Hybrids of amphibian chytrid show high virulence in native hosts
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1038/s41598-018-27828-w http://hdl.handle.net/11449/164344 |
Resumo: | Hybridization of parasites can generate new genotypes with high virulence. The fungal amphibian parasite Batrachochytrium dendrobatidis (Bd) hybridizes in Brazil's Atlantic Forest, a biodiversity hotspot where amphibian declines have been linked to Bd, but the virulence of hybrid genotypes in native hosts has never been tested. We compared the virulence (measured as host mortality and infection burden) of hybrid Bd genotypes to the parental lineages, the putatively hypovirulent lineage Bd-Brazil and the hypervirulent Global Pandemic Lineage (Bd-GPL), in a panel of native Brazilian hosts. In Brachycephalus ephippium, the hybrid exceeded the virulence (host mortality) of both parents, suggesting that novelty arising from hybridization of Bd is a conservation concern. In lschnocnema parva, host mortality in the hybrid treatment was intermediate between the parent treatments, suggesting that this species is more vulnerable to the aggressive phenotypes associated with Bd-GPL. Dendropsophus minutus showed low overall mortality, but infection burdens were higher in frogs treated with hybrid and Bd-GPL genotypes than with Bd-Brazil genotypes. Our experiment suggests that Bd hybrids have the potential to increase disease risk in native hosts. Continued surveillance is needed to track potential spread of hybrid genotypes and detect future genomic shifts in this dynamic disease system. |
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Hybrids of amphibian chytrid show high virulence in native hostsHybridization of parasites can generate new genotypes with high virulence. The fungal amphibian parasite Batrachochytrium dendrobatidis (Bd) hybridizes in Brazil's Atlantic Forest, a biodiversity hotspot where amphibian declines have been linked to Bd, but the virulence of hybrid genotypes in native hosts has never been tested. We compared the virulence (measured as host mortality and infection burden) of hybrid Bd genotypes to the parental lineages, the putatively hypovirulent lineage Bd-Brazil and the hypervirulent Global Pandemic Lineage (Bd-GPL), in a panel of native Brazilian hosts. In Brachycephalus ephippium, the hybrid exceeded the virulence (host mortality) of both parents, suggesting that novelty arising from hybridization of Bd is a conservation concern. In lschnocnema parva, host mortality in the hybrid treatment was intermediate between the parent treatments, suggesting that this species is more vulnerable to the aggressive phenotypes associated with Bd-GPL. Dendropsophus minutus showed low overall mortality, but infection burdens were higher in frogs treated with hybrid and Bd-GPL genotypes than with Bd-Brazil genotypes. Our experiment suggests that Bd hybrids have the potential to increase disease risk in native hosts. Continued surveillance is needed to track potential spread of hybrid genotypes and detect future genomic shifts in this dynamic disease system.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Alabama, Dept Biol Sci, Tuscaloosa, AL 35487 USAUniv Estadual Campinas, Dept Biol Anim, Lab Hist Nat Anfibios Brasileiros LaHNAB, BR-13083862 Campinas, SP, BrazilUniv Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USAUniv Estadual Paulista, Dept Zool, BR-13506900 Rio Claro, SP, BrazilUniv Estadual Paulista, Aquaculture Ctr CAUNESP, BR-13506900 Rio Claro, SP, BrazilUniv Estadual Paulista, Dept Zool, BR-13506900 Rio Claro, SP, BrazilUniv Estadual Paulista, Aquaculture Ctr CAUNESP, BR-13506900 Rio Claro, SP, BrazilFAPESP: 2011/51694-7FAPESP: 2013/50741-7FAPESP: 2016/25358-3CNPq: 405285/2013-2CNPq: 302518/2013-4CNPq: 300980/2014-0CNPq: 312895/2014-3CNPq: 300896/2016-6Nature Publishing GroupUniv AlabamaUniversidade Estadual de Campinas (UNICAMP)Univ MichiganUniversidade Estadual Paulista (Unesp)Greenspan, S. E.Lambertini, C.Carvalho, T.James, T. Y.Toledo, L. F.Haddad, C. F. B. [UNESP]Becker, C. G.2018-11-26T17:52:12Z2018-11-26T17:52:12Z2018-06-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://dx.doi.org/10.1038/s41598-018-27828-wScientific Reports. London: Nature Publishing Group, v. 8, 10 p., 2018.2045-2322http://hdl.handle.net/11449/16434410.1038/s41598-018-27828-wWOS:000436077800021WOS000436077800021.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reports1,533info:eu-repo/semantics/openAccess2023-12-22T06:26:02Zoai:repositorio.unesp.br:11449/164344Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:02:57.289784Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Hybrids of amphibian chytrid show high virulence in native hosts |
