L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X2006000400006 http://hdl.handle.net/11449/28081 |
Resumo: | The effects of adding L-carnitine to a whole-body and respiratory training program were determined in moderate-to-severe chronic obstructive pulmonary disease (COPD) patients. Sixteen COPD patients (66 ± 7 years) were randomly assigned to L-carnitine (CG) or placebo group (PG) that received either L-carnitine or saline solution (2 g/day, orally) for 6 weeks (forced expiratory volume on first second was 38 ± 16 and 36 ± 12%, respectively). Both groups participated in three weekly 30-min treadmill and threshold inspiratory muscle training sessions, with 3 sets of 10 loaded inspirations (40%) at maximal inspiratory pressure. Nutritional status, exercise tolerance on a treadmill and six-minute walking test, blood lactate, heart rate, blood pressure, and respiratory muscle strength were determined as baseline and on day 42. Maximal capacity in the incremental exercise test was significantly improved in both groups (P < 0.05). Blood lactate, blood pressure, oxygen saturation, and heart rate at identical exercise levels were lower in CG after training (P < 0.05). Inspiratory muscle strength and walking test tolerance were significantly improved in both groups, but the gains of CG were significantly higher than those of PG (40 ± 14 vs 14 ± 5 cmH2O, and 87 ± 30 vs 34 ± 29 m, respectively; P < 0.05). Blood lactate concentration was significantly lower in CG than in PG (1.6 ± 0.7 vs 2.3 ± 0.7 mM, P < 0.05). The present data suggest that carnitine can improve exercise tolerance and inspiratory muscle strength in COPD patients, as well as reduce lactate production. |
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L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programsChronic obstructive pulmonary diseaseL-carnitineExercise trainingRespiratory muscle trainingBlood lactateThe effects of adding L-carnitine to a whole-body and respiratory training program were determined in moderate-to-severe chronic obstructive pulmonary disease (COPD) patients. Sixteen COPD patients (66 ± 7 years) were randomly assigned to L-carnitine (CG) or placebo group (PG) that received either L-carnitine or saline solution (2 g/day, orally) for 6 weeks (forced expiratory volume on first second was 38 ± 16 and 36 ± 12%, respectively). Both groups participated in three weekly 30-min treadmill and threshold inspiratory muscle training sessions, with 3 sets of 10 loaded inspirations (40%) at maximal inspiratory pressure. Nutritional status, exercise tolerance on a treadmill and six-minute walking test, blood lactate, heart rate, blood pressure, and respiratory muscle strength were determined as baseline and on day 42. Maximal capacity in the incremental exercise test was significantly improved in both groups (P < 0.05). Blood lactate, blood pressure, oxygen saturation, and heart rate at identical exercise levels were lower in CG after training (P < 0.05). Inspiratory muscle strength and walking test tolerance were significantly improved in both groups, but the gains of CG were significantly higher than those of PG (40 ± 14 vs 14 ± 5 cmH2O, and 87 ± 30 vs 34 ± 29 m, respectively; P < 0.05). Blood lactate concentration was significantly lower in CG than in PG (1.6 ± 0.7 vs 2.3 ± 0.7 mM, P < 0.05). The present data suggest that carnitine can improve exercise tolerance and inspiratory muscle strength in COPD patients, as well as reduce lactate production.Universidade Federal de São Carlos (UFSCar) Núcleo de Pesquisas em Exercício Físico Laboratório de Fisioterapia CardiovascularUniversidade Federal de São Carlos (UFSCar) Departamento de Ciências Fisiológicas Laboratório de Fisiologia do ExercícioUniversidade Federal de São Carlos (UFSCar) Laboratório de Eletromiografia e EspirometriaUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Alimentos e NutriçãoUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Clínica MédicaUniversidade Metodista de Piracicaba Faculdade de Ciências da Saúde Departamento de FisioterapiaUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Alimentos e NutriçãoAssociação Brasileira de Divulgação Científica (ABRADIC)Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Universidade Metodista de Piracicaba (UNIMEP)Borghi-Silva, A.Baldissera, V.Sampaio, L. M. M.Pires-DiLorenzo, V. A.Jamami, M.Demonte, Aureluce [UNESP]Marchini, J. S.Costa, D.2014-05-20T15:11:34Z2014-05-20T15:11:34Z2006-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article465-474application/pdfhttp://dx.doi.org/10.1590/S0100-879X2006000400006Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 4, p. 465-474, 2006.0100-879Xhttp://hdl.handle.net/11449/2808110.1590/S0100-879X2006000400006S0100-879X2006000400006S0100-879X2006000400006.pdf5269969767845353SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Research1.492info:eu-repo/semantics/openAccess2023-11-12T06:10:21Zoai:repositorio.unesp.br:11449/28081Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-12T06:10:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs |
