Automatic Segmentation of Mandibular Ramus and Condyles
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1109/EMBC46164.2021.9630727 http://hdl.handle.net/11449/223202 |
Resumo: | In order to diagnose TMJ pathologies, we developed and tested a novel algorithm, MandSeg, that combines image processing and machine learning approaches for automatically segmenting the mandibular condyles and ramus. A deep neural network based on the U-Net architecture was trained for this task, using 109 cone-beam computed tomography (CBCT) scans. The ground truth label maps were manually segmented by clinicians. The U-Net takes 2D slices extracted from the 3D volumetric images. All the 3D scans were cropped depending on their size in order to keep only the mandibular region of interest. The same anatomic cropping region was used for every scan in the dataset. The scans were acquired at different centers with different resolutions. Therefore, we resized all scans to 512×512 in the pre-processing step where we also performed contrast adjustment as the original scans had low contrast. After the pre-processing, around 350 slices were extracted from each scan, and used to train the U-Net model. For the cross-validation, the dataset was divided into 10 folds. The training was performed with 60 epochs, a batch size of 8 and a learning rate of 2×10 -5 . The average performance of the models on the test set presented 0.95 ± 0.05 AUC, 0.93 ± 0.06 sensitivity, 0.9998 ± 0.0001 specificity, 0.9996 ± 0.0003 accuracy, and 0.91 ± 0.03 F1 score. This study findings suggest that fast and efficient CBCT image segmentation of the mandibular condyles and ramus from different clinical data sets and centers can be analyzed effectively. Future studies can now extract radiomic and imaging features as potentially relevant objective diagnostic criteria for TMJ pathologies, such as osteoarthritis (OA). The proposed segmentation will allow large datasets to be analyzed more efficiently for disease classification. |
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Automatic Segmentation of Mandibular Ramus and CondylesIn order to diagnose TMJ pathologies, we developed and tested a novel algorithm, MandSeg, that combines image processing and machine learning approaches for automatically segmenting the mandibular condyles and ramus. A deep neural network based on the U-Net architecture was trained for this task, using 109 cone-beam computed tomography (CBCT) scans. The ground truth label maps were manually segmented by clinicians. The U-Net takes 2D slices extracted from the 3D volumetric images. All the 3D scans were cropped depending on their size in order to keep only the mandibular region of interest. The same anatomic cropping region was used for every scan in the dataset. The scans were acquired at different centers with different resolutions. Therefore, we resized all scans to 512×512 in the pre-processing step where we also performed contrast adjustment as the original scans had low contrast. After the pre-processing, around 350 slices were extracted from each scan, and used to train the U-Net model. For the cross-validation, the dataset was divided into 10 folds. The training was performed with 60 epochs, a batch size of 8 and a learning rate of 2×10 -5 . The average performance of the models on the test set presented 0.95 ± 0.05 AUC, 0.93 ± 0.06 sensitivity, 0.9998 ± 0.0001 specificity, 0.9996 ± 0.0003 accuracy, and 0.91 ± 0.03 F1 score. This study findings suggest that fast and efficient CBCT image segmentation of the mandibular condyles and ramus from different clinical data sets and centers can be analyzed effectively. Future studies can now extract radiomic and imaging features as potentially relevant objective diagnostic criteria for TMJ pathologies, such as osteoarthritis (OA). The proposed segmentation will allow large datasets to be analyzed more efficiently for disease classification.School of Dentistry University of MichiganPsychiatry Department University of North CarolinaDepartment of Orthodontics University of the Pacific Arthur A. Dugoni School of DentistryDepartment of Orthodontics Federal University of Rio de JaneiroDepartment of Orthodontics Sao Paulo State UniversityDepartment of Orthodontics Federal University of CearaDepartment of Orthodontics University of Sao PauloDepartment of Orthodontics Federal University of GoiasDepartment of Computational Medicine and Bioinformatics Univ. of MichiganKitware Inc.Department of Orthodontics Sao Paulo State UniversityUniversity of MichiganUniversity of North CarolinaArthur A. Dugoni School of DentistryFederal University of Rio de JaneiroUniversidade Estadual Paulista (UNESP)Federal University of CearaUniversidade de São Paulo (USP)Federal University of GoiasUniv. of MichiganKitware Inc.Le, CeliaDeleat-Besson, RomainPrieto, JuanBrosset, SergeDumont, MaximeZhang, WinstonCevidanes, LuciaBianchi, JonasRuellas, AntonioGomes, Liliane [UNESP]Gurgel, MarcelaMassaro, CamilaAliaga-Del Castillo, AronYatabe, MariliaBenavides, ErikaSoki, FabianaAl Turkestani, NajlaEvangelista, KarineGoncalves, Joao [UNESP]Valladares-Neto, JoseAlves Garcia Silva, MariaChaves, CaubyCosta, FabioGarib, DanielaOh, HeesooGryak, JonathanStyner, MartinFillion-Robin, Jean-ChristophePaniagua, BeatrizNajarian, KayvanSoroushmehr, Reza2022-04-28T19:49:20Z2022-04-28T19:49:20Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject2952-2955http://dx.doi.org/10.1109/EMBC46164.2021.9630727Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, p. 2952-2955.1557-170Xhttp://hdl.handle.net/11449/22320210.1109/EMBC46164.2021.96307272-s2.0-85122499269Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBSinfo:eu-repo/semantics/openAccess2022-04-28T19:49:21Zoai:repositorio.unesp.br:11449/223202Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:20:51.684317Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Automatic Segmentation of Mandibular Ramus and Condyles |
