Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/cc13860 http://hdl.handle.net/11449/117328 |
Resumo: | Introduction: Selenoenzymes can modulate the extent of oxidative stress, which is recognized as a key feature of septic shock. The pathophysiologic role of erythrocyte selenium concentration in patients with septic shock remains unknown. Therefore, the objective of this study was to evaluate the association of erythrocyte selenium concentration with glutathione peroxidase (GPx1) activity, GPx1 polymorphisms and with ICU and hospital mortality in septic shock patients.Methods: This prospective study included all patients older than 18 years with septic shock on admission or during their ICU stay, admitted to one of the three ICUs of our institution, from January to August 2012. At the time of the patients' enrollment, demographic information was recorded. Blood samples were taken within the first 72 hours of the patients' admission or within 72 hours of the septic shock diagnosis for determination of selenium status, protein carbonyl concentration, GPx1 activity and GPx1 Pro198Leu polymorphism (rs 1050450) genotyping.Results: A total of 110 consecutive patients were evaluated. The mean age was 57.6 +/- 15.9 years, 63.6% were male. Regarding selenium status, only erythrocyte selenium concentration was lower in patients who died in the ICU. The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively. In the logistic regression models, erythrocyte selenium concentration was associated with ICU and hospital mortality in patients with septic shock even after adjustment for protein carbonyl concentration and acute physiology and chronic health evaluation II score (APACHE II) or sequential organ failure assessment (SOFA).Conclusions: Erythrocyte selenium concentration was a predictor of ICU and hospital mortality in patients with septic shock. However, this effect was not due to GPx1 activity or Pro198Leu polymorphism. |
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Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational studyIntroduction: Selenoenzymes can modulate the extent of oxidative stress, which is recognized as a key feature of septic shock. The pathophysiologic role of erythrocyte selenium concentration in patients with septic shock remains unknown. Therefore, the objective of this study was to evaluate the association of erythrocyte selenium concentration with glutathione peroxidase (GPx1) activity, GPx1 polymorphisms and with ICU and hospital mortality in septic shock patients.Methods: This prospective study included all patients older than 18 years with septic shock on admission or during their ICU stay, admitted to one of the three ICUs of our institution, from January to August 2012. At the time of the patients' enrollment, demographic information was recorded. Blood samples were taken within the first 72 hours of the patients' admission or within 72 hours of the septic shock diagnosis for determination of selenium status, protein carbonyl concentration, GPx1 activity and GPx1 Pro198Leu polymorphism (rs 1050450) genotyping.Results: A total of 110 consecutive patients were evaluated. The mean age was 57.6 +/- 15.9 years, 63.6% were male. Regarding selenium status, only erythrocyte selenium concentration was lower in patients who died in the ICU. The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively. In the logistic regression models, erythrocyte selenium concentration was associated with ICU and hospital mortality in patients with septic shock even after adjustment for protein carbonyl concentration and acute physiology and chronic health evaluation II score (APACHE II) or sequential organ failure assessment (SOFA).Conclusions: Erythrocyte selenium concentration was a predictor of ICU and hospital mortality in patients with septic shock. However, this effect was not due to GPx1 activity or Pro198Leu polymorphism.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)UNESP Univ Estadual Paulista, Dept Internal Med, Botucatu Med Sch, BR-18618970 Sao Paulo, BrazilUniv Sao Paulo, Dept Food & Expt Nutr, Fac Pharmaceut Sci, BR-05508070 Sao Paulo, BrazilUNESP Univ Estadual Paulista, Chem & Biochem Dept, Inst Biol Sci, BR-18618970 Sao Paulo, BrazilUNESP Univ Estadual Paulista, Dept Internal Med, Botucatu Med Sch, BR-18618970 Sao Paulo, BrazilUNESP Univ Estadual Paulista, Chem & Biochem Dept, Inst Biol Sci, BR-18618970 Sao Paulo, BrazilBiomed Central LtdUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Costa, Nara Aline [UNESP]Gut, Ana Lúcia [UNESP]Coelho Pimentel, Jose AlexandreFranciscato Cozzolino, Silvia MariaGaiolla, Paula Schmidt Azevedo [UNESP]Fernandes, Ana Angelica Henrique [UNESP]Polegato, Bertha Furlan [UNESP]Tanni, Suzana Erico [UNESP]Gaiolla, Rafael Dezen [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Minicucci, Marcos Ferreira [UNESP]2015-03-18T15:55:51Z2015-03-18T15:55:51Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1186/cc13860Critical Care. London: Biomed Central Ltd, v. 18, n. 3, 7 p., 2014.1466-609Xhttp://hdl.handle.net/11449/11732810.1186/cc13860WOS:000341163800006WOS000341163800006.pdf545209368906650850168390153945475016839015394547121314080140264774387040344716730000-0002-5843-6232Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCritical Care6.425info:eu-repo/semantics/openAccess2024-08-14T17:37:04Zoai:repositorio.unesp.br:11449/117328Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:37:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study |