title |
L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs |
spellingShingle |
L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs Borghi-Silva, A. Chronic obstructive pulmonary disease L-carnitine Exercise training Respiratory muscle training Blood lactate |
title_short |
L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs |
title_full |
L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs |
title_fullStr |
L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs |
title_full_unstemmed |
L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs |
title_sort |
L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs |
author |
Borghi-Silva, A. |
author_facet |
Borghi-Silva, A. Baldissera, V. Sampaio, L. M. M. Pires-DiLorenzo, V. A. Jamami, M. Demonte, Aureluce [UNESP] Marchini, J. S. Costa, D. |
author_role |
author |
author2 |
Baldissera, V. Sampaio, L. M. M. Pires-DiLorenzo, V. A. Jamami, M. Demonte, Aureluce [UNESP] Marchini, J. S. Costa, D. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Universidade Metodista de Piracicaba (UNIMEP) |
dc.contributor.author.fl_str_mv |
Borghi-Silva, A. Baldissera, V. Sampaio, L. M. M. Pires-DiLorenzo, V. A. Jamami, M. Demonte, Aureluce [UNESP] Marchini, J. S. Costa, D. |
dc.subject.por.fl_str_mv |
Chronic obstructive pulmonary disease L-carnitine Exercise training Respiratory muscle training Blood lactate |
topic |
Chronic obstructive pulmonary disease L-carnitine Exercise training Respiratory muscle training Blood lactate |
description |
The effects of adding L-carnitine to a whole-body and respiratory training program were determined in moderate-to-severe chronic obstructive pulmonary disease (COPD) patients. Sixteen COPD patients (66 ± 7 years) were randomly assigned to L-carnitine (CG) or placebo group (PG) that received either L-carnitine or saline solution (2 g/day, orally) for 6 weeks (forced expiratory volume on first second was 38 ± 16 and 36 ± 12%, respectively). Both groups participated in three weekly 30-min treadmill and threshold inspiratory muscle training sessions, with 3 sets of 10 loaded inspirations (40%) at maximal inspiratory pressure. Nutritional status, exercise tolerance on a treadmill and six-minute walking test, blood lactate, heart rate, blood pressure, and respiratory muscle strength were determined as baseline and on day 42. Maximal capacity in the incremental exercise test was significantly improved in both groups (P < 0.05). Blood lactate, blood pressure, oxygen saturation, and heart rate at identical exercise levels were lower in CG after training (P < 0.05). Inspiratory muscle strength and walking test tolerance were significantly improved in both groups, but the gains of CG were significantly higher than those of PG (40 ± 14 vs 14 ± 5 cmH2O, and 87 ± 30 vs 34 ± 29 m, respectively; P < 0.05). Blood lactate concentration was significantly lower in CG than in PG (1.6 ± 0.7 vs 2.3 ± 0.7 mM, P < 0.05). The present data suggest that carnitine can improve exercise tolerance and inspiratory muscle strength in COPD patients, as well as reduce lactate production. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-04-01 2014-05-20T15:11:34Z 2014-05-20T15:11:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2006000400006 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 4, p. 465-474, 2006. 0100-879X http://hdl.handle.net/11449/28081 10.1590/S0100-879X2006000400006 S0100-879X2006000400006 S0100-879X2006000400006.pdf 5269969767845353 |
url |
http://dx.doi.org/10.1590/S0100-879X2006000400006 http://hdl.handle.net/11449/28081 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 4, p. 465-474, 2006. 0100-879X 10.1590/S0100-879X2006000400006 S0100-879X2006000400006 S0100-879X2006000400006.pdf 5269969767845353 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research 1.492 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
465-474 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica (ABRADIC) |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica (ABRADIC) |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799964906497245184 |