Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4322/2179-443X.0730 http://hdl.handle.net/11449/233291 |
Resumo: | Organic inorganic hybrids present several advantages as drug release systems, such as: High flexibility, high mechanical and thermal resistance, transparency, and low water solubility. These hybrids are synthesized through a chemical route named sol-gel that usually uses as solvente tetrahydrofuran (THF). Objetives: To develop film formers from hybrid materials replacing THF with ethanol, a less toxic solvent for skin application and for the environment. Methods: Four polymers were used: Two based on polyethylene oxide (PEO) with molecular weight of 500 and 1900 g mol-1 and two based on polypropylene oxide (PPO), with molecular weight of 400 and 2000 g mol-1. The structural analysis was performed by FTIR, 1H-NMR and 29Si-NMR, and the thermal-mechanical analysis by DSC and TG-DTA. Results: The results of the thermo-mechanical analysis revealed that the solvent replacement did not affect the thermal stability and flexibility of the di-ureasil hybrid. Conclusions: Structural characterization confirmed the formation of hybrids both in THF and in ethanol. Therefore, ethanol is an excellent solvent for the synthesis of these hybrid matrices, since it allows obtaining the same material without changing its characteristics, with some advantages, however, over THF. Furthermore, this paper describes the efficiency of ethanol as a solvent, which is environmentally friendly, to replace THF in the physical-chemical characteristics of these filming former materials. |
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Repositório Institucional da UNESP |
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Synthesis of ureasil-polyether film forming materials by using environmentally friendly solventEthanolFilm formersMechanical analysisOrganic-inorganic hybridsSol-gel processStructural analysisThermal analysisOrganic inorganic hybrids present several advantages as drug release systems, such as: High flexibility, high mechanical and thermal resistance, transparency, and low water solubility. These hybrids are synthesized through a chemical route named sol-gel that usually uses as solvente tetrahydrofuran (THF). Objetives: To develop film formers from hybrid materials replacing THF with ethanol, a less toxic solvent for skin application and for the environment. Methods: Four polymers were used: Two based on polyethylene oxide (PEO) with molecular weight of 500 and 1900 g mol-1 and two based on polypropylene oxide (PPO), with molecular weight of 400 and 2000 g mol-1. The structural analysis was performed by FTIR, 1H-NMR and 29Si-NMR, and the thermal-mechanical analysis by DSC and TG-DTA. Results: The results of the thermo-mechanical analysis revealed that the solvent replacement did not affect the thermal stability and flexibility of the di-ureasil hybrid. Conclusions: Structural characterization confirmed the formation of hybrids both in THF and in ethanol. Therefore, ethanol is an excellent solvent for the synthesis of these hybrid matrices, since it allows obtaining the same material without changing its characteristics, with some advantages, however, over THF. Furthermore, this paper describes the efficiency of ethanol as a solvent, which is environmentally friendly, to replace THF in the physical-chemical characteristics of these filming former materials.Pharmaceutical Sciences School Universidade Estadual Paulista (UNESP)Pharmaceutical Sciences School Universidade Estadual Paulista (UNESP)Universidade Estadual Paulista (UNESP)Mendes, Juliana Fernandes [UNESP]Oshiro Junior, João Augusto [UNESP]Da Silva, Camila Garcia [UNESP]Chiavacci, Leila Aparecida [UNESP]2022-05-01T06:31:25Z2022-05-01T06:31:25Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.4322/2179-443X.0730Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 42.2179-443X1808-4532http://hdl.handle.net/11449/23329110.4322/2179-443X.07302-s2.0-85111002684Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista de Ciencias Farmaceuticas Basica e Aplicadainfo:eu-repo/semantics/openAccess2024-06-24T13:46:23Zoai:repositorio.unesp.br:11449/233291Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:04:46.442845Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent |
title |
Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent |
spellingShingle |
Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent Mendes, Juliana Fernandes [UNESP] Ethanol Film formers Mechanical analysis Organic-inorganic hybrids Sol-gel process Structural analysis Thermal analysis |
title_short |
Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent |
title_full |
Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent |
title_fullStr |
Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent |
title_full_unstemmed |
Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent |
title_sort |
Synthesis of ureasil-polyether film forming materials by using environmentally friendly solvent |
author |
Mendes, Juliana Fernandes [UNESP] |
author_facet |
Mendes, Juliana Fernandes [UNESP] Oshiro Junior, João Augusto [UNESP] Da Silva, Camila Garcia [UNESP] Chiavacci, Leila Aparecida [UNESP] |
author_role |
author |
author2 |
Oshiro Junior, João Augusto [UNESP] Da Silva, Camila Garcia [UNESP] Chiavacci, Leila Aparecida [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Mendes, Juliana Fernandes [UNESP] Oshiro Junior, João Augusto [UNESP] Da Silva, Camila Garcia [UNESP] Chiavacci, Leila Aparecida [UNESP] |
dc.subject.por.fl_str_mv |
Ethanol Film formers Mechanical analysis Organic-inorganic hybrids Sol-gel process Structural analysis Thermal analysis |
topic |
Ethanol Film formers Mechanical analysis Organic-inorganic hybrids Sol-gel process Structural analysis Thermal analysis |
description |
Organic inorganic hybrids present several advantages as drug release systems, such as: High flexibility, high mechanical and thermal resistance, transparency, and low water solubility. These hybrids are synthesized through a chemical route named sol-gel that usually uses as solvente tetrahydrofuran (THF). Objetives: To develop film formers from hybrid materials replacing THF with ethanol, a less toxic solvent for skin application and for the environment. Methods: Four polymers were used: Two based on polyethylene oxide (PEO) with molecular weight of 500 and 1900 g mol-1 and two based on polypropylene oxide (PPO), with molecular weight of 400 and 2000 g mol-1. The structural analysis was performed by FTIR, 1H-NMR and 29Si-NMR, and the thermal-mechanical analysis by DSC and TG-DTA. Results: The results of the thermo-mechanical analysis revealed that the solvent replacement did not affect the thermal stability and flexibility of the di-ureasil hybrid. Conclusions: Structural characterization confirmed the formation of hybrids both in THF and in ethanol. Therefore, ethanol is an excellent solvent for the synthesis of these hybrid matrices, since it allows obtaining the same material without changing its characteristics, with some advantages, however, over THF. Furthermore, this paper describes the efficiency of ethanol as a solvent, which is environmentally friendly, to replace THF in the physical-chemical characteristics of these filming former materials. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-05-01T06:31:25Z 2022-05-01T06:31:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4322/2179-443X.0730 Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 42. 2179-443X 1808-4532 http://hdl.handle.net/11449/233291 10.4322/2179-443X.0730 2-s2.0-85111002684 |
url |
http://dx.doi.org/10.4322/2179-443X.0730 http://hdl.handle.net/11449/233291 |
identifier_str_mv |
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 42. 2179-443X 1808-4532 10.4322/2179-443X.0730 2-s2.0-85111002684 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista de Ciencias Farmaceuticas Basica e Aplicada |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129390255538176 |