Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/jcmm.15419 http://hdl.handle.net/11449/200520 |
Resumo: | The objective of this study was to evaluate Spondias mombin L. (SM) pulp and its influence on cardiac remodelling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: a sham group (animals underwent simulated surgery) that received standard chow (S; n = 20), an infarcted group that received standard chow (MI; n = 24), an infarcted group supplemented with 100 mg of SM/kg bodyweight/d, (MIS100; n = 23) and an infarcted group supplemented with 250 mg of SM/kg bodyweight/d (MIS250; n = 22). After 3 months of treatment, morphological, functional and biochemical analyses were performed. MI induced structural and functional changes in the left ventricle with worsening systolic and diastolic function, and SM supplementation at different doses did not influence these variables as analysed by echocardiography and an isolated heart study (P >.05). However, SM supplementation attenuated cardiac remodelling after MI, reducing fibrosis (P =.047) and hypertrophy (P =.006). Biomarkers of oxidative stress, inflammatory processes and energy metabolism were further investigated in the myocardial tissue. SM supplementation improved the efficiency of energy metabolism and decreased lipid hydroperoxide in the myocardium [group S (n = 8): 267.26 ± 20.7; group MI (n = 8): 330.14 ± 47.3; group MIS100 (n = 8): 313.8 ± 46.2; group MIS250: 294.3 ± 38.0 nmol/mg tissue; P =.032], as well as decreased the activation of the inflammatory pathway after MI. In conclusion, SM supplementation attenuated cardiac remodelling processes after MI. We also found that energy metabolism, oxidative stress and inflammation are associated with this effect. In addition, SM supplementation at the highest dose is more effective. |
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Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulationmyocardial infarctionoxidative stressSpondias mombinventricular remodellingThe objective of this study was to evaluate Spondias mombin L. (SM) pulp and its influence on cardiac remodelling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: a sham group (animals underwent simulated surgery) that received standard chow (S; n = 20), an infarcted group that received standard chow (MI; n = 24), an infarcted group supplemented with 100 mg of SM/kg bodyweight/d, (MIS100; n = 23) and an infarcted group supplemented with 250 mg of SM/kg bodyweight/d (MIS250; n = 22). After 3 months of treatment, morphological, functional and biochemical analyses were performed. MI induced structural and functional changes in the left ventricle with worsening systolic and diastolic function, and SM supplementation at different doses did not influence these variables as analysed by echocardiography and an isolated heart study (P >.05). However, SM supplementation attenuated cardiac remodelling after MI, reducing fibrosis (P =.047) and hypertrophy (P =.006). Biomarkers of oxidative stress, inflammatory processes and energy metabolism were further investigated in the myocardial tissue. SM supplementation improved the efficiency of energy metabolism and decreased lipid hydroperoxide in the myocardium [group S (n = 8): 267.26 ± 20.7; group MI (n = 8): 330.14 ± 47.3; group MIS100 (n = 8): 313.8 ± 46.2; group MIS250: 294.3 ± 38.0 nmol/mg tissue; P =.032], as well as decreased the activation of the inflammatory pathway after MI. In conclusion, SM supplementation attenuated cardiac remodelling processes after MI. We also found that energy metabolism, oxidative stress and inflammation are associated with this effect. In addition, SM supplementation at the highest dose is more effective.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Internal Medicine Department Botucatu Medical School São Paulo State University (UNESP)School of Nutrition Sciences Faculty of Health Sciences University of OttawaChemistry and Biochemistry Department Institute of Biosciences São Paulo State University (UNESP)Internal Medicine Department Botucatu Medical School São Paulo State University (UNESP)Chemistry and Biochemistry Department Institute of Biosciences São Paulo State University (UNESP)FAPESP: 2014/23215-5FAPESP: 2015/18502-8FAPESP: 2018/03082-1Universidade Estadual Paulista (Unesp)University of OttawaPereira, Bruna Letícia Buzati [UNESP]Rodrigue, AlexaneArruda, Fernanda Caroline de Oliveira [UNESP]Bachiega, Tatiana Fernanda [UNESP]Lourenço, Maria Angélica Martins [UNESP]Correa, Camila Renata [UNESP]Azevedo, Paula Schmidt [UNESP]Polegato, Bertha Furlan [UNESP]Okoshi, Katashi [UNESP]Fernandes, Ana Angélica Henrique [UNESP]de Paiva, Sergio Alberto Rupp [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Power, Krista AnneMinicucci, Marcos Ferreira [UNESP]2020-12-12T02:08:48Z2020-12-12T02:08:48Z2020-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7862-7872http://dx.doi.org/10.1111/jcmm.15419Journal of Cellular and Molecular Medicine, v. 24, n. 14, p. 7862-7872, 2020.1582-1838http://hdl.handle.net/11449/20052010.1111/jcmm.154192-s2.0-85085503447Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Cellular and Molecular Medicineinfo:eu-repo/semantics/openAccess2024-08-14T17:36:31Zoai:repositorio.unesp.br:11449/200520Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-08-14T17:36:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation |
