SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases

Detalhes bibliográficos
Autor(a) principal: Ferreira, Gonzalo
Data de Publicação: 2021
Outros Autores: Santander, Axel, Savio, Florencia, Guirado, Mariana, Sobrevia, Luis [UNESP], Nicolson, Garth L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.bbadis.2021.166264
http://hdl.handle.net/11449/222378
Resumo: The molecular evolution of life on earth along with changing environmental, conditions has rendered mankind susceptible to endemic and pandemic emerging infectious diseases. The effects of certain systemic viral and bacterial infections on morbidity and mortality are considered as examples of recent emerging infections. Here we will focus on three examples of infections that are important in pregnancy and early childhood: SARS-CoV-2 virus, Zika virus, and Mycoplasma species. The basic structural characteristics of these infectious agents will be examined, along with their general pathogenic mechanisms. Coronavirus infections, such as caused by the SARS-CoV-2 virus, likely evolved from zoonotic bat viruses to infect humans and cause a pandemic that has been the biggest challenge for humanity since the Spanish Flu pandemic of the early 20th century. In contrast, Zika Virus infections represent an expanding infectious threat in the context of global climate change. The relationship of these infections to pregnancy, the vertical transmission and neurological sequels make these viruses highly relevant to the topics of this special issue. Finally, mycoplasmal infections have been present before mankind evolved, but they were rarely identified as human pathogens until recently, and they are now recognized as important coinfections that are able to modify the course and prognosis of various infectious diseases and other chronic illnesses. The infectious processes caused by these intracellular microorganisms are examined as well as some general aspects of their pathogeneses, clinical presentations, and diagnoses. We will finally consider examples of treatments that have been used to reduce morbidity and mortality of these infections and discuss briefly the current status of vaccines, in particular, against the SARS-CoV-2 virus. It is important to understand some of the basic features of these emerging infectious diseases and the pathogens involved in order to better appreciate the contributions of this special issue on how infectious diseases can affect human pregnancy, fetuses and neonates.
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spelling SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseasesBacteriaInfectionMorbidityPregnancyReproductionVirusThe molecular evolution of life on earth along with changing environmental, conditions has rendered mankind susceptible to endemic and pandemic emerging infectious diseases. The effects of certain systemic viral and bacterial infections on morbidity and mortality are considered as examples of recent emerging infections. Here we will focus on three examples of infections that are important in pregnancy and early childhood: SARS-CoV-2 virus, Zika virus, and Mycoplasma species. The basic structural characteristics of these infectious agents will be examined, along with their general pathogenic mechanisms. Coronavirus infections, such as caused by the SARS-CoV-2 virus, likely evolved from zoonotic bat viruses to infect humans and cause a pandemic that has been the biggest challenge for humanity since the Spanish Flu pandemic of the early 20th century. In contrast, Zika Virus infections represent an expanding infectious threat in the context of global climate change. The relationship of these infections to pregnancy, the vertical transmission and neurological sequels make these viruses highly relevant to the topics of this special issue. Finally, mycoplasmal infections have been present before mankind evolved, but they were rarely identified as human pathogens until recently, and they are now recognized as important coinfections that are able to modify the course and prognosis of various infectious diseases and other chronic illnesses. The infectious processes caused by these intracellular microorganisms are examined as well as some general aspects of their pathogeneses, clinical presentations, and diagnoses. We will finally consider examples of treatments that have been used to reduce morbidity and mortality of these infections and discuss briefly the current status of vaccines, in particular, against the SARS-CoV-2 virus. It is important to understand some of the basic features of these emerging infectious diseases and the pathogens involved in order to better appreciate the contributions of this special issue on how infectious diseases can affect human pregnancy, fetuses and neonates.Agencia Nacional de Investigación e InnovaciónComisión Sectorial de Investigación CientíficaFondo Nacional de Desarrollo Científico y TecnológicoLaboratory of Ion Channels Biological Membranes and Cell Signaling Department of Biophysics Faculty of Medicine Universidad de la RepúblicaDepartment of Infectious Diseases Faculty of Medicine Universidad de la RepúblicaCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaeology School of Medicine Faculty of Medicine Pontificia Universidad Católica de ChileDepartment of Physiology Faculty of Pharmacy Universidad de SevillaMedical School (Faculty of Medicine) São Paulo State University (UNESP)University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of QueenslandDepartment of Pathology and