Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation

Detalhes bibliográficos
Autor(a) principal: Pereira, Bruna Letícia Buzati [UNESP]
Data de Publicação: 2020
Outros Autores: Rodrigue, Alexane, Arruda, Fernanda Caroline de Oliveira [UNESP], Bachiega, Tatiana Fernanda [UNESP], Lourenço, Maria Angélica Martins [UNESP], Correa, Camila Renata [UNESP], Azevedo, Paula Schmidt [UNESP], Polegato, Bertha Furlan [UNESP], Okoshi, Katashi [UNESP], Fernandes, Ana Angélica Henrique [UNESP], de Paiva, Sergio Alberto Rupp [UNESP], Zornoff, Leonardo Antonio Mamede [UNESP], Power, Krista Anne, Minicucci, Marcos Ferreira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/jcmm.15419
http://hdl.handle.net/11449/200520
Resumo: The objective of this study was to evaluate Spondias mombin L. (SM) pulp and its influence on cardiac remodelling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: a sham group (animals underwent simulated surgery) that received standard chow (S; n = 20), an infarcted group that received standard chow (MI; n = 24), an infarcted group supplemented with 100 mg of SM/kg bodyweight/d, (MIS100; n = 23) and an infarcted group supplemented with 250 mg of SM/kg bodyweight/d (MIS250; n = 22). After 3 months of treatment, morphological, functional and biochemical analyses were performed. MI induced structural and functional changes in the left ventricle with worsening systolic and diastolic function, and SM supplementation at different doses did not influence these variables as analysed by echocardiography and an isolated heart study (P >.05). However, SM supplementation attenuated cardiac remodelling after MI, reducing fibrosis (P =.047) and hypertrophy (P =.006). Biomarkers of oxidative stress, inflammatory processes and energy metabolism were further investigated in the myocardial tissue. SM supplementation improved the efficiency of energy metabolism and decreased lipid hydroperoxide in the myocardium [group S (n = 8): 267.26 ± 20.7; group MI (n = 8): 330.14 ± 47.3; group MIS100 (n = 8): 313.8 ± 46.2; group MIS250: 294.3 ± 38.0 nmol/mg tissue; P =.032], as well as decreased the activation of the inflammatory pathway after MI. In conclusion, SM supplementation attenuated cardiac remodelling processes after MI. We also found that energy metabolism, oxidative stress and inflammation are associated with this effect. In addition, SM supplementation at the highest dose is more effective.
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spelling Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulationmyocardial infarctionoxidative stressSpondias mombinventricular remodellingThe objective of this study was to evaluate Spondias mombin L. (SM) pulp and its influence on cardiac remodelling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: a sham group (animals underwent simulated surgery) that received standard chow (S; n = 20), an infarcted group that received standard chow (MI; n = 24), an infarcted group supplemented with 100 mg of SM/kg bodyweight/d, (MIS100; n = 23) and an infarcted group supplemented with 250 mg of SM/kg bodyweight/d (MIS250; n = 22). After 3 months of treatment, morphological, functional and biochemical analyses were performed. MI induced structural and functional changes in the left ventricle with worsening systolic and diastolic function, and SM supplementation at different doses did not influence these variables as analysed by echocardiography and an isolated heart study (P >.05). However, SM supplementation attenuated cardiac remodelling after MI, reducing fibrosis (P =.047) and hypertrophy (P =.006). Biomarkers of oxidative stress, inflammatory processes and energy metabolism were further investigated in the myocardial tissue. SM supplementation improved the efficiency of energy metabolism and decreased lipid hydroperoxide in the myocardium [group S (n = 8): 267.26 ± 20.7; group MI (n = 8): 330.14 ± 47.3; group MIS100 (n = 8): 313.8 ± 46.2; group MIS250: 294.3 ± 38.0 nmol/mg tissue; P =.032], as well as decreased the activation of the inflammatory pathway after MI. In conclusion, SM supplementation attenuated cardiac remodelling processes after MI. We also found that energy metabolism, oxidative stress and inflammation are associated with this effect. In addition, SM supplementation at the highest dose is more effective.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Internal Medicine Department Botucatu Medical School São Paulo State University (UNESP)School of Nutrition Sciences Faculty of Health Sciences University of OttawaChemistry and Biochemistry Department Institute of Biosciences São Paulo State University (UNESP)Internal Medicine Department Botucatu Medical School São Paulo State University (UNESP)Chemistry and Biochemistry Department Institute of Biosciences São Paulo State University (UNESP)FAPESP: 2014/23215-5FAPESP: 2015/18502-8FAPESP: 2018/03082-1Universidade Estadual Paulista (Unesp)University of OttawaPereira, Bruna Letícia Buzati [UNESP]Rodrigue, AlexaneArruda, Fernanda Caroline de Oliveira [UNESP]Bachiega, Tatiana Fernanda [UNESP]Lourenço, Maria Angélica Martins [UNESP]Correa, Camila Renata [UNESP]Azevedo, Paula Schmidt [UNESP]Polegato, Bertha Furlan [UNESP]Okoshi, Katashi [UNESP]Fernandes, Ana Angélica Henrique [UNESP]de Paiva, Sergio Alberto Rupp [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Power, Krista AnneMinicucci, Marcos Ferreira [UNESP]2020-12-12T02:08:48Z2020-12-12T02:08:48Z2020-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7862-7872http://dx.doi.org/10.1111/jcmm.15419Journal of Cellular and Molecular Medicine, v. 24, n. 14, p. 7862-7872, 2020.1582-1838http://hdl.handle.net/11449/20052010.1111/jcmm.154192-s2.0-85085503447Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Cellular and Molecular Medicineinfo:eu-repo/semantics/openAccess2024-08-14T17:36:31Zoai:repositorio.unesp.br:11449/200520Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-08-14T17:36:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
title Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
spellingShingle Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
Pereira, Bruna Letícia Buzati [UNESP]
myocardial infarction
oxidative stress
Spondias mombin
ventricular remodelling
title_short Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
title_full Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
title_fullStr Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
title_full_unstemmed Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
title_sort Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation
author Pereira, Bruna Letícia Buzati [UNESP]
author_facet Pereira, Bruna Letícia Buzati [UNESP]
Rodrigue, Alexane
Arruda, Fernanda Caroline de Oliveira [UNESP]
Bachiega, Tatiana Fernanda [UNESP]
Lourenço, Maria Angélica Martins [UNESP]
Correa, Camila Renata [UNESP]
Azevedo, Paula Schmidt [UNESP]
Polegato, Bertha Furlan [UNESP]
Okoshi, Katashi [UNESP]
Fernandes, Ana Angélica Henrique [UNESP]
de Paiva, Sergio Alberto Rupp [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Power, Krista Anne
Minicucci, Marcos Ferreira [UNESP]
author_role author
author2 Rodrigue, Alexane
Arruda, Fernanda Caroline de Oliveira [UNESP]
Bachiega, Tatiana Fernanda [UNESP]
Lourenço, Maria Angélica Martins [UNESP]
Correa, Camila Renata [UNESP]
Azevedo, Paula Schmidt [UNESP]
Polegato, Bertha Furlan [UNESP]
Okoshi, Katashi [UNESP]
Fernandes, Ana Angélica Henrique [UNESP]
de Paiva, Sergio Alberto Rupp [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Power, Krista Anne
Minicucci, Marcos Ferreira [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
University of Ottawa
dc.contributor.author.fl_str_mv Pereira, Bruna Letícia Buzati [UNESP]
Rodrigue, Alexane
Arruda, Fernanda Caroline de Oliveira [UNESP]
Bachiega, Tatiana Fernanda [UNESP]
Lourenço, Maria Angélica Martins [UNESP]
Correa, Camila Renata [UNESP]
Azevedo, Paula Schmidt [UNESP]
Polegato, Bertha Furlan [UNESP]
Okoshi, Katashi [UNESP]
Fernandes, Ana Angélica Henrique [UNESP]
de Paiva, Sergio Alberto Rupp [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Power, Krista Anne
Minicucci, Marcos Ferreira [UNESP]
dc.subject.por.fl_str_mv myocardial infarction
oxidative stress
Spondias mombin
ventricular remodelling
topic myocardial infarction
oxidative stress
Spondias mombin
ventricular remodelling
description The objective of this study was to evaluate Spondias mombin L. (SM) pulp and its influence on cardiac remodelling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: a sham group (animals underwent simulated surgery) that received standard chow (S; n = 20), an infarcted group that received standard chow (MI; n = 24), an infarcted group supplemented with 100 mg of SM/kg bodyweight/d, (MIS100; n = 23) and an infarcted group supplemented with 250 mg of SM/kg bodyweight/d (MIS250; n = 22). After 3 months of treatment, morphological, functional and biochemical analyses were performed. MI induced structural and functional changes in the left ventricle with worsening systolic and diastolic function, and SM supplementation at different doses did not influence these variables as analysed by echocardiography and an isolated heart study (P >.05). However, SM supplementation attenuated cardiac remodelling after MI, reducing fibrosis (P =.047) and hypertrophy (P =.006). Biomarkers of oxidative stress, inflammatory processes and energy metabolism were further investigated in the myocardial tissue. SM supplementation improved the efficiency of energy metabolism and decreased lipid hydroperoxide in the myocardium [group S (n = 8): 267.26 ± 20.7; group MI (n = 8): 330.14 ± 47.3; group MIS100 (n = 8): 313.8 ± 46.2; group MIS250: 294.3 ± 38.0 nmol/mg tissue; P =.032], as well as decreased the activation of the inflammatory pathway after MI. In conclusion, SM supplementation attenuated cardiac remodelling processes after MI. We also found that energy metabolism, oxidative stress and inflammation are associated with this effect. In addition, SM supplementation at the highest dose is more effective.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:08:48Z
2020-12-12T02:08:48Z
2020-07-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/jcmm.15419
Journal of Cellular and Molecular Medicine, v. 24, n. 14, p. 7862-7872, 2020.
1582-1838
http://hdl.handle.net/11449/200520
10.1111/jcmm.15419
2-s2.0-85085503447
url http://dx.doi.org/10.1111/jcmm.15419
http://hdl.handle.net/11449/200520
identifier_str_mv Journal of Cellular and Molecular Medicine, v. 24, n. 14, p. 7862-7872, 2020.
1582-1838
10.1111/jcmm.15419
2-s2.0-85085503447
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Cellular and Molecular Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7862-7872
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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