Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0247088 http://hdl.handle.net/11449/207329 |
Resumo: | Background Increased intra-abdominal pressure causes hemodynamic changes that may affect renal biomarkers. Methods This randomized, single-blind, single-center clinical trial recruited patients undergoing laparoscopic cholecystectomy at a tertiary care center in Brazil. They were randomly allocated to a standard intra-abdominal pressure group (P10-12, 10-12 mm Hg) and a low intra-abdominal pressure group (P6-8, 6-8 mm Hg). The primary outcome was the change in neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels measured at the beginning of the procedure (T0), at the end of the procedure (T1), and 24 hours after the procedure (T2). P-values < 0.05 were considered statistically significant. Results In total, 64 patients completed the study-33 were given standard pressure and 31 were given low pressure. There was no significant difference in the biomarker between the groups (P = 0.580), but there was a significant difference between the time points with elevation at T1 (P < 0.001). Similar to NGAL, cystatin C had an elevation at T1 in both groups (P = 0.021), but no difference was found when comparing the groups. Conclusions In laparoscopic cholecystectomy, pneumoperitoneum increases NGAL and cystatin C levels intraoperatively, and the use of low-pressure pneumoperitoneum does not change the course of these biomarkers. |
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spelling |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trialBackground Increased intra-abdominal pressure causes hemodynamic changes that may affect renal biomarkers. Methods This randomized, single-blind, single-center clinical trial recruited patients undergoing laparoscopic cholecystectomy at a tertiary care center in Brazil. They were randomly allocated to a standard intra-abdominal pressure group (P10-12, 10-12 mm Hg) and a low intra-abdominal pressure group (P6-8, 6-8 mm Hg). The primary outcome was the change in neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels measured at the beginning of the procedure (T0), at the end of the procedure (T1), and 24 hours after the procedure (T2). P-values < 0.05 were considered statistically significant. Results In total, 64 patients completed the study-33 were given standard pressure and 31 were given low pressure. There was no significant difference in the biomarker between the groups (P = 0.580), but there was a significant difference between the time points with elevation at T1 (P < 0.001). Similar to NGAL, cystatin C had an elevation at T1 in both groups (P = 0.021), but no difference was found when comparing the groups. Conclusions In laparoscopic cholecystectomy, pneumoperitoneum increases NGAL and cystatin C levels intraoperatively, and the use of low-pressure pneumoperitoneum does not change the course of these biomarkers.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Surgical Specialties and Anesthesiology Botucatu School of Medicine Universidade Estadual Paulista (UNESP)Centro Universitário Estácio de Ribeirão PretoDepartment of Anesthesiology São Rafael Hospital Federal University of BahiaClínica de Anestesiologia de Ribeirão Preto (CARP)School of Medicine Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)Department of Surgical Specialties and Anesthesiology Botucatu School of Medicine Universidade Estadual Paulista (UNESP)FAPESP: 2017/27032-0Universidade Estadual Paulista (Unesp)Centro Universitário Estácio de Ribeirão PretoUniversidade Federal da Bahia (UFBA)Clínica de Anestesiologia de Ribeirão Preto (CARP)Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)Filho, Marcos Antonio Marton [UNESP]Alves, Rodrigo Lealdo Nascimento, Paulo [UNESP]dos Santos Tarquinio, GabrielMega, Paulo FerreiraMódolo, Norma Sueli Pinheiro [UNESP]2021-06-25T10:53:22Z2021-06-25T10:53:22Z2021-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0247088PLoS ONE, v. 16, n. 2 February 2021, 2021.1932-6203http://hdl.handle.net/11449/20732910.1371/journal.pone.02470882-s2.0-85101348927Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS ONEinfo:eu-repo/semantics/openAccess2021-10-23T16:52:04Zoai:repositorio.unesp.br:11449/207329Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T16:52:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial |
title |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial |
spellingShingle |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial Filho, Marcos Antonio Marton [UNESP] |
title_short |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial |
title_full |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial |
title_fullStr |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial |
title_full_unstemmed |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial |
title_sort |
Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial |
author |
Filho, Marcos Antonio Marton [UNESP] |
author_facet |
Filho, Marcos Antonio Marton [UNESP] Alves, Rodrigo Leal do Nascimento, Paulo [UNESP] dos Santos Tarquinio, Gabriel Mega, Paulo Ferreira Módolo, Norma Sueli Pinheiro [UNESP] |
author_role |
author |
author2 |
Alves, Rodrigo Leal do Nascimento, Paulo [UNESP] dos Santos Tarquinio, Gabriel Mega, Paulo Ferreira Módolo, Norma Sueli Pinheiro [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Centro Universitário Estácio de Ribeirão Preto Universidade Federal da Bahia (UFBA) Clínica de Anestesiologia de Ribeirão Preto (CARP) Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
dc.contributor.author.fl_str_mv |
Filho, Marcos Antonio Marton [UNESP] Alves, Rodrigo Leal do Nascimento, Paulo [UNESP] dos Santos Tarquinio, Gabriel Mega, Paulo Ferreira Módolo, Norma Sueli Pinheiro [UNESP] |
description |
Background Increased intra-abdominal pressure causes hemodynamic changes that may affect renal biomarkers. Methods This randomized, single-blind, single-center clinical trial recruited patients undergoing laparoscopic cholecystectomy at a tertiary care center in Brazil. They were randomly allocated to a standard intra-abdominal pressure group (P10-12, 10-12 mm Hg) and a low intra-abdominal pressure group (P6-8, 6-8 mm Hg). The primary outcome was the change in neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels measured at the beginning of the procedure (T0), at the end of the procedure (T1), and 24 hours after the procedure (T2). P-values < 0.05 were considered statistically significant. Results In total, 64 patients completed the study-33 were given standard pressure and 31 were given low pressure. There was no significant difference in the biomarker between the groups (P = 0.580), but there was a significant difference between the time points with elevation at T1 (P < 0.001). Similar to NGAL, cystatin C had an elevation at T1 in both groups (P = 0.021), but no difference was found when comparing the groups. Conclusions In laparoscopic cholecystectomy, pneumoperitoneum increases NGAL and cystatin C levels intraoperatively, and the use of low-pressure pneumoperitoneum does not change the course of these biomarkers. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:53:22Z 2021-06-25T10:53:22Z 2021-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0247088 PLoS ONE, v. 16, n. 2 February 2021, 2021. 1932-6203 http://hdl.handle.net/11449/207329 10.1371/journal.pone.0247088 2-s2.0-85101348927 |
url |
http://dx.doi.org/10.1371/journal.pone.0247088 http://hdl.handle.net/11449/207329 |
identifier_str_mv |
PLoS ONE, v. 16, n. 2 February 2021, 2021. 1932-6203 10.1371/journal.pone.0247088 2-s2.0-85101348927 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS ONE |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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