Medical Biology University of Groningen University Medical Center Groningen (UMCG)Department of Molecular Pathology The Institute for Molecular MedicineMedical School (Faculty of Medicine) São Paulo State University (UNESP)Fondo Nacional de Desarrollo Científico y Tecnológico: 1190316Universidad de la RepúblicaPontificia Universidad Católica de ChileUniversidad de SevillaUniversidade Estadual Paulista (UNESP)University of QueenslandUniversity Medical Center Groningen (UMCG)The Institute for Molecular MedicineFerreira, GonzaloSantander, AxelSavio, FlorenciaGuirado, MarianaSobrevia, Luis [UNESP]Nicolson, Garth L.2022-04-28T19:44:18Z2022-04-28T19:44:18Z2021-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bbadis.2021.166264Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1867, n. 12, 2021.1879-260X0925-4439http://hdl.handle.net/11449/22237810.1016/j.bbadis.2021.1662642-s2.0-85114621163Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiochimica et Biophysica Acta - Molecular Basis of Diseaseinfo:eu-repo/semantics/openAccess2022-04-28T19:44:18Zoai:repositorio.unesp.br:11449/222378Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:22:16.732897Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
title SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
spellingShingle SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
Ferreira, Gonzalo
Bacteria
Infection
Morbidity
Pregnancy
Reproduction
Virus
title_short SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
title_full SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
title_fullStr SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
title_full_unstemmed SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
title_sort SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
author Ferreira, Gonzalo
author_facet Ferreira, Gonzalo
Santander, Axel
Savio, Florencia
Guirado, Mariana
Sobrevia, Luis [UNESP]
Nicolson, Garth L.
author_role author
author2 Santander, Axel
Savio, Florencia
Guirado, Mariana
Sobrevia, Luis [UNESP]
Nicolson, Garth L.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de la República
Pontificia Universidad Católica de Chile
Universidad de Sevilla
Universidade Estadual Paulista (UNESP)
University of Queensland
University Medical Center Groningen (UMCG)
The Institute for Molecular Medicine
dc.contributor.author.fl_str_mv Ferreira, Gonzalo
Santander, Axel
Savio, Florencia
Guirado, Mariana
Sobrevia, Luis [UNESP]
Nicolson, Garth L.
dc.subject.por.fl_str_mv Bacteria
Infection
Morbidity
Pregnancy
Reproduction
Virus
topic Bacteria
Infection
Morbidity
Pregnancy
Reproduction
Virus
description The molecular evolution of life on earth along with changing environmental, conditions has rendered mankind susceptible to endemic and pandemic emerging infectious diseases. The effects of certain systemic viral and bacterial infections on morbidity and mortality are considered as examples of recent emerging infections. Here we will focus on three examples of infections that are important in pregnancy and early childhood: SARS-CoV-2 virus, Zika virus, and Mycoplasma species. The basic structural characteristics of these infectious agents will be examined, along with their general pathogenic mechanisms. Coronavirus infections, such as caused by the SARS-CoV-2 virus, likely evolved from zoonotic bat viruses to infect humans and cause a pandemic that has been the biggest challenge for humanity since the Spanish Flu pandemic of the early 20th century. In contrast, Zika Virus infections represent an expanding infectious threat in the context of global climate change. The relationship of these infections to pregnancy, the vertical transmission and neurological sequels make these viruses highly relevant to the topics of this special issue. Finally, mycoplasmal infections have been present before mankind evolved, but they were rarely identified as human pathogens until recently, and they are now recognized as important coinfections that are able to modify the course and prognosis of various infectious diseases and other chronic illnesses. The infectious processes caused by these intracellular microorganisms are examined as well as some general aspects of their pathogeneses, clinical presentations, and diagnoses. We will finally consider examples of treatments that have been used to reduce morbidity and mortality of these infections and discuss briefly the current status of vaccines, in particular, against the SARS-CoV-2 virus. It is important to understand some of the basic features of these emerging infectious diseases and the pathogens involved in order to better appreciate the contributions of this special issue on how infectious diseases can affect human pregnancy, fetuses and neonates.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-01
2022-04-28T19:44:18Z
2022-04-28T19:44:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.bbadis.2021.166264
Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1867, n. 12, 2021.
1879-260X
0925-4439
http://hdl.handle.net/11449/222378
10.1016/j.bbadis.2021.166264
2-s2.0-85114621163
url http://dx.doi.org/10.1016/j.bbadis.2021.166264
http://hdl.handle.net/11449/222378
identifier_str_mv Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1867, n. 12, 2021.
1879-260X
0925-4439
10.1016/j.bbadis.2021.166264
2-s2.0-85114621163
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochimica et Biophysica Acta - Molecular Basis of Disease
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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