A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-9199-JVATITD-1449-18 http://hdl.handle.net/11449/185442 |
Resumo: | Background: Tuberculosis (TB) is an infectious lung disease with high worldwide incidence that severely compromises the quality of life in affected individuals. Clinical tests are currently employed to monitor pulmonary status and treatment progression. The present study aimed to apply a three-dimensional (3D) reconstruction method based on chest radiography to quantify lung-involvement volume of TB acute-phase patients before and after treatment. In addition, these results were compared with indices from conventional clinical exams to show the coincidence level. Methods: A 3D lung reconstruction method using patient chest radiography was applied to quantify lung-involvement volume using retrospective examinations of 50 patients who were diagnosed with pulmonary TB and treated with two different drugs schemes. Twenty-five patients were treated with Scheme I (rifampicin, isoniazid, and pyrazinamide), whereas twenty-five patients were treated with Scheme II (rifampicin, isoniazid, pyrazinamide, and ethambutol). Acute-phase reaction: Serum exams included C-reactive protein levels, erythrocyte sedimentation rate, and albumin levels. Pulmonary function was tested posttreatment. Results: We found strong agreement between lung involvement and serum indices pre- and posttreatment. Comparison of the functional severity degree with lung involvement based on 3D image quantification for both treatment schemes found a high correlation. Conclusions: The present 3D reconstruction method produced a satisfactory agreement with the acute-phase reaction, most notably a higher significance level with the C-reactive protein. We also found a quite reasonable coincidence between the 3D reconstruction method and the degree of functional lung impairment posttreatment. The performance of the quantification method was satisfactory when comparing the two treatment schemes. Thus, the 3D reconstruction quantification method may be useful tools for monitoring TB treatment. The association with serum indices are not only inexpensive and sensitive but also may be incorporated into the assessment of patients during TB treatment. |
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A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment controlTuberculosisQuantificationLung involvementSerum testsPulmonary function testsBackground: Tuberculosis (TB) is an infectious lung disease with high worldwide incidence that severely compromises the quality of life in affected individuals. Clinical tests are currently employed to monitor pulmonary status and treatment progression. The present study aimed to apply a three-dimensional (3D) reconstruction method based on chest radiography to quantify lung-involvement volume of TB acute-phase patients before and after treatment. In addition, these results were compared with indices from conventional clinical exams to show the coincidence level. Methods: A 3D lung reconstruction method using patient chest radiography was applied to quantify lung-involvement volume using retrospective examinations of 50 patients who were diagnosed with pulmonary TB and treated with two different drugs schemes. Twenty-five patients were treated with Scheme I (rifampicin, isoniazid, and pyrazinamide), whereas twenty-five patients were treated with Scheme II (rifampicin, isoniazid, pyrazinamide, and ethambutol). Acute-phase reaction: Serum exams included C-reactive protein levels, erythrocyte sedimentation rate, and albumin levels. Pulmonary function was tested posttreatment. Results: We found strong agreement between lung involvement and serum indices pre- and posttreatment. Comparison of the functional severity degree with lung involvement based on 3D image quantification for both treatment schemes found a high correlation. Conclusions: The present 3D reconstruction method produced a satisfactory agreement with the acute-phase reaction, most notably a higher significance level with the C-reactive protein. We also found a quite reasonable coincidence between the 3D reconstruction method and the degree of functional lung impairment posttreatment. The performance of the quantification method was satisfactory when comparing the two treatment schemes. Thus, the 3D reconstruction quantification method may be useful tools for monitoring TB treatment. The association with serum indices are not only inexpensive and sensitive but also may be incorporated into the assessment of patients during TB treatment.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)INCT-FNAUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Fis & Biofis, Botucatu, SP, BrazilCtr Brasileiro Pesquisas Fis, Dept Altas Energias, Rio De Janeiro, RJ, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Doencas Tropicais & Diagnost Imagem, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Fis & Biofis, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Doencas Tropicais & Diagnost Imagem, Botucatu, SP, BrazilFAPESP: 2015/01948-3CAPES: 3/2016CAPES: 0722/2017CAPES: 88881.142062/2017-01CNPq: 18/2018CNPq: 404770/2018-5BmcUniversidade Estadual Paulista (Unesp)Ctr Brasileiro Pesquisas FisOliveira, Marcela de [UNESP]Duarte, Sergio BarbosaGiacomini, Guilherme [UNESP]Marques Pereira, Paulo Camara [UNESP]Souza, Lenice do Rosario de [UNESP]Arruda Miranda, Jose Ricardo de [UNESP]Pina, Diana Rodrigues de [UNESP]2019-10-04T12:35:34Z2019-10-04T12:35:34Z2019-02-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://dx.doi.org/10.1590/1678-9199-JVATITD-1449-18Journal Of Venomous Animals And Toxins Including Tropical Diseases. London: Bmc, v. 25, 10 p., 2019.1678-9199http://hdl.handle.net/11449/18544210.1590/1678-9199-JVATITD-1449-18S1678-91992019000100302WOS:000458925400001S1678-91992019000100302.pdf5020559826568182Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Venomous Animals And Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2023-12-08T06:24:17Zoai:repositorio.unesp.br:11449/185442Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-08T06:24:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control |
