The action of aminoguanidine on the liver of trained diabetic rats

• Autor(a) principal: e Nico, Edmara Tereza Meira [UNESP]
• Data de Publicação: 2013
• Outros Autores: de Oliveira, Patrícia Rosa [UNESP], de Souza, Leonardo Peres [UNESP], Pereira, Franco Dani Campos [UNESP], Delbin, Maria Andréia [UNESP], Zanesco, Angelina [UNESP], Camargo-Mathias, Maria Izabel [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1186/2251-6581-12-40
• Texto Completo: http://dx.doi.org/10.1186/2251-6581-12-40; http://hdl.handle.net/11449/75935
• topic: Aminoguanidine; Diabetes type 1; Liver; Physical exercises; Rats; aminoguanidine; polysaccharide; animal experiment; animal model; animal tissue; cellular distribution; controlled study; cytoplasm; diabetes mellitus; exercise; insulin dependent diabetes mellitus; Kupffer cell; liver; liver blood vessel; liver congestion; liver histology; liver hypertrophy; male; nonhuman; rat

Background: This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques.Methods: The rats used in this study were divided into five groups: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine.Results: The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels.Conclusion: Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin. © 2013 e Nico et al.; licensee BioMed Central Ltd.