Effects of swimming training on the femoral neck strength in growing rats with untreated streptozotocin-induced diabetes

• Autor(a) principal: da Silva, Ana Karina
• Data de Publicação: 2014
• Outros Autores: Del Carlo, Ricardo Junqueira, da Matta, Sérgio Luis Pinto, Louzada, Mario Jefferson Quirino, Rodrigues, Aurora Corrêa, da Silva, Márcia Ferreira, Drummond, Lucas Rios, de Castro, Cynthia Aparecida, Silva, Carlos Henrique Osorio, Natali, Antônio José
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/220426
• topic: Bone resistance; Exercise; Hip fracture; Osteopenia; Physical activity

Background: While type 1 diabetes mellitus (T1DM) increases bone fragility physical exercise improves bone quality and strength. Research question: To test whether swimming training attenuates the deterioration of femoral neck structural and mechanical properties in growing rats with untreated streptozotocin (STZ)-induced T1DM. Type of study: Randomised controlled study. Methods: Male Wistar rats (4-weeks-old; initial body weight: 80-90 g) were divided into 4 groups of 10 animals: diabetes sedentary (DS; 60 mg/kg of STZ, single i.p.); diabetes exercised (DE; 60 mg/kg of STZ, single i.p.); control sedentary (CS, same single dose of vehicle); and control exercised (CE, same single dose of vehicle). Six weeks later animals from DE and CE groups underwent a low- intensity swimming training (5 sessions/wk, 90 min/session, load: 4% of body weight) for 8 weeks. The femoral neck mechanical properties were measured. Bone mineral density (BMD) and mineral content (BMC), as well as the femoral neck bone volume (BV/TV) and collagen content were assessed. Results: Rats with T1DM exhibited reduced body weight, femoral weight and length, BMC and BMD, femoral neck collagen content, BV/TV, trabecular thickness, maximum load, stiffness and tenacity, and increased trabecular spacing compared to controls. Swimming training increased femoral BMC and BMD, femoral neck collagen content, BV/TV, trabecular thickness, stiffness and yield point energy, and reduced trabecular spacing in control animals, but not in T1DM animals. Conclusion: Low-intensity swimming training seems to be ineffective in attenuating the deterioration of the femoral neck structural and mechanical properties in growing rats with untreated STZ-induced T1DM.