Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats

Detalhes bibliográficos
Autor(a) principal: Rogerio, Murillo Martins
Data de Publicação: 2019
Outros Autores: Santos, Lucas Silva, Garcia, Thiago Alves, Tamura Ozaki, Guilherme Akio, Fernandes, Rodrigo Antonio [UNESP], Castoldi, Robson Chacon, Quirino Louzada, Mario Jefferson [UNESP], Okoshi, Katashi [UNESP], Junqueira, Adriana [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/s1980-6574201900010020
http://hdl.handle.net/11449/190580
Resumo: – Aim: The present study aimed to analyze the effects of N-acetylcysteine supplementation associated with concurrent training on the bone mineral density of spontaneously hypertensive elderly rats. Methods: For the present study, 28 male spontaneously hypertensive rats, six months old, were distributed in the following groups: control (C, n=7); control + N-acetylcysteine (CNAC, n=7); concurrent training (T, n=7); and concurrent training+N-acetylcysteine (TNAC, n=7). The concurrent training was composed of aerobic training on a treadmill and resistance training in the same training session, three times a week. Animals of the NAC groups received a dose equivalent to 120 mg/kg/day orally for eight weeks. The animals in the trained groups underwent training for eight weeks. The animals were evaluated at the beginning and end of the experiment. After euthanasia, the tibias and femurs were submitted to bone densitometry analysis in an X-ray dual emission device. Results: Lower weight variation was observed in the trained animals and a reduction in pressure values in all groups, but without a statistical difference (p> 0.05). The animals in the T and TNAC groups presented a better performance in the physical tests (p <0.05). In relation to bone, the NAC groups demonstrated a decrease in femoral bone density when compared to groups C and T. Finally, all experimental groups demonstrated an increase in tibial bone density, but with no statistical difference (p>0.05). Conclusion: The animals in group T demonstrated better performance in the physical tests. In addition, the NAC caused a reduction in the bone mineral density of the femur.
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spelling Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive ratsBone MatrixExerciseHypertensionOxidative Stress– Aim: The present study aimed to analyze the effects of N-acetylcysteine supplementation associated with concurrent training on the bone mineral density of spontaneously hypertensive elderly rats. Methods: For the present study, 28 male spontaneously hypertensive rats, six months old, were distributed in the following groups: control (C, n=7); control + N-acetylcysteine (CNAC, n=7); concurrent training (T, n=7); and concurrent training+N-acetylcysteine (TNAC, n=7). The concurrent training was composed of aerobic training on a treadmill and resistance training in the same training session, three times a week. Animals of the NAC groups received a dose equivalent to 120 mg/kg/day orally for eight weeks. The animals in the trained groups underwent training for eight weeks. The animals were evaluated at the beginning and end of the experiment. After euthanasia, the tibias and femurs were submitted to bone densitometry analysis in an X-ray dual emission device. Results: Lower weight variation was observed in the trained animals and a reduction in pressure values in all groups, but without a statistical difference (p> 0.05). The animals in the T and TNAC groups presented a better performance in the physical tests (p <0.05). In relation to bone, the NAC groups demonstrated a decrease in femoral bone density when compared to groups C and T. Finally, all experimental groups demonstrated an increase in tibial bone density, but with no statistical difference (p>0.05). Conclusion: The animals in group T demonstrated better performance in the physical tests. In addition, the NAC caused a reduction in the bone mineral density of the femur.Universidade do Oeste Paulista UNOESTE Physical EducationUniversidade Estadual de Campinas UNICAMP Orthopedic and traumatologyUniversidade Estadual Paulista “Julio de Mesquita Filho” UNESP Veterinary MedicineUniversidade Estadual Paulista “Julio de Mesquita Filho” UNESP Departamento de Clinica MedicaUniversidade Estadual Paulista “Julio de Mesquita Filho” UNESP Veterinary MedicineUniversidade Estadual Paulista “Julio de Mesquita Filho” UNESP Departamento de Clinica MedicaPhysical EducationUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Rogerio, Murillo MartinsSantos, Lucas SilvaGarcia, Thiago AlvesTamura Ozaki, Guilherme AkioFernandes, Rodrigo Antonio [UNESP]Castoldi, Robson ChaconQuirino Louzada, Mario Jefferson [UNESP]Okoshi, Katashi [UNESP]Junqueira, Adriana [UNESP]2019-10-06T17:17:58Z2019-10-06T17:17:58Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1590/s1980-6574201900010020Motriz. Revista de Educacao Fisica, v. 25, n. 2, 2019.1980-65741415-9805http://hdl.handle.net/11449/19058010.1590/s1980-6574201900010020S1980-657420190002003052-s2.0-85070803396S1980-65742019000200305.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMotriz. Revista de Educacao Fisicainfo:eu-repo/semantics/openAccess2024-08-14T17:37:05Zoai:repositorio.unesp.br:11449/190580Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:37:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
title Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
spellingShingle Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
Rogerio, Murillo Martins
Bone Matrix
Exercise
Hypertension
Oxidative Stress
title_short Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
title_full Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
title_fullStr Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
title_full_unstemmed Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
title_sort Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
author Rogerio, Murillo Martins
author_facet Rogerio, Murillo Martins
Santos, Lucas Silva
Garcia, Thiago Alves
Tamura Ozaki, Guilherme Akio
Fernandes, Rodrigo Antonio [UNESP]
Castoldi, Robson Chacon
Quirino Louzada, Mario Jefferson [UNESP]
Okoshi, Katashi [UNESP]
Junqueira, Adriana [UNESP]
author_role author
author2 Santos, Lucas Silva
Garcia, Thiago Alves
Tamura Ozaki, Guilherme Akio
Fernandes, Rodrigo Antonio [UNESP]
Castoldi, Robson Chacon
Quirino Louzada, Mario Jefferson [UNESP]
Okoshi, Katashi [UNESP]
Junqueira, Adriana [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Physical Education
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Rogerio, Murillo Martins
Santos, Lucas Silva
Garcia, Thiago Alves
Tamura Ozaki, Guilherme Akio
Fernandes, Rodrigo Antonio [UNESP]
Castoldi, Robson Chacon
Quirino Louzada, Mario Jefferson [UNESP]
Okoshi, Katashi [UNESP]
Junqueira, Adriana [UNESP]
dc.subject.por.fl_str_mv Bone Matrix
Exercise
Hypertension
Oxidative Stress
topic Bone Matrix
Exercise
Hypertension
Oxidative Stress
description – Aim: The present study aimed to analyze the effects of N-acetylcysteine supplementation associated with concurrent training on the bone mineral density of spontaneously hypertensive elderly rats. Methods: For the present study, 28 male spontaneously hypertensive rats, six months old, were distributed in the following groups: control (C, n=7); control + N-acetylcysteine (CNAC, n=7); concurrent training (T, n=7); and concurrent training+N-acetylcysteine (TNAC, n=7). The concurrent training was composed of aerobic training on a treadmill and resistance training in the same training session, three times a week. Animals of the NAC groups received a dose equivalent to 120 mg/kg/day orally for eight weeks. The animals in the trained groups underwent training for eight weeks. The animals were evaluated at the beginning and end of the experiment. After euthanasia, the tibias and femurs were submitted to bone densitometry analysis in an X-ray dual emission device. Results: Lower weight variation was observed in the trained animals and a reduction in pressure values in all groups, but without a statistical difference (p> 0.05). The animals in the T and TNAC groups presented a better performance in the physical tests (p <0.05). In relation to bone, the NAC groups demonstrated a decrease in femoral bone density when compared to groups C and T. Finally, all experimental groups demonstrated an increase in tibial bone density, but with no statistical difference (p>0.05). Conclusion: The animals in group T demonstrated better performance in the physical tests. In addition, the NAC caused a reduction in the bone mineral density of the femur.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T17:17:58Z
2019-10-06T17:17:58Z
2019-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/s1980-6574201900010020
Motriz. Revista de Educacao Fisica, v. 25, n. 2, 2019.
1980-6574
1415-9805
http://hdl.handle.net/11449/190580
10.1590/s1980-6574201900010020
S1980-65742019000200305
2-s2.0-85070803396
S1980-65742019000200305.pdf
url http://dx.doi.org/10.1590/s1980-6574201900010020
http://hdl.handle.net/11449/190580
identifier_str_mv Motriz. Revista de Educacao Fisica, v. 25, n. 2, 2019.
1980-6574
1415-9805
10.1590/s1980-6574201900010020
S1980-65742019000200305
2-s2.0-85070803396
S1980-65742019000200305.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Motriz. Revista de Educacao Fisica
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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