The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fphar.2019.00705 http://hdl.handle.net/11449/187891 |
Resumo: | The present study investigated the effect of the treatment with the angiotensin II type 1 receptor (AT1) antagonist losartan in the depressive-like state and memory impairment evoked by exposure to either homotypic (i.e., repeated exposure to the same type of stressor) or heterotypic (i.e., exposure to different aversive stimuli) chronic stressors in rats. For this, male Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor) while being concurrently treated daily with losartan (30 mg/kg/day, p.o.). Depressive-like state was evaluated by analysis of the alterations considered as markers of depression (decreased sucrose preference and body weight and coat state deterioration), whereas cognitive non-emotional performance was tested using the novel object recognition (NOR) test. Locomotor activity was also evaluated in the open field test. Both RRS and CVS impaired sucrose preference and caused coat state deterioration, whereas only CVS impaired body weight gain. Besides, RRS impaired short-term memory (but not long-term memory) in the NOR test. Neither depressive-like state nor memory impairment evoked by the chronic stressors was affected by the treatment with losartan. Nevertheless, CVS increased the locomotion, which was inhibited by losartan. Taken together, these results provide evidence that the chronic treatment with losartan does not affect the depressive-like state and memory impairment evoked by either homotypic or heterotypic chronic stress regimens in rats. |
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The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in ratsAnhedoniaChronic variable stressDepressionLocomotionLosartanMemoryRatsRestraint stressThe present study investigated the effect of the treatment with the angiotensin II type 1 receptor (AT1) antagonist losartan in the depressive-like state and memory impairment evoked by exposure to either homotypic (i.e., repeated exposure to the same type of stressor) or heterotypic (i.e., exposure to different aversive stimuli) chronic stressors in rats. For this, male Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor) while being concurrently treated daily with losartan (30 mg/kg/day, p.o.). Depressive-like state was evaluated by analysis of the alterations considered as markers of depression (decreased sucrose preference and body weight and coat state deterioration), whereas cognitive non-emotional performance was tested using the novel object recognition (NOR) test. Locomotor activity was also evaluated in the open field test. Both RRS and CVS impaired sucrose preference and caused coat state deterioration, whereas only CVS impaired body weight gain. Besides, RRS impaired short-term memory (but not long-term memory) in the NOR test. Neither depressive-like state nor memory impairment evoked by the chronic stressors was affected by the treatment with losartan. Nevertheless, CVS increased the locomotion, which was inhibited by losartan. Taken together, these results provide evidence that the chronic treatment with losartan does not affect the depressive-like state and memory impairment evoked by either homotypic or heterotypic chronic stress regimens in rats.School of Pharmaceutical Sciences São Paulo State University (UNESP)Joint UFSCar-UNESP Graduate Program in Physiological SciencesSchool of Pharmaceutical Sciences São Paulo State University (UNESP)Joint UFSCar-UNESP Graduate Program in Physiological SciencesUniversidade Estadual Paulista (Unesp)Costa-Ferreira, Willian [UNESP]Morais-Silva, Gessynger [UNESP]Gomesde-Souza, Lucas [UNESP]Marin, Marcelo T. [UNESP]Crestani, Carlos C. [UNESP]2019-10-06T15:50:30Z2019-10-06T15:50:30Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fphar.2019.00705Frontiers in Pharmacology, v. 10, n. JUN, 2019.1663-9812http://hdl.handle.net/11449/18789110.3389/fphar.2019.007052-s2.0-85069540956Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Pharmacologyinfo:eu-repo/semantics/openAccess2021-10-22T21:16:17Zoai:repositorio.unesp.br:11449/187891Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:39:42.218558Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats |
title |
The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats |
spellingShingle |
The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats Costa-Ferreira, Willian [UNESP] Anhedonia Chronic variable stress Depression Locomotion Losartan Memory Rats Restraint stress |
title_short |
The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats |
title_full |
The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats |
title_fullStr |
The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats |
title_full_unstemmed |
The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats |
title_sort |
The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats |
author |
Costa-Ferreira, Willian [UNESP] |
author_facet |
Costa-Ferreira, Willian [UNESP] Morais-Silva, Gessynger [UNESP] Gomesde-Souza, Lucas [UNESP] Marin, Marcelo T. [UNESP] Crestani, Carlos C. [UNESP] |
author_role |
author |
author2 |
Morais-Silva, Gessynger [UNESP] Gomesde-Souza, Lucas [UNESP] Marin, Marcelo T. [UNESP] Crestani, Carlos C. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Costa-Ferreira, Willian [UNESP] Morais-Silva, Gessynger [UNESP] Gomesde-Souza, Lucas [UNESP] Marin, Marcelo T. [UNESP] Crestani, Carlos C. [UNESP] |
dc.subject.por.fl_str_mv |
Anhedonia Chronic variable stress Depression Locomotion Losartan Memory Rats Restraint stress |
topic |
Anhedonia Chronic variable stress Depression Locomotion Losartan Memory Rats Restraint stress |
description |
The present study investigated the effect of the treatment with the angiotensin II type 1 receptor (AT1) antagonist losartan in the depressive-like state and memory impairment evoked by exposure to either homotypic (i.e., repeated exposure to the same type of stressor) or heterotypic (i.e., exposure to different aversive stimuli) chronic stressors in rats. For this, male Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor) while being concurrently treated daily with losartan (30 mg/kg/day, p.o.). Depressive-like state was evaluated by analysis of the alterations considered as markers of depression (decreased sucrose preference and body weight and coat state deterioration), whereas cognitive non-emotional performance was tested using the novel object recognition (NOR) test. Locomotor activity was also evaluated in the open field test. Both RRS and CVS impaired sucrose preference and caused coat state deterioration, whereas only CVS impaired body weight gain. Besides, RRS impaired short-term memory (but not long-term memory) in the NOR test. Neither depressive-like state nor memory impairment evoked by the chronic stressors was affected by the treatment with losartan. Nevertheless, CVS increased the locomotion, which was inhibited by losartan. Taken together, these results provide evidence that the chronic treatment with losartan does not affect the depressive-like state and memory impairment evoked by either homotypic or heterotypic chronic stress regimens in rats. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T15:50:30Z 2019-10-06T15:50:30Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fphar.2019.00705 Frontiers in Pharmacology, v. 10, n. JUN, 2019. 1663-9812 http://hdl.handle.net/11449/187891 10.3389/fphar.2019.00705 2-s2.0-85069540956 |
url |
http://dx.doi.org/10.3389/fphar.2019.00705 http://hdl.handle.net/11449/187891 |
identifier_str_mv |
Frontiers in Pharmacology, v. 10, n. JUN, 2019. 1663-9812 10.3389/fphar.2019.00705 2-s2.0-85069540956 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128260025876480 |