Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/16017 http://hdl.handle.net/11449/71405 |
Resumo: | The chronic kidney disease (CKD) it is characterized by irreversible structural lesions that can develop progressively for uremia and chronic renal failure (CRF). In the CRF it happens the incapacity of executing the functions of maintenance of the electrolyte balance and acid-base, catabolitos excretion and hormonal regulation appropriately. When the mechanism basic physiopathology of the renal upset is analyzed, it is observed that present factors, predispose to the unbalance oxidative. Most of the time, the renal patient comes badly nurtured, with lack in reservations of vitamins and minerals, what reduces the antioxidant defense mechanisms, what favors the installation of the renal oxidative stress, with the formation of species you reactivate of reactive oxygen species (ROS), substances these potentially harmful to the organism. The reduction of the glomerular filtration rate (GFR) in the evolution of CKD in dogs and cats is a component for the installation of the renal oxidative stress. The ROS possesses important action in the kidneys, and these substances are highly reactivate, and when presents in excess damage lipids, proteins, DNA and carbohydrate, driving functional and structural abnormalities taking the cellular apoptosis and necrosis. Against the harmful potential action of these substances you reactivate, she becomes fundamental a delicate control of his production and consumption in the half intracellular, in other words, a balance of his concentration intra and extracellular. That is possible due to the activity of the antioxidants. Like this, to present literature revision had as objective describes the participation of the oxidative stress in CRF, as well as the mechanisms defenses against the harmful action of those substances. |
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Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animaisOxidative stress in end-stage chronic kidney disease in small animalsAntioxidantsCatsDogsKidney diseaseAnimaliaCanis familiarisThe chronic kidney disease (CKD) it is characterized by irreversible structural lesions that can develop progressively for uremia and chronic renal failure (CRF). In the CRF it happens the incapacity of executing the functions of maintenance of the electrolyte balance and acid-base, catabolitos excretion and hormonal regulation appropriately. When the mechanism basic physiopathology of the renal upset is analyzed, it is observed that present factors, predispose to the unbalance oxidative. Most of the time, the renal patient comes badly nurtured, with lack in reservations of vitamins and minerals, what reduces the antioxidant defense mechanisms, what favors the installation of the renal oxidative stress, with the formation of species you reactivate of reactive oxygen species (ROS), substances these potentially harmful to the organism. The reduction of the glomerular filtration rate (GFR) in the evolution of CKD in dogs and cats is a component for the installation of the renal oxidative stress. The ROS possesses important action in the kidneys, and these substances are highly reactivate, and when presents in excess damage lipids, proteins, DNA and carbohydrate, driving functional and structural abnormalities taking the cellular apoptosis and necrosis. Against the harmful potential action of these substances you reactivate, she becomes fundamental a delicate control of his production and consumption in the half intracellular, in other words, a balance of his concentration intra and extracellular. That is possible due to the activity of the antioxidants. Like this, to present literature revision had as objective describes the participation of the oxidative stress in CRF, as well as the mechanisms defenses against the harmful action of those substances.Medicina Veterinária Faculdade de Ciências Agrárias e Veterinárias (FCAV/UNESP), Jaboticabal, SPMedicina Veterinária Faculdade de Ciências Agrárias e Veterinárias (FCAV/UNESP), Jaboticabal, SPUniversidade Estadual Paulista (Unesp)Galvão, A. L B [UNESP]2014-05-27T11:24:32Z2014-05-27T11:24:32Z2009-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article178-186application/pdfhttp://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/16017Archives of Veterinary Science, v. 14, n. 3, p. 178-186, 2009.1517-784Xhttp://hdl.handle.net/11449/714052-s2.0-779551602972-s2.0-77955160297.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArchives of Veterinary Scienceinfo:eu-repo/semantics/openAccess2024-01-23T07:13:26Zoai:repositorio.unesp.br:11449/71405Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:48:29.941587Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais Oxidative stress in end-stage chronic kidney disease in small animals |
title |
Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais |
spellingShingle |
Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais Galvão, A. L B [UNESP] Antioxidants Cats Dogs Kidney disease Animalia Canis familiaris |
title_short |
Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais |
title_full |
Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais |
title_fullStr |
Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais |
title_full_unstemmed |
Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais |
title_sort |
Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais |
author |
Galvão, A. L B [UNESP] |
author_facet |
Galvão, A. L B [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Galvão, A. L B [UNESP] |
dc.subject.por.fl_str_mv |
Antioxidants Cats Dogs Kidney disease Animalia Canis familiaris |
topic |
Antioxidants Cats Dogs Kidney disease Animalia Canis familiaris |
description |
The chronic kidney disease (CKD) it is characterized by irreversible structural lesions that can develop progressively for uremia and chronic renal failure (CRF). In the CRF it happens the incapacity of executing the functions of maintenance of the electrolyte balance and acid-base, catabolitos excretion and hormonal regulation appropriately. When the mechanism basic physiopathology of the renal upset is analyzed, it is observed that present factors, predispose to the unbalance oxidative. Most of the time, the renal patient comes badly nurtured, with lack in reservations of vitamins and minerals, what reduces the antioxidant defense mechanisms, what favors the installation of the renal oxidative stress, with the formation of species you reactivate of reactive oxygen species (ROS), substances these potentially harmful to the organism. The reduction of the glomerular filtration rate (GFR) in the evolution of CKD in dogs and cats is a component for the installation of the renal oxidative stress. The ROS possesses important action in the kidneys, and these substances are highly reactivate, and when presents in excess damage lipids, proteins, DNA and carbohydrate, driving functional and structural abnormalities taking the cellular apoptosis and necrosis. Against the harmful potential action of these substances you reactivate, she becomes fundamental a delicate control of his production and consumption in the half intracellular, in other words, a balance of his concentration intra and extracellular. That is possible due to the activity of the antioxidants. Like this, to present literature revision had as objective describes the participation of the oxidative stress in CRF, as well as the mechanisms defenses against the harmful action of those substances. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 2014-05-27T11:24:32Z 2014-05-27T11:24:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/16017 Archives of Veterinary Science, v. 14, n. 3, p. 178-186, 2009. 1517-784X http://hdl.handle.net/11449/71405 2-s2.0-77955160297 2-s2.0-77955160297.pdf |
url |
http://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/16017 http://hdl.handle.net/11449/71405 |
identifier_str_mv |
Archives of Veterinary Science, v. 14, n. 3, p. 178-186, 2009. 1517-784X 2-s2.0-77955160297 2-s2.0-77955160297.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Archives of Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
178-186 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129553914134528 |