Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?

Detalhes bibliográficos
Autor(a) principal: Mourao, Aline A.
Data de Publicação: 2016
Outros Autores: Moreira, Marina C. S., Melo, Aryanne B. S., Lopes, Paulo R., Rebelo, Ana C. S., Rosa, Daniel A., Freiria-Oliveira, Andre H., Colombari, Eduardo [UNESP], Pedrino, Gustavo R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.autneu.2016.02.008
http://hdl.handle.net/11449/165114
Resumo: The present study sought to determine the involvement of median preoptic nucleus (MnPO) in the regulation of the cardiovascular function and renal sympathetic activity in normotensive (NT) and spontaneously hypertensive rats (SHR). MnPO inhibition evoked by Muscimol (4 mM) nanoinjections, elicited fall in MAP and renal sympathoinhibition in NT-rats. Surprisingly, in SHRs these responses were greater than in NT-rats. These results demonstrated, for the first time that MnPO was involved in the tonic control of sympathetic activity in NT and SHRs. Furthermore, our data suggest the MnPO involvement in the increased sympathetic outflow and consequent arterial hypertension observed in SHRs. (C) 2016 Elsevier B.V. All rights reserved.
id UNSP_83c6bf88cdb2a3c2985c78188378e7ff
oai_identifier_str oai:repositorio.unesp.br:11449/165114
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?Arterial pressureHypertensionMnPORenal sympathetic nerve activitySHRThe present study sought to determine the involvement of median preoptic nucleus (MnPO) in the regulation of the cardiovascular function and renal sympathetic activity in normotensive (NT) and spontaneously hypertensive rats (SHR). MnPO inhibition evoked by Muscimol (4 mM) nanoinjections, elicited fall in MAP and renal sympathoinhibition in NT-rats. Surprisingly, in SHRs these responses were greater than in NT-rats. These results demonstrated, for the first time that MnPO was involved in the tonic control of sympathetic activity in NT and SHRs. Furthermore, our data suggest the MnPO involvement in the increased sympathetic outflow and consequent arterial hypertension observed in SHRs. (C) 2016 Elsevier B.V. All rights reserved.Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Goias, Inst Biol Sci, Dept Physiol Sci, Ctr Neurosci & Cardiovasc Res, BR-74001970 Goiania, Go, BrazilUniv Fed Goias, Inst Biol Sci, Dept Morphol, BR-74001970 Goiania, Go, BrazilSao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Sao Paulo, BrazilSao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Sao Paulo, BrazilFundacao de Amparo a Pesquisa do Estado de Goias (FAPEG): 2012/0055431086Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG): 2009/10267000352CNPq: 483411/2012-4CNPq: 447496/2014-0Elsevier B.V.Universidade Federal de Goiás (UFG)Universidade Estadual Paulista (Unesp)Mourao, Aline A.Moreira, Marina C. S.Melo, Aryanne B. S.Lopes, Paulo R.Rebelo, Ana C. S.Rosa, Daniel A.Freiria-Oliveira, Andre H.Colombari, Eduardo [UNESP]Pedrino, Gustavo R.2018-11-27T11:13:21Z2018-11-27T11:13:21Z2016-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article29-33application/pdfhttp://dx.doi.org/10.1016/j.autneu.2016.02.008Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier Science Bv, v. 195, p. 29-33, 2016.1566-0702http://hdl.handle.net/11449/16511410.1016/j.autneu.2016.02.008WOS:000372762800006WOS000372762800006.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAutonomic Neuroscience-basic & Clinical0,902info:eu-repo/semantics/openAccess2024-09-27T14:05:44Zoai:repositorio.unesp.br:11449/165114Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-27T14:05:44Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
title Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
spellingShingle Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
Mourao, Aline A.
Arterial pressure
Hypertension
MnPO
Renal sympathetic nerve activity
SHR
title_short Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
title_full Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
title_fullStr Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
title_full_unstemmed Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
title_sort Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
author Mourao, Aline A.
author_facet Mourao, Aline A.
Moreira, Marina C. S.
Melo, Aryanne B. S.
Lopes, Paulo R.
Rebelo, Ana C. S.
Rosa, Daniel A.
Freiria-Oliveira, Andre H.
Colombari, Eduardo [UNESP]
Pedrino, Gustavo R.
author_role author
author2 Moreira, Marina C. S.
Melo, Aryanne B. S.
Lopes, Paulo R.
Rebelo, Ana C. S.
Rosa, Daniel A.
Freiria-Oliveira, Andre H.
Colombari, Eduardo [UNESP]
Pedrino, Gustavo R.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Goiás (UFG)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Mourao, Aline A.
Moreira, Marina C. S.
Melo, Aryanne B. S.
Lopes, Paulo R.
Rebelo, Ana C. S.
Rosa, Daniel A.
Freiria-Oliveira, Andre H.
Colombari, Eduardo [UNESP]
Pedrino, Gustavo R.
dc.subject.por.fl_str_mv Arterial pressure
Hypertension
MnPO
Renal sympathetic nerve activity
SHR
topic Arterial pressure
Hypertension
MnPO
Renal sympathetic nerve activity
SHR
description The present study sought to determine the involvement of median preoptic nucleus (MnPO) in the regulation of the cardiovascular function and renal sympathetic activity in normotensive (NT) and spontaneously hypertensive rats (SHR). MnPO inhibition evoked by Muscimol (4 mM) nanoinjections, elicited fall in MAP and renal sympathoinhibition in NT-rats. Surprisingly, in SHRs these responses were greater than in NT-rats. These results demonstrated, for the first time that MnPO was involved in the tonic control of sympathetic activity in NT and SHRs. Furthermore, our data suggest the MnPO involvement in the increased sympathetic outflow and consequent arterial hypertension observed in SHRs. (C) 2016 Elsevier B.V. All rights reserved.
publishDate 2016
dc.date.none.fl_str_mv 2016-02-01
2018-11-27T11:13:21Z
2018-11-27T11:13:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.autneu.2016.02.008
Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier Science Bv, v. 195, p. 29-33, 2016.
1566-0702
http://hdl.handle.net/11449/165114
10.1016/j.autneu.2016.02.008
WOS:000372762800006
WOS000372762800006.pdf
url http://dx.doi.org/10.1016/j.autneu.2016.02.008
http://hdl.handle.net/11449/165114
identifier_str_mv Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier Science Bv, v. 195, p. 29-33, 2016.
1566-0702
10.1016/j.autneu.2016.02.008
WOS:000372762800006
WOS000372762800006.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Autonomic Neuroscience-basic & Clinical
0,902
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 29-33
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1813546517372338176

Registros relacionados