title |
Hybrids of amphibian chytrid show high virulence in native hosts |
spellingShingle |
Hybrids of amphibian chytrid show high virulence in native hosts Greenspan, S. E. |
title_short |
Hybrids of amphibian chytrid show high virulence in native hosts |
title_full |
Hybrids of amphibian chytrid show high virulence in native hosts |
title_fullStr |
Hybrids of amphibian chytrid show high virulence in native hosts |
title_full_unstemmed |
Hybrids of amphibian chytrid show high virulence in native hosts |
title_sort |
Hybrids of amphibian chytrid show high virulence in native hosts |
author |
Greenspan, S. E. |
author_facet |
Greenspan, S. E. Lambertini, C. Carvalho, T. James, T. Y. Toledo, L. F. Haddad, C. F. B. [UNESP] Becker, C. G. |
author_role |
author |
author2 |
Lambertini, C. Carvalho, T. James, T. Y. Toledo, L. F. Haddad, C. F. B. [UNESP] Becker, C. G. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Alabama Universidade Estadual de Campinas (UNICAMP) Univ Michigan Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Greenspan, S. E. Lambertini, C. Carvalho, T. James, T. Y. Toledo, L. F. Haddad, C. F. B. [UNESP] Becker, C. G. |
description |
Hybridization of parasites can generate new genotypes with high virulence. The fungal amphibian parasite Batrachochytrium dendrobatidis (Bd) hybridizes in Brazil's Atlantic Forest, a biodiversity hotspot where amphibian declines have been linked to Bd, but the virulence of hybrid genotypes in native hosts has never been tested. We compared the virulence (measured as host mortality and infection burden) of hybrid Bd genotypes to the parental lineages, the putatively hypovirulent lineage Bd-Brazil and the hypervirulent Global Pandemic Lineage (Bd-GPL), in a panel of native Brazilian hosts. In Brachycephalus ephippium, the hybrid exceeded the virulence (host mortality) of both parents, suggesting that novelty arising from hybridization of Bd is a conservation concern. In lschnocnema parva, host mortality in the hybrid treatment was intermediate between the parent treatments, suggesting that this species is more vulnerable to the aggressive phenotypes associated with Bd-GPL. Dendropsophus minutus showed low overall mortality, but infection burdens were higher in frogs treated with hybrid and Bd-GPL genotypes than with Bd-Brazil genotypes. Our experiment suggests that Bd hybrids have the potential to increase disease risk in native hosts. Continued surveillance is needed to track potential spread of hybrid genotypes and detect future genomic shifts in this dynamic disease system. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:52:12Z 2018-11-26T17:52:12Z 2018-06-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-018-27828-w Scientific Reports. London: Nature Publishing Group, v. 8, 10 p., 2018. 2045-2322 http://hdl.handle.net/11449/164344 10.1038/s41598-018-27828-w WOS:000436077800021 WOS000436077800021.pdf |
url |
http://dx.doi.org/10.1038/s41598-018-27828-w http://hdl.handle.net/11449/164344 |
identifier_str_mv |
Scientific Reports. London: Nature Publishing Group, v. 8, 10 p., 2018. 2045-2322 10.1038/s41598-018-27828-w WOS:000436077800021 WOS000436077800021.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports 1,533 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10 application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
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UNESP |
reponame_str |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1808129277584998400 |