Andreo, Marcio A. [UNESP]Vilegas, Wagner [UNESP]Colombo, Lucas L.Carlos, Iracilda Zeppone [UNESP]2014-05-27T11:23:53Z2014-05-27T11:23:53Z2009-03-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article32-36application/pdfhttp://www.znaturforsch.com/ac/v64c/c64c.htmZeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 64, n. 1-2, p. 32-36, 2009.0939-5075http://hdl.handle.net/11449/70961WOS:0002644369000062-s2.0-625491406142-s2.0-62549140614.pdf79278772243268370000-0003-3032-2556Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengZeitschrift fur Naturforschung - Section C Journal of Biosciences0.8820,288info:eu-repo/semantics/openAccess2023-10-20T06:07:10Zoai:repositorio.unesp.br:11449/70961Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T12:56:41.742016Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Isolated flavonoids against mammary tumour cells LM2 |
title |
Isolated flavonoids against mammary tumour cells LM2 |
spellingShingle |
Isolated flavonoids against mammary tumour cells LM2 Carli, Camila B. de A. [UNESP] Antitumour activity Cytokine Flavonoids antineoplastic agent cisplatin flavonoid animal Bagg albino mouse cell survival drug effect experimental neoplasm female isolation and purification Malpighiaceae mouse Myrtaceae pathology tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Survival Cisplatin Female Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Byrsonima crassa Davilla Mouriri Murinae Pusa |
title_short |
Isolated flavonoids against mammary tumour cells LM2 |
title_full |
Isolated flavonoids against mammary tumour cells LM2 |
title_fullStr |
Isolated flavonoids against mammary tumour cells LM2 |
title_full_unstemmed |
Isolated flavonoids against mammary tumour cells LM2 |
title_sort |
Isolated flavonoids against mammary tumour cells LM2 |
author |
Carli, Camila B. de A. [UNESP] |
author_facet |
Carli, Camila B. de A. [UNESP] De Matos, Djamile C. [UNESP] Lopes, Flávia C. M. [UNESP] Maia, Danielle C. G. [UNESP] Dias, Maristela B. [UNESP] Sannomiya, Miriam [UNESP] Rodrigues, Clenilson M. [UNESP] Andreo, Marcio A. [UNESP] Vilegas, Wagner [UNESP] Colombo, Lucas L. Carlos, Iracilda Zeppone [UNESP] |
author_role |
author |
author2 |
De Matos, Djamile C. [UNESP] Lopes, Flávia C. M. [UNESP] Maia, Danielle C. G. [UNESP] Dias, Maristela B. [UNESP] Sannomiya, Miriam [UNESP] Rodrigues, Clenilson M. [UNESP] Andreo, Marcio A. [UNESP] Vilegas, Wagner [UNESP] Colombo, Lucas L. Carlos, Iracilda Zeppone [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Buenos Aires (UBA) |
dc.contributor.author.fl_str_mv |
Carli, Camila B. de A. [UNESP] De Matos, Djamile C. [UNESP] Lopes, Flávia C. M. [UNESP] Maia, Danielle C. G. [UNESP] Dias, Maristela B. [UNESP] Sannomiya, Miriam [UNESP] Rodrigues, Clenilson M. [UNESP] Andreo, Marcio A. [UNESP] Vilegas, Wagner [UNESP] Colombo, Lucas L. Carlos, Iracilda Zeppone [UNESP] |
dc.subject.por.fl_str_mv |
Antitumour activity Cytokine Flavonoids antineoplastic agent cisplatin flavonoid animal Bagg albino mouse cell survival drug effect experimental neoplasm female isolation and purification Malpighiaceae mouse Myrtaceae pathology tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Survival Cisplatin Female Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Byrsonima crassa Davilla Mouriri Murinae Pusa |
topic |
Antitumour activity Cytokine Flavonoids antineoplastic agent cisplatin flavonoid animal Bagg albino mouse cell survival drug effect experimental neoplasm female isolation and purification Malpighiaceae mouse Myrtaceae pathology tumor cell line Animals Antineoplastic Agents Cell Line, Tumor Cell Survival Cisplatin Female Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Byrsonima crassa Davilla Mouriri Murinae Pusa |
description |
The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC 50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities. © 2009 Verlag der Zeitschrift für Naturforschung. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-03-24 2014-05-27T11:23:53Z 2014-05-27T11:23:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.znaturforsch.com/ac/v64c/c64c.htm Zeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 64, n. 1-2, p. 32-36, 2009. 0939-5075 http://hdl.handle.net/11449/70961 WOS:000264436900006 2-s2.0-62549140614 2-s2.0-62549140614.pdf 7927877224326837 0000-0003-3032-2556 |
url |
http://www.znaturforsch.com/ac/v64c/c64c.htm http://hdl.handle.net/11449/70961 |
identifier_str_mv |
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 64, n. 1-2, p. 32-36, 2009. 0939-5075 WOS:000264436900006 2-s2.0-62549140614 2-s2.0-62549140614.pdf 7927877224326837 0000-0003-3032-2556 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Zeitschrift fur Naturforschung - Section C Journal of Biosciences 0.882 0,288 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
32-36 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803045746915672064 |