title |
Automatic Segmentation of Mandibular Ramus and Condyles |
spellingShingle |
Automatic Segmentation of Mandibular Ramus and Condyles Le, Celia |
title_short |
Automatic Segmentation of Mandibular Ramus and Condyles |
title_full |
Automatic Segmentation of Mandibular Ramus and Condyles |
title_fullStr |
Automatic Segmentation of Mandibular Ramus and Condyles |
title_full_unstemmed |
Automatic Segmentation of Mandibular Ramus and Condyles |
title_sort |
Automatic Segmentation of Mandibular Ramus and Condyles |
author |
Le, Celia |
author_facet |
Le, Celia Deleat-Besson, Romain Prieto, Juan Brosset, Serge Dumont, Maxime Zhang, Winston Cevidanes, Lucia Bianchi, Jonas Ruellas, Antonio Gomes, Liliane [UNESP] Gurgel, Marcela Massaro, Camila Aliaga-Del Castillo, Aron Yatabe, Marilia Benavides, Erika Soki, Fabiana Al Turkestani, Najla Evangelista, Karine Goncalves, Joao [UNESP] Valladares-Neto, Jose Alves Garcia Silva, Maria Chaves, Cauby Costa, Fabio Garib, Daniela Oh, Heesoo Gryak, Jonathan Styner, Martin Fillion-Robin, Jean-Christophe Paniagua, Beatriz Najarian, Kayvan Soroushmehr, Reza |
author_role |
author |
author2 |
Deleat-Besson, Romain Prieto, Juan Brosset, Serge Dumont, Maxime Zhang, Winston Cevidanes, Lucia Bianchi, Jonas Ruellas, Antonio Gomes, Liliane [UNESP] Gurgel, Marcela Massaro, Camila Aliaga-Del Castillo, Aron Yatabe, Marilia Benavides, Erika Soki, Fabiana Al Turkestani, Najla Evangelista, Karine Goncalves, Joao [UNESP] Valladares-Neto, Jose Alves Garcia Silva, Maria Chaves, Cauby Costa, Fabio Garib, Daniela Oh, Heesoo Gryak, Jonathan Styner, Martin Fillion-Robin, Jean-Christophe Paniagua, Beatriz Najarian, Kayvan Soroushmehr, Reza |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Michigan University of North Carolina Arthur A. Dugoni School of Dentistry Federal University of Rio de Janeiro Universidade Estadual Paulista (UNESP) Federal University of Ceara Universidade de São Paulo (USP) Federal University of Goias Univ. of Michigan Kitware Inc. |
dc.contributor.author.fl_str_mv |
Le, Celia Deleat-Besson, Romain Prieto, Juan Brosset, Serge Dumont, Maxime Zhang, Winston Cevidanes, Lucia Bianchi, Jonas Ruellas, Antonio Gomes, Liliane [UNESP] Gurgel, Marcela Massaro, Camila Aliaga-Del Castillo, Aron Yatabe, Marilia Benavides, Erika Soki, Fabiana Al Turkestani, Najla Evangelista, Karine Goncalves, Joao [UNESP] Valladares-Neto, Jose Alves Garcia Silva, Maria Chaves, Cauby Costa, Fabio Garib, Daniela Oh, Heesoo Gryak, Jonathan Styner, Martin Fillion-Robin, Jean-Christophe Paniagua, Beatriz Najarian, Kayvan Soroushmehr, Reza |
description |
In order to diagnose TMJ pathologies, we developed and tested a novel algorithm, MandSeg, that combines image processing and machine learning approaches for automatically segmenting the mandibular condyles and ramus. A deep neural network based on the U-Net architecture was trained for this task, using 109 cone-beam computed tomography (CBCT) scans. The ground truth label maps were manually segmented by clinicians. The U-Net takes 2D slices extracted from the 3D volumetric images. All the 3D scans were cropped depending on their size in order to keep only the mandibular region of interest. The same anatomic cropping region was used for every scan in the dataset. The scans were acquired at different centers with different resolutions. Therefore, we resized all scans to 512×512 in the pre-processing step where we also performed contrast adjustment as the original scans had low contrast. After the pre-processing, around 350 slices were extracted from each scan, and used to train the U-Net model. For the cross-validation, the dataset was divided into 10 folds. The training was performed with 60 epochs, a batch size of 8 and a learning rate of 2×10 -5 . The average performance of the models on the test set presented 0.95 ± 0.05 AUC, 0.93 ± 0.06 sensitivity, 0.9998 ± 0.0001 specificity, 0.9996 ± 0.0003 accuracy, and 0.91 ± 0.03 F1 score. This study findings suggest that fast and efficient CBCT image segmentation of the mandibular condyles and ramus from different clinical data sets and centers can be analyzed effectively. Future studies can now extract radiomic and imaging features as potentially relevant objective diagnostic criteria for TMJ pathologies, such as osteoarthritis (OA). The proposed segmentation will allow large datasets to be analyzed more efficiently for disease classification. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-28T19:49:20Z 2022-04-28T19:49:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1109/EMBC46164.2021.9630727 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, p. 2952-2955. 1557-170X http://hdl.handle.net/11449/223202 10.1109/EMBC46164.2021.9630727 2-s2.0-85122499269 |
url |
http://dx.doi.org/10.1109/EMBC46164.2021.9630727 http://hdl.handle.net/11449/223202 |
identifier_str_mv |
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, p. 2952-2955. 1557-170X 10.1109/EMBC46164.2021.9630727 2-s2.0-85122499269 |
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eng |
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eng |
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Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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2952-2955 |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1808128499641221120 |