New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis

Detalhes bibliográficos
Autor(a) principal: Silva, Geraldo H. [UNESP]
Data de Publicação: 2005
Outros Autores: Araújo, Angela Regina [UNESP], Telesa, Helder L. [UNESP], Trevisana, Henrique C. [UNESP], Bolzani, Vanderlan da Silva [UNESP], Young, Maria C. M., Pfenning, Ludwig H., Eberlind, Marcos N., Haddad, Renato, Costa-Netoe, Claudio M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0103-50532005000800029
http://hdl.handle.net/11449/68473
Resumo: Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays. ©2005 Sociedade Brasileira de Química.
id UNSP_8bb870c449244ced02ecbff795b62911
oai_identifier_str oai:repositorio.unesp.br:11449/68473
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilisAntifungal activityCassia spectabilisCytotoxic metabolitesEndophytic fungiPhomopsis cassiaeTwo new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays. ©2005 Sociedade Brasileira de Química.Instituto de Química Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SPDepartamento de Fitopatologia Universidade Federal de Lavras, CP 37, 37200-000 Lavras-MGInstituto de Química Universidade Estadual de Campinas, CP 6154, 13083-970 Campinas-SPSeção de Fisiologia e Bioquímica de Plantas Instituto de Botânica, CP 4005, 97010-051 São Paulo-SPDepartamento de Bioquímica e Imunologia Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, 14049-900 Ribeirão Preto-SPInstituto de Química Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SPUniversidade Estadual Paulista (Unesp)Universidade Federal de Lavras (UFLA)Universidade Estadual de Campinas (UNICAMP)Instituto de BotânicaUniversidade de São Paulo (USP)Silva, Geraldo H. [UNESP]Araújo, Angela Regina [UNESP]Telesa, Helder L. [UNESP]Trevisana, Henrique C. [UNESP]Bolzani, Vanderlan da Silva [UNESP]Young, Maria C. M.Pfenning, Ludwig H.Eberlind, Marcos N.Haddad, RenatoCosta-Netoe, Claudio M.2014-05-27T11:21:40Z2014-05-27T11:21:40Z2005-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1463-1466application/pdfhttp://dx.doi.org/10.1590/S0103-50532005000800029Journal of the Brazilian Chemical Society, v. 16, n. 6 B, p. 1463-1466, 2005.0103-5053http://hdl.handle.net/11449/6847310.1590/S0103-50532005000800029S0103-50532005000800029WOS:0002340787000292-s2.0-308444456322-s2.0-30844445632.pdf003757905408316044840836852516730000-0001-7616-9652Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,357info:eu-repo/semantics/openAccess2023-11-11T06:15:47Zoai:repositorio.unesp.br:11449/68473Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:24:51.092683Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
title New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
spellingShingle New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
Silva, Geraldo H. [UNESP]
Antifungal activity
Cassia spectabilis
Cytotoxic metabolites
Endophytic fungi
Phomopsis cassiae
title_short New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
title_full New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
title_fullStr New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
title_full_unstemmed New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
title_sort New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
author Silva, Geraldo H. [UNESP]
author_facet Silva, Geraldo H. [UNESP]
Araújo, Angela Regina [UNESP]
Telesa, Helder L. [UNESP]
Trevisana, Henrique C. [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Young, Maria C. M.
Pfenning, Ludwig H.
Eberlind, Marcos N.
Haddad, Renato
Costa-Netoe, Claudio M.
author_role author
author2 Araújo, Angela Regina [UNESP]
Telesa, Helder L. [UNESP]
Trevisana, Henrique C. [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Young, Maria C. M.
Pfenning, Ludwig H.
Eberlind, Marcos N.
Haddad, Renato
Costa-Netoe, Claudio M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Lavras (UFLA)
Universidade Estadual de Campinas (UNICAMP)
Instituto de Botânica
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Silva, Geraldo H. [UNESP]
Araújo, Angela Regina [UNESP]
Telesa, Helder L. [UNESP]
Trevisana, Henrique C. [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Young, Maria C. M.
Pfenning, Ludwig H.
Eberlind, Marcos N.
Haddad, Renato
Costa-Netoe, Claudio M.
dc.subject.por.fl_str_mv Antifungal activity
Cassia spectabilis
Cytotoxic metabolites
Endophytic fungi
Phomopsis cassiae
topic Antifungal activity
Cassia spectabilis
Cytotoxic metabolites
Endophytic fungi
Phomopsis cassiae
description Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays. ©2005 Sociedade Brasileira de Química.
publishDate 2005
dc.date.none.fl_str_mv 2005-11-01
2014-05-27T11:21:40Z
2014-05-27T11:21:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-50532005000800029
Journal of the Brazilian Chemical Society, v. 16, n. 6 B, p. 1463-1466, 2005.
0103-5053
http://hdl.handle.net/11449/68473
10.1590/S0103-50532005000800029
S0103-50532005000800029
WOS:000234078700029
2-s2.0-30844445632
2-s2.0-30844445632.pdf
0037579054083160
4484083685251673
0000-0001-7616-9652
url http://dx.doi.org/10.1590/S0103-50532005000800029
http://hdl.handle.net/11449/68473
identifier_str_mv Journal of the Brazilian Chemical Society, v. 16, n. 6 B, p. 1463-1466, 2005.
0103-5053
10.1590/S0103-50532005000800029
S0103-50532005000800029
WOS:000234078700029
2-s2.0-30844445632
2-s2.0-30844445632.pdf
0037579054083160
4484083685251673
0000-0001-7616-9652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of the Brazilian Chemical Society
1.444
0,357
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1463-1466
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128807098384384

Registros relacionados