Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2019/9391802 http://hdl.handle.net/11449/184359 |
Resumo: | Practices described as traditional medicine may coexist with formalized, science-based medicine. In this context, the present study aimed to verify the profile of the elderly who consumed herbal medicines concomitantly with medications and to identify suspected adverse drug reactions (ADRs) in the Brazilian Amazon (Macapa, Amapa). The study was carried out in two steps: a cross-sectional study (structured questionnaire) and a clinical study (pharmacotherapeutic follow-up). Out of 208 participants, 78.8% were female with age between 60 and 69 years (58.7%), 59.1% used herbal medicines concurrently with medications, and 40.9% did not report use of herbal medicine. Losartan was the most used medication, and Lippia alba (Mill.) N.E. Br was the most common herbal medicine used. The total prevalence of suspected ADRs, among the elderly who answered the structured questionnaire, was 41.3%, with 27.4% being in the elderly who used herbal medicines and medications, and 13.9% being in the elderly who used only medications. Meanwhile, the total prevalence of suspected ADRs was 71.0% among the elderly patients who underwent pharmacotherapeutic follow-up, 60.5% in elderly who used herbal medicines and medications, and 10.5% in elderly who used only medications. The most reported ADR symptoms were related to disorders that affect the nervous system (38.4%) in the structured questionnaire and related to digestive disorders (36.4%) in the pharmacotherapeutic follow-up. The probability associated with the occurrence of a given ADR in the face of a set of demographic, socioeconomic, and clinical variables was estimated; the results showed that, in the studied population, only sex (p = 0.030) had an influence on the occurrence of ADR. The prevalence of ADRs with probable causality was high in this study population, but it was only sex-related, although more prevalent in the elderly who consume herbal medicines. |
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Phytopharmacovigilance in the Elderly: Highlights from the Brazilian AmazonPractices described as traditional medicine may coexist with formalized, science-based medicine. In this context, the present study aimed to verify the profile of the elderly who consumed herbal medicines concomitantly with medications and to identify suspected adverse drug reactions (ADRs) in the Brazilian Amazon (Macapa, Amapa). The study was carried out in two steps: a cross-sectional study (structured questionnaire) and a clinical study (pharmacotherapeutic follow-up). Out of 208 participants, 78.8% were female with age between 60 and 69 years (58.7%), 59.1% used herbal medicines concurrently with medications, and 40.9% did not report use of herbal medicine. Losartan was the most used medication, and Lippia alba (Mill.) N.E. Br was the most common herbal medicine used. The total prevalence of suspected ADRs, among the elderly who answered the structured questionnaire, was 41.3%, with 27.4% being in the elderly who used herbal medicines and medications, and 13.9% being in the elderly who used only medications. Meanwhile, the total prevalence of suspected ADRs was 71.0% among the elderly patients who underwent pharmacotherapeutic follow-up, 60.5% in elderly who used herbal medicines and medications, and 10.5% in elderly who used only medications. The most reported ADR symptoms were related to disorders that affect the nervous system (38.4%) in the structured questionnaire and related to digestive disorders (36.4%) in the pharmacotherapeutic follow-up. The probability associated with the occurrence of a given ADR in the face of a set of demographic, socioeconomic, and clinical variables was estimated; the results showed that, in the studied population, only sex (p = 0.030) had an influence on the occurrence of ADR. The prevalence of ADRs with probable causality was high in this study population, but it was only sex-related, although more prevalent in the elderly who consume herbal medicines.Univ Fed Amapa, Dept Biol & Hlth Sci, Toxicol Lab, Pharm Course, Juscelino Kubitschek Highway KM-02, BR-68903419 Macapa, AP, BrazilUniv Fed Amapa, Dept Biol & Hlth Sci, Med Course, Juscelino Kubitschek Highway KM-02, BR-68903419 Macapa, AP, BrazilState Univ Paulista Julio Mesquita Filho, Fac Pharmaceut Sci, Rodovia Araraquara Jau KM 01, BR-14800901 Machados, SP, BrazilUniv Fed Amapa, Dept Biol & Hlth Sci, Pharm Course, Qual Control & Bromatol Lab, Juscelino Kubitschek Highway KM-02, BR-68903419 Macapa, AP, BrazilState Univ Paulista Julio Mesquita Filho, Fac Pharmaceut Sci, Rodovia Araraquara Jau KM 01, BR-14800901 Machados, SP, BrazilHindawi LtdUniv Fed AmapaUniversidade Estadual Paulista (Unesp)Sousa Lima, Carolina Miranda deTeles Fujishima, Mayara AmorasFranca dos Santos, Braulio ErisonLima, Bruno de PaulaMastroianni, Patricia Carvalho [UNESP]Oliveira de Sousa, Francisco FabioSilva, Jocivania Oliveira da2019-10-04T11:57:06Z2019-10-04T11:57:06Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12http://dx.doi.org/10.1155/2019/9391802Evidence-based Complementary And Alternative Medicine. London: Hindawi Ltd, 12 p., 2019.1741-427Xhttp://hdl.handle.net/11449/18435910.1155/2019/9391802WOS:000459017800001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary And Alternative Medicineinfo:eu-repo/semantics/openAccess2021-10-22T22:23:37Zoai:repositorio.unesp.br:11449/184359Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:45:16.356171Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon |
title |
Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon |
spellingShingle |
Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon Sousa Lima, Carolina Miranda de |
title_short |
Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon |
title_full |
Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon |
title_fullStr |
Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon |
title_full_unstemmed |
Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon |
title_sort |
Phytopharmacovigilance in the Elderly: Highlights from the Brazilian Amazon |
author |
Sousa Lima, Carolina Miranda de |
author_facet |
Sousa Lima, Carolina Miranda de Teles Fujishima, Mayara Amoras Franca dos Santos, Braulio Erison Lima, Bruno de Paula Mastroianni, Patricia Carvalho [UNESP] Oliveira de Sousa, Francisco Fabio Silva, Jocivania Oliveira da |
author_role |
author |
author2 |
Teles Fujishima, Mayara Amoras Franca dos Santos, Braulio Erison Lima, Bruno de Paula Mastroianni, Patricia Carvalho [UNESP] Oliveira de Sousa, Francisco Fabio Silva, Jocivania Oliveira da |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Fed Amapa Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Sousa Lima, Carolina Miranda de Teles Fujishima, Mayara Amoras Franca dos Santos, Braulio Erison Lima, Bruno de Paula Mastroianni, Patricia Carvalho [UNESP] Oliveira de Sousa, Francisco Fabio Silva, Jocivania Oliveira da |
description |
Practices described as traditional medicine may coexist with formalized, science-based medicine. In this context, the present study aimed to verify the profile of the elderly who consumed herbal medicines concomitantly with medications and to identify suspected adverse drug reactions (ADRs) in the Brazilian Amazon (Macapa, Amapa). The study was carried out in two steps: a cross-sectional study (structured questionnaire) and a clinical study (pharmacotherapeutic follow-up). Out of 208 participants, 78.8% were female with age between 60 and 69 years (58.7%), 59.1% used herbal medicines concurrently with medications, and 40.9% did not report use of herbal medicine. Losartan was the most used medication, and Lippia alba (Mill.) N.E. Br was the most common herbal medicine used. The total prevalence of suspected ADRs, among the elderly who answered the structured questionnaire, was 41.3%, with 27.4% being in the elderly who used herbal medicines and medications, and 13.9% being in the elderly who used only medications. Meanwhile, the total prevalence of suspected ADRs was 71.0% among the elderly patients who underwent pharmacotherapeutic follow-up, 60.5% in elderly who used herbal medicines and medications, and 10.5% in elderly who used only medications. The most reported ADR symptoms were related to disorders that affect the nervous system (38.4%) in the structured questionnaire and related to digestive disorders (36.4%) in the pharmacotherapeutic follow-up. The probability associated with the occurrence of a given ADR in the face of a set of demographic, socioeconomic, and clinical variables was estimated; the results showed that, in the studied population, only sex (p = 0.030) had an influence on the occurrence of ADR. The prevalence of ADRs with probable causality was high in this study population, but it was only sex-related, although more prevalent in the elderly who consume herbal medicines. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T11:57:06Z 2019-10-04T11:57:06Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2019/9391802 Evidence-based Complementary And Alternative Medicine. London: Hindawi Ltd, 12 p., 2019. 1741-427X http://hdl.handle.net/11449/184359 10.1155/2019/9391802 WOS:000459017800001 |
url |
http://dx.doi.org/10.1155/2019/9391802 http://hdl.handle.net/11449/184359 |
identifier_str_mv |
Evidence-based Complementary And Alternative Medicine. London: Hindawi Ltd, 12 p., 2019. 1741-427X 10.1155/2019/9391802 WOS:000459017800001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evidence-based Complementary And Alternative Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 |
dc.publisher.none.fl_str_mv |
Hindawi Ltd |
publisher.none.fl_str_mv |
Hindawi Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129354573545472 |