title |
Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study |
spellingShingle |
Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study Costa, Nara Aline [UNESP] |
title_short |
Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study |
title_full |
Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study |
title_fullStr |
Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study |
title_full_unstemmed |
Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study |
title_sort |
Erythrocyte selenium concentration predicts intensive care unit and hospital mortality in patients with septic shock: a prospective observational study |
author |
Costa, Nara Aline [UNESP] |
author_facet |
Costa, Nara Aline [UNESP] Gut, Ana Lúcia [UNESP] Coelho Pimentel, Jose Alexandre Franciscato Cozzolino, Silvia Maria Gaiolla, Paula Schmidt Azevedo [UNESP] Fernandes, Ana Angelica Henrique [UNESP] Polegato, Bertha Furlan [UNESP] Tanni, Suzana Erico [UNESP] Gaiolla, Rafael Dezen [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Minicucci, Marcos Ferreira [UNESP] |
author_role |
author |
author2 |
Gut, Ana Lúcia [UNESP] Coelho Pimentel, Jose Alexandre Franciscato Cozzolino, Silvia Maria Gaiolla, Paula Schmidt Azevedo [UNESP] Fernandes, Ana Angelica Henrique [UNESP] Polegato, Bertha Furlan [UNESP] Tanni, Suzana Erico [UNESP] Gaiolla, Rafael Dezen [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Minicucci, Marcos Ferreira [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Costa, Nara Aline [UNESP] Gut, Ana Lúcia [UNESP] Coelho Pimentel, Jose Alexandre Franciscato Cozzolino, Silvia Maria Gaiolla, Paula Schmidt Azevedo [UNESP] Fernandes, Ana Angelica Henrique [UNESP] Polegato, Bertha Furlan [UNESP] Tanni, Suzana Erico [UNESP] Gaiolla, Rafael Dezen [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Minicucci, Marcos Ferreira [UNESP] |
description |
Introduction: Selenoenzymes can modulate the extent of oxidative stress, which is recognized as a key feature of septic shock. The pathophysiologic role of erythrocyte selenium concentration in patients with septic shock remains unknown. Therefore, the objective of this study was to evaluate the association of erythrocyte selenium concentration with glutathione peroxidase (GPx1) activity, GPx1 polymorphisms and with ICU and hospital mortality in septic shock patients.Methods: This prospective study included all patients older than 18 years with septic shock on admission or during their ICU stay, admitted to one of the three ICUs of our institution, from January to August 2012. At the time of the patients' enrollment, demographic information was recorded. Blood samples were taken within the first 72 hours of the patients' admission or within 72 hours of the septic shock diagnosis for determination of selenium status, protein carbonyl concentration, GPx1 activity and GPx1 Pro198Leu polymorphism (rs 1050450) genotyping.Results: A total of 110 consecutive patients were evaluated. The mean age was 57.6 +/- 15.9 years, 63.6% were male. Regarding selenium status, only erythrocyte selenium concentration was lower in patients who died in the ICU. The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively. In the logistic regression models, erythrocyte selenium concentration was associated with ICU and hospital mortality in patients with septic shock even after adjustment for protein carbonyl concentration and acute physiology and chronic health evaluation II score (APACHE II) or sequential organ failure assessment (SOFA).Conclusions: Erythrocyte selenium concentration was a predictor of ICU and hospital mortality in patients with septic shock. However, this effect was not due to GPx1 activity or Pro198Leu polymorphism. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 2015-03-18T15:55:51Z 2015-03-18T15:55:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/cc13860 Critical Care. London: Biomed Central Ltd, v. 18, n. 3, 7 p., 2014. 1466-609X http://hdl.handle.net/11449/117328 10.1186/cc13860 WOS:000341163800006 WOS000341163800006.pdf 5452093689066508 5016839015394547 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
url |
http://dx.doi.org/10.1186/cc13860 http://hdl.handle.net/11449/117328 |
identifier_str_mv |
Critical Care. London: Biomed Central Ltd, v. 18, n. 3, 7 p., 2014. 1466-609X 10.1186/cc13860 WOS:000341163800006 WOS000341163800006.pdf 5452093689066508 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Critical Care 6.425 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128210524700672 |