Flavonóides de Calotropis procera R. Br. (Asclepiadaceae)

• Autor(a) principal: Gallegos-Olea, R. S.
• Data de Publicação: 2008
• Outros Autores: Borges, M. O R, Borges, A. C R, Freire, S. M F, Silveira, L. M S, Vilegas, Wagner [UNESP], Rodrigues, C. M. [UNESP], Oliveira, A. V., Costa, J. L.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo5_v10_n1_p29a33.pdf; http://hdl.handle.net/11449/70301
• topic: Calotropis; Flavonol glycosides; n-BuOH fraction; NMR; Calotropis procera extract; flavonoid; isorhamnetin 3 o rutinoside; isorhamnetin 3 robinobioside; sephadex; calotropis procera; carbon nuclear magnetic resonance; controlled study; drug isolation; liquid liquid extraction; nonhuman; plant leaf; proton nuclear magnetic resonance; Apocynaceae; Calotropis procera

In this work we report the identification of two flavonol glycosides isolated from the leaves of Calotropis procera R. Br. (Asclepiadaceae), a plant species with large occurrence in Northwest of Brazil with some applications in folk medicine. Some proved pharmacological activities in this species could be attributed to the presence of flavonol glycosides. The extraction and isolation of flavonol glycosides was carried out firstly by a liquid-liquid partition, and then by elution of n-BuOH fraction with MeOH over a Sephadex LH-20 column. The identification of flavonol glycosides isorhamnetin-3-O-rutinoside (1), and isorhamnetin-3-O-robinobioside (2), was obtained by 1H and 13C NMR, one- and two-dimensional techniques.