title |
Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation |
spellingShingle |
Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation Pereira, Bruna Letícia Buzati [UNESP] myocardial infarction oxidative stress Spondias mombin ventricular remodelling |
title_short |
Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation |
title_full |
Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation |
title_fullStr |
Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation |
title_full_unstemmed |
Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation |
title_sort |
Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation |
author |
Pereira, Bruna Letícia Buzati [UNESP] |
author_facet |
Pereira, Bruna Letícia Buzati [UNESP] Rodrigue, Alexane Arruda, Fernanda Caroline de Oliveira [UNESP] Bachiega, Tatiana Fernanda [UNESP] Lourenço, Maria Angélica Martins [UNESP] Correa, Camila Renata [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Okoshi, Katashi [UNESP] Fernandes, Ana Angélica Henrique [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Power, Krista Anne Minicucci, Marcos Ferreira [UNESP] |
author_role |
author |
author2 |
Rodrigue, Alexane Arruda, Fernanda Caroline de Oliveira [UNESP] Bachiega, Tatiana Fernanda [UNESP] Lourenço, Maria Angélica Martins [UNESP] Correa, Camila Renata [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Okoshi, Katashi [UNESP] Fernandes, Ana Angélica Henrique [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Power, Krista Anne Minicucci, Marcos Ferreira [UNESP] |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Ottawa |
dc.contributor.author.fl_str_mv |
Pereira, Bruna Letícia Buzati [UNESP] Rodrigue, Alexane Arruda, Fernanda Caroline de Oliveira [UNESP] Bachiega, Tatiana Fernanda [UNESP] Lourenço, Maria Angélica Martins [UNESP] Correa, Camila Renata [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Okoshi, Katashi [UNESP] Fernandes, Ana Angélica Henrique [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Power, Krista Anne Minicucci, Marcos Ferreira [UNESP] |
dc.subject.por.fl_str_mv |
myocardial infarction oxidative stress Spondias mombin ventricular remodelling |
topic |
myocardial infarction oxidative stress Spondias mombin ventricular remodelling |
description |
The objective of this study was to evaluate Spondias mombin L. (SM) pulp and its influence on cardiac remodelling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: a sham group (animals underwent simulated surgery) that received standard chow (S; n = 20), an infarcted group that received standard chow (MI; n = 24), an infarcted group supplemented with 100 mg of SM/kg bodyweight/d, (MIS100; n = 23) and an infarcted group supplemented with 250 mg of SM/kg bodyweight/d (MIS250; n = 22). After 3 months of treatment, morphological, functional and biochemical analyses were performed. MI induced structural and functional changes in the left ventricle with worsening systolic and diastolic function, and SM supplementation at different doses did not influence these variables as analysed by echocardiography and an isolated heart study (P >.05). However, SM supplementation attenuated cardiac remodelling after MI, reducing fibrosis (P =.047) and hypertrophy (P =.006). Biomarkers of oxidative stress, inflammatory processes and energy metabolism were further investigated in the myocardial tissue. SM supplementation improved the efficiency of energy metabolism and decreased lipid hydroperoxide in the myocardium [group S (n = 8): 267.26 ± 20.7; group MI (n = 8): 330.14 ± 47.3; group MIS100 (n = 8): 313.8 ± 46.2; group MIS250: 294.3 ± 38.0 nmol/mg tissue; P =.032], as well as decreased the activation of the inflammatory pathway after MI. In conclusion, SM supplementation attenuated cardiac remodelling processes after MI. We also found that energy metabolism, oxidative stress and inflammation are associated with this effect. In addition, SM supplementation at the highest dose is more effective. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:08:48Z 2020-12-12T02:08:48Z 2020-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jcmm.15419 Journal of Cellular and Molecular Medicine, v. 24, n. 14, p. 7862-7872, 2020. 1582-1838 http://hdl.handle.net/11449/200520 10.1111/jcmm.15419 2-s2.0-85085503447 |
url |
http://dx.doi.org/10.1111/jcmm.15419 http://hdl.handle.net/11449/200520 |
identifier_str_mv |
Journal of Cellular and Molecular Medicine, v. 24, n. 14, p. 7862-7872, 2020. 1582-1838 10.1111/jcmm.15419 2-s2.0-85085503447 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Cellular and Molecular Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7862-7872 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1826304467288457216 |