title |
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control |
spellingShingle |
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control Oliveira, Marcela de [UNESP] Tuberculosis Quantification Lung involvement Serum tests Pulmonary function tests |
title_short |
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control |
title_full |
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control |
title_fullStr |
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control |
title_full_unstemmed |
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control |
title_sort |
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control |
author |
Oliveira, Marcela de [UNESP] |
author_facet |
Oliveira, Marcela de [UNESP] Duarte, Sergio Barbosa Giacomini, Guilherme [UNESP] Marques Pereira, Paulo Camara [UNESP] Souza, Lenice do Rosario de [UNESP] Arruda Miranda, Jose Ricardo de [UNESP] Pina, Diana Rodrigues de [UNESP] |
author_role |
author |
author2 |
Duarte, Sergio Barbosa Giacomini, Guilherme [UNESP] Marques Pereira, Paulo Camara [UNESP] Souza, Lenice do Rosario de [UNESP] Arruda Miranda, Jose Ricardo de [UNESP] Pina, Diana Rodrigues de [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Ctr Brasileiro Pesquisas Fis |
dc.contributor.author.fl_str_mv |
Oliveira, Marcela de [UNESP] Duarte, Sergio Barbosa Giacomini, Guilherme [UNESP] Marques Pereira, Paulo Camara [UNESP] Souza, Lenice do Rosario de [UNESP] Arruda Miranda, Jose Ricardo de [UNESP] Pina, Diana Rodrigues de [UNESP] |
dc.subject.por.fl_str_mv |
Tuberculosis Quantification Lung involvement Serum tests Pulmonary function tests |
topic |
Tuberculosis Quantification Lung involvement Serum tests Pulmonary function tests |
description |
Background: Tuberculosis (TB) is an infectious lung disease with high worldwide incidence that severely compromises the quality of life in affected individuals. Clinical tests are currently employed to monitor pulmonary status and treatment progression. The present study aimed to apply a three-dimensional (3D) reconstruction method based on chest radiography to quantify lung-involvement volume of TB acute-phase patients before and after treatment. In addition, these results were compared with indices from conventional clinical exams to show the coincidence level. Methods: A 3D lung reconstruction method using patient chest radiography was applied to quantify lung-involvement volume using retrospective examinations of 50 patients who were diagnosed with pulmonary TB and treated with two different drugs schemes. Twenty-five patients were treated with Scheme I (rifampicin, isoniazid, and pyrazinamide), whereas twenty-five patients were treated with Scheme II (rifampicin, isoniazid, pyrazinamide, and ethambutol). Acute-phase reaction: Serum exams included C-reactive protein levels, erythrocyte sedimentation rate, and albumin levels. Pulmonary function was tested posttreatment. Results: We found strong agreement between lung involvement and serum indices pre- and posttreatment. Comparison of the functional severity degree with lung involvement based on 3D image quantification for both treatment schemes found a high correlation. Conclusions: The present 3D reconstruction method produced a satisfactory agreement with the acute-phase reaction, most notably a higher significance level with the C-reactive protein. We also found a quite reasonable coincidence between the 3D reconstruction method and the degree of functional lung impairment posttreatment. The performance of the quantification method was satisfactory when comparing the two treatment schemes. Thus, the 3D reconstruction quantification method may be useful tools for monitoring TB treatment. The association with serum indices are not only inexpensive and sensitive but also may be incorporated into the assessment of patients during TB treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:35:34Z 2019-10-04T12:35:34Z 2019-02-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-9199-JVATITD-1449-18 Journal Of Venomous Animals And Toxins Including Tropical Diseases. London: Bmc, v. 25, 10 p., 2019. 1678-9199 http://hdl.handle.net/11449/185442 10.1590/1678-9199-JVATITD-1449-18 S1678-91992019000100302 WOS:000458925400001 S1678-91992019000100302.pdf 5020559826568182 |
url |
http://dx.doi.org/10.1590/1678-9199-JVATITD-1449-18 http://hdl.handle.net/11449/185442 |
identifier_str_mv |
Journal Of Venomous Animals And Toxins Including Tropical Diseases. London: Bmc, v. 25, 10 p., 2019. 1678-9199 10.1590/1678-9199-JVATITD-1449-18 S1678-91992019000100302 WOS:000458925400001 S1678-91992019000100302.pdf 5020559826568182 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Venomous Animals And Toxins Including Tropical Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10 application/pdf |
dc.publisher.none.fl_str_mv |
Bmc |
publisher.none.fl_str_mv |
Bmc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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