SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bbadis.2021.166264 http://hdl.handle.net/11449/222378 |
Resumo: | The molecular evolution of life on earth along with changing environmental, conditions has rendered mankind susceptible to endemic and pandemic emerging infectious diseases. The effects of certain systemic viral and bacterial infections on morbidity and mortality are considered as examples of recent emerging infections. Here we will focus on three examples of infections that are important in pregnancy and early childhood: SARS-CoV-2 virus, Zika virus, and Mycoplasma species. The basic structural characteristics of these infectious agents will be examined, along with their general pathogenic mechanisms. Coronavirus infections, such as caused by the SARS-CoV-2 virus, likely evolved from zoonotic bat viruses to infect humans and cause a pandemic that has been the biggest challenge for humanity since the Spanish Flu pandemic of the early 20th century. In contrast, Zika Virus infections represent an expanding infectious threat in the context of global climate change. The relationship of these infections to pregnancy, the vertical transmission and neurological sequels make these viruses highly relevant to the topics of this special issue. Finally, mycoplasmal infections have been present before mankind evolved, but they were rarely identified as human pathogens until recently, and they are now recognized as important coinfections that are able to modify the course and prognosis of various infectious diseases and other chronic illnesses. The infectious processes caused by these intracellular microorganisms are examined as well as some general aspects of their pathogeneses, clinical presentations, and diagnoses. We will finally consider examples of treatments that have been used to reduce morbidity and mortality of these infections and discuss briefly the current status of vaccines, in particular, against the SARS-CoV-2 virus. It is important to understand some of the basic features of these emerging infectious diseases and the pathogens involved in order to better appreciate the contributions of this special issue on how infectious diseases can affect human pregnancy, fetuses and neonates. |
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SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseasesBacteriaInfectionMorbidityPregnancyReproductionVirusThe molecular evolution of life on earth along with changing environmental, conditions has rendered mankind susceptible to endemic and pandemic emerging infectious diseases. The effects of certain systemic viral and bacterial infections on morbidity and mortality are considered as examples of recent emerging infections. Here we will focus on three examples of infections that are important in pregnancy and early childhood: SARS-CoV-2 virus, Zika virus, and Mycoplasma species. The basic structural characteristics of these infectious agents will be examined, along with their general pathogenic mechanisms. Coronavirus infections, such as caused by the SARS-CoV-2 virus, likely evolved from zoonotic bat viruses to infect humans and cause a pandemic that has been the biggest challenge for humanity since the Spanish Flu pandemic of the early 20th century. In contrast, Zika Virus infections represent an expanding infectious threat in the context of global climate change. The relationship of these infections to pregnancy, the vertical transmission and neurological sequels make these viruses highly relevant to the topics of this special issue. Finally, mycoplasmal infections have been present before mankind evolved, but they were rarely identified as human pathogens until recently, and they are now recognized as important coinfections that are able to modify the course and prognosis of various infectious diseases and other chronic illnesses. The infectious processes caused by these intracellular microorganisms are examined as well as some general aspects of their pathogeneses, clinical presentations, and diagnoses. We will finally consider examples of treatments that have been used to reduce morbidity and mortality of these infections and discuss briefly the current status of vaccines, in particular, against the SARS-CoV-2 virus. It is important to understand some of the basic features of these emerging infectious diseases and the pathogens involved in order to better appreciate the contributions of this special issue on how infectious diseases can affect human pregnancy, fetuses and neonates.Agencia Nacional de Investigación e InnovaciónComisión Sectorial de Investigación CientíficaFondo Nacional de Desarrollo Científico y TecnológicoLaboratory of Ion Channels Biological Membranes and Cell Signaling Department of Biophysics Faculty of Medicine Universidad de la RepúblicaDepartment of Infectious Diseases Faculty of Medicine Universidad de la RepúblicaCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaeology School of Medicine Faculty of Medicine Pontificia Universidad Católica de ChileDepartment of Physiology Faculty of Pharmacy Universidad de SevillaMedical School (Faculty of Medicine) São Paulo State University (UNESP)University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of QueenslandDepartment of Pathology and Medical Biology University of Groningen University Medical Center Groningen (UMCG)Department of Molecular Pathology The Institute for Molecular MedicineMedical School (Faculty of Medicine) São Paulo State University (UNESP)Fondo Nacional de Desarrollo Científico y Tecnológico: 1190316Universidad de la RepúblicaPontificia Universidad Católica de ChileUniversidad de SevillaUniversidade Estadual Paulista (UNESP)University of QueenslandUniversity Medical Center Groningen (UMCG)The Institute for Molecular MedicineFerreira, GonzaloSantander, AxelSavio, FlorenciaGuirado, MarianaSobrevia, Luis [UNESP]Nicolson, Garth L.2022-04-28T19:44:18Z2022-04-28T19:44:18Z2021-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bbadis.2021.166264Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1867, n. 12, 2021.1879-260X0925-4439http://hdl.handle.net/11449/22237810.1016/j.bbadis.2021.1662642-s2.0-85114621163Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiochimica et Biophysica Acta - Molecular Basis of Diseaseinfo:eu-repo/semantics/openAccess2022-04-28T19:44:18Zoai:repositorio.unesp.br:11449/222378Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:22:16.732897Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases |
title |
SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases |
spellingShingle |
SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases Ferreira, Gonzalo Bacteria Infection Morbidity Pregnancy Reproduction Virus |
title_short |
SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases |
title_full |
SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases |
title_fullStr |
SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases |
title_full_unstemmed |
SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases |
title_sort |
SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases |
author |
Ferreira, Gonzalo |
author_facet |
Ferreira, Gonzalo Santander, Axel Savio, Florencia Guirado, Mariana Sobrevia, Luis [UNESP] Nicolson, Garth L. |
author_role |
author |
author2 |
Santander, Axel Savio, Florencia Guirado, Mariana Sobrevia, Luis [UNESP] Nicolson, Garth L. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidad de la República Pontificia Universidad Católica de Chile Universidad de Sevilla Universidade Estadual Paulista (UNESP) University of Queensland University Medical Center Groningen (UMCG) The Institute for Molecular Medicine |
dc.contributor.author.fl_str_mv |
Ferreira, Gonzalo Santander, Axel Savio, Florencia Guirado, Mariana Sobrevia, Luis [UNESP] Nicolson, Garth L. |
dc.subject.por.fl_str_mv |
Bacteria Infection Morbidity Pregnancy Reproduction Virus |
topic |
Bacteria Infection Morbidity Pregnancy Reproduction Virus |
description |
The molecular evolution of life on earth along with changing environmental, conditions has rendered mankind susceptible to endemic and pandemic emerging infectious diseases. The effects of certain systemic viral and bacterial infections on morbidity and mortality are considered as examples of recent emerging infections. Here we will focus on three examples of infections that are important in pregnancy and early childhood: SARS-CoV-2 virus, Zika virus, and Mycoplasma species. The basic structural characteristics of these infectious agents will be examined, along with their general pathogenic mechanisms. Coronavirus infections, such as caused by the SARS-CoV-2 virus, likely evolved from zoonotic bat viruses to infect humans and cause a pandemic that has been the biggest challenge for humanity since the Spanish Flu pandemic of the early 20th century. In contrast, Zika Virus infections represent an expanding infectious threat in the context of global climate change. The relationship of these infections to pregnancy, the vertical transmission and neurological sequels make these viruses highly relevant to the topics of this special issue. Finally, mycoplasmal infections have been present before mankind evolved, but they were rarely identified as human pathogens until recently, and they are now recognized as important coinfections that are able to modify the course and prognosis of various infectious diseases and other chronic illnesses. The infectious processes caused by these intracellular microorganisms are examined as well as some general aspects of their pathogeneses, clinical presentations, and diagnoses. We will finally consider examples of treatments that have been used to reduce morbidity and mortality of these infections and discuss briefly the current status of vaccines, in particular, against the SARS-CoV-2 virus. It is important to understand some of the basic features of these emerging infectious diseases and the pathogens involved in order to better appreciate the contributions of this special issue on how infectious diseases can affect human pregnancy, fetuses and neonates. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-01 2022-04-28T19:44:18Z 2022-04-28T19:44:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bbadis.2021.166264 Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1867, n. 12, 2021. 1879-260X 0925-4439 http://hdl.handle.net/11449/222378 10.1016/j.bbadis.2021.166264 2-s2.0-85114621163 |
url |
http://dx.doi.org/10.1016/j.bbadis.2021.166264 http://hdl.handle.net/11449/222378 |
identifier_str_mv |
Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1867, n. 12, 2021. 1879-260X 0925-4439 10.1016/j.bbadis.2021.166264 2-s2.0-85114621163 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biochimica et Biophysica Acta - Molecular Basis of Disease |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129313550106624 |